-
1
-
-
0033760422
-
Epilepsy after the first drug fails: substitution or add-on?
-
Kwan P., and Brodie M.J. Epilepsy after the first drug fails: substitution or add-on?. Seizure 9 (2000) 464-468
-
(2000)
Seizure
, vol.9
, pp. 464-468
-
-
Kwan, P.1
Brodie, M.J.2
-
2
-
-
0036850041
-
Polytherapy in epilepsy: the experimental evidence
-
Czuczwar S.J., and Borowicz K.K. Polytherapy in epilepsy: the experimental evidence. Epilepsy Res 52 (2002) 15-23
-
(2002)
Epilepsy Res
, vol.52
, pp. 15-23
-
-
Czuczwar, S.J.1
Borowicz, K.K.2
-
3
-
-
0242412135
-
Separation methods that are capable of revealing blood-brain barrier permeability
-
Dash A.K., and Elmquist W.F. Separation methods that are capable of revealing blood-brain barrier permeability. J Chromatogr B 797 (2003) 241-254
-
(2003)
J Chromatogr B
, vol.797
, pp. 241-254
-
-
Dash, A.K.1
Elmquist, W.F.2
-
4
-
-
0026072033
-
Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat
-
Garske G.E., Palmer G.C., Napier J.J., et al. Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat. Epilepsy Res 9 (1991) 161-174
-
(1991)
Epilepsy Res
, vol.9
, pp. 161-174
-
-
Garske, G.E.1
Palmer, G.C.2
Napier, J.J.3
-
5
-
-
0026872481
-
Biological profile of the metabolites of the anticonvulsant remacemide
-
Palmer G.C., Murray R.J., and Wilson T.C. Biological profile of the metabolites of the anticonvulsant remacemide. Epilepsy Res 12 (1992) 9-20
-
(1992)
Epilepsy Res
, vol.12
, pp. 9-20
-
-
Palmer, G.C.1
Murray, R.J.2
Wilson, T.C.3
-
6
-
-
0024996302
-
Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice
-
Stagnitto M.L., Palmer G.C., Ordy J.M., et al. Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice. Epilepsy Res 7 (1990) 11-28
-
(1990)
Epilepsy Res
, vol.7
, pp. 11-28
-
-
Stagnitto, M.L.1
Palmer, G.C.2
Ordy, J.M.3
-
7
-
-
0027749328
-
Antiepileptic and neuroprotective potential for remacemide hydrochloride
-
Palmer G.C., Clark B., and Hutchison J.B. Antiepileptic and neuroprotective potential for remacemide hydrochloride. Drug Future 18 (1993) 1021-1042
-
(1993)
Drug Future
, vol.18
, pp. 1021-1042
-
-
Palmer, G.C.1
Clark, B.2
Hutchison, J.B.3
-
8
-
-
0028112226
-
Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of antiepileptic drugs and calcium antagonists
-
Cramer C.L., Stagnitto M.L., Knowles M.A., and Palmer G.C. Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of antiepileptic drugs and calcium antagonists. Life Sci 54 (1994) 1271-1275
-
(1994)
Life Sci
, vol.54
, pp. 1271-1275
-
-
Cramer, C.L.1
Stagnitto, M.L.2
Knowles, M.A.3
Palmer, G.C.4
-
9
-
-
0029831493
-
Update on the mechanism of action of antiepileptic drugs
-
Meldrum B.S. Update on the mechanism of action of antiepileptic drugs. Epilepsia 37 Suppl. 6 (1996) 4-11
-
(1996)
Epilepsia
, vol.37
, Issue.SUPPL. 6
, pp. 4-11
-
-
Meldrum, B.S.1
-
10
-
-
0030764536
-
Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL 12495AA on rat CA1 hippocampal neurons in vitro
-
Norris S.K., and King A.E. Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL 12495AA on rat CA1 hippocampal neurons in vitro. Neuropharmacology 36 (1997) 951-959
-
(1997)
Neuropharmacology
, vol.36
, pp. 951-959
-
-
Norris, S.K.1
King, A.E.2
-
11
-
-
0036497247
-
Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes
-
Santangeli S., Sills G.J., Thompson G.G., and Brodie M.J. Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol 438 (2002) 63-68
-
(2002)
Eur J Pharmacol
, vol.438
, pp. 63-68
-
-
Santangeli, S.1
Sills, G.J.2
Thompson, G.G.3
Brodie, M.J.4
-
12
-
-
0030047997
-
Remacemide HCl and its metabolite, FLP 12495AA, limit potential firing frequency and block NMDA responses of mouse spinal cord neurons in cell culture
-
