-
2
-
-
0141828970
-
Mechanisms of human hepatocarcinogenesis
-
Coleman WB. Mechanisms of human hepatocarcinogenesis. Curr Mol Med 2003; 3: 573-88.
-
(2003)
Curr Mol Med
, vol.3
, pp. 573-588
-
-
Coleman, W.B.1
-
3
-
-
0035467993
-
Global cancer statistics in the year 2000
-
Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001; 2: 533-43.
-
(2001)
Lancet Oncol
, vol.2
, pp. 533-543
-
-
Parkin, D.M.1
-
4
-
-
19644381818
-
Hepatocellular carcinoma: The need for progress
-
Thomas M, Zhu A. Hepatocellular carcinoma: The need for progress. J Clin Oncol 23: 2892-9.
-
J Clin Oncol
, vol.23
, pp. 2892-2899
-
-
Thomas, M.1
Zhu, A.2
-
5
-
-
0036311082
-
Hepatitis B and hepatitis C
-
Geller SA. Hepatitis B and hepatitis C. Clin Liver Dis 2002; 6: 317-34.
-
(2002)
Clin Liver Dis
, vol.6
, pp. 317-334
-
-
Geller, S.A.1
-
6
-
-
16244373665
-
Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade - Results of an explorative CGH meta-analysis
-
Moinzadeh P, Breuhahn K, Stutzer H, Schirmacher P. Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade - results of an explorative CGH meta-analysis. Br J Cancer 2005; 92: 935-41.
-
(2005)
Br J Cancer
, vol.92
, pp. 935-941
-
-
Moinzadeh, P.1
Breuhahn, K.2
Stutzer, H.3
Schirmacher, P.4
-
7
-
-
34848881905
-
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
-
Calvisi DF, Ladu S, Gorden A, et al. Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J Clin Invest 2007; 117: 2713-22.
-
(2007)
J Clin Invest
, vol.117
, pp. 2713-2722
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
-
8
-
-
34250342495
-
Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: Evidence for two distinct pathways of human hepatocarcinogenesis
-
Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR. Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: Evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res 2007; 67: 4586-94.
-
(2007)
Cancer Res
, vol.67
, pp. 4586-4594
-
-
Nishida, N.1
Nishimura, T.2
Nagasaka, T.3
Ikai, I.4
Goel, A.5
Boland, C.R.6
-
9
-
-
33846463379
-
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
-
Boyault S, Rickman DS, de Reynies A, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 2007; 45: 42-52.
-
(2007)
Hepatology
, vol.45
, pp. 42-52
-
-
Boyault, S.1
Rickman, D.S.2
de Reynies, A.3
-
10
-
-
17044387017
-
High frequency of promoter hypermethylation of RASSF1A in tumor and plasma of patients with hepatocellular carcinoma
-
Yeo W, Wong N, Wong WL, Lai PB, Zhong S, Johnson PJ. High frequency of promoter hypermethylation of RASSF1A in tumor and plasma of patients with hepatocellular carcinoma. Liver Int 2005; 25: 266-72.
-
(2005)
Liver Int
, vol.25
, pp. 266-272
-
-
Yeo, W.1
Wong, N.2
Wong, W.L.3
Lai, P.B.4
Zhong, S.5
Johnson, P.J.6
-
11
-
-
1542322897
-
Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis
-
Yu J, Zhang HY, Ma ZZ, Lu W, Wang YF, Zhu JD. Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. Cell Res 2003; 13: 319-33.
-
(2003)
Cell Res
, vol.13
, pp. 319-333
-
-
Yu, J.1
Zhang, H.Y.2
Ma, Z.Z.3
Lu, W.4
Wang, Y.F.5
Zhu, J.D.6
-
12
-
-
21644473614
-
p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma
-
Li X, Hui AM, Sun L, et al. p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma. Clin Cancer Res 2004; 10: 7484-9.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7484-7489
-
-
Li, X.1
Hui, A.M.2
Sun, L.3
-
13
-
-
0041924707
-
Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma
-
Yang B, Guo M, Herman JG, Clark DP. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 2003; 163: 1101-7.
-
(2003)
Am J Pathol
, vol.163
, pp. 1101-1107
-
-
Yang, B.1
Guo, M.2
Herman, J.G.3
Clark, D.P.4
-
14
-
-
34548090762
-
Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma
-
Su PF, Lee TC, Lin PJ, et al. Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma. Int J Cancer 2007; 121: 1257-64.
-
(2007)
Int J Cancer
, vol.121
, pp. 1257-1264
-
-
Su, P.F.1
Lee, T.C.2
Lin, P.J.3
-
15
-
-
34247190634
-
Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein
-
Park IY, Sohn BH, Yu E, et al. Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology 2007; 132: 1476-94.
-
(2007)
Gastroenterology
, vol.132
, pp. 1476-1494
-
-
Park, I.Y.1
Sohn, B.H.2
Yu, E.3
-
16
-
-
0038505659
-
Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis
-
Edamoto Y, Hara A, Biernat W, et al. Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. Int J Cancer 2003; 106: 334-41.
-
(2003)
Int J Cancer
, vol.106
, pp. 334-341
-
-
Edamoto, Y.1
Hara, A.2
Biernat, W.3
-
17
-
-
0033992478
-
p53 and human cancer: The first ten thousand mutations
-
Hainaut P, Hollstein M. p53 and human cancer: The first ten thousand mutations. Adv Cancer Res 2000; 77: 81-137.
-
(2000)
Adv Cancer Res
, vol.77
, pp. 81-137
-
-
Hainaut, P.1
Hollstein, M.2
-
18
-
-
0026518760
-
P53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China
-
Scorsone KA, Zhou YZ, Butel JS, Slagle BL. P53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res 1992; 52: 1635-8.
-
(1992)
Cancer Res
, vol.52
, pp. 1635-1638
-
-
Scorsone, K.A.1
Zhou, Y.Z.2
Butel, J.S.3
Slagle, B.L.4
-
19
-
-
0026740713
-
p53 mutations in human hepatocellular carcinomas from Germany
-
Kress S, Jahn UR, Buchmann A, Bannasch P, Schwarz M. p53 mutations in human hepatocellular carcinomas from Germany. Cancer Res 1992; 52: 3220-3.
-
(1992)
Cancer Res
, vol.52
, pp. 3220-3223
-
-
Kress, S.1
Jahn, U.R.2
Buchmann, A.3
Bannasch, P.4
Schwarz, M.5
-
20
-
-
0027337609
-
Aflatoxin B1 induces the transversion of G → T in codon 249 of the p53 tumor suppressor gene in human hepatocytes
-
Aguilar F, Hussain SP, Cerutti P. Aflatoxin B1 induces the transversion of G → T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci USA 1993; 90: 8586-90.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8586-8590
-
-
Aguilar, F.1
Hussain, S.P.2
Cerutti, P.3
-
21
-
-
0028986613
-
p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus
-
Puisieux A, Ji J, Guillot C, et al. p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus. Proc Natl Acad Sci USA 1995; 92: 1342-6.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1342-1346
-
-
Puisieux, A.1
Ji, J.2
Guillot, C.3
-
22
-
-
33644601320
-
Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma
-
Nam SW, Lee JH, Noh JH, et al. Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2006; 18: 239-47.
