IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever

American Journal of Pathology

Volumn 187, Issue 2, 2017, Pages 236-244

  Sharma, Deepika ^a   Sharma, Bhesh Raj ^a   Vogel, Peter ^a   Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; CASPASE 8; CD11B ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOGLOBIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PYRIN; TUMOR NECROSIS FACTOR; CASP8 PROTEIN, MOUSE;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOINFLAMMATORY DISEASE; CASPASE ACTIVATION AND RECRUITMENT DOMAIN; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; FAMILIAL MEDITERRANEAN FEVER; GENE DELETION; GENE MUTATION; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HETEROZYGOSITY; IN VIVO STUDY; LYMPHOCYTOPENIA; MEAN CORPUSCULAR VOLUME; MONOCYTE; MOUSE; MULTIPLE ORGAN FAILURE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; ANIMAL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE TARGETING; IMMUNOLOGY;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CASPASE 1; CASPASE 8; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FAMILIAL MEDITERRANEAN FEVER; FLOW CYTOMETRY; GENE KNOCK-IN TECHNIQUES; INTERLEUKIN-1BETA; MICE;

EID: 85009480842     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2016.10.015     Document Type: Article

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