Wamil A.W., Cheung H., Harris E.W., and McLean M.J. Remacemide HCl and its metabolite, FLP 12495AA, limit potential firing frequency and block NMDA responses of mouse spinal cord neurons in cell culture. Epilepsy Res 23 (1996) 1-14
-
(1996)
Epilepsy Res
, vol.23
, pp. 1-14
-
-
Wamil, A.W.1
Cheung, H.2
Harris, E.W.3
McLean, M.J.4
-
13
-
-
0029670420
-
Block of the N-methyl-d-aspartate receptor by remacemide and its des-glycine metabolite
-
Subramaniam S., Donevan S.D., and Rogawski M.A. Block of the N-methyl-d-aspartate receptor by remacemide and its des-glycine metabolite. J Pharmacol Exp Ther 276 (1996) 161-168
-
(1996)
J Pharmacol Exp Ther
, vol.276
, pp. 161-168
-
-
Subramaniam, S.1
Donevan, S.D.2
Rogawski, M.A.3
-
14
-
-
0000646815
-
Potential antiepileptic drugs: remacemide hydrochloride
-
Levy R.H., Mattson R.H., and Meldrum B.S. (Eds), Raven Press, New York
-
Clark B., Hutchison J.B., Jamieson V., Jones T., Palmer G.C., and Scheyer R.D. Potential antiepileptic drugs: remacemide hydrochloride. In: Levy R.H., Mattson R.H., and Meldrum B.S. (Eds). Antiepileptic drugs. 4th ed. (1995), Raven Press, New York 1035-1044
-
(1995)
Antiepileptic drugs. 4th ed.
, pp. 1035-1044
-
-
Clark, B.1
Hutchison, J.B.2
Jamieson, V.3
Jones, T.4
Palmer, G.C.5
Scheyer, R.D.6
-
15
-
-
0030954129
-
Remacemide hydrochloride: a novel antiepileptic agent
-
Davies J.A. Remacemide hydrochloride: a novel antiepileptic agent. Gen Pharmacol 28 (1997) 499-502
-
(1997)
Gen Pharmacol
, vol.28
, pp. 499-502
-
-
Davies, J.A.1
-
16
-
-
0035990514
-
Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride
-
Sills G.J., Santangeli S., Forrest G., and Brodie M.J. Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride. Epilepsy Res 49 (2002) 247-254
-
(2002)
Epilepsy Res
, vol.49
, pp. 247-254
-
-
Sills, G.J.1
Santangeli, S.2
Forrest, G.3
Brodie, M.J.4
-
17
-
-
0030064792
-
The desglycinyl metabolite of remacemide hydrochloride is neuroprotective in cultured rat cortical neurons
-
Black M.A., Tremblay R., Mealing G.A., Durkin J.P., Whitfield J.F., and Morley P. The desglycinyl metabolite of remacemide hydrochloride is neuroprotective in cultured rat cortical neurons. J Neurochem 66 (1996) 989-995
-
(1996)
J Neurochem
, vol.66
, pp. 989-995
-
-
Black, M.A.1
Tremblay, R.2
Mealing, G.A.3
Durkin, J.P.4
Whitfield, J.F.5
Morley, P.6
-
18
-
-
0037087039
-
Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice
-
Santangeli S., Sills G.J., Stone T.W., and Brodie M.J. Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice. Neurosci Lett 321 (2002) 33-36
-
(2002)
Neurosci Lett
, vol.321
, pp. 33-36
-
-
Santangeli, S.1
Sills, G.J.2
Stone, T.W.3
Brodie, M.J.4
-
19
-
-
0036265066
-
Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen
-
Chadwick D.W., Betts T.A., Broddie H.D., et al. Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 1200 mg/day) in a Q.I.D. regimen. Seizure 11 (2002) 114-123
-
(2002)
Seizure
, vol.11
, pp. 114-123
-
-
Chadwick, D.W.1
Betts, T.A.2
Broddie, H.D.3
-
20
-
-
0036258904
-
Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen
-
Jones M.W., Blume W.T., Guberman A., et al. Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg/day) in a B.I.D. regimen. Seizure 11 (2002) 104-113
-
(2002)
Seizure
, vol.11
, pp. 104-113
-
-
Jones, M.W.1
Blume, W.T.2
Guberman, A.3
-
21
-
-
0036748292
-
A double-blind, placebo-controlled study of remacemide hydrochloride in patients with refractory epilepsy following pre-surgical assessment
-
Devinsky O., Vazquez B., Faught E., et al. A double-blind, placebo-controlled study of remacemide hydrochloride in patients with refractory epilepsy following pre-surgical assessment. Seizure 11 (2002) 371-376
-
(2002)
Seizure
, vol.11