-
(2006)
Eur J Gastroenterol Hepatol
, vol.18
, pp. 239-247
-
-
Nam, S.W.1
Lee, J.H.2
Noh, J.H.3
-
23
-
-
26444496469
-
The molecular signature of metastases of human hepatocellular carcinoma
-
Budhu AS, Zipser B, Forgues M, Ye QH, Sun Z, Wang XW. The molecular signature of metastases of human hepatocellular carcinoma. Oncology 2005; 69: 23-7.
-
(2005)
Oncology
, vol.69
, pp. 23-27
-
-
Budhu, A.S.1
Zipser, B.2
Forgues, M.3
Ye, Q.H.4
Sun, Z.5
Wang, X.W.6
-
24
-
-
0036190930
-
Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: Correlation with tumor progression and postoperative survival
-
Inagawa S, Itabashi M, Adachi S, et al. Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: Correlation with tumor progression and postoperative survival. Clin Cancer Res 2002; 8: 450-6.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 450-456
-
-
Inagawa, S.1
Itabashi, M.2
Adachi, S.3
-
25
-
-
0035395236
-
Beta-catenin mutation and overexpression in hepatocellular carcinoma: Clinicopathologic and prognostic significance
-
Wong CM, Fan ST, Ng IO. Beta-catenin mutation and overexpression in hepatocellular carcinoma: Clinicopathologic and prognostic significance. Cancer 2001; 92: 136-45.
-
(2001)
Cancer
, vol.92
, pp. 136-145
-
-
Wong, C.M.1
Fan, S.T.2
Ng, I.O.3
-
26
-
-
0034746832
-
Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis
-
Mao TL, Chu JS, Jeng YM, Lai PL, Hsu HC. Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis. J Pathol 2001; 193: 95-101.
-
(2001)
J Pathol
, vol.193
, pp. 95-101
-
-
Mao, T.L.1
Chu, J.S.2
Jeng, Y.M.3
Lai, P.L.4
Hsu, H.C.5
-
27
-
-
0034953664
-
CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1
-
Devereux TR, Stern MC, Flake GP, et al. CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1. Mol Carcinog 2001; 31: 68-73.
-
(2001)
Mol Carcinog
, vol.31
, pp. 68-73
-
-
Devereux, T.R.1
Stern, M.C.2
Flake, G.P.3
-
28
-
-
0032761853
-
Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection
-
Huang H, Fujii H, Sankila A, et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol 1999; 155: 1795-801.
-
(1999)
Am J Pathol
, vol.155
, pp. 1795-1801
-
-
Huang, H.1
Fujii, H.2
Sankila, A.3
-
29
-
-
33645236561
-
In vitro RNA interference against beta-catenin inhibits the proliferation of pediatric hepatic tumors
-
Sangkhathat S, Kusafuka T, Miao J, et al. In vitro RNA interference against beta-catenin inhibits the proliferation of pediatric hepatic tumors. Int J Oncol 2006; 28: 715-22.
-
(2006)
Int J Oncol
, vol.28
, pp. 715-722
-
-
Sangkhathat, S.1
Kusafuka, T.2
Miao, J.3
-
30
-
-
7044260782
-
Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: Old and new paradigms
-
Brechot C. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: Old and new paradigms. Gastroenterology 2004; 12: S56-61.
-
(2004)
Gastroenterology
, vol.12
-
-
Brechot, C.1
-
31
-
-
0037443891
-
Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection
-
Iizuka N, Oka M, Yamada-Okabe H, et al. Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet 2003; 361: 923-9.
-
(2003)
Lancet
, vol.361
, pp. 923-929
-
-
Iizuka, N.1
Oka, M.2
Yamada-Okabe, H.3
-
32
-
-
0036859903
-
Understanding the hypercarcinogenic state in chronic hepatitis: A clue to the prevention of human hepatocellular carcinoma
-
Hino O, Kajino K, Umeda T, Arakawa Y. Understanding the hypercarcinogenic state in chronic hepatitis: A clue to the prevention of human hepatocellular carcinoma. J Gastroenterol 2002; 37: 883-87.
-
(2002)
J Gastroenterol
, vol.37
, pp. 883-887
-
-
Hino, O.1
Kajino, K.2
Umeda, T.3
Arakawa, Y.4
-
33
-
-
33646157967
-
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
-
Murakami Y, Yasuda T, Saigo K, et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2006; 25: 2537-45.
-
(2006)
Oncogene
, vol.25
, pp. 2537-2545
-
-
Murakami, Y.1
Yasuda, T.2
Saigo, K.3
-
34
-
-
34447117003
-
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
-
Gramantieri L, Ferracin M, Fornari F, et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res 2007; 67: 6092-9.
-
(2007)
Cancer Res
, vol.67
, pp. 6092-6099
-
-
Gramantieri, L.1
Ferracin, M.2
Fornari, F.3
-
35
-
-
34547524771
-
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
-
Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133: 647-58.
-
(2007)
Gastroenterology
, vol.133
, pp. 647-658
-
-
Meng, F.1
Henson, R.2
Wehbe-Janek, H.3
Ghoshal, K.4
Jacob, S.T.5
Patel, T.6
-
36
-
-
24644483623
-
Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA
-
Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science 2005; 309: 1577-81.
-
(2005)
Science
, vol.309
, pp. 1577-1581
-
-
Jopling, C.L.1
Yi, M.2
Lancaster, A.M.3
Lemon, S.M.4
Sarnow, P.5
-
37
-
-
34848878881
-
Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes
-
Shan Y, Zheng J, Lambrecht RW, Bonkovsky HL. Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes. Gastroenterology 2007; 133: 1166-74.
-
(2007)
Gastroenterology
, vol.133
, pp. 1166-1174
-
-
Shan, Y.1
Zheng, J.2
Lambrecht, R.W.3
Bonkovsky, H.L.4
-
38
-
-
34547913440
-
Cellular cofactors affecting hepatitis C virus infection and replication
-
Randall G, Panis M, Cooper JD, et al. Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci USA 2007; 104: 12884-9.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12884-12889
-
-
Randall, G.1
Panis, M.2
Cooper, J.D.3
-
39
-
-
35349009932
-
Interferon modulation of cellular microRNAs as an antiviral mechanism
-
Pedersen IM, Cheng G, Wieland S, et al. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 2007; 449: 919-22.
