메뉴 건너뛰기




Volumn 7, Issue 1, 2013, Pages 1-8

Flavonoids as Potential Anti-Hepatocellular Carcinoma Agents: Recent Approaches Using HepG2 Cell Line

Author keywords

Flavonoids; hepatocellular carcinoma; HepG2; herb medicine

Indexed keywords


EID: 85008737571     PISSN: 18817831     EISSN: 1881784x     Source Type: Journal    
DOI: 10.5582/ddt.2013.v7.1.1     Document Type: Article
Times cited : (36)

References (75)
  • 1
    • 33646413672 scopus 로고    scopus 로고
    • The global health burden of infection-associated cancers in the year 2002
    • Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006; 118:3030-3044.
    • Int J Cancer. , vol.2006 , pp. 3030-3044
    • Parkin, D.M.1
  • 2
    • 0034847219 scopus 로고    scopus 로고
    • Integration of Chinese medicine into supportive cancer care:A modern role for an ancient tradition
    • Wong R, Sagar CM, Sagar SM. Integration of Chinese medicine into supportive cancer care: A modern role for an ancient tradition. Cancer Treat Rev. 2001; 27:235-246.
    • (2001) Cancer Treat Rev. , vol.27 , pp. 235-246
    • Wong, R.1    Sagar, C.M.2    Sagar, S.M.3
  • 5
    • 35748986165 scopus 로고    scopus 로고
    • Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part II: Reconstruction of multienzyme pathways in plants and microbes.
    • Ververidis F, Trantas E, Douglas C, Vollmer G, Kretzschmar G, Panopoulos N. Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part II: Reconstruction of multienzyme pathways in plants and microbes. Biotechnol J. 2007; 2:1235-1249.
    • (2007) Biotechnol J. , vol.2 , pp. 1235-1249
    • Ververidis, F.1    Trantas, E.2    Douglas, C.3    Vollmer, G.4    Kretzschmar, G.5    Panopoulos, N.6
  • 6
    • 77956893733 scopus 로고    scopus 로고
    • Traditional Chinese medicine and related active compounds against hepatitis B virus infection
    • Cui X, Wang Y, Kokudo N, Fang D, Tang W. Traditional Chinese medicine and related active compounds against hepatitis B virus infection. Biosci Trends. 2010; 4:39-47.
    • (2010) Biosci Trends. , vol.4 , pp. 39-47
    • Cui, X.1    Wang, Y.2    Kokudo, N.3    Fang, D.4    Tang, W.5
  • 7
    • 84902198277 scopus 로고    scopus 로고
    • Spicatic acid:A 4-carboxygentisic acid from Gentiana spicata extract with potential hepatoprotective activity
    • Handoussa H, Osmanova N, Ayoub N, Mahran L. Spicatic acid: A 4-carboxygentisic acid from Gentiana spicata extract with potential hepatoprotective activity. Drug Discov Ther. 2009; 3:278-286.
    • (2009) Drug Discov Ther. , vol.3 , pp. 278-286
    • Handoussa, H.1    Osmanova, N.2    Ayoub, N.3    Mahran, L.4
  • 8
    • 85008733152 scopus 로고    scopus 로고
    • Neuroprotective and hepatoprotective effects of micronized purified flavonoid fraction (Daflon®) in lipopolysaccharide-treated rats
    • Abdel-Salam OME, Youness ER, Mohammed NA, Abd-Elmoniem M, Omara E, Sleem AA. Neuroprotective and hepatoprotective effects of micronized purified flavonoid fraction (Daflon®) in lipopolysaccharide-treated rats. Drug Discov Ther. 2012; 6:306-314.
    • (2012) Drug Discov Ther. , vol.6 , pp. 306-314
    • Abdel-Salam, O.M.E.1    Youness, E.R.2    Mohammed, N.A.3    Abd-Elmoniem, M.4    Omara, E.5    Sleem, A.A.6
  • 9
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003; 3:768-780.
