Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells

Nutrition and Cancer

Volumn 61, Issue 5, 2009, Pages 735-745

  Chang, Yuh Fang ^a   Hsu, Yi Chiung ^b   Hung, Hui Fang ^a   Lee, Hui Ju ^b   Lui, Wing Yiu ^a   Chi, Chin Wen ^b   Wang, Jane Jen ^c  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL TAIPEI UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL 3 METHYL ETHER; LIPOCORTIN 5; MESSENGER RNA; QUERCETIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL POPULATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN BINDING;

ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; ESTRADIOL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; QUERCETIN; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 70449625689     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580902825571     Document Type: Article

References (40)

1. Vital Statistic: Taipei T, ROC: Department of Health, Executive Yuan, Health statistics of the Republic of China, 2005.
2. Tang ZY: Hepatocellular carcinoma-cause, treatment, and metastasis. World J Gastroenterol 7, 445-454, 2001.
3. Fotsis T, Zhang Y, PepperMS, Adlercreutz H, Montesano R, et al.: The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature 368, 237-239, 1994.
4. Lin HL, Liu TY, Wu CW, and Chi CW: 2-Methoxyestradiol-induced caspase-3 activation and apoptosis occurs through G(2)/M arrest dependent and independent pathways in gastric carcinoma cells. Cancer 92, 500-509, 2001.
5. Qadan LR, Perez-Stable CM, Anderson C, D'Ippolito G, Herron A, et al.: 2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer. Biochem Biophys Res Commun 285, 1259-1266, 2001.
6. Huang P, Feng L, Oldham EA, Keating MJ, and Plunkett W: Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407, 390-395, 2000.
7. Lui WY, Lin HL, Chau GY, Liu TY, and Chi CW: Male predominance in hepatocellular carcinoma: newinsight and a possible therapeutic alternative. Med Hypotheses 55, 348-350, 2000.
8. Lin HL, Liu TY, Chau GY, Lui WY, and Chi CW: Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlationwith reactive oxygen species. Cancer 89, 983-994, 2000.
9. Scharf G, Prustomersky S, Knasmuller S, Schulte-Hermann R, and Huber WW: Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plantderived food and beverage components in the human hepatoma cell line HepG2. Nutr Cancer 45, 74-83, 2003.
10. Ramos AMand Aller P: Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines. Biochem Pharmacol 75, 1912-1923, 2008.
11. Kang TB and Liang NC: Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochem Pharmacol 54, 1013-1018, 1997.
12. Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, et al.: Foodderived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int J Cancer 98, 761-769, 2002.
13. Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K, et al.: Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res 54, 4952-4957, 1994.
14. Chang YF, Chi CW, and Wang JJ: Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells. Nutr Cancer 55, 201-209, 2006.
15. Carter WO, Narayanan PK, and Robinson JP: Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. J Leukoc Biol 55, 253-258, 1994.
16. ReersM, SmithTW, and Chen LB: J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry 30, 4480-4486, 1991.
17. Heerdt BG,HoustonMA, AnthonyGM, andAugenlicht LH: Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. Cancer Res 58, 2869-2875, 1998.
18. Hileman EO, Liu J, Albitar M,KeatingMJ, andHuang P: Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity. Cancer Chemother Pharmacol 53, 209-219, 2004.
19. Gao N, Rahmani M, Dent P, and Grant S: 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. Oncogene 24, 3797-3809, 2005.
20. She MR, Li JG, Guo KY, Lin W, Du X, et al.: Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2- methoxyestradiol. Acta Pharmacol Sin 28, 1037-1044, 2007.
21. Basini G, Santini SE, and Grasselli F: 2-Methoxyestradiol inhibits superoxide anion generation while it enhances superoxide dismutase activity in swine granulosa cells. Ann NY Acad Sci 1091, 34-40, 2006.
22. Lambert C, Thews O, Biesalski HK, Vaupel P, Kelleher DK, et al.: 2- Methoxyestradiol enhances reactive oxygen species formation and increases the efficacy of oxygen radical generating tumor treatment. Eur J Med Res 7, 404-414, 2002.
23. Golab J, Nowis D, Skrzycki M, Czeczot H, Baranczyk-Kuzma A, et al.: Antitumor effects of photodynamic therapy are potentiated by 2- methoxyestradiol. A superoxide dismutase inhibitor. J Biol Chem 278, 407-414, 2003.
24. Pani G, Colavitti R, Bedogni B, Fusco S, Ferraro D, et al.: Mitochondrial superoxide dismutase: a promising target for newanticancer therapies. Curr Med Chem 11, 1299-1308, 2004.
25. Kachadourian R, Liochev SI, Cabelli DE, Patel MN, Fridovich I, et al.: 2-methoxyestradiol does not inhibit superoxide dismutase. Arch Biochem Biophys 392, 349-353, 2001.
26. Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E, and Segura-Aguilar J: Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 26, 107-116, 1999.
27. Thangasamy T, Sittadjody S, Lanza-Jacoby S, Wachsberger PR, Limesand KH, et al.: Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase. Nutr Cancer 59, 258-268, 2007.
28. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, et al.: Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275, 1649-1652, 1997.
29. Huang RP, Peng A, Golard A, Hossain MZ, Huang R, et al.: Hydrogen peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal growth factor receptor. Mol Carcinog 30, 209-217, 2001.
30. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, and Finkel T: Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270, 296-299, 1995.
31. Brenner C and Grimm S: The permeability transition pore complex in cancer cell death. Oncogene 25, 4744-4756, 2006.
32. Orrenius S: Reactive oxygen species in mitochondria-mediated cell death. Drug Metab Rev 39, 443-455, 2007.
33. Kuhar M, Sen S, and Singh N: Role of mitochondria in quercetin-enhanced chemotherapeutic response in human non-small cell lung carcinoma H-520 cells. Anticancer Res 26, 1297-1303, 2006.
34. Sharma H, Sen S, and Singh N: Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer. Cancer Biol Ther 4, 949-955, 2005.
35. Huang SL, Hsu CL, and Yen GC: Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells. Life Sci 79, 203-209, 2006.
36. Djavaheri-Mergny M, Wietzerbin J, and Besancon F: 2-methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. Oncogene 22, 2558-2567, 2003.
37. Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, et al.: Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem 278, 37832-37839, 2003.
38. ZhangYM: Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells. Toxicol Sci 88, 545-550, 2005.
39. Policastro L, Molinari B, Larcher F, Blanco P, Podhajcer OL, et al.: Imbalance of antioxidant enzymes in tumor cells and inhibition of proliferation and malignant features by scavenging hydrogen peroxide. Mol Carcinog 39, 103-113, 2004.
40. Blokhina O, Virolainen E, and Fagerstedt KV: Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann Bot (Lond) 91(Spec No), 179-194, 2003.