-
1
-
-
85017027683
-
-
USRDS annual data report: Epidemiology of kidney disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2016.
-
1 United States Renal Data System. 2016 USRDS annual data report: Epidemiology of kidney disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2016.
-
(2016)
-
-
-
2
-
-
84907335380
-
An aging nation: The older population in the United States
-
US Census Bureau Publication P25-1140; May 2014. Available at: Accessed December 21,.
-
2 Ortman JM, Velkoff VA, Hogan H. An aging nation: The older population in the United States. US Census Bureau Publication P25-1140; May 2014. Available at: http://www.census.gov/library/publications/2014/demo/p25-1140.html. Accessed December 21, 2016.
-
(2016)
-
-
Ortman, J.M.1
Velkoff, V.A.2
Hogan, H.3
-
3
-
-
35348923554
-
Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction
-
3 Chen, G., Bridenbaugh, E.A., Akintola, A.D., et al. Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction. Am J Physiol Renal Physiol 293 (2007), F1272–F1281.
-
(2007)
Am J Physiol Renal Physiol
, vol.293
, pp. F1272-F1281
-
-
Chen, G.1
Bridenbaugh, E.A.2
Akintola, A.D.3
-
4
-
-
84908339615
-
The aging kidney: increased susceptibility to nephrotoxicity
-
4 Wang, X., Bonventre, J.V., Parrish, A.R., The aging kidney: increased susceptibility to nephrotoxicity. Int J Mol Sci 15 (2014), 15358–15376.
-
(2014)
Int J Mol Sci
, vol.15
, pp. 15358-15376
-
-
Wang, X.1
Bonventre, J.V.2
Parrish, A.R.3
-
5
-
-
33645465461
-
Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001
-
5 Xue, J.L., Daniels, F., Star, R.A., et al. Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol 17 (2006), 1135–1142.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1135-1142
-
-
Xue, J.L.1
Daniels, F.2
Star, R.A.3
-
6
-
-
84953327521
-
Structural and functional changes with the aging kidney
-
6 Denic, A., Glassock, R.J., Rule, A.D., Structural and functional changes with the aging kidney. Adv Chronic Kidney Dis 23 (2016), 19–28.
-
(2016)
Adv Chronic Kidney Dis
, vol.23
, pp. 19-28
-
-
Denic, A.1
Glassock, R.J.2
Rule, A.D.3
-
8
-
-
0026502417
-
Glomerular number and size in relation to age, kidney weight, and body surface in normal man
-
8 Nyengaard, J.R., Bendtsen, T.F., Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 232 (1992), 194–201.
-
(1992)
Anat Rec
, vol.232
, pp. 194-201
-
-
Nyengaard, J.R.1
Bendtsen, T.F.2
-
10
-
-
2942555556
-
Loss of N-cadherin and alpha-catenin in the proximal tubules of aging male Fischer 344 rats
-
10 Jung, K.Y., Dean, D., Jiang, J., et al. Loss of N-cadherin and alpha-catenin in the proximal tubules of aging male Fischer 344 rats. Mech Ageing Dev 125 (2004), 445–453.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 445-453
-
-
Jung, K.Y.1
Dean, D.2
Jiang, J.3
-
12
-
-
84937841351
-
Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age
-
12 Roeder, S.S., Stefanska, A., Eng, D.G., et al. Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age. Am J Physiol Renal Physiol 309 (2015), F164–F178.
-
(2015)
Am J Physiol Renal Physiol
, vol.309
, pp. F164-F178
-
-
Roeder, S.S.1
Stefanska, A.2
Eng, D.G.3
-
13
-
-
84953331151
-
Glomerular aging and focal global glomerulosclerosis: a podometric perspective
-
13 Hodgin, J.B., Bitzer, M., Wickman, L., et al. Glomerular aging and focal global glomerulosclerosis: a podometric perspective. J Am Soc Nephrol 26 (2015), 3162–3178.
-
(2015)
J Am Soc Nephrol
, vol.26
, pp. 3162-3178
-
-
Hodgin, J.B.1
Bitzer, M.2
Wickman, L.3
-
14
-
-
84957952429
-
Mitochondrial dysfunction induces senescence with a distinct secretory phenotype
-
14 Wiley, C.D., Velarde, M.C., Lecot, P., et al. Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell Metab 23 (2016), 303–314.