    • (2003) Nat Rev Cancer. , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 10
    • 6044250289 scopus 로고    scopus 로고
    • Characterization of the human hepatocellular carcinoma (hepg2) cell line as an in vitro model for cadmium toxicity studies
    • Dehn PF, White CM, Conners DE, Shipkey G, Cumbo TA. Characterization of the human hepatocellular carcinoma (hepg2) cell line as an in vitro model for cadmium toxicity studies. In Vitro Cell Dev Biol Anim. 2004; 40:172-182.
    • (2004) In Vitro Cell Dev Biol Anim. , vol.40 , pp. 172-182
    • Dehn, P.F.1    White, C.M.2    Conners, D.E.3    Shipkey, G.4    Cumbo, T.A.5
  • 12
    • 0033917216 scopus 로고    scopus 로고
    • The subapical compartment and its role in intracellular trafficking and cell polarity
    • Van ISC, Maier O, Van Der Wouden JM, Hoekstra D. The subapical compartment and its role in intracellular trafficking and cell polarity. J Cell Physiol. 2000; 184:151-160.
    • (2000) J Cell Physiol. , vol.184 , pp. 151-160
    • Van ISC, O.1    Van Der Wouden, J.M.2    Hoekstra, D.3
  • 13
    • 0034016431 scopus 로고    scopus 로고
    • Polarized sphingolipid transport from the subapical compartment changes during cell polarity development
    • van ISC, Hoekstra D. Polarized sphingolipid transport from the subapical compartment changes during cell polarity development. Mol Biol Cell. 2000; 11:1093-1101.
    • (2000) Mol Biol Cell. , vol.11 , pp. 1093-1101
    • van, I.S.C.1    Hoekstra, D.2
  • 14
    • 84865006776 scopus 로고    scopus 로고
    • Preferential inhibition of hepatocellular carcinoma by the flavonoid baicalein through blocking MEK-ERK signaling
    • Liang RR, Zhang S, Qi JA, Wang ZD, Li J, Liu PJ, Huang C, Le XF, Yang J, Li ZF. Preferential inhibition of hepatocellular carcinoma by the flavonoid baicalein through blocking MEK-ERK signaling. Int J Oncol. 2012; 41:969-978.
    • (2012) Int J Oncol. , vol.41 , pp. 969-978
    • Liang, R.R.1    Zhang, S.2    Qi, J.A.3    Wang, Z.D.4    Li, J.5    Liu, P.J.6    Huang, C.7    Le XF, J.8    Li, Z.F.9
  • 15
    • 80955151280 scopus 로고    scopus 로고
    • Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells
    • Yang J, Yang Y, Tian L, Sheng XF, Liu F, Cao JG. Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells. World J Gastroenterol. 2011; 17:4298-4307.
    • (2011) World J Gastroenterol. , vol.17 , pp. 4298-4307
    • Yang, J.1    Yang, Y.2    Tian, L.3    Sheng, X.F.4    Liu, F.5    Cao, J.G.6
  • 16
    • 79957639518 scopus 로고    scopus 로고
    • A mechanism of apigenin-induced apoptosis is potentially related to antiangiogenesis and anti-migration in human hepatocellular carcinoma cells
    • Kim BR, Jeon YK, Nam MJ. A mechanism of apigenin-induced apoptosis is potentially related to antiangiogenesis and anti-migration in human hepatocellular carcinoma cells. Food Chem Toxicol. 2011; 49:1626-1632.
    • (2011) Food Chem Toxicol. , vol.49 , pp. 1626-1632
    • Kim, B.R.1    Jeon, Y.K.2    Nam, M.J.3
  • 17
    • 84866150505 scopus 로고    scopus 로고
    • Pro- apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells
    • Jiang CP, Ding H, Shi DH, Wang YR, Li EG, Wu JH. Pro- apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells. World J Gastroenterol. 2012; 18:1753-1764.
    • (2012) World J Gastroenterol. , vol.18 , pp. 1753-1764
    • Jiang, C.P.1    Ding, H.2    Shi, D.H.3    Wang, Y.R.4    Li, E.G.5    Wu, J.H.6
  • 19
    • 70449625689 scopus 로고    scopus 로고
    • Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells
    • Chang YF, Hsu YC, Hung HF, Lee HJ, Lui WY, Chi CW, Wang JJ. Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells. Nutr Cancer. 2009; 61:735-745.
