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Volumn 16, Issue 27, 2010, Pages 3385-3393

8-bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK

Author keywords

8 bromo 7 methoxychysin; Chrysin; Hepatocellular carcinoma; Jun N terminal kinase; Reactive oxygen species

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 8 BROMO 7 METHOXYCHRYSIN; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CHRYSIN; DICHLORODIHYDROFLUORESCEIN DIACETATE; DIMETHYL SULFOXIDE; DNA; FLAVONE DERIVATIVE; FLUOROURACIL; PROPIDIUM IODIDE; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 2-CHLORO-5-NITROBENZANILIDE; 8-BROMO-7-METHOXYCHRYSIN; ANILIDE; ANTIOXIDANT; FLAVONOID;

EID: 77954843915     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i27.3385     Document Type: Article
Times cited : (50)

References (47)
  • 1
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3: 768-780
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 2
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000; 52: 673-751
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton Jr., E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 3
    • 7444225147 scopus 로고    scopus 로고
    • Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells
    • Zhang T, Chen X, Qu L, Wu J, Cui R, Zhao Y. Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells. Bioorg Med Chem 2004; 12: 6097-6105
    • (2004) Bioorg Med Chem , vol.12 , pp. 6097-6105
    • Zhang, T.1    Chen, X.2    Qu, L.3    Wu, J.4    Cui, R.5    Zhao, Y.6
  • 4
    • 8844229705 scopus 로고    scopus 로고
    • Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells
    • Woo KJ, Jeong YJ, Park JW, Kwon TK. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochem Biophys Res Commun 2004; 325: 1215-1222
    • (2004) Biochem Biophys Res Commun , vol.325 , pp. 1215-1222
    • Woo, K.J.1    Jeong, Y.J.2    Park, J.W.3    Kwon, T.K.4
  • 5
    • 9744225155 scopus 로고    scopus 로고
    • Flavonoids induce apoptosis in human leukemia U937 cells through caspase-and caspase-calpaindependent pathways
    • Monasterio A, Urdaci MC, Pinchuk IV, López-Moratalla N, Martínez-Irujo JJ. Flavonoids induce apoptosis in human leukemia U937 cells through caspase-and caspase-calpaindependent pathways. Nutr Cancer 2004; 50: 90-100
    • (2004) Nutr Cancer , vol.50 , pp. 90-100
    • Monasterio, A.1    Urdaci, M.C.2    Pinchuk, I.V.3    López-Moratalla, N.4    Martínez-Irujo, J.J.5
  • 6
    • 34250017387 scopus 로고    scopus 로고
    • Chrysin inhibited stem cell factor (SCF)/c-Kit complex-induced cell proliferation in human myeloid leukemia cells
    • Lee SJ, Yoon JH, Song KS. Chrysin inhibited stem cell factor (SCF)/c-Kit complex-induced cell proliferation in human myeloid leukemia cells. Biochem Pharmacol 2007; 74: 215-225
    • (2007) Biochem Pharmacol , vol.74 , pp. 215-225
    • Lee, S.J.1    Yoon, J.H.2    Song, K.S.3
  • 7
    • 42649083649 scopus 로고    scopus 로고
    • Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines
    • Ramos AM, Aller P. Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines. Biochem Pharmacol 2008; 75: 1912-1923
    • (2008) Biochem Pharmacol , vol.75 , pp. 1912-1923
    • Ramos, A.M.1    Aller, P.2
  • 8
    • 3042648789 scopus 로고    scopus 로고
    • Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines
    • Wang W, VanAlstyne PC, Irons KA, Chen S, Stewart JW, Birt DF. Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr Cancer 2004; 48: 106-114
    • (2004) Nutr Cancer , vol.48 , pp. 106-114
    • Wang, W.1    Vanalstyne, P.C.2    Irons, K.A.3    Chen, S.4    Stewart, J.W.5    Birt, D.F.6
  • 9
    • 42749088247 scopus 로고    scopus 로고
    • Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis
    • Zhang Q, Zhao XH, Wang ZJ. Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol 2008; 46: 2042-2053
    • (2008) Food Chem Toxicol , vol.46 , pp. 2042-2053
    • Zhang, Q.1    Zhao, X.H.2    Wang, Z.J.3
  • 10
    • 34548554576 scopus 로고    scopus 로고
    • Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: A role for glutathione depletion
