-
1
-
-
85003093901
-
Biological actions of androgens
-
Mooradian, A.D., Morley, J.E. and Korenman, S.G. (1987) Biological actions of androgens. Endocrine Reviews, 8, 1-28.
-
(1987)
Endocrine Reviews
, vol.8
, pp. 1-28
-
-
Mooradian, A.D.1
Morley, J.E.2
Korenman, S.G.3
-
2
-
-
0001877218
-
The androgen receptor: a mediator of diverse responses
-
Keller, E.T., Ershler, W.B. and Chang, C. (1996) The androgen receptor: a mediator of diverse responses. Frontiers in Bioscience: a Journal and Virtual Library, 1, 59-71.
-
(1996)
Frontiers in Bioscience: a Journal and Virtual Library
, vol.1
, pp. 59-71
-
-
Keller, E.T.1
Ershler, W.B.2
Chang, C.3
-
3
-
-
0024205612
-
The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate
-
Lubahn, D.B., Joseph, D.R., Sar, M., Tan, J., Higgs, H.N., Larson, R.E., French, F.S. and Wilson, E.M. (1988) The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Molecular Endocrinology, 2, 1265-1275.
-
(1988)
Molecular Endocrinology
, vol.2
, pp. 1265-1275
-
-
Lubahn, D.B.1
Joseph, D.R.2
Sar, M.3
Tan, J.4
Higgs, H.N.5
Larson, R.E.6
French, F.S.7
Wilson, E.M.8
-
4
-
-
0034714276
-
Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations
-
Matias, P.M., Donner, P., Coelho, R., Thomaz, M., Peixoto, C., Macedo, S., Otto, N., Joschko, S., Scholz, P., Wegg, A., Basler, S., Schafer, M., Egner, U. and Carrondo, M.A. (2000) Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations. The Journal of Biological Chemistry, 275, 26164-26171.
-
(2000)
The Journal of Biological Chemistry
, vol.275
, pp. 26164-26171
-
-
Matias, P.M.1
Donner, P.2
Coelho, R.3
Thomaz, M.4
Peixoto, C.5
Macedo, S.6
Otto, N.7
Joschko, S.8
Scholz, P.9
Wegg, A.10
Basler, S.11
Schafer, M.12
Egner, U.13
Carrondo, M.A.14
-
5
-
-
0032784653
-
The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription
-
Alen, P., Claessens, F., Verhoeven, G., Rombauts, W. and Peeters, B. (1999) The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription. Molecular and Cellular Biology, 19, 6085-6097.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 6085-6097
-
-
Alen, P.1
Claessens, F.2
Verhoeven, G.3
Rombauts, W.4
Peeters, B.5
-
6
-
-
0025935923
-
Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization
-
Jenster, G., van der Korput, H.A., van Vroonhoven, C., van der Kwast, T.H., Trapman, J. and Brinkmann, A.O. (1991) Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Molecular Endocrinology, 5, 1396-1404.
-
(1991)
Molecular Endocrinology
, vol.5
, pp. 1396-1404
-
-
Jenster, G.1
van der Korput, H.A.2
van Vroonhoven, C.3
van der Kwast, T.H.4
Trapman, J.5
Brinkmann, A.O.6
-
7
-
-
0025957233
-
Transcriptional activation and nuclear targeting signals of the human androgen receptor
-
Simental, J.A., Sar, M., Lane, M.V., French, F.S. and Wilson, E.M. (1991) Transcriptional activation and nuclear targeting signals of the human androgen receptor. The Journal of Biological Chemistry, 266, 510-518.
-
(1991)
The Journal of Biological Chemistry
, vol.266
, pp. 510-518
-
-
Simental, J.A.1
Sar, M.2
Lane, M.V.3
French, F.S.4
Wilson, E.M.5
-
8
-
-
0031974628
-
Determinants of ligand specificity of estrogen receptor-α: estrogen versus androgen discrimination
-
Ekena, K., Katzenellenbogen, J.A. and Katzenellenbogen, B.S. (1998) Determinants of ligand specificity of estrogen receptor-α: estrogen versus androgen discrimination. The Journal of Biological Chemistry, 273, 693-699.
-
(1998)
The Journal of Biological Chemistry
, vol.273
, pp. 693-699
-
-
Ekena, K.1
Katzenellenbogen, J.A.2
Katzenellenbogen, B.S.3
-
9
-
-
18444405534
-
Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition
-
Bledsoe, R.K., Montana, V.G., Stanley, T.B., Delves, C.J., Apolito, C.J., McKee, D.D., Consler, T.G., Parks, D.J., Stewart, E.L., Willson, T.M., Lambert, M.H., Moore, J.T., Pearce, K.H. and Xu, H.E. (2002) Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell, 110, 93-105.
-
(2002)
Cell
, vol.110
, pp. 93-105
-
-
Bledsoe, R.K.1
Montana, V.G.2
Stanley, T.B.3
Delves, C.J.4
Apolito, C.J.5
McKee, D.D.6
Consler, T.G.7
Parks, D.J.8
Stewart, E.L.9
Willson, T.M.10
Lambert, M.H.11
Moore, J.T.12
Pearce, K.H.13
Xu, H.E.14
-
10
-
-
17844376217
-
Structural basis for antagonism and resistance of bicalutamide in prostate cancer
-
Bohl, C.E., Gao, W., Miller, D.D., Bell, C.E. and Dalton, J.T. (2005) Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 102, 6201-6206.
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 6201-6206
-
-
Bohl, C.E.1
Gao, W.2
Miller, D.D.3
Bell, C.E.4
Dalton, J.T.5
-
11
-
-
0032568527
-
Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
-
Tanenbaum, D.M., Wang, Y., Williams, S.P. and Sigler, P.B. (1998) Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proceedings of the National Academy of Sciences of the United States of America, 95, 5998-6003.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 5998-6003
-
-
Tanenbaum, D.M.1
Wang, Y.2
Williams, S.P.3
Sigler, P.B.4
-
12
-
-
30844455992
-
Analytical and physiological factors affecting the interpretation of serum testosterone concentration in men
-
Diver, M.J. (2006) Analytical and physiological factors affecting the interpretation of serum testosterone concentration in men. Annals of Clinical Biochemistry, 43, 3-12.
-
(2006)
Annals of Clinical Biochemistry
, vol.43
, pp. 3-12
-
-
Diver, M.J.1
-
13
-
-
0026712248
-
Hormoneinduced dissociation of the androgen receptor-heat-shock protein complex:use of a new monoclonal antibody to distinguish transformed from nontransformed receptors
-
Veldscholte, J., Berrevoets, C.A., Zegers, N.D., van der Kwast, T.H., Grootegoed, J.A. and Mulder, E. (1992) Hormoneinduced dissociation of the androgen receptor-heat-shock protein complex:use of a new monoclonal antibody to distinguish transformed from nontransformed receptors. Biochemistry, 31, 7422-7430.
-
(1992)
Biochemistry
, vol.31
, pp. 7422-7430
-
-
Veldscholte, J.1
Berrevoets, C.A.2
Zegers, N.D.3
van der Kwast, T.H.4
Grootegoed, J.A.5
Mulder, E.6
-
14
-
-
0037155790
-
The FXXLF motif mediates androgen receptor-specific interactions with coregulators
-
He, B., Minges, J.T., Lee, L.W. and Wilson, E.M. (2002) The FXXLF motif mediates androgen receptor-specific interactions with coregulators. The Journal of Biological Chemistry, 277, 10226-10235.
-
(2002)
The Journal of Biological Chemistry
, vol.277
, pp. 10226-10235
-
-
He, B.1
Minges, J.T.2
Lee, L.W.3
Wilson, E.M.4
-
15
-
-
0036351145
-
2-terminal and carboxyl-terminal interaction in the human androgen receptor
-
2-terminal and carboxyl-terminal interaction in the human androgen receptor. Molecular Genetics and Metabolism, 75, 293-298.
