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Volumn 309, Issue 8, 2015, Pages E727-E735

Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: Practicality, stoichiometry, and hidden assumptions

Author keywords

Diabetes; Fatty liver; Insulin resistance; Metabolic disease; NASH; Stable isotopes

Indexed keywords

ACETATE C 13; PROPIONATE C 13; TRACER; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; CARBON; GLUCOSE BLOOD LEVEL; GLUTAMIC ACID; PARACETAMOL; PARACETAMOL GLUCURONIDE; PROPIONIC ACID DERIVATIVE;

EID: 84945218082     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00216.2015     Document Type: Article
Times cited : (28)

References (49)
  • 2
    • 51649083759 scopus 로고    scopus 로고
    • Hormonal regulation of intracellular lipolysis in C57BL/6J mice: effect of diet-induced adiposity and data normalization
    • Bederman IR, Previs SF. Hormonal regulation of intracellular lipolysis in C57BL/6J mice: effect of diet-induced adiposity and data normalization. Metab Clin Exper 57: 1405-1413, 2008.
    • (2008) Metab Clin Exper , vol.57 , pp. 1405-1413
    • Bederman, I.R.1    Previs, S.F.2
  • 5
    • 84923170817 scopus 로고    scopus 로고
    • Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate
    • Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR. Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate. Nat Med 21: 108-109, 2015.
    • (2015) Nat Med , vol.21 , pp. 108-109
    • Burgess, S.C.1    Merritt, M.E.2    Jones, J.G.3    Browning, J.D.4    Sherry, A.D.5    Malloy, C.R.6
  • 8
    • 0027335968 scopus 로고
    • Limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo
    • Consoli A, Nurjhan N, Capani F, Pangburn T, Lapenna D, Gerich J. Limitations in the use of [2-14C]acetate for measuring gluconeogenesis in vivo. Diabetes 42: 732-737, 1993.
    • (1993) Diabetes , vol.42 , pp. 732-737
    • Consoli, A.1    Nurjhan, N.2    Capani, F.3    Pangburn, T.4    Lapenna, D.5    Gerich, J.6
  • 10
    • 0033796419 scopus 로고    scopus 로고
    • Comparison of deuterium incorporation and mass isotopomer distribution analysis for measurement of human cholesterol biosynthesis
    • Di Buono M, Jones PJ, Beaumier L, Wykes LJ. Comparison of deuterium incorporation and mass isotopomer distribution analysis for measurement of human cholesterol biosynthesis. J Lipid Res 41: 1516-1523, 2000.
    • (2000) J Lipid Res , vol.41 , pp. 1516-1523
    • Di Buono, M.1    Jones, P.J.2    Beaumier, L.3    Wykes, L.J.4
  • 11
    • 0015788960 scopus 로고
    • Glutamine and glutamate metabolism in normal and diabetic subjects
    • Felig P, Wahren J, Karl I, Cerasi E, Luft R, Kipnis DM. Glutamine and glutamate metabolism in normal and diabetic subjects. Diabetes 22: 573-576, 1973.
    • (1973) Diabetes , vol.22 , pp. 573-576
    • Felig, P.1    Wahren, J.2    Karl, I.3    Cerasi, E.4    Luft, R.5    Kipnis, D.M.6
  • 14
    • 1642503087 scopus 로고    scopus 로고
    • Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative
    • Jin ES, Jones JG, Merritt M, Burgess SC, Malloy CR, Sherry AD. Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative. Anal Biochem 327: 149-155, 2004.
    • (2004) Anal Biochem , vol.327 , pp. 149-155
    • Jin, E.S.1    Jones, J.G.2    Merritt, M.3    Burgess, S.C.4    Malloy, C.R.5    Sherry, A.D.6
  • 15
    • 0032188985 scopus 로고    scopus 로고
    • Measurement of hepatic glucose output, krebs cycle, and gluconeogenic fluxes by NMR analysis of a single plasma glucose sample
    • Jones JG, Carvalho RA, Franco B, Sherry AD, Malloy CR. Measurement of hepatic glucose output, krebs cycle, and gluconeogenic fluxes by NMR analysis of a single plasma glucose sample. Anal Biochem 263: 39-45, 1998.
    • (1998) Anal Biochem , vol.263 , pp. 39-45
    • Jones, J.G.1    Carvalho, R.A.2    Franco, B.3    Sherry, A.D.4    Malloy, C.R.5
  • 17
    • 0030754203 scopus 로고    scopus 로고
    • Measurement of gluconeogenesis and pyruvate recycling in the rat liver: A simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-13C3]propionate
    • Jones JG, Naidoo R, Sherry AD, Jeffrey FM, Cottam GL, Malloy CR. Measurement of gluconeogenesis and pyruvate recycling in the rat liver: a simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-13C3]propionate. FEBS Lett 412: 131-137, 1997.
