Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages 1072-1077

  Cassel, Suzanne L ^a,b   Janczy, John R ^a   Bing, Xinyu ^b   Wilson, Shruti P ^b   Olivier, Alicia K ^b   Otero, Jesse E ^a   Iwakura, Yoichiro ^c,d   Shayakhmetov, Dmitry M ^e   Bassuk, Alexander G ^b   Abu Amer, Yousef ^f   Brogden, Kim A ^g   Burns, Trudy L ^a,b   Sutterwala, Fayyaz S ^a,b,h   Ferguson, Polly J ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF IOWA   (United States)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Chronic osteomyelitis; Innate immunity

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROLINE SERINE THREONINE PHOSPHATASE INTERACTING PROTEIN 2; PROTEIN SERINE THREONINE KINASE; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOINFLAMMATORY DISEASE; BONE MARROW; CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; DISEASE COURSE; DISEASE SEVERITY; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; WILD TYPE;

CHRONIC OSTEOMYELITIS; INNATE IMMUNITY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BONE MARROW CELLS; CYTOKINES; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; MUTATION, MISSENSE; NEUTROPHILS; OSTEOMYELITIS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-1;

EID: 84892917064     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318685111     Document Type: Article

References (31)

1. Ferguson PJ, Sandu M (2012) Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep 14(2):130-141.
2. Ferguson PJ, El-Shanti HI (2007) Autoinflammatory bone disorders. Curr Opin Rheumatol 19(5):492-498.
3. Aksentijevich I, et al. (2009) An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med 360(23):2426-2437.
4. Herlin T, et al. (2013) Efficacy of anti-IL-1 treatment in Majeed syndrome. Ann Rheum Dis 72(3):410-413.
5. Majeed HA, Al-Tarawna M, El-Shanti H, Kamel B, Al-Khalaileh F (2001) The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review. Eur J Pediatr 160(12):705-710.
6. Ferguson PJ, et al. (2006) A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis. Bone 38(1):41-47.
7. Grosse J, et al. (2006) Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Blood 107(8):3350-3358.
8. Byrd L, Grossmann M, Potter M, Shen-Ong GL (1991) Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse. Genomics 11(4):794-798.
9. Chitu V, et al. (2009) Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice. Blood 114(12):2497-2505.
10. Ting JP, Kastner DL, Hoffman HM (2006) CATERPILLERs, pyrin and hereditary immunological disorders. Nat Rev Immunol 6(3):183-195.
11. Agostini L, et al. (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20(3):319-325.
12. Leemans JC, Cassel SL, Sutterwala FS (2011) Sensing damage by the NLRP3 inflammasome. Immunol Rev 243(1):152-162.
13. Hazuda DJ, Strickler J, Kueppers F, Simon PL, Young PR (1990) Processing of precursor interleukin 1 beta and inflammatory disease. J Biol Chem 265(11):6318-6322.
14. Mizutani H, Schechter N, Lazarus G, Black RA, Kupper TS (1991) Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J Exp Med 174(4):821-825.
15. Schönbeck U, Mach F, Libby P (1998) Generation of biologically active IL-1 beta by matrix metalloproteinases: A novel caspase-1-independent pathway of IL-1 beta processing. J Immunol 161(7):3340-3346.
16. Kono H, Orlowski GM, Patel Z, Rock KL (2012) The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C. J Immunol 189(7):3734-3740.
17. Joosten LA, et al. (2009) Inflammatory arthritis in caspase 1 gene-deficient mice: Contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. Arthritis Rheum 60(12):3651-3662.
18. Irmler M, et al. (1995) Granzyme A is an interleukin 1 beta-converting enzyme. J Exp Med 181(5):1917-1922.
19. Stehlik C (2009) Multiple interleukin-1beta-converting enzymes contribute to inflammatory arthritis. Arthritis Rheum 60(12):3524-3530.
20. Fantuzzi G, et al. (1997) Response to local inflammation of IL-1 beta-converting enzyme-deficient mice. J Immunol 158(4):1818-1824.
21. Guma M, et al. (2009) Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum 60(12):3642-3650.
22. Schreiber A, et al. (2012) Neutrophil serine proteases promote IL-1β generation and injury in necrotizing crescentic glomerulonephritis. J Am Soc Nephrol 23(3):470-482.
23. Rech J, et al. (2012) Adult-onset Still's disease and chronic recurrent multifocal osteomyelitis: A hitherto undescribed manifestation of autoinflammation. Rheumatol Int 32(6):1827-1829.
24. Colina M, et al. (2010) Dysregulation of P2X7 receptor-inflammasome axis in SA-PHO syndrome: Successful treatment with anakinra. Rheumatology (Oxford) 49(7):1416-1418.
25. Eleftheriou D, et al. (2010) Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood. Rheumatology (Oxford) 49(8):1505-1512.
26. Kuida K, et al. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267(5206):2000-2003.
27. Sutterwala FS, et al. (2006) Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24(3):317-327.
28. Glaccum MB, et al. (1997) Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol 159(7):3364-3371.
29. Horai R, et al. (1998) Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 187(9):1463-1475.
30. Shornick LP, et al. (1996) Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone. J Exp Med 183(4):1427-1436.
31. Boxio R, Bossenmeyer-Pourié C, Steinckwich N, Dournon C, Nüsse O (2004) Mouse bone marrow contains large numbers of functionally competent neutrophils. J Leukoc Biol 75(4):604-611.