-
(2016)
Cell Metab
, vol.23
, pp. 303-314
-
-
Wiley, C.D.1
Velarde, M.C.2
Lecot, P.3
-
15
-
-
84959065037
-
Mitochondria are required for pro-ageing features of the senescent phenotype
-
15 Correia-Melo, C., Marques, F.D., Anderson, R., et al. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J 35 (2016), 724–742.
-
(2016)
EMBO J
, vol.35
, pp. 724-742
-
-
Correia-Melo, C.1
Marques, F.D.2
Anderson, R.3
-
16
-
-
84955201688
-
Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner
-
16 Kruse, S.E., Karunadharma, P.P., Basisty, N., et al. Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell 15 (2016), 89–99.
-
(2016)
Aging Cell
, vol.15
, pp. 89-99
-
-
Kruse, S.E.1
Karunadharma, P.P.2
Basisty, N.3
-
17
-
-
84893442805
-
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
17 Gomes, A.P., Price, N.L., Ling, A.J., et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 155 (2013), 1624–1638.
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
Price, N.L.2
Ling, A.J.3
-
18
-
-
84883614104
-
Effect of aging on formation of reactive oxygen species by mitochondria of rat heart
-
18 Kuka, S., Tatarkova, Z., Racay, P., et al. Effect of aging on formation of reactive oxygen species by mitochondria of rat heart. Gen Physiol Biophys 32 (2013), 415–420.
-
(2013)
Gen Physiol Biophys
, vol.32
, pp. 415-420
-
-
Kuka, S.1
Tatarkova, Z.2
Racay, P.3
-
19
-
-
84884344280
-
Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria
-
19 Daum, B., Walter, A., Horst, A., et al. Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria. Proc Natl Acad Sci U S A 110 (2013), 15301–15306.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 15301-15306
-
-
Daum, B.1
Walter, A.2
Horst, A.3
-
20
-
-
57449084690
-
Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin
-
20 Petrosillo, G., Matera, M., Moro, N., et al. Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin. Free Radic Biol Med 46 (2009), 88–94.
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 88-94
-
-
Petrosillo, G.1
Matera, M.2
Moro, N.3
-
21
-
-
84897457350
-
First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
-
21 Szeto, H.H., First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol 171 (2014), 2029–2050.
-
(2014)
Br J Pharmacol
, vol.171
, pp. 2029-2050
-
-
Szeto, H.H.1
-
22
-
-
84881090284
-
The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin
-
22 Birk, A.V., Liu, S., Soong, Y., et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol 24 (2013), 1250–1261.
-
(2013)
J Am Soc Nephrol
, vol.24
, pp. 1250-1261
-
-
Birk, A.V.1
Liu, S.2
Soong, Y.3
-
23
-
-
84991523754
-
Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension
-
23 Eirin, A., Ebrahimi, B., Kwon, S.H., et al. Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension. J Am Heart Assoc, 5, 2016, e003118.
-
(2016)
J Am Heart Assoc
, vol.5
, pp. e003118
-
-
Eirin, A.1
Ebrahimi, B.2
Kwon, S.H.3
-
24
-
-
84959520012
-
Chronic therapy with elamipretide (MTP-131), a novel mitochondria-targeting peptide, improves left ventricular and mitochondrial function in dogs with advanced heart failure
-
24 Sabbah, H.N., Gupta, R.C., Kohli, S., et al. Chronic therapy with elamipretide (MTP-131), a novel mitochondria-targeting peptide, improves left ventricular and mitochondrial function in dogs with advanced heart failure. Circ Heart Fail, 9, 2016, e002206.
-
(2016)
Circ Heart Fail
, vol.9
, pp. e002206
-
-
Sabbah, H.N.1
Gupta, R.C.2
Kohli, S.3
-
25
-
-
79957701753
-
Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury
-
25 Szeto, H.H., Liu, S., Soong, Y., et al. Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury. J Am Soc Nephrol 22 (2011), 1041–1052.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 1041-1052
-
-
Szeto, H.H.1
Liu, S.2
Soong, Y.3
-
26
-
-
84994165720
-
Protection of mitochondria prevents high-fat diet-induced glomerulopathy and proximal tubular injury
-
26 Szeto, H.H., Liu, S., Soong, Y., et al. Protection of mitochondria prevents high-fat diet-induced glomerulopathy and proximal tubular injury. Kidney Int 90 (2016), 997–1011.
