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Volumn 28, Issue 4, 2017, Pages 250-260

Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies

Author keywords

diabetes; fatty liver; glucagon like peptide 1; mitochondria; nonalcoholic steatohepatitis; obesity; pioglitazone

Indexed keywords

GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; METFORMIN; PIOGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUCAGON LIKE PEPTIDE 1;

EID: 85008222802     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2016.11.006     Document Type: Review
Times cited : (248)

References (87)
  • 1
    • 84930788424 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a systematic review
    • 1 Rinella, M.E., Nonalcoholic fatty liver disease: a systematic review. JAMA 313 (2015), 2263–2273.
    • (2015) JAMA , vol.313 , pp. 2263-2273
    • Rinella, M.E.1
  • 2
    • 84859404868 scopus 로고    scopus 로고
    • Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications
    • 711-725.e6
    • 2 Cusi, K., Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology, 142, 2012 711-725.e6.
    • (2012) Gastroenterology , vol.142
    • Cusi, K.1
  • 4
    • 84944397311 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease review: diagnosis, treatment, and outcomes
    • 4 Ahmed, A., et al. Nonalcoholic fatty liver disease review: diagnosis, treatment, and outcomes. Clin. Gastroenterol. Hepatol. 13 (2015), 2062–2070.
    • (2015) Clin. Gastroenterol. Hepatol. , vol.13 , pp. 2062-2070
    • Ahmed, A.1
  • 5
    • 84896690517 scopus 로고    scopus 로고
    • Extrahepatic complications of nonalcoholic fatty liver disease
    • 5 Armstrong, M.J., et al. Extrahepatic complications of nonalcoholic fatty liver disease. Hepatology 59 (2014), 1174–1197.
    • (2014) Hepatology , vol.59 , pp. 1174-1197
    • Armstrong, M.J.1
  • 6
    • 84955213803 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009
    • 6 Younossi, Z.M., et al. Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009. Hepatology 62 (2015), 1723–1730.
    • (2015) Hepatology , vol.62 , pp. 1723-1730
    • Younossi, Z.M.1
  • 7
    • 85015583297 scopus 로고    scopus 로고
    • Management of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a call to action
    • Diabetes Care (in press).
    • 7 Bril, F. and Cusi, K. Management of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a call to action. Diabetes Care (in press).
    • Bril, F.1    Cusi, K.2
  • 9
    • 84930791899 scopus 로고    scopus 로고
    • High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels
    • 9 Portillo-Sanchez, P., et al. High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels. J. Clin. Endocrinol. Metab. 100 (2015), 2231–2238.
    • (2015) J. Clin. Endocrinol. Metab. , vol.100 , pp. 2231-2238
    • Portillo-Sanchez, P.1
  • 10
    • 84920998988 scopus 로고    scopus 로고
    • The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease
    • 10 Maximos, M., et al. The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease. Hepatology 61 (2015), 153–160.
    • (2015) Hepatology , vol.61 , pp. 153-160
    • Maximos, M.1
  • 11
    • 84964331001 scopus 로고    scopus 로고
    • Treatment of patients with type 2 diabetes and non-alcoholic fatty liver disease: current approaches and future directions
    • 11 Cusi, K., Treatment of patients with type 2 diabetes and non-alcoholic fatty liver disease: current approaches and future directions. Diabetologia 59 (2016), 1112–1120.
    • (2016) Diabetologia , vol.59 , pp. 1112-1120
    • Cusi, K.1
  • 12
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
    • 12 Targher, G., et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 30 (2007), 1212–1218.
    • (2007) Diabetes Care , vol.30 , pp. 1212-1218
    • Targher, G.1
  • 13
    • 79953321393 scopus 로고    scopus 로고
    • Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors
    • 13 Leite, N.C., et al. Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors. Liver Int. 31 (2011), 700–706.
    • (2011) Liver Int. , vol.31 , pp. 700-706
    • Leite, N.C.1
  • 14
    • 79956062113 scopus 로고    scopus 로고
    • Prevalence of and risk factors for hepatic steatosis and nonalcoholic fatty liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    • 14 Williamson, R.M., et al. Prevalence of and risk factors for hepatic steatosis and nonalcoholic fatty liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes Care 34 (2011), 1139–1144.