    • Kachadourian R, Leitner HM, Day BJ. Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion. Int J Oncol 2007; 31: 161-168
    • (2007) Int J Oncol , vol.31 , pp. 161-168
    • Kachadourian, R.1    Leitner, H.M.2    Day, B.J.3
  • 12
    • 25444480747 scopus 로고    scopus 로고
    • Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives
    • Park H, Dao TT, Kim HP. Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. Eur J Med Chem 2005; 40: 943-948
    • (2005) Eur J Med Chem , vol.40 , pp. 943-948
    • Park, H.1    Dao, T.T.2    Kim, H.P.3
  • 13
    • 33748916241 scopus 로고    scopus 로고
    • Methylated flavonoids have greatly improved intestinal absorption and metabolic stability
    • Wen X, Walle T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos 2006; 34: 1786-1792
    • (2006) Drug Metab Dispos , vol.34 , pp. 1786-1792
    • Wen, X.1    Walle, T.2
  • 15
    • 33846861995 scopus 로고    scopus 로고
    • Systhesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives
    • Zheng X, Cao JG, Liao DF, Liu HT. Systhesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives. Zhongguo Huaxue Kuaibao 2006; 17: 1439-1442
    • (2006) Zhongguo Huaxue Kuaibao , vol.17 , pp. 1439-1442
    • Zheng, X.1    Cao, J.G.2    Liao, D.F.3    Liu, H.T.4
  • 16
    • 58149194818 scopus 로고    scopus 로고
    • Induction of apoptosis of human gastric carcinoma SGC-790 cell line by 8-bromo-7-mehoxychrysin
    • Xiang HL, Zheng X, Cao JG. Induction of apoptosis of human gastric carcinoma SGC-790 cell line by 8-bromo-7-mehoxychrysin. Zhongguo Yaolixue Tongbao 2008; 24: 1370-1372
    • (2008) Zhongguo Yaolixue Tongbao , vol.24 , pp. 1370-1372
    • Xiang, H.L.1    Zheng, X.2    Cao, J.G.3
  • 17
    • 34547991503 scopus 로고    scopus 로고
    • Induction of apoptosis of human gastric carcinoma SGC-7901 cell line by 5, 7-dihydroxy-8-nitrochrysin in vitro
    • Ai XH, Zheng X, Tang XQ, Sun L, Zhang YQ, Qin Y, Liu HQ, Xia H, Cao JG. Induction of apoptosis of human gastric carcinoma SGC-7901 cell line by 5, 7-dihydroxy-8-nitrochrysin in vitro. World J Gastroenterol 2007; 13: 3824-3828
    • (2007) World J Gastroenterol , vol.13 , pp. 3824-3828
    • Ai, X.H.1    Zheng, X.2    Tang, X.Q.3    Sun, L.4    Zhang, Y.Q.5    Qin, Y.6    Liu, H.Q.7    Xia, H.8    Cao, J.G.9
  • 18
    • 0031020195 scopus 로고    scopus 로고
    • Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships
    • Cao G, Sofic E, Prior RL. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic Biol Med 1997; 22: 749-760
    • (1997) Free Radic Biol Med , vol.22 , pp. 749-760
    • Cao, G.1    Sofic, E.2    Prior, R.L.3
  • 19
    • 33744996911 scopus 로고    scopus 로고
    • Flavonoid-induced glutathione depletion: Potential implications for cancer treatment
    • Kachadourian R, Day BJ. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic Biol Med 2006; 41: 65-76
    • (2006) Free Radic Biol Med , vol.41 , pp. 65-76
    • Kachadourian, R.1    Day, B.J.2
  • 20
    • 0031708666 scopus 로고    scopus 로고
    • Induction of oxidative stress by redox active flavonoids
    • Hodnick WF, Ahmad S, Pardini RS. Induction of oxidative stress by redox active flavonoids. Adv Exp Med Biol 1998; 439: 131-150
    • (1998) Adv Exp Med Biol , vol.439 , pp. 131-150
    • Hodnick, W.F.1    Ahmad, S.2    Pardini, R.S.3
  • 21
    • 20144367578 scopus 로고    scopus 로고
    • Chalcones: An update on cytotoxic and chemoprotective properties
    • Go ML, Wu X, Liu XL. Chalcones: an update on cytotoxic and chemoprotective properties. Curr Med Chem 2005; 12: 481-499
    • (2005) Curr Med Chem , vol.12 , pp. 481-499
    • Go, M.L.1    Wu, X.2    Liu, X.L.3
  • 23
    • 17444419342 scopus 로고    scopus 로고
    • Molecular mechanisms of reduced glutathione transport: Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
    • Ballatori N, Hammond CL, Cunningham JB, Krance SM, Marchan R. Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins. Toxicol Appl Pharmacol 2005; 204: 238-255
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 238-255
    • Ballatori, N.1    Hammond, C.L.2    Cunningham, J.B.3    Krance, S.M.4    Marchan, R.5
  • 24
