Podocytes and Glomerular Function with Aging

Seminars in Nephrology

Volumn 29, Issue 6, 2009, Pages 587-593

  Wiggins, Jocelyn ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Aging; calorie restriction; glomerulus; podocyte

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CERULOPLASMIN; DESMIN; NEPHRIN; WT1 PROTEIN;

AGING; ALPORT SYNDROME; ARTICLE; CALORIC RESTRICTION; DIABETES MELLITUS; FOCAL GLOMERULOSCLEROSIS; GENE EXPRESSION; GLOMERULOSCLEROSIS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY FAILURE; KIDNEY HYPERTROPHY; LUPUS ERYTHEMATOSUS NEPHRITIS; NONHUMAN; OXIDATIVE STRESS; PODOCYTE; PRIORITY JOURNAL;

AGED; AGING; ANIMALS; CALORIC RESTRICTION; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; GLOMERULAR FILTRATION RATE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; KIDNEY GLOMERULUS; MALE; MIDDLE AGED; PODOCYTES; RATS;

EID: 71549130719     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2009.07.012     Document Type: Article

References (51)

1. U.S. Renal Data System. USRDS 2008 annual data report: atlas of end-stage renal disease in the United States (2008), National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
2. In: Jennette J.C., Olson J.L., Schwartz M.M., and Silva F.G. (Eds). Heptinstall's pathology of the kidney. 6th ed. (2006), Lippincott-Raven, Philadelphia
3. Kaplan C., Pasternack B., Shah H., et al. Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 80 (1975) 227-234
4. Goyal V.K. Changes with age in the human kidney. Exp Gerontol 17 (1982) 321-331
5. Lindeman R.D., Tobin J., and Shock N.W. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33 (1985) 278-285
6. Anderson S., and Brenner B.M. The aging kidney: structure, function, mechanisms and therapeutic implications. J Am Geriatr Soc 35 (1987) 590-593
7. Coleman G.L., Barthold S.W., Osbaldiston G.W., Foster S.J., and Jonas A.M. Pathological changes during aging in barrier-reared Fischer 344 male rats. J Gerontol 32 (1977) 258-278
8. Lindeman R.D., and Goldman R. Anatomic and physiologic age changes in the kidney. Exp Gerontol 21 (1986) 379-406
9. Brandis A., Bianchi G., Reale E., Helmchen U., and Kuhn K. Age-dependant glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain. Lab Invest 55 (1986) 234-243
10. Kleinknecht C., Laouari D., Hinglais N., Habib R., Dodu C., Lacour B., et al. Role of amount and nature of carbohydrates in the course of experimental renal failure. Kidney Int 30 (1986) 687-693
11. Tapp D.C., Wortham W.G., Addison J.F., Hammonds D.N., Barnes J.L., and Venkatachalam M.A. Food restriction retards body growth and prevents end-stage renal pathology in remnant kidneys of rats regardless of protein intake. Lab Invest 60 (1989) 184-195
12. Keenan K.P., Coleman J.B., McCoy C.L., Hoe C.M., Soper K.A., and Laroque P. Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth. Toxicol Pathol 28 (2000) 788-798
13. Pabst R., and Sterzel R.B. Cell renewal of glomerular cell types in normal rats. An autoradiographic analysis. Kidney Int 24 (1983) 626-631
14. Kriz W., Gretz N., and Lemley K.V. Progression of glomerular diseases: is the podocyte the culprit?. Kidney Int 54 (1998) 687-697
15. Kriz W. Podocyte is the major culprit accounting for the progression of chronic renal disease. Microsc Res Tech 15 (2002) 189-195
16. Griffin S.V., Petermann A.T., Durvasula R.V., and Shankland S.J. Podocyte proliferation and differentiation in glomerular disease: role of cell-cycle regulatory proteins. Nephrol Dial Transplant 18 Suppl 6 (2003) vi8-vi13
17. Asanuma K., and Mundel P. The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 7 (2003) 255-259
18. Kriz W. Podocyte is the major culprit accounting for the progression of chronic renal disease. Microsc Res Tech 15 (2002) 189-195
19. Pavenstadt H., Kriz W., and Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 83 (2003) 253-307
20. Kestila M., Lenkkeri U., Mannikko M., Lamerdin J., McCready P., Putaala H., et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1 (1998) 575-582
21. Boute N., Gribouval O., Roselli S., Benessy F., Lee H., Fuchshuber A., et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24 (2000) 349-354
22. Kaplan J.M., Kim S.H., North K.N., Rennke H., Correia L.A., Tong H.Q., et al. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 24 (2000) 251-256
23. Laurens W.E., Vanrenterghem Y.F., Steels P.S., and Van Damme B.J. A new single nephron model of focal and segmental glomerulosclerosis in the Munich-Wistar rat. Kidney Int 45 (1994) 143-149