    • (2011) Diabetes Care , vol.34 , pp. 1139-1144
    • Williamson, R.M.1
  • 15
    • 84952637667 scopus 로고    scopus 로고
    • Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study
    • 15 Koehler, E.M., et al. Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study. Hepatology 63 (2016), 138–147.
    • (2016) Hepatology , vol.63 , pp. 138-147
    • Koehler, E.M.1
  • 16
    • 84930401292 scopus 로고    scopus 로고
    • Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study
    • 16 Kwok, R., et al. Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study. Gut 65 (2016), 1359–1368.
    • (2016) Gut , vol.65 , pp. 1359-1368
    • Kwok, R.1
  • 17
    • 84938057875 scopus 로고    scopus 로고
    • Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease
    • 389-397.e10
    • 17 Angulo, P., et al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology, 149, 2015 389-397.e10.
    • (2015) Gastroenterology , vol.149
    • Angulo, P.1
  • 18
    • 84959378477 scopus 로고    scopus 로고
    • Hepatic steatosis and insulin resistance, but not steatohepatitis, promote atherogenic dyslipidemia in NAFLD
    • 18 Bril, F., et al. Hepatic steatosis and insulin resistance, but not steatohepatitis, promote atherogenic dyslipidemia in NAFLD. J. Clin. Endocrinol. Metab. 101 (2016), 644–652.
    • (2016) J. Clin. Endocrinol. Metab. , vol.101 , pp. 644-652
    • Bril, F.1
  • 19
    • 84901623578 scopus 로고    scopus 로고
    • Relationship between disease severity, hyperinsulinemia, and impaired insulin clearance in patients with nonalcoholic steatohepatitis
    • 19 Bril, F., et al. Relationship between disease severity, hyperinsulinemia, and impaired insulin clearance in patients with nonalcoholic steatohepatitis. Hepatology 59 (2014), 2178–2187.
    • (2014) Hepatology , vol.59 , pp. 2178-2187
    • Bril, F.1
  • 20
    • 84937738375 scopus 로고    scopus 로고
    • Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis
    • 20 Koliaki, C., et al. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 21 (2015), 739–746.
    • (2015) Cell Metab. , vol.21 , pp. 739-746
    • Koliaki, C.1
  • 21
    • 84969704993 scopus 로고    scopus 로고
    • Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity
    • 21 Patterson, R.E., et al. Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity. Am. J. Physiol. Endocrinol. Metab. 310 (2016), E484–E494.
    • (2016) Am. J. Physiol. Endocrinol. Metab. , vol.310 , pp. E484-E494
    • Patterson, R.E.1
  • 22
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • 22 Donnelly, K.L., et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115 (2005), 1343–1351.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1
  • 23
    • 84894327806 scopus 로고    scopus 로고
    • Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
    • 23 Lambert, J.E., et al. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 146 (2014), 726–735.
    • (2014) Gastroenterology , vol.146 , pp. 726-735
    • Lambert, J.E.1
  • 24
    • 84859942552 scopus 로고    scopus 로고
    • Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
    • 24 Lomonaco, R., et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology 55 (2012), 1389–1397.
    • (2012) Hepatology , vol.55 , pp. 1389-1397
    • Lomonaco, R.1
  • 25
    • 84861451144 scopus 로고    scopus 로고
    • Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
    • 25 Satapati, S., et al. Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J. Lipid Res. 53 (2012), 1080–1092.
    • (2012) J. Lipid Res. , vol.53 , pp. 1080-1092
    • Satapati, S.1
  • 26
    • 84948799410 scopus 로고    scopus 로고
    • Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver
    • 26 Satapati, S., et al. Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J. Clin. Invest. 125 (2015), 4447–4462.
    • (2015) J. Clin. Invest. , vol.125 , pp. 4447-4462
    • Satapati, S.1
  • 27
    • 0142245750 scopus 로고    scopus 로고
    • 13C-octanoate breath test
    • 13C-octanoate breath test. Am. J. Gastroenterol. 98 (2003), 2335–2336.
    • (2003) Am. J. Gastroenterol. , vol.98 , pp. 2335-2336
    • Miele, L.1
  • 28
    • 77956151046 scopus 로고    scopus 로고
    • Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals
    • 856.e1–e6
    • 28 Iozzo, P., et al. Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals. Gastroenterology 139 (2010), 846–856 856.e1–e6.
    • (2010) Gastroenterology , vol.139 , pp. 846-856
    • Iozzo, P.1
  • 29
    • 82955239838 scopus 로고    scopus 로고
    • Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    • 29 Sunny, N.E., et al. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 14 (2011), 804–810.
