The anti-convulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator

Neuropharmacology

Volumn 56, Issue 1, 2009, Pages 190-197

  Fisher, Janet L ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Anti convulsant; Electrophysiology; GABA; Patch clamp; Recombinant; Site directed mutagenesis

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ION CHANNEL; NEUROSTEROID; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; STIRIPENTOL;

ALLOSTERISM; ANTICONVULSANT ACTIVITY; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GABAERGIC TRANSMISSION; HUMAN; HUMAN CELL; PATCH CLAMP; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ALLOSTERIC REGULATION; ANTICONVULSANTS; CELL LINE, TRANSFORMED; DIAZEPAM; DIOXOLANES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; GAMMA-AMINOBUTYRIC ACID; HUMANS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POINT MUTATION; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 58049084097     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.06.004     Document Type: Article

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