    • (1997) FEBS Lett , vol.412 , pp. 131-137
    • Jones, J.G.1    Naidoo, R.2    Sherry, A.D.3    Jeffrey, F.M.4    Cottam, G.L.5    Malloy, C.R.6
  • 18
    • 0032209269 scopus 로고    scopus 로고
    • 13C NMR measurements of human gluconeogenic fluxes after ingestion of [U-13C]propionate, phenylacetate, and acetaminophen
    • Jones JG, Solomon MA, Sherry AD, Jeffrey FM, Malloy CR. 13C NMR measurements of human gluconeogenic fluxes after ingestion of [U-13C]propionate, phenylacetate, and acetaminophen. Am J Physiol Endocrinol Metab 275: E843-E852, 1998.
    • (1998) Am J Physiol Endocrinol Metab , vol.275
    • Jones, J.G.1    Solomon, M.A.2    Sherry, A.D.3    Jeffrey, F.M.4    Malloy, C.R.5
  • 20
    • 0021873259 scopus 로고
    • Determination of gluconeogenesis in vivo with 14C-labeled substrates
    • Katz J. Determination of gluconeogenesis in vivo with 14C-labeled substrates. Am J Physiol Regul Integr Comp Physiol 248: R391-R399, 1985.
    • (1985) Am J Physiol Regul Integr Comp Physiol , vol.248
    • Katz, J.1
  • 21
    • 50449131116 scopus 로고
    • Synthesis via the Krebs’ cycle in the utilization of acetate by rat liver slices
    • Katz J, Chaikoff IL. Synthesis via the Krebs’ cycle in the utilization of acetate by rat liver slices. Biochim Biophys Acta 18: 87-101, 1955.
    • (1955) Biochim Biophys Acta , vol.18 , pp. 87-101
    • Katz, J.1    Chaikoff, I.L.2
  • 22
    • 0024344150 scopus 로고
    • Studies of glycogen synthesis and the Krebs cycle by mass isotopomer analysis with [U-13C]glucose in rats
    • Katz J, Lee WN, Wals PA, Bergner EA. Studies of glycogen synthesis and the Krebs cycle by mass isotopomer analysis with [U-13C]glucose in rats. J Biol Chem 264: 12994-13004, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 12994-13004
    • Katz, J.1    Lee, W.N.2    Wals, P.A.3    Bergner, E.A.4
  • 23
    • 0027438281 scopus 로고
    • Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate
    • Katz J, Wals P, Lee WN. Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate. J Biol Chem 268: 25509-25521, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 25509-25521
    • Katz, J.1    Wals, P.2    Lee, W.N.3
  • 24
    • 0013956638 scopus 로고
    • The fate of isotopic carbon in kidney cortex synthesizing glucose from lactate
    • Krebs HA, Hems R, Weidemann MJ, Speake RN. The fate of isotopic carbon in kidney cortex synthesizing glucose from lactate. Biochem J 101: 242-249, 1966.
    • (1966) Biochem J , vol.101 , pp. 242-249
    • Krebs, H.A.1    Hems, R.2    Weidemann, M.J.3    Speake, R.N.4
  • 29
    • 34248141585 scopus 로고    scopus 로고
    • Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics
    • Magkos F, Patterson BW, Mittendorfer B. Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics. J Lipid Res 48: 1204-1211, 2007.
    • (2007) J Lipid Res , vol.48 , pp. 1204-1211
    • Magkos, F.1    Patterson, B.W.2    Mittendorfer, B.3
  • 34
    • 33745052970 scopus 로고
    • Interpretation of experiments on metabolic processes, using isotopic tracer elements
    • Ogston AG. Interpretation of experiments on metabolic processes, using isotopic tracer elements. Nature 162: 963, 1948.
    • (1948) Nature , vol.162 , pp. 963
    • Ogston, A.G.1
  • 35
    • 0037163021 scopus 로고    scopus 로고
    • The key role of anaplerosis and cataplerosis for citric acid cycle function
    • Owen OE, Kalhan SC, Hanson RW. The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem 277: 30409-30412, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 30409-30412
    • Owen, O.E.1    Kalhan, S.C.2    Hanson, R.W.3
  • 36
    • 0030783598 scopus 로고    scopus 로고
    • Glucose production and gluconeogenesis in postabsorptive and starved normal and streptozotocindiabetic rats
    • Peroni O, Large V, Diraison F, Beylot M. Glucose production and gluconeogenesis in postabsorptive and starved normal and streptozotocindiabetic rats. Metabolism 46: 1358-1363, 1997.
    • (1997) Metabolism , vol.46 , pp. 1358-1363
    • Peroni, O.1    Large, V.2    Diraison, F.3    Beylot, M.4
  • 37
    • 0029556146 scopus 로고
    • Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver
