The Familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-{kappa}B through its N-terminal fragment

Blood

Volumn 112, Issue 5, 2008, Pages 1794-1803

  Chae, Jae Jin ^a   Wood, Geryl ^a   Richard, Katharina ^a   Jaffe, Howard ^b   Colburn, Nona T ^a   Masters, Seth L ^a   Gumucio, Deborah L ^c   Shoham, Nitza G ^a   Kastner, Daniel L ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CALPAIN; COLCHICINE; CYTOSKELETON PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN PYRIN; UNCLASSIFIED DRUG; I KAPPA B; MARENOSTRIN; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR RELA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; AUTOINFLAMMATORY DISEASE; CONTROLLED STUDY; ENZYME SUBSTRATE; FAMILIAL MEDITERRANEAN FEVER; GENE MUTATION; HUMAN; HUMAN CELL; LEUKOCYTE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; BINDING SITE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HELA CELL; IN VITRO STUDY; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; CALPAIN; CASPASE 1; CELL LINE; COLCHICINE; CYTOSKELETAL PROTEINS; FAMILIAL MEDITERRANEAN FEVER; GENOTYPE; HELA CELLS; HUMANS; I-KAPPA B PROTEINS; MUTATION; NF-KAPPA B; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTOR RELA; TRANSFECTION;

EID: 52649104806     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-01-134932     Document Type: Article

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