, pp. 371-376
-
-
Devinsky, O.1
Vazquez, B.2
Faught, E.3
-
22
-
-
0029843239
-
Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites
-
Leach J.P., Blacklaw J., Jamieson V., Jones T., Richens A., and Brodie M.J. Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites. Epilepsia 37 (1996) 1100-1106
-
(1996)
Epilepsia
, vol.37
, pp. 1100-1106
-
-
Leach, J.P.1
Blacklaw, J.2
Jamieson, V.3
Jones, T.4
Richens, A.5
Brodie, M.J.6
-
23
-
-
0030841925
-
Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients
-
Leach J.P., Grivan J., Jamieson V., Jones T., Richens A., and Brodie M.J. Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients. Seizure 6 (1997) 179-184
-
(1997)
Seizure
, vol.6
, pp. 179-184
-
-
Leach, J.P.1
Grivan, J.2
Jamieson, V.3
Jones, T.4
Richens, A.5
Brodie, M.J.6
-
24
-
-
84951384024
-
A simplified method of evaluating dose-effect experiments
-
Litchfield J.T., and Wilcoxon F. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96 (1949) 99-113
-
(1949)
J Pharmacol Exp Ther
, vol.96
, pp. 99-113
-
-
Litchfield, J.T.1
Wilcoxon, F.2
-
25
-
-
84940816667
-
Une nouvelle methode simple pour explorer l'action tranquilisante: le test de la cheminee
-
Boissier J.R., Tardy J., and Diverres J.C. Une nouvelle methode simple pour explorer l'action tranquilisante: le test de la cheminee. Med Exp (Basel) 3 (1960) 81-84
-
(1960)
Med Exp (Basel)
, vol.3
, pp. 81-84
-
-
Boissier, J.R.1
Tardy, J.2
Diverres, J.C.3
-
26
-
-
0022647809
-
Benzodiazepines impair and beta-carbolines enhance performance in learning and memory tasks
-
Venault P., Chapouthier G., De Carvalho L.P., et al. Benzodiazepines impair and beta-carbolines enhance performance in learning and memory tasks. Nature 321 (1986) 864-866
-
(1986)
Nature
, vol.321
, pp. 864-866
-
-
Venault, P.1
Chapouthier, G.2
De Carvalho, L.P.3
-
28
-
-
0038045883
-
Interactions between oxcarbazepine and conventional antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis
-
Luszczki J.J., Borowicz K.K., Swiader M., and Czuczwar S.J. Interactions between oxcarbazepine and conventional antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis. Epilepsia 44 (2003) 489-499
-
(2003)
Epilepsia
, vol.44
, pp. 489-499
-
-
Luszczki, J.J.1
Borowicz, K.K.2
Swiader, M.3
Czuczwar, S.J.4
-
30
-
-
0036713855
-
Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis
-
Borowicz K.K., Swiader M., Luszczki J., and Czuczwar S.J. Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis. Epilepsia 43 (2002) 956-963
-
(2002)
Epilepsia
, vol.43
, pp. 956-963
-
-
Borowicz, K.K.1
Swiader, M.2
Luszczki, J.3
Czuczwar, S.J.4
-
31
-
-
2142660737
-
Isobolographic profile of interaction between tiagabine and gabapentin: a preclinical study
-
Luszczki J.J., and Czuczwar S.J. Isobolographic profile of interaction between tiagabine and gabapentin: a preclinical study. Naunyn Schmiedeberg's Arch Pharmacol 369 (2004) 434-446
-
(2004)
Naunyn Schmiedeberg's Arch Pharmacol
, vol.369
, pp. 434-446
-
-
Luszczki, J.J.1
Czuczwar, S.J.2
-
32
-
-
0025817126
-
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs
-
Löscher W., Fassbender C.P., and Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. Epilepsy Res 8 (1991) 171-189
-
(1991)
Epilepsy Res
, vol.8
, pp. 171-189
-
-
Löscher, W.1
Fassbender, C.P.2
Nolting, B.3
-
33
-
-
0026072033
-
Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat
-
Garske G.E., Palmer G.C., Napier J.J., et al. Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat. Epilepsy Res 9 (1991) 161-174
-
(1991)
Epilepsy Res
, vol.9
, pp. 161-174
-
-
Garske, G.E.1
Palmer, G.C.2
Napier, J.J.3
-
34
-
-
0032916583
-
Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat
-
