메뉴 건너뛰기




Volumn 12, Issue 1, 2015, Pages

Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes

Author keywords

Astrocytes; Interleukin 22; Multiple sclerosis; Survival

Indexed keywords

7 AMINODACTINOMYCIN; CARRIER PROTEINS AND BINDING PROTEINS; INTERLEUKIN 22; INTERLEUKIN 22 BINDING PROTEIN; INTERLEUKIN 22 RECEPTOR 1; INTERLEUKIN RECEPTOR; LIPOCORTIN 5; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IL22RA2 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; TUMOR NECROSIS FACTOR;

EID: 84933045525     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0335-3     Document Type: Article
Times cited : (83)

References (60)
  • 1
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372:1502-17.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 2
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol. 2005;23:683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 3
    • 84862695017 scopus 로고    scopus 로고
    • Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies
    • Maddur MS, Miossec P, Kaveri SV, Bayry J. Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol. 2012;181:8-18.
    • (2012) Am J Pathol , vol.181 , pp. 8-18
    • Maddur, M.S.1    Miossec, P.2    Kaveri, S.V.3    Bayry, J.4
  • 4
    • 84908022527 scopus 로고    scopus 로고
    • IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: current and future developments
    • Luchtman DW, Ellwardt E, Larochelle C, Zipp F. IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: current and future developments. Cytokine Growth Factor Rev. 2014;25:403-13.
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 403-413
    • Luchtman, D.W.1    Ellwardt, E.2    Larochelle, C.3    Zipp, F.4
  • 5
    • 84908658274 scopus 로고    scopus 로고
    • Th17 cells in central nervous system autoimmunity
    • Sie C, Korn T, Mitsdoerffer M. Th17 cells in central nervous system autoimmunity. Exp Neurol. 2014;262:18-27.
    • (2014) Exp Neurol , vol.262 , pp. 18-27
    • Sie, C.1    Korn, T.2    Mitsdoerffer, M.3
  • 7
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421:744-8.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 8
    • 70350052626 scopus 로고    scopus 로고
    • Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis
    • Kebir H, Ifergan I, Alvarez JI, Bernard M, Poirier J, Arbour N, et al. Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis. Ann Neurol. 2009;66:390-402.
    • (2009) Ann Neurol , vol.66 , pp. 390-402
    • Kebir, H.1    Ifergan, I.2    Alvarez, J.I.3    Bernard, M.4    Poirier, J.5    Arbour, N.6
  • 9
    • 72649089874 scopus 로고    scopus 로고
    • Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
    • Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain. 2009;132:3329-41.
    • (2009) Brain , vol.132 , pp. 3329-3341
    • Brucklacher-Waldert, V.1    Stuerner, K.2    Kolster, M.3    Wolthausen, J.4    Tolosa, E.5
  • 10
  • 11
    • 82955228112 scopus 로고    scopus 로고
    • T(H)17 cytokines in autoimmune neuro-inflammation
    • Becher B, Segal BM. T(H)17 cytokines in autoimmune neuro-inflammation. Curr Opin Immunol. 2011;23:707-12.
    • (2011) Curr Opin Immunol , vol.23 , pp. 707-712
    • Becher, B.1    Segal, B.M.2
  • 12
    • 79958721221 scopus 로고    scopus 로고
    • Th17 cell, the new player of neuroinflammatory process in multiple sclerosis
    • Jadidi-Niaragh F, Mirshafiey A. Th17 cell, the new player of neuroinflammatory process in multiple sclerosis. Scand J Immunol. 2011;74:1-13.
    • (2011) Scand J Immunol , vol.74 , pp. 1-13
    • Jadidi-Niaragh, F.1    Mirshafiey, A.2
  • 13
    • 79953048089 scopus 로고    scopus 로고
    • Regulation and functions of the IL-10 family of cytokines in inflammation and disease
    • Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol. 2011;29:71-109.
    • (2011) Annu Rev Immunol , vol.29 , pp. 71-109
    • Ouyang, W.1    Rutz, S.2    Crellin, N.K.3    Valdez, P.A.4    Hymowitz, S.G.5
  • 15
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med. 2006;203:2271-9.
    • (2006) J Exp Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3    Karim, R.4    Dunussi-Joannopoulos, K.5    Collins, M.6
  • 16
    • 35348983341 scopus 로고    scopus 로고
    • Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    • Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity. 2007;27:647-59.
    • (2007) Immunity , vol.27 , pp. 647-659
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3    Murphy, A.J.4    Karow, M.5    Flavell, R.A.6
  • 17
    • 40049098958 scopus 로고    scopus 로고
    • IL-22 mediates mucosal host defense against gram-negative bacterial pneumonia
    • Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, et al. IL-22 mediates mucosal host defense against gram-negative bacterial pneumonia. Nat Med. 2008;14:275-81.
    • (2008) Nat Med , vol.14 , pp. 275-281
    • Aujla, S.J.1    Chan, Y.R.2    Zheng, M.3    Fei, M.4    Askew, D.J.5    Pociask, D.A.6
  • 18
    • 42149190657 scopus 로고    scopus 로고
    • CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis
    • Zhang B, Chan YK, Lu B, Diamond MS, Klein RS. CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis. J Immunol. 2008;180:2641-9.
    • (2008) J Immunol , vol.180 , pp. 2641-2649
    • Zhang, B.1    Chan, Y.K.2    Lu, B.3    Diamond, M.S.4    Klein, R.S.5
  • 19
    • 72849131815 scopus 로고    scopus 로고
    • Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    • Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, Pallotta S, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest. 2009;119:3573-85.
    • (2009) J Clin Invest , vol.119 , pp. 3573-3585
    • Eyerich, S.1    Eyerich, K.2    Pennino, D.3    Carbone, T.4    Nasorri, F.5    Pallotta, S.6
  • 20
    • 78649757427 scopus 로고    scopus 로고
    • Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection
    • Witte E, Witte K, Warszawska K, Sabat R, Wolk K. Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection. Cytokine Growth Factor Rev. 2010;21:365-79.
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 365-379
    • Witte, E.1    Witte, K.2    Warszawska, K.3    Sabat, R.4    Wolk, K.5
  • 21
    • 77958489808 scopus 로고    scopus 로고
    • Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces
    • Sonnenberg GF, Fouser LA, Artis D. Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces. Adv Immunol. 2010;107:1-29.
    • (2010) Adv Immunol , vol.107 , pp. 1-29
    • Sonnenberg, G.F.1    Fouser, L.A.2    Artis, D.3
  • 22
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med. 2007;13:1173-5.
    • (2007) Nat Med , vol.13 , pp. 1173-1175
    • Kebir, H.1    Kreymborg, K.2    Ifergan, I.3    Dodelet-Devillers, A.4    Cayrol, R.5    Bernard, M.6
  • 24
    • 84867735795 scopus 로고    scopus 로고
    • Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system
    • Larochelle C, Cayrol R, Kebir H, Alvarez JI, Lecuyer MA, Ifergan I, et al. Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system. Brain. 2012;135:2906-24.
    • (2012) Brain , vol.135 , pp. 2906-2924
    • Larochelle, C.1    Cayrol, R.2    Kebir, H.3    Alvarez, J.I.4    Lecuyer, M.A.5    Ifergan, I.6
  • 25
    • 84870664698 scopus 로고    scopus 로고
    • Epitope-specific CD8+ T cells play a differential pathogenic role in the development of a viral disease model for multiple sclerosis
    • Myoung J, Kang HS, Hou W, Meng L, Dal Canto MC, Kim BS. Epitope-specific CD8+ T cells play a differential pathogenic role in the development of a viral disease model for multiple sclerosis. J Virol. 2012;86:13717-28.
    • (2012) J Virol , vol.86 , pp. 13717-13728
    • Myoung, J.1    Kang, H.S.2    Hou, W.3    Meng, L.4    Dal Canto, M.C.5    Kim, B.S.6
  • 27
    • 0035877222 scopus 로고    scopus 로고
    • Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22
    • Dumoutier L, Lejeune D, Colau D, Renauld JC. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol. 2001;166:7090-5.
    • (2001) J Immunol , vol.166 , pp. 7090-7095
    • Dumoutier, L.1    Lejeune, D.2    Colau, D.3    Renauld, J.C.4
  • 28
    • 0035951795 scopus 로고    scopus 로고
    • Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes
    • Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, et al. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J Biol Chem. 2001;276:2725-32.
    • (2001) J Biol Chem , vol.276 , pp. 2725-2732