-
(2007)
Nature
, vol.449
, pp. 919-922
-
-
Pedersen, I.M.1
Cheng, G.2
Wieland, S.3
-
40
-
-
0025239328
-
Hepatitis B: Global importance and need for control
-
Maynard JE. Hepatitis B: Global importance and need for control. Vaccine 1990; 8: S18-20.
-
(1990)
Vaccine
, vol.8
-
-
Maynard, J.E.1
-
41
-
-
0036292006
-
Molecular mechanism of viral hepatocarcinogenesis
-
Koike K, Tsutsumi T, Fujie H, Shintani Y, Kyoji M. Molecular mechanism of viral hepatocarcinogenesis. Oncology 2002; 62: 29-37.
-
(2002)
Oncology
, vol.62
, pp. 29-37
-
-
Koike, K.1
Tsutsumi, T.2
Fujie, H.3
Shintani, Y.4
Kyoji, M.5
-
42
-
-
0020060218
-
Hepatitis B virus as the etiologic agent in hepatocellular carcinoma
-
Beasley RP. Hepatitis B virus as the etiologic agent in hepatocellular carcinoma. Hepatology 1982; 2: 21S-6S.
-
(1982)
Hepatology
, vol.2
-
-
Beasley, R.P.1
-
43
-
-
0025887360
-
Hepatocellular carcinoma in Italian patients with cirrhosis
-
Colombo M, de Franchis R, Del Ninno E, et al. Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med 1991; 325: 675-80.
-
(1991)
N Engl J Med
, vol.325
, pp. 675-680
-
-
Colombo, M.1
de Franchis, R.2
Del Ninno, E.3
-
44
-
-
0027243462
-
Risk factors for hepatocellular carcinoma among patients with chronic liver disease
-
Tsukuma H, Hiyama T, Tanaka S, et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993; 328: 1797-801.
-
(1993)
N Engl J Med
, vol.328
, pp. 1797-1801
-
-
Tsukuma, H.1
Hiyama, T.2
Tanaka, S.3
-
45
-
-
0024550770
-
Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China
-
Yeh FS, Yu MC, Mo CC, et al. Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China. Cancer Res 1989; 49: 2506-9.
-
(1989)
Cancer Res
, vol.49
, pp. 2506-2509
-
-
Yeh, F.S.1
Yu, M.C.2
Mo, C.C.3
-
46
-
-
0031014425
-
The relative roles of hepatitis B and C viruses in the etiology of hepatocellular carcinoma in southern African blacks
-
Kew MC, Yu MC, Kedda MA, et al. The relative roles of hepatitis B and C viruses in the etiology of hepatocellular carcinoma in southern African blacks. Gastroenterology 1997; 112: 184-7.
-
(1997)
Gastroenterology
, vol.112
, pp. 184-187
-
-
Kew, M.C.1
Yu, M.C.2
Kedda, M.A.3
-
47
-
-
84984592523
-
Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
-
Lai CL, Shouval D, Lok AS, et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. Gastroenterology 2006; 130: 2039-49.
-
(2006)
Gastroenterology
, vol.130
, pp. 2039-2049
-
-
Lai, C.L.1
Shouval, D.2
Lok, A.S.3
-
48
-
-
0034874826
-
Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan
-
Orito E, Ichida T, Sakugawa H, Sata M. Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology 2001; 34: 590-4.
-
(2001)
Hepatology
, vol.34
, pp. 590-594
-
-
Orito, E.1
Ichida, T.2
Sakugawa, H.3
Sata, M.4
-
49
-
-
0035115032
-
Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China
-
Ding X, Mizokami M, Yao G, Xu B. Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China. Intervirology 2001; 44: 43-7.
-
(2001)
Intervirology
, vol.44
, pp. 43-47
-
-
Ding, X.1
Mizokami, M.2
Yao, G.3
Xu, B.4
-
50
-
-
4644219526
-
Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma
-
Chan HL, Hui AY, Wong ML, et al. Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut 2004; 53: 1494-8.
-
(2004)
Gut
, vol.53
, pp. 1494-1498
-
-
Chan, H.L.1
Hui, A.Y.2
Wong, M.L.3
-
51
-
-
0024427902
-
Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection
-
Carman WF, Hadziyannis S, McGarvey MJ, et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 1989; 2: 588-91.
-
(1989)
Lancet
, vol.2
, pp. 588-591
-
-
Carman, W.F.1
Hadziyannis, S.2
McGarvey, M.J.3
-
52
-
-
0025012035
-
Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region
-
Akahane Y, Yamanaka T, Suzuki H, et al. Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region. Gastroenterology 1990; 99: 1113-9.
-
(1990)
Gastroenterology
, vol.99
, pp. 1113-1119
-
-
Akahane, Y.1
Yamanaka, T.2
Suzuki, H.3
-
53
-
-
24044464859
-
Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations
-
Yuen MF, Tanaka Y, Ng IO, et al. Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations. J Viral Hepat 2005; 12: 513-8.
-
(2005)
J Viral Hepat
, vol.12
, pp. 513-518
-
-
Yuen, M.F.1
Tanaka, Y.2
Ng, I.O.3
-
54
-
-
0036838283
-
Relationship between the development of precore and core promotor mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus
-
Yuen MF, Sablon E, Yuan HJ, et al. Relationship between the development of precore and core promotor mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus. J Infect Dis 2002; 186: 1335-8.
-
(2002)
J Infect Dis
, vol.186
, pp. 1335-1338
-
-
Yuen, M.F.1
Sablon, E.2
Yuan, H.J.3
-
55
-
-
84984549253
-
Basal core promotor mutations of hepatitis B virus increase the risk of hepatocellular carcinoma
-
Kao JH, Chen PJ, Lai MY, Chen DS. Basal core promotor mutations of hepatitis B virus increase the risk of hepatocellular carcinoma. Gastroenterology 2003; 124: 327-34.
-
(2003)
Gastroenterology
, vol.124
, pp. 327-334
-
-
Kao, J.H.1
Chen, P.J.2
Lai, M.Y.3
Chen, D.S.4
-
56
-
-
0346434156
-
Hepatitis B virus DNA in liver, serum, and peripheral blood mononuclear cells after the clearance of serum hepatitis B virus surface antigen
-
Murakami Y, Minami M, Daimon Y, et al. Hepatitis B virus DNA in liver, serum, and peripheral blood mononuclear cells after the clearance of serum hepatitis B virus surface antigen. J Med Virol 2004; 72: 203-14.
-
(2004)
J Med Virol
, vol.72
, pp. 203-214
-
-
Murakami, Y.1
Minami, M.2
Daimon, Y.3
-
57
-
-
14744291990
-
Molecular mechanisms in hepatocellular carcinoma development
-
Cha C, Dematteo RP. Molecular mechanisms in hepatocellular carcinoma development. Best Pract Res Clin Gastroenterol 2005; 19: 25-37.
