Tiagabine: Efficacy and safety in partial seizures - Current status

Neuropsychiatric Disease and Treatment

Volumn 4, Issue 4, 2008, Pages 731-736

  Bauer, Jürgen ^a   Cooper Mahkorn, Déirdre ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Antiepileptic drugs; Epilepsy; Pharmacotherapy; Status epilepticus; Tiagabine

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; ETIRACETAM; FELBAMATE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; SULTIAME; TIAGABINE; TOPIRAMATE; VALPROIC ACID;

ABDOMINAL PAIN; ABNORMAL THINKING; ADD ON THERAPY; ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; ARTICLE; ASTHENIA; ATHETOSIS; ATTENTION DEFICIT DISORDER; CLINICAL TRIAL; COGNITIVE DEFECT; COLOR VISION DEFECT; COMA; COMBINATION CHEMOTHERAPY; COMPLEX PARTIAL SEIZURE; CONFUSION; DEPRESSION; DIZZINESS; DOSAGE SCHEDULE COMPARISON; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG ERUPTION; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG METABOLISM; DRUG OVERDOSE; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SELECTIVITY; EPILEPTIC STATE; FOCAL EPILEPSY; FRACTURE; GASTROINTESTINAL SYMPTOM; GRAND MAL SEIZURE; HUMAN; MONOTHERAPY; NAUSEA; NERVOUSNESS; OUTCOMES RESEARCH; SEDATION; SEIZURE; SIDE EFFECT; SOMNOLENCE; SPEECH DISORDER; TONIC CLONIC SEIZURE; TREMOR;

EID: 52649141658     PISSN: 11766328     EISSN: None     Source Type: Journal    
DOI: 10.2147/ndt.s833     Document Type: Article

References (35)