    • Kotenko, S.V.1    Izotova, L.S.2    Mirochnitchenko, O.V.3    Esterova, E.4    Dickensheets, H.5    Donnelly, R.P.6
  • 31
    • 78650673588 scopus 로고    scopus 로고
    • IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation
    • Beyeen AD, Adzemovic MZ, Ockinger J, Stridh P, Becanovic K, Laaksonen H, et al. IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation. J Immunol. 2010;185:6883-90.
    • (2010) J Immunol , vol.185 , pp. 6883-6890
    • Beyeen, A.D.1    Adzemovic, M.Z.2    Ockinger, J.3    Stridh, P.4    Becanovic, K.5    Laaksonen, H.6
  • 32
  • 34
    • 84904386052 scopus 로고    scopus 로고
    • Recent advances and future challenges in the genetics of multiple sclerosis
    • Lill CM. Recent advances and future challenges in the genetics of multiple sclerosis. Front Neurol. 2014;5:130.
    • (2014) Front Neurol , vol.5 , pp. 130
    • Lill, C.M.1
  • 36
    • 79952501096 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
    • Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69:292-302.
    • (2011) Ann Neurol , vol.69 , pp. 292-302
    • Polman, C.H.1    Reingold, S.C.2    Banwell, B.3    Clanet, M.4    Cohen, J.A.5    Filippi, M.6
  • 37
    • 84860330754 scopus 로고    scopus 로고
    • HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis
    • Jilek S, Schluep M, Harari A, Canales M, Lysandropoulos A, Zekeridou A, et al. HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis. J Immunol. 2012;188:4671-80.
    • (2012) J Immunol , vol.188 , pp. 4671-4680
    • Jilek, S.1    Schluep, M.2    Harari, A.3    Canales, M.4    Lysandropoulos, A.5    Zekeridou, A.6
  • 38
    • 79955646245 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha (TNF-alpha), anti-TNF-alpha and demyelination revisited: an ongoing story
    • Caminero A, Comabella M, Montalban X. Tumor necrosis factor alpha (TNF-alpha), anti-TNF-alpha and demyelination revisited: an ongoing story. J Neuroimmunol. 2011;234:1-6.
    • (2011) J Neuroimmunol , vol.234 , pp. 1-6
    • Caminero, A.1    Comabella, M.2    Montalban, X.3
  • 40
    • 84908120294 scopus 로고    scopus 로고
    • IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection
    • Ahlfors H, Morrison PJ, Duarte JH, Li Y, Biro J, Tolaini M, et al. IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection. J Immunol. 2014;193:4602-13.
    • (2014) J Immunol , vol.193 , pp. 4602-4613
    • Ahlfors, H.1    Morrison, P.J.2    Duarte, J.H.3    Li, Y.4    Biro, J.5    Tolaini, M.6
  • 41
    • 0036604122 scopus 로고    scopus 로고
    • Cutting edge: immune cells as sources and targets of the IL-10 family members?
    • Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol. 2002;168:5397-402.
    • (2002) J Immunol , vol.168 , pp. 5397-5402
    • Wolk, K.1    Kunz, S.2    Asadullah, K.3    Sabat, R.4
  • 42
    • 84868615556 scopus 로고    scopus 로고
    • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    • Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012;491:259-63.
    • (2012) Nature , vol.491 , pp. 259-263
    • Huber, S.1    Gagliani, N.2    Zenewicz, L.A.3    Huber, F.J.4    Bosurgi, L.5    Hu, B.6
  • 44
    • 0034613201 scopus 로고    scopus 로고
    • Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
    • Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem. 2000;275:31335-9.
    • (2000) J Biol Chem , vol.275 , pp. 31335-31339
    • Xie, M.H.1    Aggarwal, S.2    Ho, W.H.3    Foster, J.4    Zhang, Z.5    Stinson, J.6
  • 45
    • 51349156105 scopus 로고    scopus 로고
    • IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22
    • Wu PW, Li J, Kodangattil SR, Luxenberg DP, Bennett F, Martino M, et al. IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22. J Mol Biol. 2008;382:1168-83.
    • (2008) J Mol Biol , vol.382 , pp. 1168-1183
    • Wu, P.W.1    Li, J.2    Kodangattil, S.R.3    Luxenberg, D.P.4    Bennett, F.5    Martino, M.6
  • 46
    • 40049103352 scopus 로고    scopus 로고
    • IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
    • Kreymborg K, Etzensperger R, Dumoutier L, Haak S, Rebollo A, Buch T, et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol. 2007;179:8098-104.
    • (2007) J Immunol , vol.179 , pp. 8098-8104