-
(2016)
Kidney Int
, vol.90
, pp. 997-1011
-
-
Szeto, H.H.1
Liu, S.2
Soong, Y.3
-
27
-
-
84866156089
-
Mitochondrial swelling and incipient outer membrane rupture in preapoptotic and apoptotic cells
-
27 Sesso, A., Belizario, J.E., Marques, M.M., et al. Mitochondrial swelling and incipient outer membrane rupture in preapoptotic and apoptotic cells. Anat Rec (Hoboken) 295 (2012), 1647–1659.
-
(2012)
Anat Rec (Hoboken)
, vol.295
, pp. 1647-1659
-
-
Sesso, A.1
Belizario, J.E.2
Marques, M.M.3
-
28
-
-
84908574562
-
Mitochondrial oxidative stress in aging and healthspan
-
28 Dai, D.F., Chiao, Y.A., Marcinek, D.J., et al. Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan, 3, 2014, 6.
-
(2014)
Longev Healthspan
, vol.3
, pp. 6
-
-
Dai, D.F.1
Chiao, Y.A.2
Marcinek, D.J.3
-
29
-
-
77953807521
-
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
-
29 Daiber, A., Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species. Biochim Biophys Acta 1797 (2010), 897–906.
-
(2010)
Biochim Biophys Acta
, vol.1797
, pp. 897-906
-
-
Daiber, A.1
-
30
-
-
84938410708
-
Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension
-
30 Adesina, S.E., Kang, B.Y., Bijli, K.M., et al. Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension. Free Radic Biol Med 87 (2015), 36–47.
-
(2015)
Free Radic Biol Med
, vol.87
, pp. 36-47
-
-
Adesina, S.E.1
Kang, B.Y.2
Bijli, K.M.3
-
31
-
-
84921798565
-
Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation
-
31 Bijli, K.M., Kleinhenz, J.M., Murphy, T.C., et al. Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation. Free Radic Biol Med 80 (2015), 111–120.
-
(2015)
Free Radic Biol Med
, vol.80
, pp. 111-120
-
-
Bijli, K.M.1
Kleinhenz, J.M.2
Murphy, T.C.3
-
32
-
-
70349719148
-
Aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure
-
32 Gomes, P., Simao, S., Silva, E., et al. Aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure. Oxid Med Cell Longev 2 (2009), 138–145.
-
(2009)
Oxid Med Cell Longev
, vol.2
, pp. 138-145
-
-
Gomes, P.1
Simao, S.2
Silva, E.3
-
33
-
-
85003726485
-
Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy
-
33 Thallas-Bonke, V., Jha, J.C., Gray, S.P., et al. Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy. Physiol Rep, 2, 2014, e12192.
-
(2014)
Physiol Rep
, vol.2
, pp. e12192
-
-
Thallas-Bonke, V.1
Jha, J.C.2
Gray, S.P.3
-
34
-
-
84874242635
-
Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy
-
34 Matsushima, S., Kuroda, J., Ago, T., et al. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circ Res 112 (2013), 651–663.
-
(2013)
Circ Res
, vol.112
, pp. 651-663
-
-
Matsushima, S.1
Kuroda, J.2
Ago, T.3
-
35
-
-
29244468563
-
The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells
-
35 Kuroda, J., Nakagawa, K., Yamasaki, T., et al. The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells. Genes Cells 10 (2005), 1139–1151.
-
(2005)
Genes Cells
, vol.10
, pp. 1139-1151
-
-
Kuroda, J.1
Nakagawa, K.2
Yamasaki, T.3
-
36
-
-
70149091965
-
Subcellular localization of Nox4 and regulation in diabetes
-
36 Block, K., Gorin, Y., Abboud, H.E., Subcellular localization of Nox4 and regulation in diabetes. Proc Natl Acad Sci U S A 106 (2009), 14385–14390.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 14385-14390
-
-
Block, K.1
Gorin, Y.2
Abboud, H.E.3
-
37
-
-
84888136345
-
Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4 pathway
-
37 Sciarretta, S., Zhai, P., Shao, D., et al. Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4 pathway. Circ Res 113 (2013), 1253–1264.