    • (2009) Nutr Cancer. , vol.61 , pp. 735-745
    • Chang, Y.F.1    Hsu, Y.C.2    Hung, H.F.3    Lee, H.J.4    Lui, W.Y.5    Chi, C.W.6    Wang, J.J.7
  • 20
    • 57049117856 scopus 로고    scopus 로고
    • Cell death and endoplasmic reticulum stress:Disease relevance and therapeutic opportunities
    • Kim I, Xu W, Reed JC. Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities. Nat Rev Drug Discov. 2008; 7:1013-1030.
    • (2008) Nat Rev Drug Discov. , vol.7 , pp. 1013-1030
    • Kim, I.1    Xu, W.2    Reed, J.C.3
  • 21
    • 18144407267 scopus 로고    scopus 로고
    • Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography
    • Li HB, Chen F. Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. J Chromatogr A. 2005; 1074:107-110.
    • (2005) J Chromatogr A. , vol.1074 , pp. 107-110
    • Li, H.B.1    Chen, F.2
  • 23
    • 36549013178 scopus 로고    scopus 로고
    • Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    • Schmitz KJ, Wohlschlaeger J, Lang H, Sotiropoulos GC, Malago M, Steveling K, Reis H, Cicinnati VR, Schmid KW, Baba HA. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol. 2008; 48:83-90.
    • (2008) J Hepatol. , vol.48 , pp. 83-90
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Lang, H.3    Sotiropoulos, G.C.4    Malago, M.5    Steveling, K.6    Reis, H.7    Cicinnati, V.R.8    Schmid, K.W.9    Baba, H.A.10
  • 24
    • 84861812085 scopus 로고    scopus 로고
    • Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cells
    • Xu M, Lu N, Sun Z, Zhang H, Dai Q, Wei L, Li Z, You Q, Guo Q. Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cells. Toxicol Lett. 2012; 212:113-125.
    • (2012) Toxicol Lett. , vol.212 , pp. 113-125
    • Xu, M.1    Lu, N.2    Sun, Z.3    Zhang, H.4    Dai, Q.5    Wei, L.6    Li, Z.7    You, Q.8    Guo, Q.9
  • 26
    • 84882586115 scopus 로고    scopus 로고
    • Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT
    • Xu M, Lu N, Zhang H, Dai Q, Wei L, Li Z, You Q, Guo Q. Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT. Hepatol Res. 2012. DOI: 10.1111/hepr.12036
    • (2012) Hepatol Res.
    • Xu, M.1    Lu, N.2    Zhang, H.3    Dai, Q.4    Wei, L.5    Li, Z.6    You, Q.7    Guo, Q.8
  • 27
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science. 2004; 305:626-629.
    • (2004) Science. , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 28
    • 0032031920 scopus 로고    scopus 로고
    • Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c. Free Radic Biol Med
    • Yang JC, Cortopassi GA. Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c. Free Radic Biol Med. 1998; 24:624-631.
    • (1998) 24 , pp. 624-631
    • Yang, J.C.1    Cortopassi, G.A.2
  • 29
    • 0033521741 scopus 로고    scopus 로고
    • Molecular characterization of mitochondrial apoptosis-inducing factor
    • Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999; 397: 441-446.
    • (1999) Nature. , vol.397 , pp. 441-446
    • Susin, S.A.1    Lorenzo, H.K.2    Zamzami, N.3
  • 31
    • 16644394363 scopus 로고    scopus 로고
    • Caspases:Potential targets for regulating cell death
    • Philchenkov A. Caspases: Potential targets for regulating cell death. J Cell Mol Med. 2004; 8:432-444.
    • (2004) J Cell Mol Med. , vol.8 , pp. 432-444
    • Philchenkov, A.1
  • 32
  • 33
    • 45449117450 scopus 로고    scopus 로고
    • Cytotoxic effects of compounds from Iris tectorum on human cancer cell lines
    • Fang R, Houghton PJ, Hylands PJ. Cytotoxic effects of compounds from Iris tectorum on human cancer cell lines. J Ethnopharmacol. 2008; 118:257-263.
