1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1227-1230

  Semple, Graeme ^a   Skinner, Philip J ^a   Cherrier, Martin C ^a   Webb, Peter J ^a   Sage, Carleton R ^a   Tamura, Susan Y ^a   Chen, Ruoping ^a   Richman, Jeremy G ^a   Connolly, Daniel T ^a  

^a ARENA PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYLBENZOTRIAZOLE 5 CARBOXYLIC ACID; 1 CYCLOBUTYLBENZOTRIAZOLE 5 CARBOXYLIC ACID; 1 CYCLOHEXYLBENZOTRIAZOLE 5 CARBOXYLIC ACID; 1 CYCLOPROPYLBENZOTRIAZOLE 5 CARBOXYLIC ACID; 1 ISOPROPYLBENZOTRIAZOLE 5 CARBOXYLIC ACID; BENZOTRIAZOLE 5 CARBOXYLIC ACID DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 109A; G PROTEIN COUPLED RECEPTOR 109B; HIGH DENSITY LIPOPROTEIN; NICOTINIC ACID; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CHOLESTEROL BLOOD LEVEL; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING;

ADIPOCYTES; ANTILIPEMIC AGENTS; BINDING SITES; CARBOXYLIC ACIDS; CYCLIC AMP; HUMANS; LIGANDS; LIPOLYSIS; NIACIN; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 33144455148     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051099t     Document Type: Article

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