-
(2013)
Circ Res
, vol.113
, pp. 1253-1264
-
-
Sciarretta, S.1
Zhai, P.2
Shao, D.3
-
38
-
-
0035964315
-
Does oxidative damage to DNA increase with age?
-
38 Hamilton, M.L., Van Remmen, H., Drake, J.A., et al. Does oxidative damage to DNA increase with age?. Proc Natl Acad Sci U S A 98 (2001), 10469–10474.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10469-10474
-
-
Hamilton, M.L.1
Van Remmen, H.2
Drake, J.A.3
-
39
-
-
77951157657
-
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
-
39 Kume, S., Uzu, T., Horiike, K., et al. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest 120 (2010), 1043–1055.
-
(2010)
J Clin Invest
, vol.120
, pp. 1043-1055
-
-
Kume, S.1
Uzu, T.2
Horiike, K.3
-
40
-
-
33846174664
-
Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence
-
40 Rodriguez-Iturbe, B., Sepassi, L., Quiroz, Y., et al. Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence. J Appl Physiol (1985) 102 (2007), 255–260.
-
(2007)
J Appl Physiol (1985)
, vol.102
, pp. 255-260
-
-
Rodriguez-Iturbe, B.1
Sepassi, L.2
Quiroz, Y.3
-
41
-
-
84947618982
-
Glomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis
-
41 Eng, D.G., Sunseri, M.W., Kaverina, N.V., et al. Glomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis. Kidney Int 88 (2015), 999–1012.
-
(2015)
Kidney Int
, vol.88
, pp. 999-1012
-
-
Eng, D.G.1
Sunseri, M.W.2
Kaverina, N.V.3
-
42
-
-
84896724981
-
Prevalence of CD44-positive glomerular parietal epithelial cells reflects podocyte injury in adriamycin nephropathy
-
42 Okamoto, T., Sasaki, S., Yamazaki, T., et al. Prevalence of CD44-positive glomerular parietal epithelial cells reflects podocyte injury in adriamycin nephropathy. Nephron Exp Nephrol 124 (2013), 11–18.
-
(2013)
Nephron Exp Nephrol
, vol.124
, pp. 11-18
-
-
Okamoto, T.1
Sasaki, S.2
Yamazaki, T.3
-
43
-
-
84900820000
-
Cells of renin lineage take on a podocyte phenotype in aging nephropathy
-
43 Pippin, J.W., Glenn, S.T., Krofft, R.D., et al. Cells of renin lineage take on a podocyte phenotype in aging nephropathy. Am J Physiol Renal Physiol 306 (2014), F1198–F1209.
-
(2014)
Am J Physiol Renal Physiol
, vol.306
, pp. F1198-F1209
-
-
Pippin, J.W.1
Glenn, S.T.2
Krofft, R.D.3
-
44
-
-
84906538163
-
Estimating podocyte number and density using a single histologic section
-
44 Venkatareddy, M., Wang, S., Yang, Y., et al. Estimating podocyte number and density using a single histologic section. J Am Soc Nephrol 25 (2014), 1118–1129.
-
(2014)
J Am Soc Nephrol
, vol.25
, pp. 1118-1129
-
-
Venkatareddy, M.1
Wang, S.2
Yang, Y.3
-
45
-
-
18244384042
-
Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner
-
45 Asanuma, K., Kim, K., Oh, J., et al. Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. J Clin Invest 115 (2005), 1188–1198.
-
(2005)
J Clin Invest
, vol.115
, pp. 1188-1198
-
-
Asanuma, K.1
Kim, K.2
Oh, J.3
-
46
-
-
84857646471
-
Semi-automated quantitative image analysis of podocyte desmin immunoreactivity as a sensitive marker for acute glomerular damage in the rat puromycin aminonucleoside nephrosis (PAN) model
-
46 Herrmann, A., Tozzo, E., Funk, J., Semi-automated quantitative image analysis of podocyte desmin immunoreactivity as a sensitive marker for acute glomerular damage in the rat puromycin aminonucleoside nephrosis (PAN) model. Exp Toxicol Pathol 64 (2012), 45–49.
