Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 39, 2016, Pages E5702-E5710

  Yan, Yunfeng ^a,b   Liu, Li ^b   Xiong, Hu ^a,b   Miller, Jason B ^a,b   Zhou, Kejin ^a,b   Kos, Petra ^a,b   Huffman, Kenneth E ^c   Elkassih, Sussana ^a,b   Norman, John W ^a,b   Carstens, Ryan ^c   Kim, James ^b,c   Minna, John D ^c   Siegwart, Daniel J ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cancer; Drug delivery; Functional polyesters; Nanoparticles; SiRNA

Indexed keywords

NANOCARRIER; POLYESTER; SMALL INTERFERING RNA; UBIQUITIN; CARBOCYANINE; CY5.5 CYANINE DYE; NANOPARTICLE; UBB PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; COLONY FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; ENDOCYTOSIS; FEMALE; FLUORESCENCE IMAGING; GENE SILENCING; HELA CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CANCER CELL LINE; MOLECULAR WEIGHT; MOUSE; NANOPHARMACEUTICS; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TUMOR XENOGRAFT; ANIMAL; CELL PROLIFERATION; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG SCREENING; GENE TRANSFER; LUNG TUMOR; METABOLISM; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CARBOCYANINES; CELL LINE, TUMOR; CELL PROLIFERATION; COMBINATORIAL CHEMISTRY TECHNIQUES; ENDOCYTOSIS; GENE SILENCING; GENE TRANSFER TECHNIQUES; HUMANS; LUNG NEOPLASMS; MICE; NANOPARTICLES; POLYESTERS; RNA, SMALL INTERFERING; UBIQUITIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84989855719     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1606886113     Document Type: Article

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