Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Machado, Mariana Verdelho ^a,b   Michelotti, Gregory Alexander ^a   Xie, Guanhua ^a   De Almeida, Thiago Pereira ^a   Boursier, Jerome ^a   Bohnic, Brittany ^a   Guy, Cynthia D ^a   Diehl, Anna Mae ^a  

^a DUKE UNIVERSITY   (United States)

^b HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; SONIC HEDGEHOG PROTEIN; CHOLINE; METHIONINE; TRIACYLGLYCEROL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CHOW DIET; CONTROLLED STUDY; DIET; DISEASE COURSE; DISEASE SEVERITY; DUCTULAR REACTION; ENDOPLASMIC RETICULUM STRESS; FATTY ACID ANALYSIS; HUMAN; INFLAMMATION; LIPID COMPOSITION; LIPID STORAGE; LIVER FIBROSIS; MALE; METABOLIC ACTIVATION; METHIONINE CHOLINE DEFICIENT DIET; MOUSE; MOUSE MODEL; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PATHOLOGY; WESTERN DIET; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DISEASE MODEL; LIVER; LIVER CIRRHOSIS; METABOLISM; METABOLOME; NON-ALCOHOLIC FATTY LIVER DISEASE; PHYSIOLOGY; VITAMIN DEFICIENCY;

ANIMALS; APOPTOSIS; CHOLINE; CHOLINE DEFICIENCY; DIET; DISEASE MODELS, ANIMAL; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; METABOLOME; METHIONINE; MICE; MICE, INBRED C57BL; NON-ALCOHOLIC FATTY LIVER DISEASE; OXIDATIVE STRESS; TRIGLYCERIDES;

EID: 84959315041     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127991     Document Type: Article

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