-
(2002)
Molecular Genetics and Metabolism
, vol.75
, pp. 293-298
-
-
He, B.1
Wilson, E.M.2
-
16
-
-
19344376991
-
Recognition and accommodation at the androgen receptor coactivator binding interface
-
Hur, E., Pfaff, S.J., Payne, E.S., Gron, H., Buehrer, B.M. and Fletterick, R.J. (2004) Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biology, 2, e274.
-
(2004)
PLoS Biology
, vol.2
, pp. e274
-
-
Hur, E.1
Pfaff, S.J.2
Payne, E.S.3
Gron, H.4
Buehrer, B.M.5
Fletterick, R.J.6
-
17
-
-
0345874610
-
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
-
Norman, A.W., Mizwicki, M.T. and Norman, D.P. (2004) Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nature Reviews Drug Discovery, 3, 27-41.
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, pp. 27-41
-
-
Norman, A.W.1
Mizwicki, M.T.2
Norman, D.P.3
-
18
-
-
0016394857
-
Familial incomplete male pseudohermaphroditism, type 1. Evidence for androgen resistance and variable clinical manifestations in a family with the Reifenstein syndrome
-
Wilson, J.D., Harrod, M.J., Goldstein, J.L., Hemsell, D.L. and MacDonald, P.C. (1974) Familial incomplete male pseudohermaphroditism, type 1. Evidence for androgen resistance and variable clinical manifestations in a family with the Reifenstein syndrome. The New England Journal of Medicine, 290, 1097-1103.
-
(1974)
The New England Journal of Medicine
, vol.290
, pp. 1097-1103
-
-
Wilson, J.D.1
Harrod, M.J.2
Goldstein, J.L.3
Hemsell, D.L.4
MacDonald, P.C.5
-
20
-
-
0033616207
-
Androgen insensitivity
-
Gottlieb, B., Pinsky, L., Beitel, L.K. and Trifiro, M. (1999) Androgen insensitivity. American Journal of Medical Genetics, 89, 210-217.
-
(1999)
American Journal of Medical Genetics
, vol.89
, pp. 210-217
-
-
Gottlieb, B.1
Pinsky, L.2
Beitel, L.K.3
Trifiro, M.4
-
21
-
-
33644675811
-
Biology of progressive, castrationresistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis
-
Scher, H.I. and Sawyers, C.L. (2005) Biology of progressive, castrationresistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. Journal of Clinical Oncology, 23, 8253-8261.
-
(2005)
Journal of Clinical Oncology
, vol.23
, pp. 8253-8261
-
-
Scher, H.I.1
Sawyers, C.L.2
-
22
-
-
27544485276
-
Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamidetreated patient
-
Yoshida, T., Kinoshita, H., Segawa, T., Nakamura, E., Inoue, T., Shimizu, Y., Kamoto, T. and Ogawa, O. (2005) Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamidetreated patient. Cancer Research, 65, 9611-9616.
-
(2005)
Cancer Research
, vol.65
, pp. 9611-9616
-
-
Yoshida, T.1
Kinoshita, H.2
Segawa, T.3
Nakamura, E.4
Inoue, T.5
Shimizu, Y.6
Kamoto, T.7
Ogawa, O.8
-
23
-
-
0036645414
-
Molecular biology of the androgen receptor
-
Gelmann, E.P. (2002) Molecular biology of the androgen receptor. Journal of Clinical Oncology, 20, 3001-3015.
-
(2002)
Journal of Clinical Oncology
, vol.20
, pp. 3001-3015
-
-
Gelmann, E.P.1
-
24
-
-
2642544224
-
The androgens receptor gene mutations database (ARDB): 2004 update
-
Gottlieb, B., Beitel, L.K., Wu, J.H. and Trifiro, M. (2004) The androgens receptor gene mutations database (ARDB): 2004 update. Human Mutation, 23, 527-533.
-
(2004)
Human Mutation
, vol.23
, pp. 527-533
-
-
Gottlieb, B.1
Beitel, L.K.2
Wu, J.H.3
Trifiro, M.4
-
25
-
-
85003173512
-
Mutant androgens receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone
-
Culig, Z., Hobisch, A., Cronauer, M.V., Cato, A.C., Hittmair, A., Radmayr, C., Eberle, J., Bartsch, G. and Klocker, H. (1993) Mutant androgens receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Molecular Endocrinology, 7, 1541-1550.
-
(1993)
Molecular Endocrinology
, vol.7
, pp. 1541-1550
-
-
Culig, Z.1
Hobisch, A.2
Cronauer, M.V.3
Cato, A.C.4
Hittmair, A.5
Radmayr, C.6
Eberle, J.7
Bartsch, G.8
Klocker, H.9
-
26
-
-
0028845865
-
Mutated human androgens receptor gene detected in a prostatic cancer patient is also activated by estradiol
-
Elo, J.P., Kvist, L., Leinonen, K., Isomaa, V., Henttu, P., Lukkarinen, O. and Vihko, P. (1995) Mutated human androgens receptor gene detected in a prostatic cancer patient is also activated by estradiol. The Journal of Clinical Endocrinology and Metabolism, 80, 3494-3500.
-
(1995)
The Journal of Clinical Endocrinology and Metabolism
, vol.80
, pp. 3494-3500
-
-
Elo, J.P.1
Kvist, L.2
Leinonen, K.3
Isomaa, V.4
Henttu, P.5
Lukkarinen, O.6
Vihko, P.7
-
27
-
-
0037143096
-
Broadened ligand responsiveness of androgens receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer
-
Steketee, K., Timmerman, L., Ziel-van der Made, A.C., Doesburg, P., Brinkmann, A.O. and Trapman, J. (2002) Broadened ligand responsiveness of androgens receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer. International Journal of Cancer, 100, 309-317.
-
(2002)
International Journal of Cancer
, vol.100
, pp. 309-317
-
-
Steketee, K.1
Timmerman, L.2
Ziel-van der Made, A.C.3
Doesburg, P.4
Brinkmann, A.O.5
Trapman, J.6
-
28
-
-
0037226103
-
Novel mutations of androgens receptor: a possible mechanism of bicalutamide withdrawal syndrome
-
Hara, T., Miyazaki, J., Araki, H., Yamaoka, M., Kanzaki, N., Kusaka, M. and Miyamoto, M. (2003) Novel mutations of androgens receptor: a possible mechanism of bicalutamide withdrawal syndrome. Cancer Research, 63, 149-153.
-
(2003)
Cancer Research
, vol.63
, pp. 149-153
-
-
Hara, T.1
Miyazaki, J.2
Araki, H.3
Yamaoka, M.4
Kanzaki, N.5
Kusaka, M.6
Miyamoto, M.7
-
29
-
-
0029129227
-
Spinal and bulbar muscular atrophy: a trinucleotide-repeat expansion neurodegenerative disease
-
Brooks, B.P. and Fischbeck, K.H. (1995) Spinal and bulbar muscular atrophy: a trinucleotide-repeat expansion neurodegenerative disease. Trends in Neurosciences, 18, 459-461.
-
(1995)
Trends in Neurosciences
, vol.18
, pp. 459-461
-
-
Brooks, B.P.1
Fischbeck, K.H.2
-
30
-
-
0030947287
-
The CAG repeat within the androgens receptor gene and its relationship to prostate cancer
-
Giovannucci, E., Stampfer, M.J., Krithivas, K., Brown, M., Dahl, D., Brufsky, A., Talcott, J., Hennekens, C.H. and Kantoff, P.W. (1997) The CAG repeat within the androgens receptor gene and its relationship to prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 94, 3320-3323.
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, pp. 3320-3323
-
-
Giovannucci, E.1
Stampfer, M.J.2
Krithivas, K.3
Brown, M.4
Dahl, D.5
Brufsky, A.6
Talcott, J.7
Hennekens, C.H.8
Kantoff, P.W.9
-
31
-
-
0037205905
-
The androgens receptor CAG repeat:a modifier of carcinogenesis?
-
Ferro, P., Catalano, M.G., Dell'Eva, R., Fortunati, N. and Pfeffer, U. (2002) The androgens receptor CAG repeat:a modifier of carcinogenesis? Molecular and Cellular Endocrinology, 193, 109-120.