-
(2005)
Best Pract Res Clin Gastroenterol
, vol.19
, pp. 25-37
-
-
Cha, C.1
Dematteo, R.P.2
-
58
-
-
0037422535
-
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
-
Hofseth LJ, Saito S, Hussain SP, et al. Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci USA 2003; 100: 143-8.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 143-148
-
-
Hofseth, L.J.1
Saito, S.2
Hussain, S.P.3
-
59
-
-
17044423502
-
Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: A key to the cell cycle and apoptosis
-
Peng Z, Zhang Y, Gu W, et al. Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: A key to the cell cycle and apoptosis. Int J Oncol 2005; 26: 467-73.
-
(2005)
Int J Oncol
, vol.26
, pp. 467-473
-
-
Peng, Z.1
Zhang, Y.2
Gu, W.3
-
60
-
-
15244357567
-
Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death
-
Leupin O, Bontron S, Schaeffer C, Strubin M. Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death. J Virol 2005; 79: 4238-45.
-
(2005)
J Virol
, vol.79
, pp. 4238-4245
-
-
Leupin, O.1
Bontron, S.2
Schaeffer, C.3
Strubin, M.4
-
61
-
-
4344634335
-
Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells
-
Mathonnet G, Lachance S, Alaoui-Jamali M, et al. Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells. Mutat Res 2004; 554: 305-18.
-
(2004)
Mutat Res
, vol.554
, pp. 305-318
-
-
Mathonnet, G.1
Lachance, S.2
Alaoui-Jamali, M.3
-
62
-
-
0001655748
-
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
-
Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 1994; 91: 2230-4.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 2230-2234
-
-
Wang, X.W.1
Forrester, K.2
Yeh, H.3
Feitelson, M.A.4
Gu, J.R.5
Harris, C.C.6
-
63
-
-
0034688143
-
Transcriptional repression of the human p53 gene by hepatitis B viral X protein
-
Lee SG, Rho HM. Transcriptional repression of the human p53 gene by hepatitis B viral X protein. Oncogene 2000; 19: 468-71.
-
(2000)
Oncogene
, vol.19
, pp. 468-471
-
-
Lee, S.G.1
Rho, H.M.2
-
64
-
-
0027905008
-
DNA repair helicase: A component of BTF2 (TFIIH) basic transcription factor
-
Schaeffer L, Roy R, Humbert S, et al. DNA repair helicase: A component of BTF2 (TFIIH) basic transcription factor. Science 1993; 260: 58-63.
-
(1993)
Science
, vol.260
, pp. 58-63
-
-
Schaeffer, L.1
Roy, R.2
Humbert, S.3
-
65
-
-
0038780018
-
Transgenic mouse models of hepatitis B virus-associated hepatocellular carcinoma
-
Singh M, Kumar V. Transgenic mouse models of hepatitis B virus-associated hepatocellular carcinoma. Rev Med Virol 2003; 13: 243-53.
-
(2003)
Rev Med Virol
, vol.13
, pp. 243-253
-
-
Singh, M.1
Kumar, V.2
-
66
-
-
7044272630
-
Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
-
Fattovich G, Stroffolini T, Zagni I, et al. Hepatocellular carcinoma in cirrhosis: Incidence and risk factors. Gastroenterology 2004; 127: S35-50.
-
(2004)
Gastroenterology
, vol.127
-
-
Fattovich, G.1
Stroffolini, T.2
Zagni, I.3
-
67
-
-
22644435919
-
Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas
-
Murakami Y, Saigo K, Takashima H, et al. Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 2005; 54: 1162-8.
-
(2005)
Gut
, vol.54
, pp. 1162-1168
-
-
Murakami, Y.1
Saigo, K.2
Takashima, H.3
-
68
-
-
0030756523
-
Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum
-
Xu Z, Jensen G, Yen TS. Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol 1997; 71: 7387-92.
-
(1997)
J Virol
, vol.71
, pp. 7387-7392
-
-
Xu, Z.1
Jensen, G.2
Yen, T.S.3
-
69
-
-
0036061173
-
Hypermodification and immune escape of an internally deleted middle-envelope (M) protein of frequent and predominant hepatitis B virus variants
-
Tai PC, Suk FM, Gerlich WH, et al. Hypermodification and immune escape of an internally deleted middle-envelope (M) protein of frequent and predominant hepatitis B virus variants. Virology 2002; 292: 44-58.
-
(2002)
Virology
, vol.292
, pp. 44-58
-
-
Tai, P.C.1
Suk, F.M.2
Gerlich, W.H.3
-
70
-
-
1542494151
-
Integration of hepatitis B virus containing mutations in the core promoter/X gene in patients with hepatocellular carcinoma
-
Momosaki S, Hsia CC, Nakashima Y, et al. Integration of hepatitis B virus containing mutations in the core promoter/X gene in patients with hepatocellular carcinoma. Dig Liver Dis 2003; 35: 795-800.
-
(2003)
Dig Liver Dis
, vol.35
, pp. 795-800
-
-
Momosaki, S.1
Hsia, C.C.2
Nakashima, Y.3
-
71
-
-
0027229211
-
A multivariate analysis of risk factors for hepatocellular carcinogenesis: A prospective observation of 795 patients with viral and alcoholic cirrhosis
-
Ikeda K, Saitoh S, Koida I, et al. A multivariate analysis of risk factors for hepatocellular carcinogenesis: A prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology 1993; 18: 47-53.
-
(1993)
Hepatology
, vol.18
, pp. 47-53
-
-
Ikeda, K.1
Saitoh, S.2
Koida, I.3
-
72
-
-
0035120328
-
Differential gene expression between chronic hepatitis B and C hepatic lesion
-
Honda M, Kaneko S, Kawai H, Shirota Y, Kobayashi K. Differential gene expression between chronic hepatitis B and C hepatic lesion. Gastroenterology 2001; 120: 955-66.
-
(2001)
Gastroenterology
, vol.120
, pp. 955-966
-
-
Honda, M.1
Kaneko, S.2
Kawai, H.3
Shirota, Y.4
Kobayashi, K.5
-
73
-
-
84984548383
-
Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level
-
Chiu CM, Yeh SH, Chen PJ, et al. Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level. Proc Natl Acad Sci USA 2007; 104: 2571-8.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2571-2578
-
-
Chiu, C.M.1
Yeh, S.H.2
Chen, P.J.3
-
74
-
-
0027157304
-
Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
-
Feitelson MA, Zhu M, Duan LX, London WT. Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene 1993; 8: 1109-17.
-
(1993)
Oncogene
, vol.8
, pp. 1109-1117
-
-
Feitelson, M.A.1
Zhu, M.2
Duan, L.X.3
London, W.T.4
-
75
-
-
0038418494
-
Hepatitis B virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells
-
Chung TW, Lee YC, Ko JH, Kim CH. Hepatitis B virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. Cancer Res 2003; 63: 3453-8.