-
(2012)
Exp Toxicol Pathol
, vol.64
, pp. 45-49
-
-
Herrmann, A.1
Tozzo, E.2
Funk, J.3
-
47
-
-
34547828145
-
Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly patients
-
47 Maruyama, M., Sugiyama, H., Sada, K., et al. Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly patients. Clin Nephrol 68 (2007), 73–80.
-
(2007)
Clin Nephrol
, vol.68
, pp. 73-80
-
-
Maruyama, M.1
Sugiyama, H.2
Sada, K.3
-
48
-
-
33645266951
-
Podocyte hypertrophy, “adaptation,” and “decompensation” associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction
-
48 Wiggins, J.E., Goyal, M., Sanden, S.K., et al. Podocyte hypertrophy, “adaptation,” and “decompensation” associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction. J Am Soc Nephrol 16 (2005), 2953–2966.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 2953-2966
-
-
Wiggins, J.E.1
Goyal, M.2
Sanden, S.K.3
-
49
-
-
84883807865
-
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice
-
49 Siegel, M.P., Kruse, S.E., Percival, J.M., et al. Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Aging Cell 12 (2013), 763–771.
-
(2013)
Aging Cell
, vol.12
, pp. 763-771
-
-
Siegel, M.P.1
Kruse, S.E.2
Percival, J.M.3
-
50
-
-
68949213947
-
Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
-
50 Yang, L., Zhao, K., Calingasan, N.Y., et al. Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Antioxid Redox Signal 11 (2009), 2095–2104.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 2095-2104
-
-
Yang, L.1
Zhao, K.2
Calingasan, N.Y.3
-
51
-
-
84945556096
-
A mitochondrion-targeted antioxidant ameliorates isoflurane-induced cognitive deficits in aging mice
-
51 Wu, J., Li, H., Sun, X., et al. A mitochondrion-targeted antioxidant ameliorates isoflurane-induced cognitive deficits in aging mice. PLoS One, 10, 2015, e0138256.
-
(2015)
PLoS One
, vol.10
, pp. e0138256
-
-
Wu, J.1
Li, H.2
Sun, X.3
-
52
-
-
77956207531
-
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons
-
52 Manczak, M., Mao, P., Calkins, M.J., et al. Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis 20 Suppl 2 (2010), S609–S631.
-
(2010)
J Alzheimers Dis
, vol.20 Suppl 2
, pp. S609-S631
-
-
Manczak, M.1
Mao, P.2
Calkins, M.J.3
-
53
-
-
84928635881
-
Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney
-
53 Szeto, H.H., Liu, S., Soong, Y., Birk, A.V., Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney. Am J Physiol Renal Physiol 308 (2015), F11–F21.
-
(2015)
Am J Physiol Renal Physiol
, vol.308
, pp. F11-F21
-
-
Szeto, H.H.1
Liu, S.2
Soong, Y.3
Birk, A.V.4
-
54
-
-
84887454400
-
Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides
-
54 Dai, D.F., Hsieh, E.J., Chen, T., et al. Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides. Circ Heart Fail 6 (2013), 1067–1076.
-
(2013)
Circ Heart Fail
, vol.6
, pp. 1067-1076
-
-
Dai, D.F.1
Hsieh, E.J.2
Chen, T.3
-
55
-
-
84890911734
-
Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia
-
55 Brown, D.A., Hale, S.L., Baines, C.P., et al. Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther 19 (2014), 121–132.
-
(2014)
J Cardiovasc Pharmacol Ther
, vol.19
, pp. 121-132
-
-
Brown, D.A.1
Hale, S.L.2
Baines, C.P.3
-
56
-
-
84905132634
-
Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension
-
56 Eirin, A., Williams, B.J., Ebrahimi, B., et al. Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension. J Hypertens 32 (2014), 154–165.