-
(2002)
Molecular and Cellular Endocrinology
, vol.193
, pp. 109-120
-
-
Ferro, P.1
Catalano, M.G.2
Dell'Eva, R.3
Fortunati, N.4
Pfeffer, U.5
-
33
-
-
0037241928
-
Testosterone supplementation therapy for older men: potential benefits and risks
-
discussion 115
-
Gruenewald, D.A. and Matsumoto, A.M. (2003) Testosterone supplementation therapy for older men: potential benefits and risks. Journal of the American Geriatrics Society, 51, 101-115. discussion 115.
-
(2003)
Journal of the American Geriatrics Society
, vol.51
, pp. 101-115
-
-
Gruenewald, D.A.1
Matsumoto, A.M.2
-
34
-
-
0026708173
-
Testicular steroidogenesis and androgens use and abuse
-
Wu, F.C. (1992) Testicular steroidogenesis and androgens use and abuse. Baillieres Clinical Endocrinology and Metabolism, 6, 373-403.
-
(1992)
Baillieres Clinical Endocrinology and Metabolism
, vol.6
, pp. 373-403
-
-
Wu, F.C.1
-
35
-
-
25444496757
-
Chemistry and structural biology of androgens receptor
-
Gao, W., Bohl, C.E. and Dalton, J.T. (2005) Chemistry and structural biology of androgens receptor. Chemical Reviews, 105, 3352-3370.
-
(2005)
Chemical Reviews
, vol.105
, pp. 3352-3370
-
-
Gao, W.1
Bohl, C.E.2
Dalton, J.T.3
-
36
-
-
0017653384
-
Toxicity of methyl testosterone in the beagle dog
-
Heywood, R., Chesterman, H., Ball, S.A. and Wadsworth, P.F. (1977) Toxicity of methyl testosterone in the beagle dog. Toxicology, 7, 357-365.
-
(1977)
Toxicology
, vol.7
, pp. 357-365
-
-
Heywood, R.1
Chesterman, H.2
Ball, S.A.3
Wadsworth, P.F.4
-
37
-
-
0023631310
-
Hepatotoxic effects of the anabolic/androgensic steroids
-
Ishak, K.G. and Zimmerman, H.J. (1987) Hepatotoxic effects of the anabolic/androgensic steroids. Seminars in Liver Disease, 7, 230-236.
-
(1987)
Seminars in Liver Disease
, vol.7
, pp. 230-236
-
-
Ishak, K.G.1
Zimmerman, H.J.2
-
39
-
-
34249077217
-
Androgen therapy in women: what we think we know
-
Drillich, A. and Davis, S.R. (2007) Androgen therapy in women: what we think we know. Experimental Gerontology, 42, 457-462.
-
(2007)
Experimental Gerontology
, vol.42
, pp. 457-462
-
-
Drillich, A.1
Davis, S.R.2
-
40
-
-
0026765457
-
Developments in the control of testicular function
-
Swerdloff, R.S., Wang, C. and Bhasin, S. (1992) Developments in the control of testicular function. Baillieres Clinical Endocrinology and Metabolism, 6, 451-483.
-
(1992)
Baillieres Clinical Endocrinology and Metabolism
, vol.6
, pp. 451-483
-
-
Swerdloff, R.S.1
Wang, C.2
Bhasin, S.3
-
41
-
-
0018663001
-
Effects of anabolic steroids on hepatic enzymes of amino acid catabolism
-
Rodway, R.G. and Galbraith, H. (1979) Effects of anabolic steroids on hepatic enzymes of amino acid catabolism. Hormone and Metabolic Research, 11, 489-490.
-
(1979)
Hormone and Metabolic Research
, vol.11
, pp. 489-490
-
-
Rodway, R.G.1
Galbraith, H.2
-
42
-
-
0018858245
-
The pathogenesis of gynecomastia
-
Wilson, J.D., Aiman, J. and MacDonald, P.C. (1980) The pathogenesis of gynecomastia. Advanced Internal Medicine, 25, 1-32.
-
(1980)
Advanced Internal Medicine
, vol.25
, pp. 1-32
-
-
Wilson, J.D.1
Aiman, J.2
MacDonald, P.C.3
-
43
-
-
0015377166
-
A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4'-nitro-3'-trifluoromethylisobutyranilide)
-
Neri, R., Florance, K., Koziol, P. and Van Cleave, S. (1972) A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4'-nitro-3'-trifluoromethylisobutyranilide). Endocrinology, 91, 427-437.
-
(1972)
Endocrinology
, vol.91
, pp. 427-437
-
-
Neri, R.1
Florance, K.2
Koziol, P.3
Van Cleave, S.4
-
44
-
-
0018405978
-
Anti-androgensicity of flutamide and its metabolite Sch 16423
-
Neri, R., Peets, E. and Watnick, A. (1979) Anti-androgensicity of flutamide and its metabolite Sch 16423. Biochemical Society Transactions, 7, 565-569.
-
(1979)
Biochemical Society Transactions
, vol.7
, pp. 565-569
-
-
Neri, R.1
Peets, E.2
Watnick, A.3
-
46
-
-
0027356895
-
Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer
-
Harris, M.G., Coleman, S.G., Faulds, D. and Chrisp, P. (1993) Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging, 3, 9-25.
-
(1993)
Drugs Aging
, vol.3
, pp. 9-25
-
-
Harris, M.G.1
Coleman, S.G.2
Faulds, D.3
Chrisp, P.4
-
47
-
-
0023495363
-
Pharmacological and clinical studies of the antiandrogens Anandron
-
Moguilewsky, M., Bertagna, C. and Hucher, M. (1987) Pharmacological and clinical studies of the antiandrogens Anandron. Journal of Steroid Biochemistry, 27, 871-875.
-
(1987)
Journal of Steroid Biochemistry
, vol.27
, pp. 871-875
-
-
Moguilewsky, M.1
Bertagna, C.2
Hucher, M.3
-
48
-
-
0021224888
-
The pure antiandrogens RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer: a review
-
Raynaud, J.P., Bonne, C., Moguilewsky, M., Lefebvre, F.A., Belanger, A. and Labrie, F. (1984) The pure antiandrogens RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer: a review. Prostate, 5, 299-311.
-
(1984)
Prostate
, vol.5
, pp. 299-311
-
-
Raynaud, J.P.1
Bonne, C.2
Moguilewsky, M.3
Lefebvre, F.A.4
Belanger, A.5
Labrie, F.6
-
49
-
-
0023180623
-
ICI 176, 334: a novel non-steroidal, peripherally selective antiandrogens
-
Furr, B.J., Valcaccia, B., Curry, B., Woodburn, J.R., Chesterson, G. and Tucker, H. (1987) ICI 176, 334: a novel non-steroidal, peripherally selective antiandrogens. The Journal of Endocrinology, 113, R7-R9.
-
(1987)
The Journal of Endocrinology
, vol.113
, pp. R7-R9
-
-
Furr, B.J.1
Valcaccia, B.2
Curry, B.3
Woodburn, J.R.4
Chesterson, G.5
Tucker, H.6
-
50
-
-
0028290668
-
Current clinical studies with a new nonsteroidal antiandrogens, Casodex
-
Kaisary, A.V. (1994) Current clinical studies with a new nonsteroidal antiandrogens, Casodex. Prostate. Supplement, 5, 27-33.
-
(1994)
Prostate. Supplement
, vol.5
, pp. 27-33
-
-
Kaisary, A.V.1
-
51
-
-
0029165337
-
Efficacy and tolerability of Casodex in patients with advanced prostate cancer. International Casodex Study Group
-
Lunglmayr, G. (1995) Efficacy and tolerability of Casodex in patients with advanced prostate cancer. International Casodex Study Group, Anti-Cancer Drugs, 6, 508-513.