1. Aikiï M, Jutila L, Salmenperä T, et al. 2006. Comparsion of the cognitive effects of tiagabine and carbamazepine as monotherapy in newly diagnosed adult patients with partial epilepsy: pooled analysis of two long-term, randomized, follow-up studies. Epilepsia, 47:1121-7.
2. Arif H, Buchsbaum R, Weintraub D, et al. 2007. Comparison and predictors of rash associated with 15 antiepileptic drugs. Neurology, 68:1701-9.
3. Arroyo S, Boothman BR, Brodie MJ, et al. 2005. A randomized open-label study of tiagabine given two or three times daily in refractory epilepsy. Epilepsy Behav, 14:81-4.
4. Bauer J. 1996. Seizure inducing effects of antiepileptic drugs. Acta Neurol Scand, 94:367-77.
5. Bauer J, Reuber M. 2003. Medical treatment of epilepsy. Expert Opin Emerg Drugs, 8:457-67.
6. Bauer J, Ruocco A. 2006. Epilepsy therapy with pregabalin. Treatment follow-up in 103 patients (in German). Aktuel Neurol, 33:439-441.
7. Bauer J, Stawowy B, Lenders T, et al. 1995. EfFicacy and tolerabilty of tiagabine: Results of an add-on study in patients with refractory partial seizures. J Epilepsy, 8:83-6.
8. Bauer J, Bergmann A, Reuber M, et al. 2002. Tolerability of tiagabine: a prospective open-label study. Epileptic Disord, 4:257-60.
9. Bauer J, Ben-Menachem E, Krämer G, et al. 2006. Levetiracetam: a long-term follow-up study of efficacy and safety. Acta Neurol Scand, 114:169-76.
10. Bauer J, Buchmüller L, Reuber M, et al. 2008. Which patients become seizure-free with antiepileptic drugs? An observational study in 821 patients with epilepsy. Acta Neurol Scand, 117:55-9.
11. Beerlage S, Bauer J. 2007. Treatment of epilepsy with topiramate. A 12- and 24-months treatment analysis in 98 patients (in German). Aktuel Neurol, 34: 555-8.
12. Bialer M, Johannessen SI, Kupferberg HJ, et al. 2007. Progress report on new antiepileptic drugs: A summary of the eighth Eilat conference (EILAT VIII). Epilepsy Res, 73:1-52.
13. Cantrell FL, Ritter M, Himes E. 2004. Intentional overdose with tiagabine: an unusual clinical presentation. J Emerg Med, 27:271-2.
14. Chahem J, Bauer J. 2007. Treatment of epilepsy with third-line antiepileptic drugs: felbamate, tiagabine and sulthiame (in German). Nervenarzt, 78:1407-12.
15. Crawford P, Meinardi H, Brown S, et al. 2001. Tiagabine: efficacy and safety in adjunctive treatment of partial seizures. Epilepsia, 42:531-8.
16. Fritz N, Glogau S, Hoffmann J, et al. 2005. Efficacy and cognitive side effcts of tiagabine and topiramate in patients with epilepsy. Epilepsy Behav, 6:373-81.
17. Gazzola DM, Balcer LJ, French JA. 2007. Seizure-free outcome in randomized add-on trials of the new antiepileptic drugs. Epilepsia, 48:1303-7.
18. Gustavson LE, Cato A, Guenther HJ, et al. 1995. Lack of clinically important drug interactions between tiagabine and carbamazepine, phenytoin or valproate. Epilepsia, 36:159.
19. Haddad NI, Umashankar G, Harik SI. 2007. Tiagabine-induced non-convulsive status epilepticus in a patient without history of epilepsy. Neurosciences, 2:152-4.
20. Harden CL, Leppik I. 2006. Optimizing therapy of seizures in women who use oral contraceptives. Neurology, 67:S56-8.
21. Jedrzejczak J. 2005. Tiagabine as add-on therapy may be more effective with valproate - open label, multicentre study of patients with focal epilepsy. Eur J Neurol, 12:176-80.
22. Jette N, Cappell J, VanPassel L, et al. 2006. Tiagabine-induced nonconvulsive status epilepticus in an adolescent without epilepsy. Neurology, 67:1514-5.
23. Koepp MJ, Edwards M, Collins J, et al. 2005. Status epilepticus and tiagabine therapy revisited. Epilepsia, 46:1625-32.
24. Lassen LC. 1994. Phase II study of of tiagabine: efficacy and safety in adjunctive treatment of partial seizures. Novo Nordisk Clinical Study Report, TIA-103/CNS/1, October 18.
25. Mula M, Sander JW. 2007. Negative effects of antiepileptic drugs on mood in patients with epilepsy. Drug Saf, 30:555-67.
26. Richens A, Gustavson LE, McKelvy JF, et al. 1991. Parmacokinetics and safety of single-dose tiagabine HCl in epileptic patients chronically treated with four other antiepileptic drug regimens. Epilepsia, 32:12.
27. Rowan AJ, Uthman B, Ahmann P, et al. 1994. Safety and efficacy of three dose levels of tiagabine HCl versus placebo as adjunctive treatment for complex partial seizures. Epilepsia, 35:54.
28. Sommerville KW 1997. Tiagabine. In: Engel JJr, Pedley TA (eds) Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven, pp. 645-53.
29. Sorri I, Kälviäinen R, Mäntyjärvi M. 2005. Color vision and contrast sensitivity in epilepsy patients treated with initial tiagabine monotherapy. Epilepsy Res, 67:101-7.
30. Spiller HA, Winter ML, Ryan M, et al. 2005. Retrospective evaluation of tiagabine overdose. Clin Toxicol (Phila), 43:855-9.
31. Tombini M, Pacifici L, Passarelli F, et al. 2006. Transient athetosis induced by tiagabine. Epilepsia, 47:799-800.
32. Tomson T, Battino D. 2007. Pharmacokinetics and therapeutic drug monitoring of newer antiepileptic drugs during pregnancy and puerperium. Clin Pharmacokinet, 46:209-19.
33. Vestergaard P, Rejnmark L, Mosekilde L. 2004. Fracture risk associated with use of antiepileptic drugs. Epilepsia, 45:1330-7.
34. Vinton A, Kornberg AJ, Cowley M, et al. 2005. Tiagabine-induced generalised non convulsive status epilepticus in patients with lesional focal epilepsy. J Clin Neurosci, 12:128-33.
35. Zaccara G, Messori A, Cincotta M, et al. 2006. Comparison of the efficacy and tolerability of new antiepileptic drugs: what can we learn from long-term studies? Acta Neurol Scand, 114:157-68.