    • (2011) Cell Metab. , vol.14 , pp. 804-810
    • Sunny, N.E.1
  • 30
    • 84984985836 scopus 로고    scopus 로고
    • The role of mitochondrial genomics in patients with non-alcoholic steatohepatitis (NASH)
    • 30 Mehta, R., et al. The role of mitochondrial genomics in patients with non-alcoholic steatohepatitis (NASH). BMC Med. Genet., 17, 2016, 63.
    • (2016) BMC Med. Genet. , vol.17 , pp. 63
    • Mehta, R.1
  • 31
    • 77952618580 scopus 로고    scopus 로고
    • Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet
    • 31 Sunny, N.E., et al. Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 298 (2010), E1226–E1235.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , pp. E1226-E1235
    • Sunny, N.E.1
  • 32
    • 84915820736 scopus 로고    scopus 로고
    • Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia
    • 32 Cotter, D.G., et al. Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia. J. Clin. Invest. 124 (2014), 5175–5190.
    • (2014) J. Clin. Invest. , vol.124 , pp. 5175-5190
    • Cotter, D.G.1
  • 33
    • 84931571498 scopus 로고    scopus 로고
    • Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans
    • 33 Mannisto, V.T., et al. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Liver Int. 35 (2015), 1853–1861.
    • (2015) Liver Int. , vol.35 , pp. 1853-1861
    • Mannisto, V.T.1
  • 34
    • 0033520771 scopus 로고    scopus 로고
    • Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study
    • 34 Cortez-Pinto, H., et al. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA 282 (1999), 1659–1664.
    • (1999) JAMA , vol.282 , pp. 1659-1664
    • Cortez-Pinto, H.1
  • 35
    • 79951697487 scopus 로고    scopus 로고
    • Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes
    • 35 Schmid, A.I., et al. Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes. Diabetes Care 34 (2011), 448–453.
    • (2011) Diabetes Care , vol.34 , pp. 448-453
    • Schmid, A.I.1
  • 36
    • 84865552258 scopus 로고    scopus 로고
    • Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes
    • 36 Abdelmalek, M.F., et al. Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology 56 (2012), 952–960.
    • (2012) Hepatology , vol.56 , pp. 952-960
    • Abdelmalek, M.F.1
  • 37
    • 70350043496 scopus 로고    scopus 로고
    • Abnormal hepatic energy homeostasis in type 2 diabetes
    • 37 Szendroedi, J., et al. Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology 50 (2009), 1079–1086.
    • (2009) Hepatology , vol.50 , pp. 1079-1086
    • Szendroedi, J.1
  • 38
    • 84946068429 scopus 로고    scopus 로고
    • Time course of postprandial hepatic phosphorus metabolites in lean, obese, and type 2 diabetes patients
    • 38 Fritsch, M., et al. Time course of postprandial hepatic phosphorus metabolites in lean, obese, and type 2 diabetes patients. Am. J. Clin. Nutr. 102 (2015), 1051–1058.
    • (2015) Am. J. Clin. Nutr. , vol.102 , pp. 1051-1058
    • Fritsch, M.1
  • 39
    • 84891859110 scopus 로고    scopus 로고
    • 13C magnetic resonance spectroscopy
    • 13C magnetic resonance spectroscopy. Nat. Med. 20 (2014), 98–102.
    • (2014) Nat. Med. , vol.20 , pp. 98-102
    • Befroy, D.E.1
  • 40
    • 84923170817 scopus 로고    scopus 로고
    • 13C] acetate
    • 13C] acetate. Nat. Med. 21 (2015), 108–109.
    • (2015) Nat. Med. , vol.21 , pp. 108-109
    • Burgess, S.C.1
  • 41
    • 84923351028 scopus 로고    scopus 로고
    • Response to burgess
    • 41 Befroy, D.E., et al. Response to burgess. Nat. Med. 21 (2015), 109–110.
    • (2015) Nat. Med. , vol.21 , pp. 109-110
    • Befroy, D.E.1
  • 42
    • 84974555732 scopus 로고    scopus 로고
    • Propionate increases hepatic pyruvate cycling and anaplerosis and alters mitochondrial metabolism
    • 42 Perry, R.J., et al. Propionate increases hepatic pyruvate cycling and anaplerosis and alters mitochondrial metabolism. J. Biol. Chem. 291 (2016), 12161–12170.