    • Petersen KF, Blair JB, Shulman GI. Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver. Metabolism 44: 1380-1383, 1995.
    • (1995) Metabolism , vol.44 , pp. 1380-1383
    • Petersen, K.F.1    Blair, J.B.2    Shulman, G.I.3
  • 38
    • 0028121599 scopus 로고
    • Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3=-5-triiodo-Lthyronine- treated rats
    • Petersen KF, Cline GW, Blair JB, Shulman GI. Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3=-5-triiodo-Lthyronine- treated rats. Am J Physiol Endocrinol Metab 267: E273-E277, 1994.
    • (1994) Am J Physiol Endocrinol Metab , vol.267
    • Petersen, K.F.1    Cline, G.W.2    Blair, J.B.3    Shulman, G.I.4
  • 39
    • 0032810949 scopus 로고    scopus 로고
    • A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo
    • Previs SF, Cline GW, Shulman GI. A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo. Am J Physiol Endocrinol Metab 277: E154-E160, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Previs, S.F.1    Cline, G.W.2    Shulman, G.I.3
  • 40
    • 0029090128 scopus 로고
    • Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis-substrate cycling between glycerol and triose phosphates in liver
    • Previs SF, Fernandez CA, Yang DW, Soloviev MV, David F, Brunengraber H. Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis-substrate cycling between glycerol and triose phosphates in liver. J Biol Chem 270: 19806-19815, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 19806-19815
    • Previs, S.F.1    Fernandez, C.A.2    Yang, D.W.3    Soloviev, M.V.4    David, F.5    Brunengraber, H.6
  • 42
    • 0026320213 scopus 로고
    • Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR
    • Rothman DL, Magnusson I, Katz LD, Shulman RG, Shulman GI. Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science 254: 573-576, 1991.
    • (1991) Science , vol.254 , pp. 573-576
    • Rothman, D.L.1    Magnusson, I.2    Katz, L.D.3    Shulman, R.G.4    Shulman, G.I.5
  • 44
    • 0025923486 scopus 로고
    • Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis
    • Schumann WC, Magnusson I, Chandramouli V, Kumaran K, Wahren J, Landau BR. Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis. J Biol Chem 266: 6985-6990, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 6985-6990
    • Schumann, W.C.1    Magnusson, I.2    Chandramouli, V.3    Kumaran, K.4    Wahren, J.5    Landau, B.R.6
  • 45
    • 0028895785 scopus 로고
    • Pathway of free fatty acid oxidation in human subjects. Implications for tracer studies
    • Sidossis LS, Coggan AR, Gastaldelli A, Wolfe RR. Pathway of free fatty acid oxidation in human subjects. Implications for tracer studies. J Clin Invest 95: 278-284, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 278-284
    • Sidossis, L.S.1    Coggan, A.R.2    Gastaldelli, A.3    Wolfe, R.R.4
  • 46
    • 82955239838 scopus 로고    scopus 로고
    • Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    • Sunny NE, Parks EJ, Browning JD, Burgess SC. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab 14: 804-810, 2011.
    • (2011) Cell Metab , vol.14 , pp. 804-810
    • Sunny, N.E.1    Parks, E.J.2    Browning, J.D.3    Burgess, S.C.4
  • 47
    • 0000491361 scopus 로고
    • Conversion of fatty acids to carbohydrate; application of isotopes to this problem and role of the Krebs cycle as a synthetic pathway
    • Weinman EO, Strisower EH, Chaikoff IL. Conversion of fatty acids to carbohydrate; application of isotopes to this problem and role of the Krebs cycle as a synthetic pathway. Physiol Rev 37: 252-272, 1957.
    • (1957) Physiol Rev , vol.37 , pp. 252-272
    • Weinman, E.O.1    Strisower, E.H.2    Chaikoff, I.L.3
  • 48
    • 0025194501 scopus 로고
    • Recovery of labeled CO2 during the infusion of C-1- vs C-2-labeled acetate: Implications for tracer studies of substrate oxidation
    • Wolfe RR, Jahoor F. Recovery of labeled CO2 during the infusion of C-1- vs C-2-labeled acetate: implications for tracer studies of substrate oxidation. Am J Clin Nutr 51: 248-252, 1990.
    • (1990) Am J Clin Nutr , vol.51 , pp. 248-252
    • Wolfe, R.R.1    Jahoor, F.2


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