BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer

Cancer Cell

Volumn 31, Issue 1, 2017, Pages 79-93

  López García, Carlos ^a   Sansregret, Laurent ^a   Domingo, Enric ^b,c   McGranahan, Nicholas ^a,d   Hobor, Sebastijan ^a   Birkbak, Nicolai Juul ^a,d   Horswell, Stuart ^a   Grönroos, Eva ^a   Favero, Francesco ^a,e   Rowan, Andrew J ^a   Matthews, Nicholas ^a   Begum, Sharmin ^a   Phillimore, Benjamin ^a   Burrell, Rebecca ^a   Oukrif, Dahmane ^f   Spencer Dene, Bradley ^a   Kovac, Michal ^b   Stamp, Gordon ^a   Stewart, Aengus ^a   Danielsen, Havard ^g   Novelli, Marco ^f   Tomlinson, Ian ^b   Swanton, Charles ^a,d   more..

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^f ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^g OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

aneuploidy tolerance; BCL9L; BID; caspase 2; chromosomal instability; chromosome segregation errors; colorectal cancer evolution; intratumor heterogeneity; mitotic checkpoint; p53

Indexed keywords

BCL9L PROTEIN; BETA CATENIN; CASPASE 2; MESSENGER RNA; OLIGONUCLEOTIDE; PROTEIN BID; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG; BCL9L PROTEIN, HUMAN; BID PROTEIN, HUMAN; CASP2 PROTEIN, HUMAN; CYSTEINE PROTEINASE; DNA BINDING PROTEIN; MDM2 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; ANEUPLOIDY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; COLON CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOKINESIS; G1 PHASE CELL CYCLE CHECKPOINT; GENE MUTATION; GENETIC HETEROGENEITY; GENOME; GENOMIC INSTABILITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; METAPHASE; NONSENSE MUTATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SOMATIC MUTATION; WNT SIGNALING PATHWAY; AGED; ANIMAL; COLORECTAL TUMOR; GENETICS; HCT 116 CELL LINE; MIDDLE AGED; MOUSE; MUTATION; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANEUPLOIDY; ANIMALS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 2; CHROMOSOME SEGREGATION; COLORECTAL NEOPLASMS; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; HCT116 CELLS; HUMANS; MICE; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS C-MDM2; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85009126467     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2016.11.001     Document Type: Article

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