-
(2014)
J Hypertens
, vol.32
, pp. 154-165
-
-
Eirin, A.1
Williams, B.J.2
Ebrahimi, B.3
-
57
-
-
84891805774
-
The mouse age phenome knowledgebase and disease-specific inter-species age mapping
-
57 Geifman, N., Rubin, E., The mouse age phenome knowledgebase and disease-specific inter-species age mapping. PLoS One, 8, 2013, e81114.
-
(2013)
PLoS One
, vol.8
, pp. e81114
-
-
Geifman, N.1
Rubin, E.2
-
58
-
-
71549130719
-
Podocytes and glomerular function with aging
-
58 Wiggins, J., Podocytes and glomerular function with aging. Semin Nephrol 29 (2009), 587–593.
-
(2009)
Semin Nephrol
, vol.29
, pp. 587-593
-
-
Wiggins, J.1
-
59
-
-
24944557079
-
Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endothelial cells
-
59 Hu, T., Ramachandrarao, S.P., Siva, S., et al. Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endothelial cells. Am J Physiol Renal Physiol 289 (2005), F816–F825.
-
(2005)
Am J Physiol Renal Physiol
, vol.289
, pp. F816-F825
-
-
Hu, T.1
Ramachandrarao, S.P.2
Siva, S.3
-
60
-
-
84901835198
-
Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in long-term diabetic nephropathy
-
60 Jha, J.C., Gray, S.P., Barit, D., et al. Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in long-term diabetic nephropathy. J Am Soc Nephrol 25 (2014), 1237–1254.
-
(2014)
J Am Soc Nephrol
, vol.25
, pp. 1237-1254
-
-
Jha, J.C.1
Gray, S.P.2
Barit, D.3
-
61
-
-
84891689987
-
Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury
-
Diabetes. 62:2935–2947.
-
61 Eid AA, Ford BM, Bhandary B, et al. Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury. Diabetes. 62:2935–2947.
-
-
-
Eid, A.A.1
Ford, B.M.2
Bhandary, B.3
-
62
-
-
84980370984
-
Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy
-
62 Hou, Y., Li, S., Wu, M., et al. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy. Am J Physiol Renal Physiol 310 (2016), F547–F559.
-
(2016)
Am J Physiol Renal Physiol
, vol.310
, pp. F547-F559
-
-
Hou, Y.1
Li, S.2
Wu, M.3
-
63
-
-
84958093401
-
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
-
63 Baker, D.J., Childs, B.G., Durik, M., et al. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 530 (2016), 184–189.
-
(2016)
Nature
, vol.530
, pp. 184-189
-
-
Baker, D.J.1
Childs, B.G.2
Durik, M.3
-
64
-
-
75149174337
-
NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts
-
64 Bondi, C.D., Manickam, N., Lee, D.Y., et al. NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. J Am Soc Nephrol 21 (2010), 93–102.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 93-102
-
-
Bondi, C.D.1
Manickam, N.2
Lee, D.Y.3
-
65
-
-
84863153340
-
Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway
-
65 Chen, J., Chen, J.K., Harris, R.C., Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol 32 (2012), 981–991.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 981-991
-
-
Chen, J.1
Chen, J.K.2
Harris, R.C.3
-
66
-
-
84901288438
-
The role of senescent cells in ageing
-
66 van Deursen, J.M., The role of senescent cells in ageing. Nature 509 (2014), 439–446.
-
(2014)
Nature
, vol.509
, pp. 439-446
-
-
van Deursen, J.M.1
-
67
-
-
77649099572
-
De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease
-
67 Ohse, T., Vaughan, M.R., Kopp, J.B., et al. De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease. Am J Physiol Renal Physiol 298 (2010), F702–F711.
-
(2010)
Am J Physiol Renal Physiol
, vol.298
, pp. F702-F711
-
-
Ohse, T.1
Vaughan, M.R.2
Kopp, J.B.3
-
68
-
-
71449084301
-
A new function for parietal epithelial cells: a second glomerular barrier
-
68 Ohse, T., Chang, A.M., Pippin, J.W., et al. A new function for parietal epithelial cells: a second glomerular barrier. Am J Physiol Renal Physiol 297 (2009), F1566–F1574.
-
(2009)
Am J Physiol Renal Physiol
, vol.297
, pp. F1566-F1574
-
-
Ohse, T.1
Chang, A.M.2
Pippin, J.W.3
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