A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery

Angewandte Chemie - International Edition

Volumn 55, Issue 33, 2016, Pages 9591-9595

  Jarzębińska, Anita ^b   Pasewald, Tamara ^a   Lambrecht, Jana ^c   Mykhaylyk, Olga ^c   Kümmerling, Linda ^c   Beck, Philipp ^a   Hasenpusch, Günther ^a   Rudolph, Carsten ^a,b   Plank, Christian ^a,c   Dohmen, Christian ^a  

^a ETHRIS GMBH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

drug delivery; lipids; mRNA; polymers; transcript therapy

Indexed keywords

AMINES; CONTROLLED DRUG DELIVERY; DRUG DELIVERY; LIPIDS; RNA; TARGETED DRUG DELIVERY;

ALKYL CHAIN LENGTHS; BUFFERING CAPACITIES; CHEMICALLY MODIFIED; FUNDAMENTAL STRUCTURES; INTRACELLULAR DELIVERY; MRNA; TRANSCRIPT THERAPY; TRANSFECTION EFFICIENCY;

POLYMERS;

AMINE; CATION; LIPID; MESSENGER RNA; POLYMER;

ANIMAL; CHEMISTRY; GENETICS; MOUSE; NIH 3T3 CELL LINE; PIG; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; CATIONS; LIPIDS; MICE; NIH 3T3 CELLS; POLYMERS; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 84978075334     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201603648     Document Type: Article

References (17)

1. M. S. D. Kormann, G. Hasenpusch, M. K. Aneja, G. Nica, A. W. Flemmer, S. Herber-Jonat, M. Huppmann, L. E. Mays, M. Illenyi, A. Schams, et al., Nat. Biotechnol. 2011, 29, 154–157.
2. A. Yamamoto, M. Kormann, J. Rosenecker, C. Rudolph, Eur. J. Pharm. Biopharm. 2009, 71, 484–489.
3. H. Yin, R. L. Kanasty, A. Eltoukhy, A. J. Vegas, J. R. Dorkin, D. G. Anderson, Nat. Rev. Genet. 2014, 15, 541–555.
4. E. Wagner, in Non-Viral Vectors Gene Ther. Lipid- Polym. Gene Transf. (Eds.: L. Huang, D. Liu, E. Wagner), Academic Press, 2014, pp. 231–261.
5. R. Kanasty, J. R. Dorkin, A. Vegas, D. Anderson, Nat. Mater. 2013, 12, 967–977.
6. C. Rudolph, J. Lausier, S. Naundorf, R. H. Müller, J. Rosenecker, J. Gene Med. 2000, 2, 269–278.
7. M. Jayaraman, S. M. Ansell, B. L. Mui, Y. K. Tam, J. Chen, X. Du, D. Butler, L. Eltepu, S. Matsuda, J. K. Narayanannair, et al., Angew. Chem. Int. Ed. 2012, 51, 8529–8533;
8. Angew. Chem. 2012, 124, 8657–8661.
9. S. C. Semple, S. K. Klimuk, T. O. Harasym, N. Dos Santos, S. M. Ansell, K. F. Wong, N. Maurer, H. Stark, P. R. Cullis, M. J. Hope, et al., Biochim. Biophys. Acta Biomembr. 2001, 1510, 152–166.
10. K. T. Love, K. P. Mahon, G. Christopher, K. A. Whitehead, W. Querbes, J. Robert, J. Qin, W. Cantley, L. L. Qin, M. Frank-Kamenetsky, et al., Proc. Natl. Acad. Sci. USA 2010, 107, 9915–9915.
11. K. A. Whitehead, J. R. Dorkin, A. J. Vegas, P. H. Chang, O. Veiseh, J. Matthews, O. S. Fenton, Y. Zhang, K. T. Olejnik, V. Yesilyurt, et al., Nat. Commun. 2014, 5, 4277.
12. T. Suma, K. Miyata, T. Ishii, S. Uchida, H. Uchida, K. Itaka, N. Nishiyama, K. Kataoka, Biomaterials 2012, 33, 2770–2779.
13. O. F. Khan, E. W. Zaia, H. Yin, R. L. Bogorad, J. M. Pelet, M. J. Webber, I. Zhuang, J. E. Dahlman, R. Langer, D. G. Anderson, Angew. Chem. Int. Ed. 2014, 53, 14397–14401;
14. Angew. Chem. 2014, 126, 14625–14629.
15. H. Uchida, K. Itaka, T. Nomoto, T. Ishii, T. Suma, M. Ikegami, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka, J. Am. Chem. Soc. 2014, 136, 12396–12405.
16. Y. Dong, J. R. Dorkin, W. Wang, P. H. Chang, M. J. Webber, B. C. Tang, J. Yang, I. Abutbul-Ionita, D. Danino, F. DeRosa, et al., Nano Lett. 2016, 16, 842–848.
17. J. Gilleron, W. Querbes, A. Zeigerer, A. Borodovsky, G. Marsico, U. Schubert, K. Manygoats, S. Seifert, C. Andree, M. Stöter, et al., Nat. Biotechnol. 2013, 31, 638–646.