-
(2003)
Cancer Res
, vol.63
, pp. 3453-3458
-
-
Chung, T.W.1
Lee, Y.C.2
Ko, J.H.3
Kim, C.H.4
-
76
-
-
0031460372
-
Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis
-
Elmore LW, Hancock AR, Chang SF, et al. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci USA 1997; 94: 14707-12.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 14707-14712
-
-
Elmore, L.W.1
Hancock, A.R.2
Chang, S.F.3
-
77
-
-
0037064038
-
Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2
-
Bontron S, Lin-Marq N, Strubin M. Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2. J Biol Chem 2002; 277: 38847-54.
-
(2002)
J Biol Chem
, vol.277
, pp. 38847-38854
-
-
Bontron, S.1
Lin-Marq, N.2
Strubin, M.3
-
78
-
-
0038182537
-
HBXIP functions as a cofactor of survivin in apoptosis suppression
-
Marusawa H, Matsuzawa S, Welsh K, et al. HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J 2003; 22: 2729-40.
-
(2003)
EMBO J
, vol.22
, pp. 2729-2740
-
-
Marusawa, H.1
Matsuzawa, S.2
Welsh, K.3
-
79
-
-
0031952176
-
Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication
-
Melegari M, Scaglioni PP, Wands JR. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol 1998; 72: 1737-43.
-
(1998)
J Virol
, vol.72
, pp. 1737-1743
-
-
Melegari, M.1
Scaglioni, P.P.2
Wands, J.R.3
-
80
-
-
0037155818
-
Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription
-
Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J Biol Chem 2002; 277: 9982-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 9982-9988
-
-
Shamay, M.1
Barak, O.2
Doitsh, G.3
Ben-Dor, I.4
Shaul, Y.5
-
81
-
-
0038558163
-
Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal
-
Kim KH, Seong BL. Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J 2003; 22: 2104-16.
-
(2003)
EMBO J
, vol.22
, pp. 2104-2116
-
-
Kim, K.H.1
Seong, B.L.2
-
82
-
-
0035896631
-
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway
-
Diao J, Khine AA, Sarangi F, et al. X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway. J Biol Chem 2001; 276: 8328-40.
-
(2001)
J Biol Chem
, vol.276
, pp. 8328-8340
-
-
Diao, J.1
Khine, A.A.2
Sarangi, F.3
-
83
-
-
9144250174
-
Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor gamma through protein-protein interaction
-
Choi YH, Kim HI, Seong JK, et al. Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor gamma through protein-protein interaction. FEBS Lett 2004; 557: 73-80.
-
(2004)
FEBS Lett
, vol.557
, pp. 73-80
-
-
Choi, Y.H.1
Kim, H.I.2
Seong, J.K.3
-
84
-
-
0030989802
-
Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5
-
Lin Y, Nomura T, Cheong J, Dorjsuren D, Iida K, Murakami S. Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J Biol Chem 1997; 272: 7132-9.
-
(1997)
J Biol Chem
, vol.272
, pp. 7132-7139
-
-
Lin, Y.1
Nomura, T.2
Cheong, J.3
Dorjsuren, D.4
Iida, K.5
Murakami, S.6
-
85
-
-
0028878098
-
Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation
-
Cheong JH, Yi M, Lin Y, Murakami S. Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. EMBO J 1995; 14: 143-50.
-
(1995)
EMBO J
, vol.14
, pp. 143-150
-
-
Cheong, J.H.1
Yi, M.2
Lin, Y.3
Murakami, S.4
-
86
-
-
0028890351
-
Hepatitis B virus transactivator protein X interacts with the TATA-binding protein
-
Qadri I, Maguire HF, Siddiqui A. Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proc Natl Acad Sci USA 1995; 92: 1003-7.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1003-1007
-
-
Qadri, I.1
Maguire, H.F.2
Siddiqui, A.3
-
87
-
-
0029743407
-
Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH
-
Qadri I, Conaway JW, Conaway RC, Schaack J, Siddiqui A. Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH. Proc Natl Acad Sci USA 1996; 93: 10578-83.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10578-10583
-
-
Qadri, I.1
Conaway, J.W.2
Conaway, R.C.3
Schaack, J.4
Siddiqui, A.5
-
88
-
-
0029008054
-
The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB
-
Williams JS, Andrisani OM. The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB. Proc Natl Acad Sci USA 1995; 92: 3819-23.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 3819-3823
-
-
Williams, J.S.1
Andrisani, O.M.2
-
89
-
-
33947528120
-
The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription
-
Cougot D, Wu Y, Cairo S, et al. The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription. J Biol Chem 2007; 282: 4277-87.
-
(2007)
J Biol Chem
, vol.282
, pp. 4277-4287
-
-
Cougot, D.1
Wu, Y.2
Cairo, S.3
-
90
-
-
0034693076
-
Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation
-
Kong HJ, Hong SH, Lee MY, Kim HD, Lee JW, Cheong J. Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation. FEBS Lett 2000; 483: 114-8.
-
(2000)
FEBS Lett
, vol.483
, pp. 114-118
-
-
Kong, H.J.1
Hong, S.H.2
Lee, M.Y.3
Kim, H.D.4
Lee, J.W.5
Cheong, J.6
-
91
-
-
0142182771
-
Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2
-
Kong HJ, Park MJ, Hong S, et al. Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2. Hepatology 2003; 38: 1258-66.
-
(2003)
Hepatology
, vol.38
, pp. 1258-1266
-
-
Kong, H.J.1
Park, M.J.2
Hong, S.3
-
92
-
-
31544457365
-
The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1
-
Tanaka Y, Kanai F, Ichimura T, et al. The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1. Oncogene 2006; 25: 633-42.
-
(2006)
Oncogene
, vol.25
, pp. 633-642
-
-
Tanaka, Y.1
Kanai, F.2
Ichimura, T.3
-
93
-
-
0342905085
-
Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential
-
Rahmani Z, Huh KW, Lasher R, Siddiqui A. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J Virol 2000; 74: 2840-6.
-
(2000)
J Virol
, vol.74
, pp. 2840-2846
-
-
Rahmani, Z.1
Huh, K.W.2
Lasher, R.3
Siddiqui, A.4
-
94
-
-
0034685805
-
Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex
-
Zhang Z, Torii N, Furusaka A, Malayaman N, Hu Z, Liang TJ. Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex. J Biol Chem 2000; 275: 15157-65.
-
(2000)
J Biol Chem
, vol.275
, pp. 15157-15165
-
-
Zhang, Z.1
Torii, N.2
Furusaka, A.3
Malayaman, N.4
Hu, Z.5
Liang, T.J.6
-
95
-
-
0029986179
-
Proteasome complex as a potential cellular target of hepatitis B virus X protein
-
Huang J, Kwong J, Sun EC, Liang TJ. Proteasome complex as a potential cellular target of hepatitis B virus X protein. J Virol 1996; 70: 5582-91.
