Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

Angewandte Chemie - International Edition

Volumn 56, Issue 4, 2017, Pages 1059-1063

  Miller, Jason B ^a   Zhang, Shuyuan ^a   Kos, Petra ^a   Xiong, Hu ^a   Zhou, Kejin ^a   Perelman, Sofya S ^b   Zhu, Hao ^a   Siegwart, Daniel J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

CRISPR Cas; gene editing; mRNA delivery; nanoparticles; sgRNA delivery

Indexed keywords

MAMMALS; NANOPARTICLES; PROTEINS;

CRISPR/CAS; EDITING TECHNOLOGY; MRNA DELIVERY; NON-VIRAL DELIVERIES; PROTEIN EXPRESSIONS; RATIONAL DESIGN; SGRNA DELIVERY; SYNTHETIC NANOPARTICLES;

GENES;

GUIDE RNA; LIPID; MESSENGER RNA; NANOPARTICLE;

CHEMICAL STRUCTURE; CHEMISTRY; CRISPR CAS SYSTEM; GENE EDITING; GENE TRANSFER; GENETICS;

CRISPR-CAS SYSTEMS; GENE EDITING; GENE TRANSFER TECHNIQUES; LIPIDS; MOLECULAR STRUCTURE; NANOPARTICLES; RNA, GUIDE; RNA, MESSENGER;

EID: 85007325110     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201610209     Document Type: Article

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