    • (2016) J. Biol. Chem. , vol.291 , pp. 12161-12170
    • Perry, R.J.1
  • 43
    • 84945218082 scopus 로고    scopus 로고
    • Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions
    • 43 Previs, S.F., Kelley, D.E., Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions. Am. J. Physiol. Endocrinol. Metab. 309 (2015), E727–E735.
    • (2015) Am. J. Physiol. Endocrinol. Metab. , vol.309 , pp. E727-E735
    • Previs, S.F.1    Kelley, D.E.2
  • 44
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • 44 Perry, R.J., et al. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510 (2014), 84–91.
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1
  • 45
    • 84901936622 scopus 로고    scopus 로고
    • Sphingolipid metabolites in inflammatory disease
    • 45 Maceyka, M., Spiegel, S., Sphingolipid metabolites in inflammatory disease. Nature 510 (2014), 58–67.
    • (2014) Nature , vol.510 , pp. 58-67
    • Maceyka, M.1    Spiegel, S.2
  • 46
    • 84924778498 scopus 로고    scopus 로고
    • Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
    • 46 Perry, R.J., et al. Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. Science 347 (2015), 1253–1256.
    • (2015) Science , vol.347 , pp. 1253-1256
    • Perry, R.J.1
  • 47
    • 84959315041 scopus 로고    scopus 로고
    • Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease
    • 47 Machado, M.V., et al. Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. PLoS One, 10, 2015, e0127991.
    • (2015) PLoS One , vol.10 , pp. e0127991
    • Machado, M.V.1
  • 48
    • 84962779454 scopus 로고    scopus 로고
    • Lifestyle and dietary interventions in the management of nonalcoholic fatty liver disease
    • 48 Hannah, W.N. Jr., Harrison, S.A., Lifestyle and dietary interventions in the management of nonalcoholic fatty liver disease. Dig. Dis. Sci. 61 (2016), 1365–1374.
    • (2016) Dig. Dis. Sci. , vol.61 , pp. 1365-1374
    • Hannah, W.N.1    Harrison, S.A.2
  • 49
    • 84884984755 scopus 로고    scopus 로고
    • Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with NAFLD (The RAED2 randomized trial)
    • 49 Bacchi, E., et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with NAFLD (The RAED2 randomized trial). Hepatology 58 (2013), 1287–1295.
    • (2013) Hepatology , vol.58 , pp. 1287-1295
    • Bacchi, E.1
  • 50
    • 79955107467 scopus 로고    scopus 로고
    • Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
    • 50 Haufe, S., et al. Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology 53 (2011), 1504–1514.
    • (2011) Hepatology , vol.53 , pp. 1504-1514
    • Haufe, S.1
  • 51
    • 84929354082 scopus 로고    scopus 로고
    • Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis
    • 367–378.e5, quiz e14–e15
    • 51 Vilar-Gomez, E., et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology, 149, 2015 367–378.e5, quiz e14–e15.
    • (2015) Gastroenterology , vol.149
    • Vilar-Gomez, E.1
  • 52
    • 84924364818 scopus 로고    scopus 로고
    • Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis
    • 52 Verbeek, J., et al. Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis. Gut 64 (2015), 673–683.
    • (2015) Gut , vol.64 , pp. 673-683
    • Verbeek, J.1
  • 53
    • 42449094965 scopus 로고    scopus 로고
    • Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content
    • 53 Toledo, F.G., et al. Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content. Diabetes 57 (2008), 987–994.
    • (2008) Diabetes , vol.57 , pp. 987-994
    • Toledo, F.G.1
  • 54
    • 84962056389 scopus 로고    scopus 로고
    • Exercise and weight loss improve muscle mitochondrial respiration, lipid partitioning, and insulin sensitivity after gastric bypass surgery
    • 54 Coen, P.M., et al. Exercise and weight loss improve muscle mitochondrial respiration, lipid partitioning, and insulin sensitivity after gastric bypass surgery. Diabetes 64 (2015), 3737–3750.
    • (2015) Diabetes , vol.64 , pp. 3737-3750
    • Coen, P.M.1
  • 55
    • 33947710793 scopus 로고    scopus 로고
    • Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    • 55 Civitarese, A.E., et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med., 4, 2007, e76.