-
(1995)
Anti-Cancer Drugs
, vol.6
, pp. 508-513
-
-
Lunglmayr, G.1
-
52
-
-
0028256464
-
Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgens receptor
-
Teutsch, G., Goubet, F., Battmann, T., Bonfils, A., Bouchoux, F., Cerede, E., Gofflo, D., Gaillard-Kelly, M. and Philibert, D. (1994) Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgens receptor. The Journal of Steroid Biochemistry and Molecular Biology, 48, 111-119.
-
(1994)
The Journal of Steroid Biochemistry and Molecular Biology
, vol.48
, pp. 111-119
-
-
Teutsch, G.1
Goubet, F.2
Battmann, T.3
Bonfils, A.4
Bouchoux, F.5
Cerede, E.6
Gofflo, D.7
Gaillard-Kelly, M.8
Philibert, D.9
-
53
-
-
0015947022
-
On the mechanism of the antiandrogensic action of flutamide (α-α-α-trifluoro-2-methyl-4'-nitro-mpropionotoluidide) in the rat
-
Peets, E.A., Henson, M.F. and Neri, R. (1974) On the mechanism of the antiandrogensic action of flutamide (α-α-α-trifluoro-2-methyl-4'-nitro-mpropionotoluidide) in the rat. Endocrinology, 94, 532-540.
-
(1974)
Endocrinology
, vol.94
, pp. 532-540
-
-
Peets, E.A.1
Henson, M.F.2
Neri, R.3
-
54
-
-
0022551509
-
Pharmacology of an antiandrogens, anandron, used as an adjuvant therapy in the treatment of prostate cancer
-
Moguilewsky, M., Fiet, J., Tournemine, C. and Raynaud, J.P. (1986) Pharmacology of an antiandrogens, anandron, used as an adjuvant therapy in the treatment of prostate cancer. Journal of Steroid Biochemistry, 24, 139-146.
-
(1986)
Journal of Steroid Biochemistry
, vol.24
, pp. 139-146
-
-
Moguilewsky, M.1
Fiet, J.2
Tournemine, C.3
Raynaud, J.P.4
-
55
-
-
0025969989
-
Pharmacokinetics and metabolism of nilutamide
-
Creaven, P.J., Pendyala, L. and Tremblay, D. (1991) Pharmacokinetics and metabolism of nilutamide. Urology, 37 (2 Suppl), 13-19.
-
(1991)
Urology
, vol.37
, Issue.2
, pp. 13-19
-
-
Creaven, P.J.1
Pendyala, L.2
Tremblay, D.3
-
56
-
-
0025900428
-
Generation of free radicals during the reductive metabolism of the nitroaromatic compound, nilutamide
-
Berson, A., Wolf, C., Berger, V., Fau, D., Chachaty, C., Fromenty, B. and Pessayre, D. (1991) Generation of free radicals during the reductive metabolism of the nitroaromatic compound, nilutamide. The Journal of Pharmacology and Experimental Therapeutics, 257, 714-719.
-
(1991)
The Journal of Pharmacology and Experimental Therapeutics
, vol.257
, pp. 714-719
-
-
Berson, A.1
Wolf, C.2
Berger, V.3
Fau, D.4
Chachaty, C.5
Fromenty, B.6
Pessayre, D.7
-
57
-
-
0026669915
-
Mechanism for the hepatotoxicity of the antiandrogens, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes
-
Fau, D., Berson, A., Eugene, D., Fromenty, B., Fisch, C. and Pessayre, D. (1992) Mechanism for the hepatotoxicity of the antiandrogens, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes. The Journal of Pharmacology and Experimental Therapeutics, 263, 69-77.
-
(1992)
The Journal of Pharmacology and Experimental Therapeutics
, vol.263
, pp. 69-77
-
-
Fau, D.1
Berson, A.2
Eugene, D.3
Fromenty, B.4
Fisch, C.5
Pessayre, D.6
-
58
-
-
0026033434
-
Use of the nonsteroidal anti-androgens Casodex in advanced prostatic carcinoma
-
Kennealey, G.T. and Furr, B.J. (1991) Use of the nonsteroidal anti-androgens Casodex in advanced prostatic carcinoma. Urologic Clinics of North America, 18, 99-110.
-
(1991)
Urologic Clinics of North America
, vol.18
, pp. 99-110
-
-
Kennealey, G.T.1
Furr, B.J.2
-
59
-
-
0025602805
-
The pharmacokinetics of Casodex in prostate cancer patients after single and during multiple dosing
-
Cockshott, I.D., Cooper, K.J., Sweetmore, D.S., Blacklock, N.J. and Denis, L. (1990) The pharmacokinetics of Casodex in prostate cancer patients after single and during multiple dosing. European Urology, 18 (Suppl 3), 10-17.
-
(1990)
European Urology
, vol.18
, pp. 10-17
-
-
Cockshott, I.D.1
Cooper, K.J.2
Sweetmore, D.S.3
Blacklock, N.J.4
Denis, L.5
-
60
-
-
0024788019
-
.Casodex. (ICI 176, 334) - a new, pure, peripherally-selective antiandrogens:preclinical studies
-
Furr, B.J. (1989) .Casodex. (ICI 176, 334) - a new, pure, peripherally-selective antiandrogens:preclinical studies. Hormone Research, 32 (Suppl 1), 69-76.
-
(1989)
Hormone Research
, vol.32
, pp. 69-76
-
-
Furr, B.J.1
-
61
-
-
84964130498
-
Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method
-
Hershberger, L.G., Shipley, E.G. and Meyer, R.K. (1953) Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method. Proceedings of the Society for Experimental Biology and Medicine, 83, 175-180.
-
(1953)
Proceedings of the Society for Experimental Biology and Medicine
, vol.83
, pp. 175-180
-
-
Hershberger, L.G.1
Shipley, E.G.2
Meyer, R.K.3
-
62
-
-
7444242095
-
Bicalutamide:clinical pharmacokinetics and metabolism
-
Cockshott, I.D. (2004) Bicalutamide:clinical pharmacokinetics and metabolism. Clinical Pharmacokinetics, 43, 855-878.
-
(2004)
Clinical Pharmacokinetics
, vol.43
, pp. 855-878
-
-
Cockshott, I.D.1
-
63
-
-
10644220145
-
Identification of a novel class of androgens receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus
-
Salvati, M.E., Balog, A., Wei, D.D., Pickering, D., Attar, R.M., Geng, J., Rizzo, C.A., Hunt, J.T., Gottardis, M.M., Weinmann, R. and Martinez, R. (2005) Identification of a novel class of androgens receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus. Bioorganic & Medicinal Chemistry Letters, 15, 389-393.
-
(2005)
Bioorganic & Medicinal Chemistry Letters
, vol.15
, pp. 389-393
-
-
Salvati, M.E.1
Balog, A.2
Wei, D.D.3
Pickering, D.4
Attar, R.M.5
Geng, J.6
Rizzo, C.A.7
Hunt, J.T.8
Gottardis, M.M.9
Weinmann, R.10
Martinez, R.11
-
64
-
-
10644273395
-
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgens receptor antagonists
-
Salvati, M.E., Balog, A., Shan, W., Wei, D.D., Pickering, D., Attar, R.M., Geng, J., Rizzo, C.A., Gottardis, M.M., Weinmann, R., Krystek, S.R., Sack, J., An, Y. and Kish, K. (2005) Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgens receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 15, 271-276.
-
(2005)
Bioorganic & Medicinal Chemistry Letters
, vol.15
, pp. 271-276
-
-
Salvati, M.E.1
Balog, A.2
Shan, W.3
Wei, D.D.4
Pickering, D.5
Attar, R.M.6
Geng, J.7
Rizzo, C.A.8
Gottardis, M.M.9
Weinmann, R.10
Krystek, S.R.11
Sack, J.12
An, Y.13
Kish, K.14
-
65
-
-
33846389383
-
Synthesis and SAR of potent and selective androgens receptor antagonists: 5, 6-dichloro-benzimidazole derivatives
-
Ng, R.A., Guan, J., Alford, V.C., Jr. Lanter, J.C., Allan, G.F., Sbriscia, T., Linton, O., Lundeen, S.G. and Sui, Z. (2007) Synthesis and SAR of potent and selective androgens receptor antagonists: 5, 6-dichloro-benzimidazole derivatives. Bioorganic & Medicinal Chemistry Letters, 17, 784-788.