Halonen T., Nissinen J., and Pitkanen A. Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat. Epilepsy Res 34 (1999) 251-269
-
(1999)
Epilepsy Res
, vol.34
, pp. 251-269
-
-
Halonen, T.1
Nissinen, J.2
Pitkanen, A.3
-
35
-
-
0024996302
-
Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice
-
Stagnitto M.L., Palmer G.C., Ordy J.M., et al. Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice. Epilepsy Res 7 (1990) 11-28
-
(1990)
Epilepsy Res
, vol.7
, pp. 11-28
-
-
Stagnitto, M.L.1
Palmer, G.C.2
Ordy, J.M.3
-
36
-
-
0028112226
-
Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of anti-epileptic agents and calcium antagonists
-
Cramer C.L., Stagnitto, Knowles M.A., and Palmer G.C. Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of anti-epileptic agents and calcium antagonists. Life Sci 54 (1994) PL271-PL275
-
(1994)
Life Sci
, vol.54
-
-
Cramer, C.L.1
Stagnitto2
Knowles, M.A.3
Palmer, G.C.4
-
37
-
-
0032797436
-
Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures
-
Gasior M., Ungard J.T., and Witkin J.M. Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures. J Pharmacol Exp Ther 290 (1999) 1148-1156
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 1148-1156
-
-
Gasior, M.1
Ungard, J.T.2
Witkin, J.M.3
-
38
-
-
0037236399
-
Effects of remacemide in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS
-
Nehlig A., and Boehrer A. Effects of remacemide in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS. Epilepsy Res 52 (2003) 253-261
-
(2003)
Epilepsy Res
, vol.52
, pp. 253-261
-
-
Nehlig, A.1
Boehrer, A.2
-
39
-
-
0034500351
-
A placebo-controlled, double-blind cross- over trial of adjunctive one month remacemide hydrochloride treatment in patients with refractory epilepsy
-
Richens A., Mawer G., Crawford P., and Harrison B. A placebo-controlled, double-blind cross- over trial of adjunctive one month remacemide hydrochloride treatment in patients with refractory epilepsy. Seizure 9 (2000) 537-543
-
(2000)
Seizure
, vol.9
, pp. 537-543
-
-
Richens, A.1
Mawer, G.2
Crawford, P.3
Harrison, B.4
-
41
-
-
0036554690
-
Efficacy and safety of remacemide versus carbamazepine in newly diagnosed epilepsy: comparison by sequential analysis
-
Brodie M.J., Wroe S.J., Dean A.D., Holdich T.A., Whitehead J., and Stevens J.W. Efficacy and safety of remacemide versus carbamazepine in newly diagnosed epilepsy: comparison by sequential analysis. Epilepsy Behav 3 (2002) 140-146
-
(2002)
Epilepsy Behav
, vol.3
, pp. 140-146
-
-
Brodie, M.J.1
Wroe, S.J.2
Dean, A.D.3
Holdich, T.A.4
Whitehead, J.5
Stevens, J.W.6
-
42
-
-
0033761218
-
Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed
-
Deckers C.L., Czuczwar S.J., Hekster Y.A., et al. Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia 41 (2000) 1364-1374
-
(2000)
Epilepsia
, vol.41
, pp. 1364-1374
-
-
Deckers, C.L.1
Czuczwar, S.J.2
Hekster, Y.A.3
-
43
-
-
12244288290
-
Current limitations of antiepileptic drug therapy: a conference review
-
Deckers C.L., Genton P., Sills G.J., and Schmidt D. Current limitations of antiepileptic drug therapy: a conference review. Epilepsy Res 53 (2003) 1-17
-
(2003)
Epilepsy Res
, vol.53
, pp. 1-17
-
-
Deckers, C.L.1
Genton, P.2
Sills, G.J.3
Schmidt, D.4
-
44
-
-
0031966045
-
Sodium channels as molecular targets for antiepileptic drugs
-
Ragsdale D.S., and Avoli M. Sodium channels as molecular targets for antiepileptic drugs. Brain Res Rev 26 (1998) 16-28
-
(1998)
Brain Res Rev
, vol.26
, pp. 16-28
-
-
Ragsdale, D.S.1
Avoli, M.2
-
45
-
-
0035009415
-
The new generation of GABA enhancers
-
Czuczwar S.J., and Patsalos P.N. The new generation of GABA enhancers. CNS Drugs 15 (2001) 339-350
-
(2001)
CNS Drugs
, vol.15
, pp. 339-350
-
-
Czuczwar, S.J.1
Patsalos, P.N.2
|