    • (2007) PLoS Med. , vol.4 , pp. e76
    • Civitarese, A.E.1
  • 56
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • 56 Chalasani, N., et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142 (2012), 1592–1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1
  • 57
    • 84979066985 scopus 로고    scopus 로고
    • Pharmacological management of nonalcoholic fatty liver disease
    • 57 Barb, D., et al. Pharmacological management of nonalcoholic fatty liver disease. Metabolism 65 (2016), 1183–1195.
    • (2016) Metabolism , vol.65 , pp. 1183-1195
    • Barb, D.1
  • 58
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • 58 Belfort, R., et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N. Engl. J. Med. 355 (2006), 2297–2307.
    • (2006) N. Engl. J. Med. , vol.355 , pp. 2297-2307
    • Belfort, R.1
  • 59
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • 59 Sanyal, A.J., et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N. Engl. J. Med. 362 (2010), 1675–1685.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1
  • 60
    • 84985993965 scopus 로고    scopus 로고
    • Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial
    • 60 Cusi, K., et al. Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial. Ann. Intern. Med. 165 (2016), 305–315.
    • (2016) Ann. Intern. Med. , vol.165 , pp. 305-315
    • Cusi, K.1
  • 61
    • 70350064027 scopus 로고    scopus 로고
    • Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis
    • 61 Gastaldelli, A., et al. Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology 50 (2009), 1087–1093.
    • (2009) Hepatology , vol.50 , pp. 1087-1093
    • Gastaldelli, A.1
  • 62
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • 62 Ratziu, V., et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 135 (2008), 100–110.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1
  • 63
    • 75449116707 scopus 로고    scopus 로고
    • Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the Fatty Liver Improvement by Rosiglitazone Therapy (FLIRT 2) extension trial
    • 63 Ratziu, V., et al. Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the Fatty Liver Improvement by Rosiglitazone Therapy (FLIRT 2) extension trial. Hepatology 51 (2010), 445–453.
    • (2010) Hepatology , vol.51 , pp. 445-453
    • Ratziu, V.1
  • 64
    • 77955042456 scopus 로고    scopus 로고
    • Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes
    • 64 Rabol, R., et al. Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes. Diabetes Obes. Metab. 12 (2010), 806–814.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 806-814
    • Rabol, R.1
  • 65
    • 36348938829 scopus 로고    scopus 로고
    • The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis
    • 65 Caldwell, S.H., et al. The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis. Hepatology 46 (2007), 1101–1107.
    • (2007) Hepatology , vol.46 , pp. 1101-1107
    • Caldwell, S.H.1
  • 66
    • 12144291275 scopus 로고    scopus 로고
    • Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?
    • 66 Brunmair, B., et al. Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?. Diabetes 53 (2004), 1052–1059.
    • (2004) Diabetes , vol.53 , pp. 1052-1059
    • Brunmair, B.1
  • 67
    • 83755183436 scopus 로고    scopus 로고
    • Acute mitochondrial actions of glitazones on the liver: a crucial parameter for their antidiabetic properties
    • 67 Sanz, M.N., et al. Acute mitochondrial actions of glitazones on the liver: a crucial parameter for their antidiabetic properties. Cell. Physiol. Biochem. 28 (2011), 899–910.
    • (2011) Cell. Physiol. Biochem. , vol.28 , pp. 899-910
    • Sanz, M.N.1
  • 68
    • 84875858252 scopus 로고    scopus 로고
    • Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier
    • 68 Divakaruni, A.S., et al. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc. Natl. Acad. Sci. U.S.A. 110 (2013), 5422–5427.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 5422-5427
    • Divakaruni, A.S.1
  • 69
    • 84877771544 scopus 로고    scopus 로고
    • Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) – relationship to newly identified mitochondrial pyruvate carrier proteins
    • 69 Colca, J.R., et al. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) – relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One, 8, 2013, e61551.
    • (2013) PLoS One , vol.8 , pp. e61551
    • Colca, J.R.1
  • 70
    • 33745869049 scopus 로고    scopus 로고
    • Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues
    • 70 LeBrasseur, N.K., et al. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. Am. J. Physiol. Endocrinol. Metab. 291 (2006), E175–E181.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291 , pp. E175-E181
    • LeBrasseur, N.K.1
  • 71
    • 17844385363 scopus 로고    scopus 로고
    • Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
    • 71 Bogacka, I., et al. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes 54 (2005), 1392–1399.
