Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

Journal of the American Chemical Society

Volumn 137, Issue 29, 2015, Pages 9206-9209

  Hao, Jing ^a   Kos, Petra ^a   Zhou, Kejin ^a   Miller, Jason B ^a   Xue, Lian ^a   Yan, Yunfeng ^a   Xiong, Hu ^a   Elkassih, Sussana ^a   Siegwart, Daniel J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTERS; MONOMERS; POLYESTERS; POLYMERIZATION; POLYMERS; RNA;

CHEMICAL FUNCTIONALITY; DIRECT POLYMERIZATION; DRUG DELIVERY SYSTEM; FUNCTIONAL MONOMER; POLYMER SCIENCE; PROTECTING GROUP; RAPID SYNTHESIS; VERSATILE METHODS;

RING OPENING POLYMERIZATION;

ESTER; LACTONE; MONOMER; POLYESTER; POLYMER; SMALL INTERFERING RNA; TERTIARY AMINE; DRUG CARRIER; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; INTERNALIZATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PARTICLE SIZE; POLYMER PRODUCTION; POLYMERIZATION; RING OPENING; TUMOR XENOGRAFT; ANIMAL; CELL TRANSFORMATION; CHEMISTRY; HELA CELL LINE; SYNTHESIS;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG CARRIERS; HELA CELLS; HUMANS; LACTONES; LIPIDS; MICE; POLYESTERS; POLYMERIZATION; RNA, SMALL INTERFERING;

EID: 84938332753     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b03429     Document Type: Article

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