Colorectal cancer without high microsatellite instability and chromosomal instability - An alternative genetic pathway to human colorectal cancer

Carcinogenesis

Volumn 25, Issue 5, 2004, Pages 841-846

  Tang, Reiping ^a   Changchien, Chung Rong ^a   Wu, Meng Chih ^a   Fan, Chung Wei ^a   Liu, Kwang Wen ^a   Chen, Jinn Shiun ^a   Chien, Huei Tzu ^b   Hsieh, Ling Ling ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; PROTEIN P53;

ADULT; AGED; ANEUPLOIDY; ARTICLE; CHROMOSOME DISORDER; CHROMOSOME LOSS; CHROMOSOME REARRANGEMENT; COLORECTAL CANCER; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; GENE MUTATION; GENETIC HETEROGENEITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROSATELLITE INSTABILITY; MUCINOUS CARCINOMA; MUTATION RATE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STABILITY; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; ADENOCARCINOMA, MUCINOUS; ANEUPLOIDY; CARRIER PROTEINS; CELL CYCLE; CELL DIFFERENTIATION; CHROMOSOMAL INSTABILITY; COLON; COLORECTAL NEOPLASMS; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; GENES, RAS; HUMANS; IMMUNOENZYME TECHNIQUES; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2442619253     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh074     Document Type: Article

References (40)

