5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4207-4209

  Skinner, Philip J ^a   Webb, Peter J ^a   Sage, Carleton R ^a   Dang, Huong T ^a   Pride, Cameron C ^a   Chen, Ruoping ^a   Tamura, Susan Y ^a   Richman, Jeremy G ^a   Connolly, Daniel T ^a   Semple, Graeme ^a  

^a ARENA PHARMACEUTICALS   (United States)

Author keywords

Atherosclerosis; Dyslipidemia; Flushing; GPCR; GPR109a; GPR109b; HDL; HM74; HM74a; LDL; Niacin; Pyrazole; Reductive amination

Indexed keywords

5 AMINOPYRAZOLE 3 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 109B; NICOTINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SUBSTITUTION; DRUG SYNTHESIS; NONHUMAN;

ANIMALS; ATHEROSCLEROSIS; CARBOXYLIC ACIDS; CHEMISTRY, PHARMACEUTICAL; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; DYSLIPIDEMIAS; HUMANS; LIGANDS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MODELS, CHEMICAL; NIACIN; PYRAZOLES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC;

EID: 67649984195     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.108     Document Type: Article

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