    • 18044364401 scopus 로고    scopus 로고
    • Differential modulation of normal and tumor cell proliferation by reactive oxygen species
    • Nicco C, Laurent A, Chereau C, Weill B, Batteux F. Differential modulation of normal and tumor cell proliferation by reactive oxygen species. Biomed Pharmacother 2005; 59: 169-174
    • (2005) Biomed Pharmacother , vol.59 , pp. 169-174
    • Nicco, C.1    Laurent, A.2    Chereau, C.3    Weill, B.4    Batteux, F.5
  • 25
    • 23844455227 scopus 로고    scopus 로고
    • Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR
    • Tang XQ, Bi H, Feng JQ, Cao JG. Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR. Acta Pharmacol Sin 2005; 26: 1009-1016
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1009-1016
    • Tang, X.Q.1    Bi, H.2    Feng, J.Q.3    Cao, J.G.4
  • 26
    • 67650106882 scopus 로고    scopus 로고
    • Induction of apoptosis in human liver carcinoma HepG2 cell line by 5-allyl-7-gen-difluoromethylenechrysin
    • Tan XW, Xia H, Xu JH, Cao JG. Induction of apoptosis in human liver carcinoma HepG2 cell line by 5-allyl-7-gen-difluoromethylenechrysin. World J Gastroenterol 2009; 15: 2234-2239
    • (2009) World J Gastroenterol , vol.15 , pp. 2234-2239
    • Tan, X.W.1    Xia, H.2    Xu, J.H.3    Cao, J.G.4
  • 28
    • 0035525733 scopus 로고    scopus 로고
    • Cellular stress response and apoptosis in cancer therapy
    • Herr I, Debatin KM. Cellular stress response and apoptosis in cancer therapy. Blood 2001; 98: 2603-2614
    • (2001) Blood , vol.98 , pp. 2603-2614
    • Herr, I.1    Debatin, K.M.2
  • 29
    • 0037230304 scopus 로고    scopus 로고
    • Activation of the JNK signaling pathway: Breaking the brake on apoptosis
    • Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays 2003; 25: 17-24
    • (2003) Bioessays , vol.25 , pp. 17-24
    • Lin, A.1
  • 30
    • 0141723393 scopus 로고    scopus 로고
    • Role of JNK in tumor development
    • Kennedy NJ, Davis RJ. Role of JNK in tumor development. Cell Cycle 2003; 2: 199-201
    • (2003) Cell Cycle , vol.2 , pp. 199-201
    • Kennedy, N.J.1    Davis, R.J.2
  • 31
    • 0036708902 scopus 로고    scopus 로고
    • Antioxidants and oxidants regulated signal transduction pathways
    • Owuor ED, Kong AN. Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol 2002; 64: 765-770
    • (2002) Biochem Pharmacol , vol.64 , pp. 765-770
    • Owuor, E.D.1    Kong, A.N.2
  • 32
    • 0036088559 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl
    • Kitazawa M, Wagner JR, Kirby ML, Anantharam V, Kanthasamy AG. Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. J Pharmacol Exp Ther 2002; 302: 26-35
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 26-35
    • Kitazawa, M.1    Wagner, J.R.2    Kirby, M.L.3    Anantharam, V.4    Kanthasamy, A.G.5
  • 34
    • 51249100204 scopus 로고    scopus 로고
    • Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: Mitochondrial targeted preconditioning
    • Busija DW, Gaspar T, Domoki F, Katakam PV, Bari F. Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: mitochondrial targeted preconditioning. Adv Drug Deliv Rev 2008; 60: 1471-1477
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1471-1477
    • Busija, D.W.1    Gaspar, T.2    Domoki, F.3    Katakam, P.V.4    Bari, F.5
  • 35
    • 61849154200 scopus 로고    scopus 로고
    • Apoptosis induced by 2-acetyl-3-(6-methoxybenzothiazo)-2-yl-amino-acrylonitrile in human leukemia cells involves ROS-mitochondrial mediated death signaling and activation of p38 MAPK
    • Repicky A, Jantova S, Cipak L. Apoptosis induced by 2-acetyl-3-(6-methoxybenzothiazo)-2-yl-amino-acrylonitrile in human leukemia cells involves ROS-mitochondrial mediated death signaling and activation of p38 MAPK. Cancer Lett 2009; 277: 55-63
    • (2009) Cancer Lett , vol.277 , pp. 55-63
    • Repicky, A.1    Jantova, S.2    Cipak, L.3
  • 36
    • 0023226978 scopus 로고
    • Inhibition of mitochondrial NADH oxidase, succinoxidase, and ATPase by naturally occurring flavonoids
    • Bohmont C, Aaronson LM, Mann K, Pardini RS. Inhibition of mitochondrial NADH oxidase, succinoxidase, and ATPase by naturally occurring flavonoids. J Nat Prod 1987; 50: 427-433