-
(2007)
Bioorganic & Medicinal Chemistry Letters
, vol.17
, pp. 784-788
-
-
Ng, R.A.1
Guan, J.2
Alford, V.C.3
Lanter, J.C.4
Allan, G.F.5
Sbriscia, T.6
Linton, O.7
Lundeen, S.G.8
Sui, Z.9
-
66
-
-
33845659432
-
The discovery of a potent orally efficacious indole androgens receptor antagonist through in vivo screening
-
Lanter, J.C., Fiordeliso, J.J., Jiang, W., Allan, G.F., Lai, M.T., Linton, O., Hahn do, W., Lundeen, S.G. and Sui, Z. (2007) The discovery of a potent orally efficacious indole androgens receptor antagonist through in vivo screening. Bioorganic & Medicinal Chemistry Letters, 17, 123-126.
-
(2007)
Bioorganic & Medicinal Chemistry Letters
, vol.17
, pp. 123-126
-
-
Lanter, J.C.1
Fiordeliso, J.J.2
Jiang, W.3
Allan, G.F.4
Lai, M.T.5
Linton, O.6
Hahn do, W.7
Lundeen, S.G.8
Sui, Z.9
-
67
-
-
85019780794
-
-
WO 2005/102990
-
Pfizer, Inc., WO 2005/102990.
-
-
-
-
68
-
-
85019810260
-
-
WO 2005/100305
-
Pfizer, Inc., WO 2005/100305.
-
-
-
-
69
-
-
85019803329
-
-
WO 2005/049574
-
Pfizer, Inc., WO 2005/049574.
-
-
-
-
70
-
-
85019829971
-
-
US 6,933,321
-
Endorecherche, Inc., US 6,933,321, (2005).
-
(2005)
-
-
-
71
-
-
85019784575
-
-
WO 2006/133567
-
Endorecherche, Inc., WO 2006/133567.
-
-
-
-
72
-
-
34247159601
-
Circumventing anti-androgens resistance by molecular design
-
McGinley, P.L. and Koh, J. (2007) Circumventing anti-androgens resistance by molecular design. Journal of the American Chemical Society, 129, 3822-3823.
-
(2007)
Journal of the American Chemical Society
, vol.129
, pp. 3822-3823
-
-
McGinley, P.L.1
Koh, J.2
-
73
-
-
33747163669
-
Arylisothiocyanato selective androgens receptor modulators (SARMs) for prostate cancer
-
Hwang, D.J., Yang, J., Xu, H., Rakov, I.M., Mohler, M.L., Dalton, J.T. and Miller, D.D. (2006) Arylisothiocyanato selective androgens receptor modulators (SARMs) for prostate cancer. Bioorganic and Medicinal Chemistry, 14, 6525-6538.
-
(2006)
Bioorganic and Medicinal Chemistry
, vol.14
, pp. 6525-6538
-
-
Hwang, D.J.1
Yang, J.2
Xu, H.3
Rakov, I.M.4
Mohler, M.L.5
Dalton, J.T.6
Miller, D.D.7
-
74
-
-
0033999069
-
Chiral nonsteroidal affinity ligands for the androgens receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring
-
Kirkovsky, L., Mukherjee, A., Yin, D., Dalton, J.T. and Miller, D.D. (2000) Chiral nonsteroidal affinity ligands for the androgens receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring. Journal of Medicinal Chemistry, 43, 581-590.
-
(2000)
Journal of Medicinal Chemistry
, vol.43
, pp. 581-590
-
-
Kirkovsky, L.1
Mukherjee, A.2
Yin, D.3
Dalton, J.T.4
Miller, D.D.5
-
75
-
-
33645114469
-
Preclinical pharmacology of a nonsteroidal ligand for androgens receptor-mediated imaging of prostate cancer
-
Yang, J., Bohl, C.E., Nair, V.A., Mustafa, S.M., Hong, S.S., Miller, D.D. and Dalton, J.T. (2006) Preclinical pharmacology of a nonsteroidal ligand for androgens receptor-mediated imaging of prostate cancer. The Journal of Pharmacology and Experimental Therapeutics, 317, 402-408.
-
(2006)
The Journal of Pharmacology and Experimental Therapeutics
, vol.317
, pp. 402-408
-
-
Yang, J.1
Bohl, C.E.2
Nair, V.A.3
Mustafa, S.M.4
Hong, S.S.5
Miller, D.D.6
Dalton, J.T.7
-
76
-
-
0032866664
-
Affinity labeling of the androgens receptor with nonsteroidal chemoaffinity ligands
-
Mukherjee, A., Kirkovsky, L.I., Kimura, Y., Marvel, M.M., Miller, D.D. and Dalton, J.T. (1999) Affinity labeling of the androgens receptor with nonsteroidal chemoaffinity ligands. Biochemical Pharmacology, 58, 1259-1267.
-
(1999)
Biochemical Pharmacology
, vol.58
, pp. 1259-1267
-
-
Mukherjee, A.1
Kirkovsky, L.I.2
Kimura, Y.3
Marvel, M.M.4
Miller, D.D.5
Dalton, J.T.6
-
77
-
-
0029863106
-
Enantioselective binding of Casodex to the androgens receptor
-
Mukherjee, A., Kirkovsky, L., Yao, X.T., Yates, R.C., Miller, D.D. and Dalton, J.T. (1996) Enantioselective binding of Casodex to the androgens receptor. Xenobiotica; The Fate of Foreign Compounds in Biological Systems, 26, 117-122.
-
(1996)
Xenobiotica; The Fate of Foreign Compounds in Biological Systems
, vol.26
, pp. 117-122
-
-
Mukherjee, A.1
Kirkovsky, L.2
Yao, X.T.3
Yates, R.C.4
Miller, D.D.5
Dalton, J.T.6
-
78
-
-
0032489326
-
Discovery of nonsteroidal androgens
-
Dalton, J.T., Mukherjee, A., Zhu, Z., Kirkovsky, L. and Miller, D.D. (1998) Discovery of nonsteroidal androgens. Biochemical and Biophysical Research Communications, 244, 1-4.
-
(1998)
Biochemical and Biophysical Research Communications
, vol.244
, pp. 1-4
-
-
Dalton, J.T.1
Mukherjee, A.2
Zhu, Z.3
Kirkovsky, L.4
Miller, D.D.5
-
79
-
-
0037205938
-
Novel nonsteroidal ligands with high binding affinity and potent functional activity for the androgens receptor
-
He, Y., Yin, D., Perera, M., Kirkovsky, L., Stourman, N., Li, W., Dalton, J.T. and Miller, D.D. (2002) Novel nonsteroidal ligands with high binding affinity and potent functional activity for the androgens receptor. European Journal of Medicinal Chemistry, 37, 619-634.
-
(2002)
European Journal of Medicinal Chemistry
, vol.37
, pp. 619-634
-
-
He, Y.1
Yin, D.2
Perera, M.3
Kirkovsky, L.4
Stourman, N.5
Li, W.6
Dalton, J.T.7
Miller, D.D.8
-
80
-
-
0032492668
-
New nonsteroidal androgens receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone
-
Edwards, J.P., West, S.J., Pooley, C.L., Marschke, K.B., Farmer, L.J. and Jones, T.K. (1998) New nonsteroidal androgens receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone. Bioorganic & Medicinal Chemistry Letters, 8, 745-750.
-
(1998)
Bioorganic & Medicinal Chemistry Letters
, vol.8
, pp. 745-750
-
-
Edwards, J.P.1
West, S.J.2
Pooley, C.L.3
Marschke, K.B.4
Farmer, L.J.5
Jones, T.K.6
-
81
-
-
0033519183
-
4-Alkyl-and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: potent, nonsteroidal androgens receptor agonists
-
Higuchi, R.I., Edwards, J.P., Caferro, T.R., Ringgenberg, J.D., Kong, J.W., Hamann, L.G., Arienti, K.L., Marschke, K.B., Davis, R.L., Farmer, L.J. and Jones, T.K. (1999) 4-Alkyl-and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: potent, nonsteroidal androgens receptor agonists. Bioorganic &Medicinal Chemistry Letters, 9, 1335-1340.
