Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells

European Journal of Pharmacology

Volumn 654, Issue 1, 2011, Pages 10-16

  Kim, Sun Hee ^a   Ahn, Kwang Seok ^a   Jeong, Soo Jin ^a   Kwon, Tae Rin ^a   Jung, Ji Hoon ^a   Yun, Sun Mi ^a   Han, Ihn ^a   Lee, Seok Geun ^a   Kim, Dae Keun ^b   Kang, Minkyung ^c   Chen, Chang Yan ^d   Lee, Jung Weon ^c   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Woosuk University   (South Korea)

^c Seoul National University   (South Korea)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Bortezomib; Icariside II; Multiple myeloma; STAT3; Thalidomide

Indexed keywords

BORTEZOMIB; CASPASE 3; CYCLIN D1; CYCLOOXYGENASE 2; FLAVONOID; ICARISIDE II; JANUS KINASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; STAT3 PROTEIN; SURVIVIN; THALIDOMIDE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BORONIC ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JANUS KINASE 2; MULTIPLE MYELOMA; PYRAZINES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; THALIDOMIDE;

EID: 78951483886     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.11.032     Document Type: Article

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