1. Ried,T., Heselmeyer-Haddad,K., Blegen,H., Schrock,E. and Auer,G. (1999) Genomic changes defining the genesis, progression and malignancy potential in solid human tumors: a phenotype/genotype correlation. Genes Chromosomes Cancer, 25, 195-204.
2. Luebeck,E.G. and Moolgavkar,S.H. (2002) Multistage carcinogenesis and the incidence of colorectal cancer. Proc. Natl Acad. Sci. USA, 99, 15095-15100.
3. Stoler,D.L., Chen,N., Basik,M., Kahlenberg,M.S., Rodriguez-Bigas,M.A., Petrelli,N.J. and Anderson,G.R. (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl Acad. Sci. USA, 96, 15121-15126.
4. Lengauer,C., Kinzler,K.W. and Vogelstein,B. (1997) Genetic instability in colorectal cancers. Nature, 386, 623-627.
5. Lengauer,C., Kinzler,K.W. and Vogelstein,B. (1998) Genetic instabilities in human cancers. Nature, 396, 643-649.
6. Nowak,M.A., Komarova,N.L., Sengupta,A., Jallepalli,P.V., Shih,I.M., Vogelstein,B. and Lengauer,C. (2002) The role of chromosomal instability in tumor initiation. Proc. Natl Acad. Sci. USA, 99, 16226-16231.
7. Boland,C.R., Thibodeau,S.N., Hamilton,S.R. et al. (1998) A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res., 58, 5248-5257.
8. Strand,M., Prolla,T.A., Liskay,R.M. and Petes,T.D. (1993) Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature, 365, 274-276.
9. Herman,J.G., Umar,A., Polyak,K. et al. (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl Acad. Sci. USA, 95, 6870-6875.
10. Duval,A. and Hamelin,R. (2002) Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability. Cancer Res., 62, 2447-2454.
11. Smith,G., Carey,F.A., Beattie,J., Wilkie,M.J.V., Lightfoot,T.J., Coxhead,J., Garner,R.C., Steele,R.J.C. and Wolf,C.R. (2002) Mutations in APC, Kirsten-ras and p53 - alternative genetic pathways to colorectal cancer. Proc. Natl Acad. Sci. USA, 99, 9433-9438.
12. Goel,A., Arnold,C.N., Niedzwiecki,D. et al. (2003) Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res., 63, 1608-1614.
13. Thibodeau,S.N., Bren,G. and Schaid,D. (1993) Microsatellite instability in cancer of the proximal colon. Science, 260, 816-819.
14. Georgiades,I.B., Curtis,L.J., Morris,R.M., Bird,C.C. and Wyllie,A.H. (1999) Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability. Oncogene, 18, 7933-7940.
15. Hawkins,N.J., Tomlinson,I., Meagher,A. and Ward,R.L. (2001) Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer. Br. J. Cancer, 84, 232-236.
16. Yao,J., Eu,K.W., Seow-Choen,F., Vuayan,V. and Cheah,O.Y. (1999) Microsatellite instability and aneuploidy rate in young colorectal-cancer patients do not differ significantly form those in older patients. Int. J. Cancer, 80, 667-670.
17. Chan,T.L., Curtis,L.C., Leung,S.Y. et al. (2001) Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes. Oncogene, 20, 4871-4876.
18. Tang,R., Wang,P.F., Wang,H.C., Wang,J.Y. and Hsieh,L.L. (2001) Mutations of p53 gene in human colorectal cancer: distinct frameshifts among populations. Int. J. Cancer, 91, 863-868.
19. Tang,R., Ho,Y.S., Chen,H.H., See,L.C. and Wang,J.Y. (1998) Different prognostic effect of postoperative chemoradiation therapy on diploid and nondiploid high-risk rectal cancers. Dis. Colon Rectum, 41, 1494-1499.
20. Jiang,W., Kahn,S.M., Guillem,J.G., Lu,S.H. and Weinstein,I.B. (1989) Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal and gastric cancer. Oncogene, 4, 923-928.
21. Nollau,P., Moser,C., Weinland,G. and Wagener,C. (1996) Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR. Int. J. Cancer, 66, 332-336.
22. Tominaga,O., Hamelin,R., Trouvat,V., Salmon,R.J., Lesec,G., Thomas,G. and Remvikos,Y. (1993) Frequently elevated content of immunochemically defined wild-type p53 protein in colorectal adenomas. Oncogene, 8, 2653-2658.
23. Bosari,S., Viale,G., Bossi,P., Maggioni,M., Coggi,G., Murray,J.J. and Lee,A.K. (1994) Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas. J. Natl Cancer Inst., 86, 681-687.
24. Freedman,A.N., Michalek,A.M., Marshall,J.R., Mettlin,C.J., Petrelli,N.J., Black,J.D., Zhang,Z.F., Satchidanand,S. and Asirwatham,J.E. (1996) Familial and nutritional risk factors for p53 overexpression in colorectal cancer. Cancer Epidemiol. Biomarkers Prev., 5, 285-291.
25. Poller,D.N., Baxter,K.J. and Shepherd,N.A. (1997) p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer? Br. J. Cancer, 75, 87-93.
26. Baas,I.O., Mulder,J.W., Offerhaus,G.J., Vogelstein,B. and Hamilton,S.R. (1994) An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms. J. Pathol., 172, 5-12.
27. Costa,A., Marasca,R., Valentinis,B., Savarino,M., Faranda,A., Silvestrini,R. and Torelli,G. (1995) p53 gene point mutations in relation to p53 nuclear protein accumulation in colorectal cancers. J. Pathol., 176, 45-53.
28. Lindor,N.M., Burgart,L.J., Leontovich,O. et al. (2002) Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J. Clin. Oncol., 20, 1043-1048.
29. Lothe,R.A., Peltomaki,P., Meling,G.I. et al. (1993) Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res., 53, 5849-5852.
30. Aaltonen,L.A., Peltomaki,P., Leach,F.S. et al. (1993) Clues to the pathogenesis of familial colorectal cancer. Science, 260, 812-816.
31. Olschwang,S., Hamelin,R., Laurent-Puig,P., Thuille,B., De Rycke,Y., Li,Y.J., Muzeau,F., Girodet,J., Salmon,R.J. and Thomas,G. (1997) Alternative genetic pathways in colorectal carcinogenesis. Proc. Natl Acad. Sci. USA, 94, 12122-12127.
32. Samowitz,W.S., Holden,J.A., Curtin,K. et al. (2001) Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer. Am. J. Pathol., 158, 1517-1524.
33. Greenblatt,M.S., Bennett,W.P., Hollstein,M. and Harris,C.C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54, 4855-4878.
34. Haupt,Y., Maya,R., Kazaz,A. and Oren,M. (1997) Mdm2 promotes the rapid degradation of p53. Nature, 387, 296-299.
35. Kubbutat,M.H., Jones,S.N. and Vousden,K.H. (1997) Regulation of p53 stability by Mdm2. Nature, 387, 299-303.
36. Yin,Y., Stephen,C.W., Luciani,M.G. and Fahraeus,R. (2002) p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat. Cell Biol., 4, 462-467.
37. Lane,D.P. (1994) The regulation of p53 function: Steiner Award Lecture. Int. J. Cancer, 57, 623-627.
38. Vogelstein,B., Lane,D. and Levine,A.J. (2000) Surfing the p53 network. Nature, 408, 307-310.
39. Burri,N., Shaw,P., Bouzourene,H., Sordat,I., Sordat,B., Gillet,M., Schorderet,D., Bosman,F.T. and Chaubert,P. (2001) Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. Lab. Invest., 81, 217-229.
40. Esteller,M., Tortola,S., Toyota,M., Capella,G., Peinado,M.A., Baylin,S.B. and Herman,J.G. (2000) Hypermethylation-associated inactivation of p14 (ARF) is independent of p16 (INK4a) methylation and p53 mutational status. Cancer Res., 60, 129-133.