-
(1999)
Bioorganic &Medicinal Chemistry Letters
, vol.9
, pp. 1335-1340
-
-
Higuchi, R.I.1
Edwards, J.P.2
Caferro, T.R.3
Ringgenberg, J.D.4
Kong, J.W.5
Hamann, L.G.6
Arienti, K.L.7
Marschke, K.B.8
Davis, R.L.9
Farmer, L.J.10
Jones, T.K.11
-
82
-
-
0033526095
-
Switching androgens receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g]quinolinone
-
Zhi, L., Tegley, C.M., Marschke, K.B. and Jones, T.K. (1999) Switching androgens receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g]quinolinone. Bioorganic & Medicinal Chemistry Letters, 9, 1009-1012.
-
(1999)
Bioorganic & Medicinal Chemistry Letters
, vol.9
, pp. 1009-1012
-
-
Zhi, L.1
Tegley, C.M.2
Marschke, K.B.3
Jones, T.K.4
-
83
-
-
0037222170
-
Key structural features of nonsteroidal ligands for binding and activation of the androgens receptor
-
Yin, D., He, Y., Perera, M.A., Hong, S.S., Marhefka, C., Stourman, N., Kirkovsky, L., Miller, D.D. and Dalton, J.T. (2003) Key structural features of nonsteroidal ligands for binding and activation of the androgens receptor. Molecular Pharmacology, 63, 211-223.
-
(2003)
Molecular Pharmacology
, vol.63
, pp. 211-223
-
-
Yin, D.1
He, Y.2
Perera, M.A.3
Hong, S.S.4
Marhefka, C.5
Stourman, N.6
Kirkovsky, L.7
Miller, D.D.8
Dalton, J.T.9
-
84
-
-
0035942522
-
Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgens receptor ligand binding domain bound to testosterone and nonsteroidal ligands
-
Marhefka, C.A., Moore, B.M., 2nd, Bishop, T.C., Kirkovsky, L., Mukherjee, A., Dalton, J.T. and Miller, D.D. (2001) Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgens receptor ligand binding domain bound to testosterone and nonsteroidal ligands. Journal of Medicinal Chemistry, 44, 1729-1740.
-
(2001)
Journal of Medicinal Chemistry
, vol.44
, pp. 1729-1740
-
-
Marhefka, C.A.1
Moore, B.M.2
Bishop, T.C.3
Kirkovsky, L.4
Mukherjee, A.5
Dalton, J.T.6
Miller, D.D.7
-
85
-
-
0037373345
-
Pharmacology, pharmacokinetics, and metabolism of acetothiolutamide, a novel nonsteroidal agonist for the androgens receptor
-
Yin, D., Xu, H., He, Y., Kirkovsky, L.I., Miller, D.D. and Dalton, J.T. (2003) Pharmacology, pharmacokinetics, and metabolism of acetothiolutamide, a novel nonsteroidal agonist for the androgens receptor. The Journal of Pharmacology and Experimental Therapeutics, 304, 1323-1333.
-
(2003)
The Journal of Pharmacology and Experimental Therapeutics
, vol.304
, pp. 1323-1333
-
-
Yin, D.1
Xu, H.2
He, Y.3
Kirkovsky, L.I.4
Miller, D.D.5
Dalton, J.T.6
-
86
-
-
0842325914
-
Design, synthesis, and biological characterization of metabolically stable selective androgens receptor modulators
-
Marhefka, C.A., Gao, W., Chung, K., Kim, J., He, Y., Yin, D., Bohl, C., Dalton, J.T. and Miller, D.D. (2004) Design, synthesis, and biological characterization of metabolically stable selective androgens receptor modulators. Journal of Medicinal Chemistry, 47, 993-998.
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, pp. 993-998
-
-
Marhefka, C.A.1
Gao, W.2
Chung, K.3
Kim, J.4
He, Y.5
Yin, D.6
Bohl, C.7
Dalton, J.T.8
Miller, D.D.9
-
87
-
-
0037371461
-
Pharmacodynamics of selective androgens receptor modulators
-
Yin, D., Gao, W., Kearbey, J.D., Xu, H., Chung, K., He, Y., Marhefka, C.A., Veverka, K.A., Miller, D.D. and Dalton, J.T. (2003) Pharmacodynamics of selective androgens receptor modulators. The Journal of Pharmacology and Experimental Therapeutics, 304, 1334-1340.
-
(2003)
The Journal of Pharmacology and Experimental Therapeutics
, vol.304
, pp. 1334-1340
-
-
Yin, D.1
Gao, W.2
Kearbey, J.D.3
Xu, H.4
Chung, K.5
He, Y.6
Marhefka, C.A.7
Veverka, K.A.8
Miller, D.D.9
Dalton, J.T.10
-
88
-
-
1842627842
-
Pharmacokinetics of S-3-(4-acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgens receptor modulator
-
Kearbey, J.D., Wu, D., Gao, W., Miller, D.D. and Dalton, J.T. (2004) Pharmacokinetics of S-3-(4-acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgens receptor modulator. Xenobiotica; The Fate of Foreign Compounds in Biological Systems, 34, 273-280.
-
(2004)
Xenobiotica; The Fate of Foreign Compounds in Biological Systems
, vol.34
, pp. 273-280
-
-
Kearbey, J.D.1
Wu, D.2
Gao, W.3
Miller, D.D.4
Dalton, J.T.5
-
89
-
-
3142617910
-
A ligand-based approach to identify quantitative structure-activity relationships for the androgens receptor
-
Bohl, C.E., Chang, C., Mohler, M.L., Chen, J., Miller, D.D., Swaan, P.W. and Dalton, J.T. (2004) A ligand-based approach to identify quantitative structure-activity relationships for the androgens receptor. Journal of Medicinal Chemistry, 47, 3765-3776.
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, pp. 3765-3776
-
-
Bohl, C.E.1
Chang, C.2
Mohler, M.L.3
Chen, J.4
Miller, D.D.5
Swaan, P.W.6
Dalton, J.T.7
-
90
-
-
22544440481
-
The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgens receptor modulators
-
Kim, J., Wu, D., Hwang, D.J., Miller, D.D. and Dalton, J.T. (2005) The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgens receptor modulators. The Journal of Pharmacology and Experimental Therapeutics, 315, 230-239.
-
(2005)
The Journal of Pharmacology and Experimental Therapeutics
, vol.315
, pp. 230-239
-
-
Kim, J.1
Wu, D.2
Hwang, D.J.3
Miller, D.D.4
Dalton, J.T.5
-
91
-
-
27844550753
-
In vitro and in vivo structure-activity relationships of novel androgens receptor ligands with multiple substituents in the B-ring
-
Chen, J., Hwang, D.J., Chung, K., Bohl, C.E., Fisher, S.J., Miller, D.D. and Dalton, J.T. (2005) In vitro and in vivo structure-activity relationships of novel androgens receptor ligands with multiple substituents in the B-ring. Endocrinology, 146, 5444-5454.
-
(2005)
Endocrinology
, vol.146
, pp. 5444-5454
-
-
Chen, J.1
Hwang, D.J.2
Chung, K.3
Bohl, C.E.4
Fisher, S.J.5
Miller, D.D.6
Dalton, J.T.7
-
92
-
-
13244284678
-
A selective androgens receptor modulator for hormonal male contraception
-
Chen, J., Hwang, D.J., Bohl, C.E., Miller, D.D. and Dalton, J.T. (2005) A selective androgens receptor modulator for hormonal male contraception. The Journal of Pharmacology and Experimental Therapeutics, 312, 546-553.