    • (2008) J Ethnopharmacol. , vol.118 , pp. 257-263
    • Fang, R.1    Houghton, P.J.2    Hylands, P.J.3
  • 34
    • 78649428161 scopus 로고    scopus 로고
    • Solanum nigrum L. polyphenolic extract inhibits hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis
    • Wang HC, Chung PJ, Wu CH, Lan KP, Yang MY, Wang CJ. Solanum nigrum L. polyphenolic extract inhibits hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis. J Sci Food Agric. 2011; 91:178-185.
    • (2011) J Sci Food Agric. , vol.91 , pp. 178-185
    • Wang, H.C.1    Chung, P.J.2    Wu, C.H.3    Lan, K.P.4    Yang, M.Y.5    Wang, C.J.6
  • 35
    • 77957273073 scopus 로고    scopus 로고
    • Genistein synergizes with arsenic trioxide to suppress human hepatocellular carcinoma.
    • Jiang H, Ma Y, Chen X, Pan S, Sun B, Krissansen GW, Sun X. Genistein synergizes with arsenic trioxide to suppress human hepatocellular carcinoma. Cancer Sci. 2010; 101:975-983.
    • (2010) Cancer Sci. , vol.101 , pp. 975-983
    • Jiang, H.1    Ma, Y.2    Chen, X.3    Pan, S.4    Sun, B.5    Krissansen, G.W.6    Sun, X.7
  • 36
    • 77952298545 scopus 로고    scopus 로고
    • Inhibition of Hhsp27 and Hhsp40 potentiates 5-fluorouracil and carboplatin mediated cell killing in hepatoma cells
    • Sharma A, Upadhyay AK, Bhat MK. Inhibition of Hhsp27 and Hhsp40 potentiates 5-fluorouracil and carboplatin mediated cell killing in hepatoma cells. Cancer Biol Ther. 2009; 8:2104-2111.
    • (2009) Cancer Biol Ther. , vol.8 , pp. 2104-2111
    • Sharma, A.1    Upadhyay, A.K.2    Bhat, M.K.3
  • 37
    • 54249119561 scopus 로고    scopus 로고
    • JNK signaling in apoptosis
    • Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene. 2008; 27:6245-6251.
    • (2008) Oncogene. , vol.27 , pp. 6245-6251
    • Dhanasekaran, D.N.1    Reddy, E.P.2
  • 38
    • 77954843915 scopus 로고    scopus 로고
    • 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK
    • Yang XH, Zheng X, Cao JG, Xiang HL, Liu F, Lv Y. 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK. World J Gastroenterol. 2010; 16:3385-3393.
    • (2010) World J Gastroenterol. , vol.16 , pp. 3385-3393
    • Yang, X.H.1    Zheng, X.2    Cao, J.G.3    Xiang, H.L.4    Liu, F.5    Lv, Y.6
  • 39
    • 3142707564 scopus 로고    scopus 로고
    • Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells
    • Fischer OM, Giordano S, Comoglio PM, Ullrich A. Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells. J Biol Chem. 2004; 279:28970-28978.
    • (2004) J Biol Chem. , vol.279 , pp. 28970-28978
    • Fischer, O.M.1    Giordano, S.2    Comoglio, P.M.3    Ullrich, A.4
  • 40
    • 40449113978 scopus 로고    scopus 로고
    • Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells.
    • Shattuck DL, Miller JK, Carraway KL, 3rd, Sweeney C. Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res. 2008; 68:1471-1477.
    • (2008) Cancer Res. , vol.68 , pp. 1471-1477
    • Shattuck, D.L.1    Miller, J.K.2    Carraway, K.L.3
  • 41
    • 0034708826 scopus 로고    scopus 로고
    • Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells
    • Jo MJ, Stolz DB, Esplen JE, Dorko K, Michalopoulos GK, Strom SC. Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. J Biol Chem. 2000; 275:8806-8811.