    • Kreymborg, K.1    Etzensperger, R.2    Dumoutier, L.3    Haak, S.4    Rebollo, A.5    Buch, T.6
  • 47
    • 84880851958 scopus 로고    scopus 로고
    • IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis
    • Xu W, Li R, Dai Y, Wu A, Wang H, Cheng C, et al. IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis. J Neuroimmunol. 2013;261:87-91.
    • (2013) J Neuroimmunol , vol.261 , pp. 87-91
    • Xu, W.1    Li, R.2    Dai, Y.3    Wu, A.4    Wang, H.5    Cheng, C.6
  • 48
    • 84914155967 scopus 로고    scopus 로고
    • Th22 cells are expanded in multiple sclerosis and are resistant to IFN-beta
    • Rolla S, Bardina V, De Mercanti S, Quaglino P, De Palma R, Gned D, et al. Th22 cells are expanded in multiple sclerosis and are resistant to IFN-beta. J Leukoc Biol. 2014;96:1155-64.
    • (2014) J Leukoc Biol , vol.96 , pp. 1155-1164
    • Rolla, S.1    Bardina, V.2    Mercanti, S.3    Quaglino, P.4    Palma, R.5    Gned, D.6
  • 49
    • 80455131298 scopus 로고    scopus 로고
    • Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat
    • Almolda B, Costa M, Montoya M, Gonzalez B, Castellano B. Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat. PLoS One. 2011;6:e27473.
    • (2011) PLoS One , vol.6 , pp. e27473
    • Almolda, B.1    Costa, M.2    Montoya, M.3    Gonzalez, B.4    Castellano, B.5
  • 50
    • 0036694645 scopus 로고    scopus 로고
    • The balance between IL-1 and IL-1Ra in disease
    • Arend WP. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 2002;13:323-40.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 323-340
    • Arend, W.P.1
  • 52
    • 0034565220 scopus 로고    scopus 로고
    • IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes
    • Dumoutier L, Van Roost E, Ameye G, Michaux L, Renauld JC. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immun. 2000;1:488-94.
    • (2000) Genes Immun , vol.1 , pp. 488-494
    • Dumoutier, L.1    Roost, E.2    Ameye, G.3    Michaux, L.4    Renauld, J.C.5
  • 53
    • 34547130094 scopus 로고    scopus 로고
    • Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases
    • Levillayer F, Mas M, Levi-Acobas F, Brahic M, Bureau JF. Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases. Genetics. 2007;176:1835-44.
    • (2007) Genetics , vol.176 , pp. 1835-1844
    • Levillayer, F.1    Mas, M.2    Levi-Acobas, F.3    Brahic, M.4    Bureau, J.F.5
  • 55
    • 84890565442 scopus 로고    scopus 로고
    • Neuromyelitis optica: concept, immunology and treatment
    • Uzawa A, Mori M, Kuwabara S. Neuromyelitis optica: concept, immunology and treatment. J Clin Neurosci. 2013;21:12-21.
    • (2013) J Clin Neurosci , vol.21 , pp. 12-21
    • Uzawa, A.1    Mori, M.2    Kuwabara, S.3
  • 56
    • 84862736732 scopus 로고    scopus 로고
    • The innate immune system in demyelinating disease
    • Mayo L, Quintana FJ, Weiner HL. The innate immune system in demyelinating disease. Immunol Rev. 2012;248:170-87.
    • (2012) Immunol Rev , vol.248 , pp. 170-187
    • Mayo, L.1    Quintana, F.J.2    Weiner, H.L.3
  • 57
    • 84873709602 scopus 로고    scopus 로고
    • The astrocyte in multiple sclerosis revisited
    • Brosnan CF, Raine CS. The astrocyte in multiple sclerosis revisited. Glia. 2013;61:453-65.
    • (2013) Glia , vol.61 , pp. 453-465
    • Brosnan, C.F.1    Raine, C.S.2
  • 59
    • 84868576761 scopus 로고    scopus 로고
    • Interleukin-22 protects rat PC12 pheochromocytoma cells from serum deprivation-induced cell death
    • Liu Y, Pan W, Yang S, Wu X, Wu J, Ma J, et al. Interleukin-22 protects rat PC12 pheochromocytoma cells from serum deprivation-induced cell death. Mol Cell Biochem. 2012;371:137-46.
    • (2012) Mol Cell Biochem , vol.371 , pp. 137-146
    • Liu, Y.1    Pan, W.2    Yang, S.3    Wu, X.4    Wu, J.5    Ma, J.6
  • 60
    • 14844342604 scopus 로고    scopus 로고
    • IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
    • Boniface K, Bernard FX, Garcia M, Gurney AL, Lecron JC, Morel F. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol. 2005;174:3695-702.
    • (2005) J Immunol , vol.174 , pp. 3695-3702
    • Boniface, K.1    Bernard, F.X.2    Garcia, M.3    Gurney, A.L.4    Lecron, J.C.5    Morel, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.