    • (2005) Diabetes , vol.54 , pp. 1392-1399
    • Bogacka, I.1
  • 72
    • 49249095124 scopus 로고    scopus 로고
    • Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome
    • 72 Skov, V., et al. Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome. PLoS One, 3, 2008, e2466.
    • (2008) PLoS One , vol.3 , pp. e2466
    • Skov, V.1
  • 73
    • 34648836511 scopus 로고    scopus 로고
    • Standards of Medical Care in Diabetes-2016: Summary of Revisions
    • Diabetes Care 39 (Suppl 1)
    • 73 (2016) Standards of Medical Care in Diabetes-2016: Summary of Revisions. Diabetes Care 39 (Suppl 1), S4-S5.
    • (2016) , pp. S4-S5
  • 74
    • 0029819936 scopus 로고    scopus 로고
    • Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus
    • 74 Cusi, K., et al. Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 81 (1996), 4059–4067.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 4059-4067
    • Cusi, K.1
  • 75
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • 75 Owen, M.R., et al. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J. 348:Pt 3 (2000), 607–614.
    • (2000) Biochem. J. , vol.348 , pp. 607-614
    • Owen, M.R.1
  • 76
    • 84991644009 scopus 로고    scopus 로고
    • Oral drugs related with muscle wasting and sarcopenia. A review
    • 76 Campins, L., et al. Oral drugs related with muscle wasting and sarcopenia. A review. Pharmacology 99:1–2 (2016), 1–8.
    • (2016) Pharmacology , vol.99 , Issue.1-2 , pp. 1-8
    • Campins, L.1
  • 77
    • 84908080513 scopus 로고    scopus 로고
    • The target of metformin in type 2 diabetes
    • 77 Ferrannini, E., The target of metformin in type 2 diabetes. N. Engl. J. Med. 371 (2014), 1547–1548.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1547-1548
    • Ferrannini, E.1
  • 78
    • 84903524608 scopus 로고    scopus 로고
    • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
    • 78 Madiraju, A.K., et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510 (2014), 542–546.
    • (2014) Nature , vol.510 , pp. 542-546
    • Madiraju, A.K.1
  • 79
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • 79 Bugianesi, E., et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am. J. Gastroenterol. 100 (2005), 1082–1090.
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 1082-1090
    • Bugianesi, E.1
  • 80
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    • 80 Lavine, J.E., et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 305 (2011), 1659–1668.
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1
  • 81
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • 81 Marso, S.P., et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N. Engl. J. Med. 375 (2016), 311–322.
    • (2016) N. Engl. J. Med. , vol.375 , pp. 311-322
    • Marso, S.P.1
  • 82
    • 84922790807 scopus 로고    scopus 로고
    • GLP-1 receptor agonists: a review of head-to-head clinical studies
    • 82 Trujillo, J.M., et al. GLP-1 receptor agonists: a review of head-to-head clinical studies. Ther. Adv. Endocrinol. Metab. 6 (2015), 19–28.
    • (2015) Ther. Adv. Endocrinol. Metab. , vol.6 , pp. 19-28
    • Trujillo, J.M.1
  • 83
    • 84957840942 scopus 로고    scopus 로고
    • Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
    • 83 Armstrong, M.J., et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet 387 (2016), 679–690.
    • (2016) Lancet , vol.387 , pp. 679-690
    • Armstrong, M.J.1
  • 84
    • 84954384684 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis
    • 84 Armstrong, M.J., et al. Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis. J. Hepatol. 64 (2016), 399–408.
    • (2016) J. Hepatol. , vol.64 , pp. 399-408
    • Armstrong, M.J.1
  • 85
    • 84857185142 scopus 로고    scopus 로고
    • Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice
    • 85 Lee, J., et al. Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice. PLoS One, 7, 2012, e31394.
    • (2012) PLoS One , vol.7 , pp. e31394
    • Lee, J.1
  • 86
    • 84908632327 scopus 로고    scopus 로고
    • SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
    • 86 Xu, F., et al. SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis. Diabetes 63 (2014), 3637–3646.
    • (2014) Diabetes , vol.63 , pp. 3637-3646
    • Xu, F.1
  • 87
    • 84992386882 scopus 로고    scopus 로고
    • 13C magnetic resonance spectroscopy
    • 13C magnetic resonance spectroscopy. Cell Metab. 24 (2016), 167–171.
    • (2016) Cell Metab. , vol.24 , pp. 167-171
    • Petersen, K.F.1


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