    • (1987) J Nat Prod , vol.50 , pp. 427-433
    • Bohmont, C.1    Aaronson, L.M.2    Mann, K.3    Pardini, R.S.4
  • 37
    • 0023278602 scopus 로고
    • Inhibition of the mitochondrial NADH-oxidase (NADH-coenzyme Q oxido-reductase) enzyme system by flavonoids: A structureactivity study
    • Hodnick WF, Bohmont CW, Capps C, Pardini RS. Inhibition of the mitochondrial NADH-oxidase (NADH-coenzyme Q oxido-reductase) enzyme system by flavonoids: a structureactivity study. Biochem Pharmacol 1987; 36: 2873-2874
    • (1987) Biochem Pharmacol , vol.36 , pp. 2873-2874
    • Hodnick, W.F.1    Bohmont, C.W.2    Capps, C.3    Pardini, R.S.4
  • 38
    • 0030476808 scopus 로고    scopus 로고
    • Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids
    • Siess MH, Mas JP, Canivenc-Lavier MC, Suschetet M. Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids. J Toxicol Environ Health 1996; 49: 481-496
    • (1996) J Toxicol Environ Health , vol.49 , pp. 481-496
    • Siess, M.H.1    Mas, J.P.2    Canivenc-Lavier, M.C.3    Suschetet, M.4
  • 39
    • 0142043984 scopus 로고    scopus 로고
    • Redox signaling and the MAP kinase pathways
    • Torres M, Forman HJ. Redox signaling and the MAP kinase pathways. Biofactors 2003; 17: 287-296
    • (2003) Biofactors , vol.17 , pp. 287-296
    • Torres, M.1    Forman, H.J.2
  • 40
    • 3242752786 scopus 로고    scopus 로고
    • Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells
    • Boonstra J, Post JA. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 2004; 337: 1-13
    • (2004) Gene , vol.337 , pp. 1-13
    • Boonstra, J.1    Post, J.A.2
  • 41
    • 0036673395 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in aclarubicin-induced differentiation and invasiveness of HL-60 leukemia cells
    • Richard D, Hollender P, Chénais B. Involvement of reactive oxygen species in aclarubicin-induced differentiation and invasiveness of HL-60 leukemia cells. Int J Oncol 2002; 21: 393-399
    • (2002) Int J Oncol , vol.21 , pp. 393-399
    • Richard, D.1    Hollender, P.2    Chénais, B.3
  • 42
    • 21744450904 scopus 로고    scopus 로고
    • Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs)
    • Batista EL Jr, Warbington M, Badwey JA, Van Dyke TE. Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs). J Cell Biochem 2005; 94: 774-793
    • (2005) J Cell Biochem , vol.94 , pp. 774-793
    • Batista Jr., E.L.1    Warbington, M.2    Badwey, J.A.3    van Dyke, T.E.4
  • 44
    • 47249154397 scopus 로고    scopus 로고
    • Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK)
    • Sánchez Y, Amrán D, Fernández C, de Blas E, Aller P. Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK). Int J Cancer 2008; 123: 1205-1214
    • (2008) Int J Cancer , vol.123 , pp. 1205-1214
    • Sánchez, Y.1    Amrán, D.2    Fernández, C.3    de Blas, E.4    Aller, P.5
  • 45
    • 36248949141 scopus 로고    scopus 로고
    • The endoplasmic reticulum and the unfolded protein response
    • Malhotra JD, Kaufman RJ. The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 2007; 18: 716-731
    • (2007) Semin Cell Dev Biol , vol.18 , pp. 716-731
    • Malhotra, J.D.1    Kaufman, R.J.2
  • 46
    • 5644258322 scopus 로고    scopus 로고
    • C-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12- dioxooleana-1, 9-dien-28-oate in human lung cancer cells
    • Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12- dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res 2004; 64: 7570-7578
    • (2004) Cancer Res , vol.64 , pp. 7570-7578
    • Zou, W.1    Liu, X.2    Yue, P.3    Zhou, Z.4    Sporn, M.B.5    Lotan, R.6    Khuri, F.R.7    Sun, S.Y.8
  • 47
    • 33646771034 scopus 로고    scopus 로고
    • Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28- oate (CDDO-Me)
    • Yue P, Zhou Z, Khuri FR, Sun SY. Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28- oate (CDDO-Me). Cancer Biol Ther 2006; 5: 492-497
    • (2006) Cancer Biol Ther , vol.5 , pp. 492-497
    • Yue, P.1    Zhou, Z.2    Khuri, F.R.3    Sun, S.Y.4


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