    • (2000) J Biol Chem. , vol.275 , pp. 8806-8811
    • Jo, M.J.1    Stolz, D.B.2    Esplen, J.E.3    Dorko, K.4    Michalopoulos, G.K.5    Strom, S.C.6
  • 44
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling-Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ. Specificity of receptor tyrosine kinase signaling-Transient versus sustained extracellular signal-regulated kinase activation. Cell. 1995; 80:179-185.
    • (1995) Cell. , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 45
    • 0025788025 scopus 로고
    • The tyrosine-phosphorylated hepatocyte growth-factor scatter factor receptor associates with phosphatidylinositol 3-kinase
    • Graziani A, Gramaglia D, Cantley LC, Comoglio PM. The tyrosine-phosphorylated hepatocyte growth-factor scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem. 1991; 266:22087-22090.
    • (1991) J Biol Chem. , vol.266 , pp. 22087-22090
    • Graziani, A.1    Gramaglia, D.2    Cantley, L.C.3    Comoglio, P.M.4
  • 46
    • 34548304315 scopus 로고    scopus 로고
    • Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non-small-cell lung cancer
    • Siegfried JM, Gubish CT, Rothstein ME, de Oliveira PEQ, Stabile LP. Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non-small-cell lung cancer. Mol Pharmacol. 2007; 72:769-779.
    • (2007) Mol Pharmacol. , vol.72 , pp. 769-779
    • Siegfried, J.M.1    Gubish, C.T.2    Rothstein, M.E.3    de Oliveira, P.E.Q.4    Stabile, L.P.5
  • 47
    • 84860756404 scopus 로고    scopus 로고
    • Prostanoid EP1 receptor as the target of (-)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro.
    • Jin J, Chang Y, Wei W, He YF, Hu SS, Wang D, Wu YJ. Prostanoid EP1 receptor as the target of (-)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro. Acta Pharmacol Sin. 2012; 33:701-709.
    • (2012) Acta Pharmacol Sin. , vol.33 , pp. 701-709
    • Jin, J.1    Chang, Y.2    Wei, W.3    He, Y.F.4    Hu, S.S.5    Wang, D.6    Wu, Y.J.7
  • 48
    • 79960691382 scopus 로고    scopus 로고
    • EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells
    • Shimizu M, Shirakami Y, Sakai H, Tatebe H, Nakagawa T, Hara Y, Weinstein IB, Moriwaki H. EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells. Cancer Lett. 2008; 262:10-18.
    • (2008) Cancer Lett. , vol.262 , pp. 10-18
    • Shimizu, M.1    Shirakami, Y.2    Sakai, H.3    Tatebe, H.4    Nakagawa, T.5    Hara, Y.6    Weinstein, I.B.7    Moriwaki, H.8
  • 49
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-kB:Players, pathways
    • Gilmore TD. Introduction to NF-kB: Players, pathways, perspectives. Oncogene. 2006; 25:6680-6684.
    • (2006) perspectives. Oncogene. , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 50
    • 43749098070 scopus 로고    scopus 로고
    • cancer-identifyingtargets and mechanisms
    • Naugler WE, Karin M. NF-kappaB and cancer-identifyingtargets and mechanisms. Curr Opin Genet Dev. 2008, 18:19-26.
    • (2008) Curr Opin Genet Dev. , pp. 19-26
    • Naugler, W.E.1    Karin, M.2
  • 51
    • 38449111027 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF) biology and cell death
    • Bertazza L, Mocellin S. Tumor necrosis factor (TNF) biology and cell death. Front Biosci. 2008; 13:2736-2743.
    • (2008) Front Biosci. , vol.13 , pp. 2736-2743
    • Bertazza, L.1    Mocellin, S.2
  • 52
    • 25144507526 scopus 로고    scopus 로고
    • Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis
    • Kubo F, Ueno S, Hiwatashi K, Sakoda M, Kawaida K, Nuruki K, Aikou T. Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis. Ann Surg Oncol. 2005; 12:800-807.