-
(1996)
J Virol
, vol.70
, pp. 5582-5591
-
-
Huang, J.1
Kwong, J.2
Sun, E.C.3
Liang, T.J.4
-
96
-
-
30644461154
-
The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc
-
Kalra N, Kumar V. The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc. FEBS Lett 2006; 580: 431-6.
-
(2006)
FEBS Lett
, vol.580
, pp. 431-436
-
-
Kalra, N.1
Kumar, V.2
-
97
-
-
33750316808
-
The interaction of hepatitis B virus X protein and protein phosphatase type 2 C alpha and its effect on IL-6
-
Kim JS, Rho B, Lee TH, Lee JM, Kim SJ, Park JH. The interaction of hepatitis B virus X protein and protein phosphatase type 2 C alpha and its effect on IL-6. Biochem Biophys Res Commun 2006; 351: 253-8.
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 253-258
-
-
Kim, J.S.1
Rho, B.2
Lee, T.H.3
Lee, J.M.4
Kim, S.J.5
Park, J.H.6
-
98
-
-
35948946094
-
Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1
-
Hsieh YH, Su IJ, Wang HC, et al. Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1. Mol Cancer Res 2007; 5: 1063-72.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 1063-1072
-
-
Hsieh, Y.H.1
Su, I.J.2
Wang, H.C.3
-
99
-
-
0030729202
-
Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor
-
Chen CM, You LR, Hwang LH, Lee YH. Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor. J Virol 1997; 71: 9417-26.
-
(1997)
J Virol
, vol.71
, pp. 9417-9426
-
-
Chen, C.M.1
You, L.R.2
Hwang, L.H.3
Lee, Y.H.4
-
100
-
-
0142123224
-
Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus
-
Watashi K, Hijikata M, Tagawa A, Doi T, Marusawa H, Shimotohno K. Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. Mol Cell Biol 2003; 23: 7498-509.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7498-7509
-
-
Watashi, K.1
Hijikata, M.2
Tagawa, A.3
Doi, T.4
Marusawa, H.5
Shimotohno, K.6
-
101
-
-
0032504223
-
Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K
-
Hsieh TY, Matsumoto M, Chou HC, et al. Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K. J Biol Chem 1998; 273: 17651-9.
-
(1998)
J Biol Chem
, vol.273
, pp. 17651-17659
-
-
Hsieh, T.Y.1
Matsumoto, M.2
Chou, H.C.3
-
102
-
-
0032975740
-
Hepatitis C virus core protein interacts with cellular putative RNA helicase
-
You LR, Chen CM, Yeh TS, et al. Hepatitis C virus core protein interacts with cellular putative RNA helicase. J Virol 1999; 73: 2841-53.
-
(1999)
J Virol
, vol.73
, pp. 2841-2853
-
-
You, L.R.1
Chen, C.M.2
Yeh, T.S.3
-
103
-
-
33845341103
-
Interaction of HCV core protein with 14-3-3epsilon protein releases Bax to activate apoptosis
-
Lee SK, Park SO, Joe CO, Kim YS. Interaction of HCV core protein with 14-3-3epsilon protein releases Bax to activate apoptosis. Biochem Biophys Res Commun 2007; 352: 756-62.
-
(2007)
Biochem Biophys Res Commun
, vol.352
, pp. 756-762
-
-
Lee, S.K.1
Park, S.O.2
Joe, C.O.3
Kim, Y.S.4
-
104
-
-
33947163850
-
Mapping of the interacting domains of hepatitis C virus core protein and the double-stranded RNA-activated protein kinase PKR
-
Yan XB, Battaglia S, Boucreux D, Chen Z, Brechot C, Pavio N. Mapping of the interacting domains of hepatitis C virus core protein and the double-stranded RNA-activated protein kinase PKR. Virus Res 2007; 125: 79-87.
-
(2007)
Virus Res
, vol.125
, pp. 79-87
-
-
Yan, X.B.1
Battaglia, S.2
Boucreux, D.3
Chen, Z.4
Brechot, C.5
Pavio, N.6
-
105
-
-
30944457329
-
Hepatitis C virus core protein recruits nucleolar phosphoprotein B23 and coactivator p300 to relieve the repression effect of transcriptional factor YY1 on B23 gene expression
-
Mai RT, Yeh TS, Kao CF, Sun SK, Huang HH, Wu Lee YH. Hepatitis C virus core protein recruits nucleolar phosphoprotein B23 and coactivator p300 to relieve the repression effect of transcriptional factor YY1 on B23 gene expression. Oncogene 2006; 25: 448-62.
-
(2006)
Oncogene
, vol.25
, pp. 448-462
-
-
Mai, R.T.1
Yeh, T.S.2
Kao, C.F.3
Sun, S.K.4
Huang, H.H.5
Wu Lee, Y.H.6
-
106
-
-
0033880570
-
Complex formation between hepatitis C virus core protein and p21Waf1/ Cip1/Sdi1
-
Wang F, Yoshida I, Takamatsu M, et al. Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1. Biochem Biophys Res Commun 2000; 273: 479-84.
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 479-484
-
-
Wang, F.1
Yoshida, I.2
Takamatsu, M.3
-
107
-
-
20044377791
-
Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein
-
Kang SM, Shin MJ, Kim JH, Oh JW. Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein. Proteomics 2005; 5: 2227-37.
-
(2005)
Proteomics
, vol.5
, pp. 2227-2237
-
-
Kang, S.M.1
Shin, M.J.2
Kim, J.H.3
Oh, J.W.4
-
108
-
-
0035061788
-
Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: An evidence-based approach
-
Camma C, Glunta M, Andreone P, Craxi A. Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: An evidence-based approach. J Hepatol 2001; 34: 593-602.
-
(2001)
J Hepatol
, vol.34
, pp. 593-602
-
-
Camma, C.1
Glunta, M.2
Andreone, P.3
Craxi, A.4
-
109
-
-
0032169816
-
Retrospective analysis of the effect of interferon therapy on the clinical outcome of patients with viral cirrhosis
-
Benvegnu L, Chemello L, Noventa F, Fattovich G, Pontisso P, Alberti A. Retrospective analysis of the effect of interferon therapy on the clinical outcome of patients with viral cirrhosis. Cancer 1998; 83: 901-9.
-
(1998)
Cancer
, vol.83
, pp. 901-909
-
-
Benvegnu, L.1
Chemello, L.2
Noventa, F.3
Fattovich, G.4
Pontisso, P.5
Alberti, A.6
-
110
-
-
0033027690
-
Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection
-
Lin SM, Sheen IS, Chien RN, Chu CM, Liaw YF. Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection. Hepatology 1999; 29: 971-5.
-
(1999)
Hepatology
, vol.29
, pp. 971-975
-
-
Lin, S.M.1
Sheen, I.S.2
Chien, R.N.3
Chu, C.M.4
Liaw, Y.F.5
-
111
-
-
19544391413
-
Lamivudine for patients with chronic hepatitis B and advanced liver disease
-
Liaw YF, Sung JJ, Chow WC, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 2004; 351: 1521-31.
