Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine

Nature Chemical Biology

Volumn 13, Issue 2, 2017, Pages 181-187

  Liu, Monica Yun ^a,b   Torabifard, Hedieh ^c   Crawford, Daniel J ^a,b   DeNizio, Jamie E ^a,b   Cao, Xing Jun ^b   Garcia, Benjamin A ^b   Cisneros, G Andrés ^c,d   Kohli, Rahul M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 CARBOXYLCYTOSINE; 5 FORMYLCYTOSINE; 5 HYDROXYMETHYLCYTOSINE; CYTARABINE DERIVATIVE; ENZYME VARIANT; PROTEIN; TEN ELEVEN TRANSLOCATION 2; UNCLASSIFIED DRUG; 5 METHYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, HUMAN;

ARTICLE; BIOLOGICAL FUNCTIONS; ENZYME ACTIVE SITE; GENE CONTROL; GENE MUTATION; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTAGENESIS; OXIDATION; PRIORITY JOURNAL; STUDY; ANALOGS AND DERIVATIVES; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MUTATION; OXIDATION REDUCTION REACTION;

5-METHYLCYTOSINE; CATALYTIC DOMAIN; DNA-BINDING PROTEINS; HEK293 CELLS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS;

EID: 85001976357     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2250     Document Type: Article

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