    • (2005) Ann Surg Oncol. , vol.12 , pp. 800-807
    • Kubo, F.1    Ueno, S.2    Hiwatashi, K.3    Sakoda, M.4    Kawaida, K.5    Nuruki, K.6    Aikou, T.7
  • 53
    • 75449084734 scopus 로고    scopus 로고
    • a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells
    • Dorn C, Weiss TS, Heilmann J, Hellerbrand C. Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. Int J Oncol. 2010; 36:435-441.
    • (2010) Int J Oncol. , vol.36 , pp. 435-441
    • Dorn, C.1    Weiss, T.S.2    Heilmann, J.3    Hellerbrand, C.4
  • 54
    • 33846582444 scopus 로고    scopus 로고
    • The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kB pathway in Chang Liver cells
    • Garcia-Mediavilla V, Crespo I, Collado PS, Esteller A, Sanchez-Campos S, Tunon MJ, Gonzalez-Gallego J. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kB pathway in Chang Liver cells. Eur J Pharmacol. 2007; 557:221-229.
    • (2007) Eur J Pharmacol. , vol.557 , pp. 221-229
    • Garcia-Mediavilla, V.1    Crespo, I.2    Collado, P.S.3    Esteller, A.4    Sanchez-Campos, S.5    Tunon, M.J.6    Gonzalez-Gallego, J.7
  • 55
    • 84861436981 scopus 로고    scopus 로고
    • Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-kB pathway
    • Granado-Serrano AB, Martin MA, Bravo L, Goya L, Ramos S. Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-kB pathway. Nutr Cancer. 2012; 64:588-598.
    • (2012) Nutr Cancer. , vol.64 , pp. 588-598
    • Granado-Serrano, A.B.1    Martin, M.A.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 56
    • 84867820107 scopus 로고    scopus 로고
    • LYG-202 augments tumor necrosis factor-α-induced apoptosis via attenuating casein kinase 2-depend ent nuclear factor-KB pathway in HepG2 cells
    • Chen FH, Lu N, Zhang HW, Zhao L, He LC, Sun HP, You QD, Li ZY, Guo QL. LYG-202 augments tumor necrosis factor-α-induced apoptosis via attenuating casein kinase 2-depend ent nuclear factor-KB pathway in HepG2 cells. Mol Pharmacol. 2012, 82: 958-971.
    • (2012) Mol Pharmacol. , pp. 958-971
    • Chen, F.H.1    Lu, N.2    Zhang, H.W.3    Zhao, L.4    He, L.C.5    Sun, H.P.6    You, Q.D.7    Li, Z.Y.8    Guo, Q.L.9
  • 57
    • 79955838953 scopus 로고    scopus 로고
    • Antitumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-KB modulation in HepG2 hepatocarcinoma cells
    • Hwang JT, Park OJ, Lee YK, Sung MJ, Hur HJ, Kim MS, Ha JH, Kwon DY. Antitumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-KB modulation in HepG2 hepatocarcinoma cells. Int J Mol Med. 2011, 28:25-31.
    • (2011) Int J Mol Med. , pp. 25-31
    • Hwang, J.T.1    Park, O.J.2    Lee, Y.K.3    Sung, M.J.4    Hur, H.J.5    Kim, M.S.6    Ha, J.H.7    Kwon, D.Y.8
  • 58
    • 75549090203 scopus 로고    scopus 로고
    • Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells
    • Granado-Serrano AB, Martin MA, Haegeman G, Goya L, Bravo L, Ramos S. Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells. Br J Nutr. 2010; 103:168-179.
    • (2010) Br J Nutr. , vol.103 , pp. 168-179
    • Granado-Serrano, A.B.1    Martin, M.A.2    Haegeman, G.3    Goya, L.4    Bravo, L.5    Ramos, S.6
  • 59
    • 58249142786 scopus 로고    scopus 로고
    • Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells
    • Yeh MH, Kao ST, Hung CM, Liu CJ, Lee KH, Yeh CC. Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells. Toxicol Lett. 2009; 184:204-210.
    • (2009) Toxicol Lett. , vol.184 , pp. 204-210
    • Yeh, M.H.1    Kao, S.T.2    Hung, C.M.3    Liu, C.J.4    Lee, K.H.5    Yeh, C.C.6
  • 60
    • 0032608038 scopus 로고    scopus 로고
    • Heat shock proteins:Facts, thoughts, and dreams
    • De Maio A. Heat shock proteins: Facts, thoughts, and dreams. Shock. 1999; 11:1-12.
