miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone

Oncotarget

Volumn 7, Issue 43, 2016, Pages 70613-70622

  Fan, Jian Bo ^a,d   Ruan, Jian Wei ^b   Liu, Wei ^a   Zhu, Lun Qing ^c   Zhu, Xin Hui ^a   Yi, Hong ^a   Cui, Sheng Yu ^a   Zhao, Jian Ning ^d   Cui, Zhi Ming ^a  

^a NANTONG UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

AMP activated protein kinase (AMPK); Dexamethasone (Dex); MicroRNA 135b; Osteoblastic cells; Phosphatase 1E (Ppm1e)

Indexed keywords

DEXAMETHASONE; MICRORNA; MICRORNA 135B; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHATASE; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; GLUCOCORTICOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MIRN135 MICRORNA, HUMAN; PPM1E PROTEIN, HUMAN; PROTEIN PHOSPHATASE 2C;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; BONE NECROSIS; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENERGY METABOLISM; ENZYME ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; OSTEOBLAST; OXIDATIVE STRESS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

3' UNTRANSLATED REGIONS; AMP-ACTIVATED PROTEIN KINASES; CYTOPROTECTION; DEXAMETHASONE; DOWN-REGULATION; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; MICRORNAS; OSTEOBLASTS; OSTEONECROSIS; PROTEIN PHOSPHATASE 2C; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84994339006     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.12138     Document Type: Article

References (37)

1. Schacke H, Docke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther. 2002; 96:23-43.
2. Ding H, Wang T, Xu D, Cha B, Liu J, Li Y. Dexamethasoneinduced apoptosis of osteocytic and osteoblastic cells is mediated by TAK1 activation. Biochem Biophys Res Commun. 2015; 460:157-163.
3. Yun SI, Yoon HY, Jeong SY, Chung YS. Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase 3beta. J Bone Miner Metab. 2009; 27:140-148.
4. Ji F, Mao L, Liu Y, Cao X, Xie Y, Wang S, Fei H. K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. Biochem Biophys Res Commun. 2015; 458:568-575.
5. Fan JB, Liu W, Zhu XH, Yuan K, Xu DW, Chen JJ, Cui ZM. EGFR-AKT-mTOR activation mediates epiregulin-induced pleiotropic functions in cultured osteoblasts. Mol Cell Biochem. 2015; 398:105-113.
6. Zhen YF, Wang GD, Zhu LQ, Tan SP, Zhang FY, Zhou XZ, Wang XD. P53 dependent mitochondrial permeability transition pore opening is required for dexamethasoneinduced death of osteoblasts. J Cell Physiol. 2014; 229:1475-1483.
7. Fan JB, Liu W, Yuan K, Zhu XH, Xu DW, Chen JJ, Cui ZM. EGFR trans-activation mediates pleiotrophininduced activation of Akt and Erk in cultured osteoblasts. Biochem Biophys Res Commun. 2014; 447: 425-430.
8. Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest. 1999; 104:1363-1374.
9. Gohel A, McCarthy MB, Gronowicz G. Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro. Endocrinology. 1999; 140:5339-5347.
10. Carling D, Thornton C, Woods A, Sanders MJ. AMPactivated protein kinase: new regulation, new roles? Biochem J. 2012; 445:11-27.
11. Wang S, Song P, Zou MH. AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin Sci (Lond). 2012; 122:555-573.
12. Kim I, He YY. Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy. Front Oncol. 2013; 3:175.
13. Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011; 13:1016-1023.
14. Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature. 2012; 485:661-665.
15. Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Mechanism of action of compound-13: an alpha1-selective small molecule activator of AMPK. Chem Biol. 2014; 21:866-879.
16. Guo S, Mao L, Ji F, Wang S, Xie Y, Fei H, Wang XD. Activating AMP-activated protein kinase by an alpha1 selective activator Compound 13 attenuates dexamethasoneinduced osteoblast cell death. Biochem Biophys Res Commun. 2016.
17. Zhu Y, Zhou J, Ao R, Yu B. A-769662 protects osteoblasts from hydrogen dioxide-induced apoptosis through activating of AMP-activated protein kinase (AMPK). Int J Mol Sci. 2014; 15:11190-11203.
18. She C, Zhu LQ, Zhen YF, Wang XD, Dong QR. Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: New implications for osteonecrosis treatment? Cell Signal. 2014; 26:1-8.
19. Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012; 13:251-262.
20. Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 2007; 8:774-785.
21. Voss M, Paterson J, Kelsall IR, Martin-Granados C, Hastie CJ, Peggie MW, Cohen PT. Ppm1E is an in cellulo AMPactivated protein kinase phosphatase. Cell Signal. 2011; 23:114-124.
22. Takeuchi M, Taniguchi T, Fujisawa H. Identification and characterization of nuclear localization signals of CaMKP-N. J Biochem. 2004; 136:183-188.
23. Takeuchi M, Ishida A, Kameshita I, Kitani T, Okuno S, Fujisawa H. Identification and characterization of CaMKP-N, nuclear calmodulin-dependent protein kinase phosphatase. J Biochem. 2001; 130:833-840.
24. Balteau M, Van Steenbergen A, Timmermans AD, Dessy C, Behets-Wydemans G, Tajeddine N, Castanares-Zapatero D, Gilon P, Vanoverschelde JL, Horman S, Hue L, Bertrand L, Beauloye C. AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes. Am J Physiol Heart Circ Physiol. 2014.
25. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor alpha increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011; 286:44326-44335.
26. Zheng K, Lu H, Sheng Z, Li Y, Xu B. Low-concentration of perifosine surprisingly protects cardiomyocytes from oxygen glucose deprivation. Biochem Biophys Res Commun. 2016; 469:753-760.
27. den Uyl D, Bultink IE, Lems WF. Advances in glucocorticoid-induced osteoporosis. Curr Rheumatol Rep. 2011; 13:233-240.
28. Weinstein RS. Clinical practice. Glucocorticoid-induced bone disease. N Engl J Med. 2011; 365:62-70.
29. Kerachian MA, Seguin C, Harvey EJ. Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action. J Steroid Biochem Mol Biol. 2009; 114:121-128.
30. Xu Y, Li G, Du B, Zhang P, Xiao L, Sirois P, Li K. Hepcidin increases intracellular Ca2+ of osteoblast hFOB1.19 through L-type Ca2+ channels. Regul Pept. 2011; 172:58-61.
31. Zhu LQ, Zhen YF, Zhang Y, Guo ZX, Dai J, Wang XD. Salinomycin activates AMP-activated protein kinasedependent autophagy in cultured osteoblastoma cells: a negative regulator against cell apoptosis. PLoS One. 2013; 8:e84175.
32. Hentges KE, Kyttala M, Justice MJ, Peltonen L. Comparative physical maps of the human and mouse Meckel syndrome critical regions. Mamm Genome. 2004; 15:252-264.
33. Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014; 25:469-483.
34. Umezu T, Tadokoro H, Azuma K, Yoshizawa S, Ohyashiki K, Ohyashiki JH. Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. Blood. 2014; 124:3748-3757.
35. Chen MB, Wei MX, Han JY, Wu XY, Li C, Wang J, Shen W, Lu PH. MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer. Cell Signal. 2014; 26:102-109.
36. Lu PH, Chen MB, Ji C, Li WT, Wei MX, Wu MH. Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings. Oncotarget. 2016. doi: 10.18632/oncotarget.9969.
37. Hu X, Jiang F, Bao Q, Qian H, Fang Q, Shao Z. Compound 13, an alpha1-selective small molecule activator of AMPK, potently inhibits melanoma cell proliferation. Tumour Biol. 2015.