-
(2005)
The Journal of Pharmacology and Experimental Therapeutics
, vol.312
, pp. 546-553
-
-
Chen, J.1
Hwang, D.J.2
Bohl, C.E.3
Miller, D.D.4
Dalton, J.T.5
-
93
-
-
9444244523
-
Comparison of the pharmacological effects of a novel selective androgens receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogens hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia
-
Gao, W., Kearbey, J.D., Nair, V.A., Chung, K., Parlow, A.F., Miller, D.D. and Dalton, J.T. (2004) Comparison of the pharmacological effects of a novel selective androgens receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogens hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology, 145, 5420-5428.
-
(2004)
Endocrinology
, vol.145
, pp. 5420-5428
-
-
Gao, W.1
Kearbey, J.D.2
Nair, V.A.3
Chung, K.4
Parlow, A.F.5
Miller, D.D.6
Dalton, J.T.7
-
94
-
-
26844496083
-
Selective androgens receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats
-
Gao, W., Reiser, P.J., Coss, C.C., Phelps, M.A., Kearbey, J.D., Miller, D.D. and Dalton, J.T. (2005) Selective androgens receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology, 146, 4887-4897.
-
(2005)
Endocrinology
, vol.146
, pp. 4887-4897
-
-
Gao, W.1
Reiser, P.J.2
Coss, C.C.3
Phelps, M.A.4
Kearbey, J.D.5
Miller, D.D.6
Dalton, J.T.7
-
95
-
-
33846154582
-
Selective androgens receptor modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats
-
Kearbey, J.D., Gao, W., Narayanan, R., Fisher, S.J., Wu, D., Miller, D.D. and Dalton, J.T. (2007) Selective androgens receptor modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharmaceutical Research, 24, 328-335.
-
(2007)
Pharmaceutical Research
, vol.24
, pp. 328-335
-
-
Kearbey, J.D.1
Gao, W.2
Narayanan, R.3
Fisher, S.J.4
Wu, D.5
Miller, D.D.6
Dalton, J.T.7
-
96
-
-
85019798392
-
GTx announces that ostarine achieved primary endpoint of lean body mass and a secondary endpoint of improved functional performance in a phase II clinical trial and reacquisition of full rights to GTx SARM program
-
8 December
-
Press release, 8 December 2006, GTx announces that ostarine achieved primary endpoint of lean body mass and a secondary endpoint of improved functional performance in a phase II clinical trial and reacquisition of full rights to GTx SARM program. http://www.gtxinc.com.
-
(2006)
-
-
-
97
-
-
85019784654
-
GTx, Inc. announces positive clinical results and development plans for ostarine
-
7 September
-
Press release, 7 September 2005, GTx, Inc. announces positive clinical results and development plans for ostarine. http://www.gtxinc.com.
-
(2005)
-
-
-
98
-
-
85019819172
-
-
WO 2005/000794
-
Orion Corp., WO 2005/000794.
-
-
-
-
99
-
-
85019780821
-
R&D pipeline of Orion Pharma - update of the progress of project
-
Heinonen, E. R&D pipeline of Orion Pharma - update of the progress of project. http://img.orion.fi/liitteet/200857.pdf.
-
-
-
Heinonen, E.1
-
100
-
-
85019796237
-
-
WO 2004/0113309
-
Janssen Pharmaceutica NV, WO 2004/0113309.
-
-
-
-
101
-
-
85019805475
-
-
US 2006/0211756
-
Johnson & Johnson Co., US 2006/0211756.
-
-
-
-
102
-
-
85019788209
-
-
US 2006/0063819
-
Johnson & Johnson Co., US 2006/0063819.
-
-
-
-
103
-
-
85019791939
-
-
US 2005/245485
-
Janssen Pharmaceutica NV, US 2005/245485.
-
-
-
-
104
-
-
85019825101
-
-
US 2005/250741
-
Janssen Pharmaceutica NV, US 2005/250741.
-
-
-
-
105
-
-
33748798930
-
Abioisosteric approach to the discovery of indole carbinol androgens receptor ligands
-
Lanter, J.C., Fiordeliso, J.J., Allan, G.F., Musto, A., Hahn do, W. and Sui, Z. (2006) Abioisosteric approach to the discovery of indole carbinol androgens receptor ligands. Bioorganic & Medicinal Chemistry Letters, 16, 5646-5649.
-
(2006)
Bioorganic & Medicinal Chemistry Letters
, vol.16
, pp. 5646-5649
-
-
Lanter, J.C.1
Fiordeliso, J.J.2
Allan, G.F.3
Musto, A.4
Hahn do, W.5
Sui, Z.6
-
106
-
-
85019780960
-
-
WO 2006/044707
-
SmithKline Beecham Corp., WO 2006/044707.
-
-
-
-
107
-
-
85019782950
-
-
WO 2007/016358
-
Merck & Co., Inc., WO 2007/016358.
-
-
-
-
108
-
-
85019810613
-
-
WO 2006/060108
-
Merck & Co., Inc., WO 2006/060108.
-
-
-
-
109
-
-
85019784687
-
-
US 2005/277681
-
Merck & Co., Inc., US 2005/277681.
-
-
-
-
110
-
-
85019819766
-
-
WO 2004/041277
-
Merck & Co., Inc., WO 2004/041277.
-
-
-
-
111
-
-
85019788076
-
-
WO 2005/094810
-
Karo Bio AB, WO 2005/094810.
-
-
-
-
112
-
-
0033526028
-
Nonsteroidal androgens receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g] quinolin-2-one
-
Edwards, J.P., Higuchi, R.I., Winn, D.T., Pooley, C.L., Caferro, T.R., Hamann, L.G., Zhi, L., Marschke, K.B., Goldman, M.E. and Jones, T.K. (1999) Nonsteroidal androgens receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g] quinolin-2-one. Bioorganic & Medicinal Chemistry Letters, 9, 1003-1008.
-
(1999)
Bioorganic & Medicinal Chemistry Letters
, vol.9
, pp. 1003-1008
-
-
Edwards, J.P.1
Higuchi, R.I.2
Winn, D.T.3
Pooley, C.L.4
Caferro, T.R.5
Hamann, L.G.6
Zhi, L.7
Marschke, K.B.8
Goldman, M.E.9
Jones, T.K.10
-
113
-
-
0032906159
-
Discovery of a potent, orally active, nonsteroidal androgens receptor agonist: 4-ethyl-1,2,3,4-tetrahydro-6-(trifluoromethyl)-8-pyridono[5,6-g]-quinoline (LG121071)
-
Hamann, L.G., Mani, N.S., Davis, R.L., Wang, X.N., Marschke, K.B. and Jones, T.K. (1999) Discovery of a potent, orally active, nonsteroidal androgens receptor agonist: 4-ethyl-1,2,3,4-tetrahydro-6-(trifluoromethyl)-8-pyridono[5,6-g]-quinoline (LG121071). Journal of Medicinal Chemistry, 42, 210-212.
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, pp. 210-212
-
-
Hamann, L.G.1
Mani, N.S.2
Davis, R.L.3
Wang, X.N.4
Marschke, K.B.5
Jones, T.K.6
-
114
-
-
85019814947
-
-
US 6,017,924
-
Ligand Pharmaceuticals, Inc., US 6,017,924 (2000).
-
(2000)
-
-
-
115
-
-
85019782892
-
-
WO 2002/068427
-
Ligand Pharmaceuticals, Inc., WO 2002/068427.
-
-
-
-
116
-
-
85019800160
-
-
US 7,026,484
-
Ligand Pharmaceuticals, Inc., US 7,026,484 (2007).
-
(2007)
-
-
-
117
-
-
85019802034
-
Potent, nonsteroidal androgens receptor modulators based on 2-quinolinone scaffolds: a platform for selective androgens receptor modulators (SARMs)
-
20-24 August, abstract MEDI 5
-
Higuchi, R.I., Zhi, L., Edwards, J.P., Caferro, T.R., Ringgenberg, J.D., West, S.J., Kong, J.W., Hamann, L.G., Arienti, K.L., Cummings, M.L., Wu, M., Tegley, C.M., Jones, T.K., Lopez, F.J., Marschke, K.B. and Schrader, W.T. (20-24 August 2000) Potent, nonsteroidal androgens receptor modulators based on 2-quinolinone scaffolds: a platform for selective androgens receptor modulators (SARMs), 220th American Chemical Society National Meeting, abstract MEDI 5.
