Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells

Cell Cycle

Volumn 14, Issue 17, 2015, Pages 2810-2820

  Kuznetsova, Anastasia Y ^a   Seget, Katarzyna ^a   Moeller, Giuliana K ^a   de Pagter, Mirjam S ^b   de Roos, Jeroen A D M ^c   Dürrbaum, Milena ^a   Kuffer, Christian ^a   Müller, Stefan ^d   Zaman, Guido J R ^c   Kloosterman, Wigard P ^b   Storchová, Zuzana ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Netherlands Translational Research Center BV   (Netherlands)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Aneuploidy; Cancer; CIN; Drug resistance; p53; Tetraploidy; Whole genome doubling

Indexed keywords

CISPLATIN; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; MERCAPTOPURINE; PACLITAXEL; PELITINIB; PROTEIN P53; ANTINEOPLASTIC AGENT;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DOWN REGULATION; GENOME; HUMAN; HUMAN CELL; KARYOTYPING; MITOSIS; MULTIDRUG RESISTANCE; PHENOTYPE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TETRAPLOIDY; DOSE RESPONSE; DRUG EFFECTS; HCT 116 CELL LINE; PHYSIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; HCT116 CELLS; HUMANS; MITOSIS; TETRAPLOIDY;

EID: 84954540103     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1068482     Document Type: Article

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