-
(2004)
N Engl J Med
, vol.351
, pp. 1521-1531
-
-
Liaw, Y.F.1
Sung, J.J.2
Chow, W.C.3
-
112
-
-
33644818518
-
A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
-
Chang TT, Gish RG, de Man R, et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 2006; 354: 1001-10.
-
(2006)
N Engl J Med
, vol.354
, pp. 1001-1010
-
-
Chang, T.T.1
Gish, R.G.2
de Man, R.3
-
113
-
-
4544239807
-
Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B
-
Marcellin P, Lau GK, Bonino F, et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2004; 351: 1206-17.
-
(2004)
N Engl J Med
, vol.351
, pp. 1206-1217
-
-
Marcellin, P.1
Lau, G.K.2
Bonino, F.3
-
114
-
-
84983725895
-
Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion
-
Ni YH, Chang MH, Chen PJ, et al. Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion. Gastroenterology 2007; 132: 2340-5.
-
(2007)
Gastroenterology
, vol.132
, pp. 2340-2345
-
-
Ni, Y.H.1
Chang, M.H.2
Chen, P.J.3
-
115
-
-
29244437488
-
A mathematical model to estimate global hepatitis B disease burden and vaccination impact
-
Goldstein ST, Zhou F, Hadler SC, Bell BP, Mast EE, Margolis HS. A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int J Epidemiol 2005; 34: 1329-39.
-
(2005)
Int J Epidemiol
, vol.34
, pp. 1329-1339
-
-
Goldstein, S.T.1
Zhou, F.2
Hadler, S.C.3
Bell, B.P.4
Mast, E.E.5
Margolis, H.S.6
-
116
-
-
33646242513
-
A Practical Approach to Managing Patients with HCV Infection
-
Huang RH, Hu KQ. A Practical Approach to Managing Patients with HCV Infection. Int J Med Sci 2006; 3: 63-8.
-
(2006)
Int J Med Sci
, vol.3
, pp. 63-68
-
-
Huang, R.H.1
Hu, K.Q.2
-
117
-
-
33644520948
-
Therapy of hepatitis C: From empiricism to eradication
-
Pawlotsky JM. Therapy of hepatitis C: From empiricism to eradication. Hepatology 2006; 43: S207-20.
-
(2006)
Hepatology
, vol.43
-
-
Pawlotsky, J.M.1
-
118
-
-
0034802218
-
Estimating progression to cirrhosis in chronic hepatitis C virus infection
-
Freeman AJ, Dore GJ, Law MG, et al. Estimating progression to cirrhosis in chronic hepatitis C virus infection. Hepatology 2001; 34: 809-16.
-
(2001)
Hepatology
, vol.34
, pp. 809-816
-
-
Freeman, A.J.1
Dore, G.J.2
Law, M.G.3
-
119
-
-
0031041924
-
Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients
-
Fattovich G, Giustina G, Degos F, et al. Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients. Gastroenterology 1997; 112: 463.
-
(1997)
Gastroenterology
, vol.112
, pp. 463
-
-
Fattovich, G.1
Giustina, G.2
Degos, F.3
-
120
-
-
0032955838
-
The long-term outcomes of patients with compensated hepatitis C virus-related cirrhosis and history of parenteral exposure in the United States
-
Hu KQ, Tong MJ. The long-term outcomes of patients with compensated hepatitis C virus-related cirrhosis and history of parenteral exposure in the United States. Hepatology 1999; 29: 1311.
-
(1999)
Hepatology
, vol.29
, pp. 1311
-
-
Hu, K.Q.1
Tong, M.J.2
-
121
-
-
34447322281
-
Molecular biology of hepatitis C virus
-
Suzuki T, Aizaki H, Murakami K, Shoji I, Wakita T. Molecular biology of hepatitis C virus. J Gastroenterol 2007; 42: 411-23.
-
(2007)
J Gastroenterol
, vol.42
, pp. 411-423
-
-
Suzuki, T.1
Aizaki, H.2
Murakami, K.3
Shoji, I.4
Wakita, T.5
-
122
-
-
0028293828
-
A proposed system for the nomenclature of hepatitis C viral genotypes (letter)
-
Simmonds P, Alberti A, Alter HJ, et al. A proposed system for the nomenclature of hepatitis C viral genotypes (letter). Hepatology 1994; 19: 1321-4.
-
(1994)
Hepatology
, vol.19
, pp. 1321-1324
-
-
Simmonds, P.1
Alberti, A.2
Alter, H.J.3
-
123
-
-
0034623816
-
Efficient initiation of HCV RNA replication in cell culture
-
Blight KJ, Kolykhalov AA, Rice CM. Efficient initiation of HCV RNA replication in cell culture. Science 2000; 290: 1972-74.
-
(2000)
Science
, vol.290
, pp. 1972-1974
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Rice, C.M.3
-
124
-
-
23044437222
-
Complete replication of hepatitis C virus in cell culture
-
Lindenbach BD, Evans MJ, Syder AJ, et al. Complete replication of hepatitis C virus in cell culture. Science 2005; 309: 623-26.
-
(2005)
Science
, vol.309
, pp. 623-626
-
-
Lindenbach, B.D.1
Evans, M.J.2
Syder, A.J.3
-
125
-
-
0031712813
-
The core protein of hepatitis-C virus induces hepatocellular carcinoma in transgenic mice
-
Moriya K, Fujie H, Shintani Y, et al. The core protein of hepatitis-C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998; 4: 1065-67.
-
(1998)
Nat Med
, vol.4
, pp. 1065-1067
-
-
Moriya, K.1
Fujie, H.2
Shintani, Y.3
-
126
-
-
0032508414
-
NF-kappaB antiapoptosis. Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS. NF-kappaB antiapoptosis. Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998; 281: 1680-83.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin, A.S.5
-
127
-
-
0000516274
-
Mitochondrial redox signaling during apoptosis
-
Cai J, Jones DP Mitochondrial redox signaling during apoptosis. J Bioenerg Biomembr 1999; 31: 327-34.
-
(1999)
J Bioenerg Biomembr
, vol.31
, pp. 327-334
-
-
Cai, J.1
Jones, D.P.2
-
128
-
-
0030218609
-
Characterization of cell lines allowing tightly regulated expression of hepatitis-C virus core protein
-
Moradpour D, Englert C, Wakita T, Wands JR. Characterization of cell lines allowing tightly regulated expression of hepatitis-C virus core protein. Virology 1996; 222: 51-63.
-
(1996)
Virology
, vol.222
, pp. 51-63
-
-
Moradpour, D.1
Englert, C.2
Wakita, T.3
Wands, J.R.4
-
129
-
-
0037707408
-
Dual effects of hepatitis-C virus Core protein on the transcription of cyclin-dependent kinase inhibitor p21 gene
-
Kwun HJ, Jang KL. Dual effects of hepatitis-C virus Core protein on the transcription of cyclin-dependent kinase inhibitor p21 gene. J Viral Hepat 2003; 10: 249-55.
