Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 11, 2016, Pages 2868-2873

  Wang, Ming ^a   Zuris, John A ^b,c   Meng, Fantao ^d   Rees, Holly ^b,c   Sun, Shuo ^a   Deng, Pu ^a   Han, Yong ^d   Gao, Xue ^b,c   Pouli, Dimitra ^a   Wu, Qi ^d   Georgakoudi, Irene ^a   Liu, David R ^b,c   Xu, Qiaobing ^a  

^a Tufts University   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD UNIVERSITY   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cre recombinase; CRISPR Cas9; Genome editing; Lipid nanoparticle; Protein delivery

Indexed keywords

CRE RECOMBINASE; LIPID; TRANSFER RNA; 1,2-DIOLEOYL-GLYCERO-3-PHOSPHATIDYL ETHANOLAMINE; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; CERAMIDE; CHOLESTEROL; DRUG CARRIER; ENDONUCLEASE; FLUORESCENT PROTEIN 583; GREEN FLUORESCENT PROTEIN; INTEGRASE; LIPOFECTAMINE; NANOPARTICLE; PHOSPHATIDYLETHANOLAMINE; PHOTOPROTEIN; RECOMBINANT PROTEIN; RNA; SYNTHETIC DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOSOME; GENE DELIVERY SYSTEM; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; HUMAN GENOME; IN VITRO STUDY; IN VIVO STUDY; MICHAEL ADDITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; STATIC ELECTRICITY; TARGET CELL; ANIMAL; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CRISPR CAS SYSTEM; ENDOCYTOSIS; GENE INACTIVATION; GENETIC ENGINEERING; GENETICS; HELA CELL LINE; HYPOTHALAMUS; METABOLISM; PROCEDURES; REPORTER GENE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THALAMUS;

ANIMALS; BACTERIAL PROTEINS; CERAMIDES; CHOLESTEROL; CRISPR-CAS SYSTEMS; DRUG CARRIERS; ENDOCYTOSIS; ENDONUCLEASES; ENDOSOMES; GENE KNOCKOUT TECHNIQUES; GENES, REPORTER; GENES, SYNTHETIC; GENETIC ENGINEERING; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; HYPOTHALAMUS; INTEGRASES; LIPIDS; LUMINESCENT PROTEINS; MICE; MOLECULAR STRUCTURE; NANOPARTICLES; PHOSPHATIDYLETHANOLAMINES; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; RNA; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; THALAMUS;

EID: 84962593365     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1520244113     Document Type: Article

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