24. Kretzler M., Koeppen-Hagemann I., and Kritz W. Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomized-desoxycorticosterone hypertensive rat. Virchows Arch 425 (1994) 181-193
25. Kim Y.H., Goyal M., Kurnit D., Wharram B., Wiggins J., Holzman L., et al. Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 60 (2001) 957-968
26. Schiffer M., Bitzer M., Roberts I.S., Kopp J.B., Dijke P., Mundel P., et al. Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest 108 (2001) 807-816
27. Wharram B.L., Sanden S.K., Filipiak W.E., Goyal M., Wiggins J.E., Saunders T.L., et al. Podocyte depletion causes focal segmental glomerulosclerosis (FSGS) in rats. [abstract]. J Am Soc Nephrol 15 (2004) 240A
28. Sharif K., Goyal M., Kershaw D., Kunkel R., and Wiggins R. Podocyte phenotypes as defined by expression and distribution of GLEPP1 in the developing glomerulus and in nephrotic glomeruli from MCD, CNF, and FSGS. A dedifferentiation hypothesis for the nephrotic syndrome. Exp Nephrol 6 (1998) 234-244
29. Barisoni L., Kriz W., Mundel P., and D'Agati V. The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 10 (1999) 51-61
30. Hara M., Yanagihara T., and Kihara I. Urinary podocytes in primary focal segmental glomerulosclerosis. Nephron 89 (2001) 342-347
31. Kanno K., Kawachi H., Uchida Y., Hara M., Shimizu F., and Uchiyama M. Urinary sediment podocalyxin in children with glomerular diseases. Nephron Clin Pract 95 (2003) c91-c99
32. Vogelmann S.U., Nelson W.J., Myers B.D., and Lemley K.V. Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol 285 (2003) F40-F48
33. Floege J., Hackman B., Kliem V., Kriz W., Alpers C.E., Johnson R.J., et al. Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats: a podocyte disease. Kidney Int 51 (1997) 230-243
34. Yu B.P., Masoro E.J., and McMahan C.A. Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J Gerontol 40 (1985) 657-670
35. Kenyon C., Chang J., Gensch E., Rudner A., and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 366 (1993) 461-464
36. Mukhopadhyay A., and Tissenbaum H.A. Reproduction and longevity: secrets revealed by C. elegans. Trends Cell Biol 17 (2007) 65-71
37. Shaw P., Ocorr K., Bodmer R., and Oldham S. Drosophila aging 2006/2007. Exp Gerontol 43 (2008) 5-10
38. Bartke A. New findings in transgenic, gene knockout and mutant mice. Exp Gerontol 41 (2006) 1217-1219
39. Cai W., He J.C., Zhu L., Chen X., Zheng F., Striker G.E., et al. Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan. Am J Pathol 173 (2008) 327
40. Wiggins J.E., Goyal M., Sanden S.K., Wharram B.L., Shedden K.A., Misek D.E., et al. Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction. J Am Soc Nephrol 16 (2005) 2953-2966
41. Ruf R.G., Schultheiss M., Lichtenberger A., Karle S.M., Zalewski I., Mucha B., et al. APN Study Group: prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome. Kidney Int 66 (2004) 564-570
42. Quaggin S.E. Transcriptional regulation of podocyte specification and differentiation. Microsc Res Tech 57 (2002) 208-211
43. Patrakka J., and Tryggvason K. Nephrin-a unique structural and signaling protein of the kidney filter. Trends Mol Med 13 (2007) 396-403
44. Thomas P.E., Wharram B.L., Goyal M., Wiggins J.E., Holzman L.B., and Wiggins R.C. GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit. J Biol Chem 269 (1994) 19953-19962
45. Hudson B.G. The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family. J Am Soc Nephrol 15 (2004) 2514-2527
46. Wiggins J.E., Goyal M., Wharram B.L., and Wiggins R.C. Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet. J Am Soc Nephrol 17 (2006) 1382-1387
47. Patel B.N., Dunn R.J., Jeong S.Y., Julien J.-P., and David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci 22 (2002) 6578-6586
48. Goldstein I.M., Kaplan H.B., Edelson H.S., and Weissmann G. Ceruloplasmin: an acute phase reactant that scavenges oxygen-derived free radicals. Ann N Y Acad Sci 389 (1982) 368-379
49. Gutteridge J.M. Iron and oxygen radicals in the brain. Ann Neurol 32 (1992) S16-S21
50. Ferrucci L., Cavazzini C., Corsi A., Bartali B., Russo C.R., Lauretani F., et al. Biomarkers of frailty in older persons. J Endocrinol Invest 25 (2002) S10-S15
51. Cunningham J., Leffell M., Mearkle P., and Harmatz P. Elevated plasma ceruloplasmin in insulin-dependent diabetes mellitus: evidence for increased oxidative stress as a variable complication. Metabolism 44 (1995) 996-999