    • (1999) Shock. , vol.11 , pp. 1-12
    • De Maio, A.1
  • 61
    • 15944368140 scopus 로고    scopus 로고
    • Protein folding assisted by chaperones
    • Borges JC, Ramos CHI. Protein folding assisted by chaperones. Protein Pept Lett. 2005; 12:257-261.
    • (2005) Protein Pept Lett. , vol.12 , pp. 257-261
    • Borges, J.C.1    Ramos, C.H.I.2
  • 62
    • 0033796051 scopus 로고    scopus 로고
    • Inhibition of Daxx-mediated apoptosis by heat shock protein 27
    • Charette SJ, Lavoie JN, Lambert H, Landry J. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol. 2000; 20:7602-7612.
    • (2000) Mol Cell Biol. , vol.20 , pp. 7602-7612
    • Charette, S.J.1    Lavoie, J.N.2    Lambert, H.3    Landry, J.4
  • 64
    • 33747041690 scopus 로고    scopus 로고
    • Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin:comparison with caspase-inhibitor-and cycle-arrest-mediated cytoprotection
    • Demidenko ZN, Vivo C, Halicka HD, Li CJ, Bhalla K, Broude EV, Blagosklonny MV. Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor-and cycle-arrest-mediated cytoprotection. Cell Death Differ. 2006; 13:1434-1441.
    • (2006) Cell Death Differ. , vol.13 , pp. 1434-1441
    • Demidenko, Z.N.1    Vivo, C.2    Halicka, H.D.3    Li, C.J.4    Bhalla, K.5    Broude, E.V.6    Blagosklonny, M.V.7
  • 66
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • Sherr CJ. Principles of tumor suppression. Cell. 2004; 116:235-246.
    • (2004) Cell. , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 68
    • 84872805497 scopus 로고    scopus 로고
    • The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 upregulation
    • Androutsopoulos VP, Spandidos DA. The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 upregulation. J Nutr Biochem. 2013; 24:496-504.
    • (2013) J Nutr Biochem. , vol.24 , pp. 496-504
    • Androutsopoulos, V.P.1    Spandidos, D.A.2
  • 69
    • 84984552538 scopus 로고    scopus 로고
    • Viral hepatocarcinogenesis:from infection to cancer
    • Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ. Viral hepatocarcinogenesis: from infection to cancer. Liver Int. 2008; 28:175-188.
    • (2008) Liver Int. , vol.28 , pp. 175-188
    • Tan, A.1    Yeh, S.H.2    Liu, C.J.3    Cheung, C.4    Chen, P.J.5
  • 70
    • 79955942412 scopus 로고    scopus 로고
    • Epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication-inducible cell line
    • He W, Li LX, Liao QJ, Liu CL, Chen XL. Epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication-inducible cell line. World J Gastroenterol. 2011; 17:1507-1514.
    • (2011) World J Gastroenterol. , vol.17 , pp. 1507-1514
    • He, W.1    Li, L.X.2    Liao, Q.J.3    Liu, C.L.4    Chen, X.L.5
  • 73
    • 79959605633 scopus 로고    scopus 로고
    • San-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expression.
    • Lee JC, Tseng CK, Wu SF, Chang FR, Chiu CC, Wu YC. San-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expression. J Viral Hepat. 2011; 18:e315-324.
    • (2011) J Viral Hepat. , vol.18 , pp. e315-324
    • Lee, J.C.1    Tseng, C.K.2    Wu, S.F.3    Chang, F.R.4    Chiu, C.C.5    Wu, Y.C.6
  • 74
    • 84862004384 scopus 로고    scopus 로고
    • A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes
    • Haid S, Novodomska A, Gentzsch J, et al. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology. 2012; 143:213-222.
    • (2012) Gastroenterology. , vol.143 , pp. 213-222
    • Haid, S.1    Novodomska, A.2    Gentzsch, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.