Reaction mechanism of the ε subunit of E. coli DNA polymerase III: Insights into active site metal coordination and catalytically significant residues

Journal of the American Chemical Society

Volumn 131, Issue 4, 2009, Pages 1550-1556

  Andres Cisneros G ^a   Perera, Lalith ^a   Sehaaper, Roel M ^a   Pedersen, Lars C ^a   London, Robert E ^a   Pedersen, Lee G ^a,b   Darden, Thomas A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC METALS; DIVALENT METALS; DNA POLYMERASE; E. COLI; ENERGY DECOMPOSITION ANALYSIS; EXONUCLEASE; EXONUCLEASE ACTIVITY; FRONTIER ORBITAL ANALYSIS; LOWER ENERGY BARRIERS; METAL COORDINATION; N-TERMINAL DOMAINS; NUCLEOPHILIC ATTACK; PENTACOORDINATED; PENTACOORDINATION; REACTION CATALYZED; REACTION MECHANISM; WATER MOLECULE;

CATALYSIS; COORDINATION REACTIONS; DNA; ESCHERICHIA COLI; GENES; ION EXCHANGE; MANGANESE; MANGANESE COMPOUNDS; METALS; NUCLEIC ACIDS; POLYMERS;

PROTON TRANSFER;

DNA DIRECTED DNA POLYMERASE GAMMA; MAGNESIUM; MANGANESE; METAL; PHOSPHATE; PROTEIN SUBUNIT;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DECOMPOSITION; ESCHERICHIA COLI; HYDROLYSIS; MOLECULAR MECHANICS; MUTAGENESIS; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS; BIOCATALYSIS; CHEMISTRY; COMPUTER SIMULATION; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

BIOCATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DNA POLYMERASE III; ESCHERICHIA COLI; METALS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS;

EID: 63149121847     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja8082818     Document Type: Article

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