-
(2003)
J Viral Hepat
, vol.10
, pp. 249-255
-
-
Kwun, H.J.1
Jang, K.L.2
-
130
-
-
0036290134
-
Subcellular localization of HCV CORE protein regulates its ability for p53 activation and p21 suppression
-
Yamanaka T, Kodama T, Doi T. Subcellular localization of HCV CORE protein regulates its ability for p53 activation and p21 suppression. Biochem Biophys Res Commun 2002; 294: 528-34.
-
(2002)
Biochem Biophys Res Commun
, vol.294
, pp. 528-534
-
-
Yamanaka, T.1
Kodama, T.2
Doi, T.3
-
131
-
-
0037124073
-
Alternate translation occurs within the core coding region of the hepatitis-C viral genome
-
Varaklioti A, Vassilaki N, Georgopoulou U, Mavromara P. Alternate translation occurs within the core coding region of the hepatitis-C viral genome. J Biol Chem 2002; 277: 17713-21.
-
(2002)
J Biol Chem
, vol.277
, pp. 17713-17721
-
-
Varaklioti, A.1
Vassilaki, N.2
Georgopoulou, U.3
Mavromara, P.4
-
133
-
-
0031738083
-
Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor
-
Ishido S, Hotta H. Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor. FEBS Lett 1998; 438: 258-62.
-
(1998)
FEBS Lett
, vol.438
, pp. 258-262
-
-
Ishido, S.1
Hotta, H.2
-
134
-
-
0034852454
-
P53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3
-
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL. P53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3. J Gen Virol 2001; 82: 2235-41.
-
(2001)
J Gen Virol
, vol.82
, pp. 2235-2241
-
-
Kwun, H.J.1
Jung, E.Y.2
Ahn, J.Y.3
Lee, M.N.4
Jang, K.L.5
-
135
-
-
0036017204
-
The nonstructural NS5A protein of hepatitis C virus: An expanding, multifunctional role in enhancing hepatitis C virus pathogenesis
-
Reyes GR. The nonstructural NS5A protein of hepatitis C virus: An expanding, multifunctional role in enhancing hepatitis C virus pathogenesis. J Biomed Sci 2002; 9: 187-97.
-
(2002)
J Biomed Sci
, vol.9
, pp. 187-197
-
-
Reyes, G.R.1
-
136
-
-
0037152313
-
Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3
-
Qadri I, Iwahashi M, Simon F. Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3. Biochem Biophys Acta 2002; 1592: 193-204.
-
(2002)
Biochem Biophys Acta
, vol.1592
, pp. 193-204
-
-
Qadri, I.1
Iwahashi, M.2
Simon, F.3
-
137
-
-
0037130462
-
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis
-
Lan KH, Sheu ML, Huang SJ, et al. HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. Oncogene 2002; 21: 4801-11.
-
(2002)
Oncogene
, vol.21
, pp. 4801-4811
-
-
Lan, K.H.1
Sheu, M.L.2
Huang, S.J.3
-
138
-
-
0036172292
-
Insights into the pathobiology of hepatitis C virus-associated cirrhosis: Analysis of intrahepatic differential gene expression
-
Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, McCaughan GW. Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression. Am J Pathol 2002; 160: 641-54.
-
(2002)
Am J Pathol
, vol.160
, pp. 641-654
-
-
Shackel, N.A.1
McGuinness, P.H.2
Abbott, C.A.3
Gorrell, M.D.4
McCaughan, G.W.5
-
139
-
-
34249862369
-
Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV
-
Dou J, Liu P, Wang J, Zhang X. Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV. Cell Mol Immunol 2006; 3: 227-33.
-
(2006)
Cell Mol Immunol
, vol.3
, pp. 227-233
-
-
Dou, J.1
Liu, P.2
Wang, J.3
Zhang, X.4
-
140
-
-
17844372967
-
Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression
-
Fukutomi T, Zhou Y, Kawai S, Eguchi H, Wands JR, Li J. Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression. Hepatology 2005; 41: 1096-105.
-
(2005)
Hepatology
, vol.41
, pp. 1096-1105
-
-
Fukutomi, T.1
Zhou, Y.2
Kawai, S.3
Eguchi, H.4
Wands, J.R.5
Li, J.6
-
141
-
-
10744232290
-
Gene expression profile linked to p53 status in hepatitis C virus-related hepatocellular carcinoma
-
Okada T, Iizuka N, Yamada-Okabe H, et al. Gene expression profile linked to p53 status in hepatitis C virus-related hepatocellular carcinoma. FEBS Lett 2003; 555: 583-90.
-
(2003)
FEBS Lett
, vol.555
, pp. 583-590
-
-
Okada, T.1
Iizuka, N.2
Yamada-Okabe, H.3
-
142
-
-
32944477003
-
Cellular response to gene expression profiles of different hepatitis C virus core proteins in the Huh-7 cell line with microarray analysis
-
Dou J, Liu P, Zhang X. Cellular response to gene expression profiles of different hepatitis C virus core proteins in the Huh-7 cell line with microarray analysis. J Nanosci Nanotechnol 2005; 5: 1230-5.
-
(2005)
J Nanosci Nanotechnol
, vol.5
, pp. 1230-1235
-
-
Dou, J.1
Liu, P.2
Zhang, X.3
-
143
-
-
34447248532
-
Analysis of ribavirin mutagenicity in human hepatitis C virus infection
-
Chevaliez S, Brillet R, et al. Analysis of ribavirin mutagenicity in human hepatitis C virus infection. J Virol 2007; 81: 7732-41.
-
(2007)
J Virol
, vol.81
, pp. 7732-7741
-
-
Chevaliez, S.1
Brillet, R.2
-
144
-
-
15644380122
-
Long term histologic improvement and disappearance of intra hepatic HCV RNA after alpha interferon therapy in patients with chronic hepatitis C
-
Marcellin P, Boyer N, Gervais A, et al. Long term histologic improvement and disappearance of intra hepatic HCV RNA after alpha interferon therapy in patients with chronic hepatitis C. Ann Intern Med 1997; 127: 875-81.
-
(1997)
Ann Intern Med
, vol.127
, pp. 875-881
-
-
Marcellin, P.1
Boyer, N.2
Gervais, A.3
-
145
-
-
34247570948
-
Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: A multicenter, retrospective cohort study of 1124 patients
-
Kobayashi S, Takeda T, Enomoto M, et al. Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: A multicenter, retrospective cohort study of 1124 patients. Liver Int 2007; 27: 186-91.
-
(2007)
Liver Int
, vol.27
, pp. 186-191
-
-
Kobayashi, S.1
Takeda, T.2
Enomoto, M.3
|