-
(2000)
220th American Chemical Society National Meeting
-
-
Higuchi, R.I.1
Zhi, L.2
Edwards, J.P.3
Caferro, T.R.4
Ringgenberg, J.D.5
West, S.J.6
Kong, J.W.7
Hamann, L.G.8
Arienti, K.L.9
Cummings, M.L.10
Wu, M.11
Tegley, C.M.12
Jones, T.K.13
Lopez, F.J.14
Marschke, K.B.15
Schrader, W.T.16
-
118
-
-
27944464560
-
Nonsteroidal tissue selective androgens receptor modulators: a promising class of clinical candidates
-
Mohler, M.L., Nair, V.A., Hwang, D.J., Rakov, I.M., Patil, R. and Miller, D.D. (2005) Nonsteroidal tissue selective androgens receptor modulators: a promising class of clinical candidates. Expert Opinion on Therapeutic Patents, 15, 1565-1585.
-
(2005)
Expert Opinion on Therapeutic Patents
, vol.15
, pp. 1565-1585
-
-
Mohler, M.L.1
Nair, V.A.2
Hwang, D.J.3
Rakov, I.M.4
Patil, R.5
Miller, D.D.6
-
119
-
-
18744368209
-
Non-steroidal steroid receptor modulators
-
Buijsman, R.C., Hermkens, P.H., van Rijn, R.D., Stock, H.T. and Teerhuis, N.M. (2005) Non-steroidal steroid receptor modulators. Current Medicinal Chemistry, 12, 1017-1075.
-
(2005)
Current Medicinal Chemistry
, vol.12
, pp. 1017-1075
-
-
Buijsman, R.C.1
Hermkens, P.H.2
van Rijn, R.D.3
Stock, H.T.4
Teerhuis, N.M.5
-
120
-
-
85019780951
-
-
US 6,667,313
-
Ligand Pharmaceuticals, Inc., US 6,667,313 (2003).
-
(2003)
-
-
-
121
-
-
85019799369
-
-
US 6,462,038
-
Ligand Pharmaceuticals, Inc., US 6,462,038 (2002).
-
(2002)
-
-
-
122
-
-
85019830008
-
-
US 6,566,372
-
Ligand Pharmaceuticals, Inc., US 6,566,372 (2003).
-
(2003)
-
-
-
123
-
-
33750332656
-
Steroid receptor modulators: approaches to selectivity for androgens receptor
-
21 September, Keystone Meeting
-
Miner, J.N., Burnett, K., Chang, W. et al. (21 September 2005) Steroid receptor modulators: approaches to selectivity for androgens receptor, Tissue-Selective Nuclear Receptor Symposia, Keystone Meeting.
-
(2005)
Tissue-Selective Nuclear Receptor Symposia
-
-
Miner, J.N.1
Burnett, K.2
Chang, W.3
-
124
-
-
33847056151
-
Novel selective androgens receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones
-
van Oeveren, A., Motamedi, M., Martinborough, E., Zhao, S., Shen, Y., West, S., Chang, W., Kallel, A., Marschke, K.B., Lopez, F.J., Negro-Vilar, A. and Zhi, L. (2007) Novel selective androgens receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones. Bioorganic & Medicinal Chemistry Letters, 17, 1527-1531.
-
(2007)
Bioorganic & Medicinal Chemistry Letters
, vol.17
, pp. 1527-1531
-
-
van Oeveren, A.1
Motamedi, M.2
Martinborough, E.3
Zhao, S.4
Shen, Y.5
West, S.6
Chang, W.7
Kallel, A.8
Marschke, K.B.9
Lopez, F.J.10
Negro-Vilar, A.11
Zhi, L.12
-
125
-
-
33847045081
-
Discovery of an androgens receptor modulator pharmacophore based on 2-quinolinones
-
van Oeveren, A., Pio, B.A., Tegley, C.M., Higuchi, R.I., Wu, M., Jones, T.K., Marschke, K.B., Negro-Vilar, A. and Zhi, L. (2007) Discovery of an androgens receptor modulator pharmacophore based on 2-quinolinones. Bioorganic & Medicinal Chemistry Letters, 17, 1523-1526.
-
(2007)
Bioorganic & Medicinal Chemistry Letters
, vol.17
, pp. 1523-1526
-
-
van Oeveren, A.1
Pio, B.A.2
Tegley, C.M.3
Higuchi, R.I.4
Wu, M.5
Jones, T.K.6
Marschke, K.B.7
Negro-Vilar, A.8
Zhi, L.9
-
126
-
-
33750105276
-
Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino-4-trifluoromethylquinolin-2(1H)-one as a novel selective androgens receptor modulator
-
van Oeveren, A., Motamedi, M., Mani, N.S., Marschke, K.B., Lopez, F.J., Schrader, W.T., Negro-Vilar, A. and Zhi, L. (2006) Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino-4-trifluoromethylquinolin-2(1H)-one as a novel selective androgens receptor modulator. Journal ofMedicinal Chemistry, 49, 6143-6146.
-
(2006)
Journal ofMedicinal Chemistry
, vol.49
, pp. 6143-6146
-
-
van Oeveren, A.1
Motamedi, M.2
Mani, N.S.3
Marschke, K.B.4
Lopez, F.J.5
Schrader, W.T.6
Negro-Vilar, A.7
Zhi, L.8
-
127
-
-
33750593652
-
Structure of the ligand-binding domain (LBD) of human androgens receptor in complex with a selective modulator LGD2226
-
Wang, F., Liu, X.Q., Li, H., Liang, K.N., Miner, J.N., Hong, M., Kallel, E.A., van Oeveren, A., Zhi, L. and Jiang, T. (2006) Structure of the ligand-binding domain (LBD) of human androgens receptor in complex with a selective modulator LGD2226. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62, 1067-1071.
-
(2006)
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
, vol.62
, pp. 1067-1071
-
-
Wang, F.1
Liu, X.Q.2
Li, H.3
Liang, K.N.4
Miner, J.N.5
Hong, M.6
Kallel, E.A.7
van Oeveren, A.8
Zhi, L.9
Jiang, T.10
-
128
-
-
33845888293
-
An orally active selective androgens receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate
-
Miner, J.N., Chang, W., Chapman, M.S., Finn, P.D., Hong, M.H., Lopez, F.J., Marschke, K.B., Rosen, J., Schrader, W., Turner, R., van Oeveren, A., Viveros, H., Zhi, L. and Negro-Vilar, A. (2007) An orally active selective androgens receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate. Endocrinology, 148, 363-373.
-
(2007)
Endocrinology
, vol.148
, pp. 363-373
-
-
Miner, J.N.1
Chang, W.2
Chapman, M.S.3
Finn, P.D.4
Hong, M.H.5
Lopez, F.J.6
Marschke, K.B.7
Rosen, J.8
Schrader, W.9
Turner, R.10
van Oeveren, A.11
Viveros, H.12
Zhi, L.13
Negro-Vilar, A.14
-
129
-
-
85019830203
-
LGD2941 is a potent, orallyavailable selective androgens receptor modulator (SARM) with superior activity in bone and muscle in male rats
-
15-19 September, abstract M388
-
Chang, W.Y., Vajda, E.G., Burnett, K., Talaoc, E.C., Mais, D.E., Marschke, K., Lopez, F.J., Viveros, O.H., Shen, Y., Martinborough, E., Hudson, A., Zhi, L. and Negro-Vilar, A. (15-19 September 2006) LGD2941 is a potent, orallyavailable selective androgens receptor modulator (SARM) with superior activity in bone and muscle in male rats, 28th Annual Meeting of the American Society for Bone and Mineral Research, abstract M388.
-
(2006)
28th Annual Meeting of the American Society for Bone and Mineral Research
-
-
Chang, W.Y.1
Vajda, E.G.2
Burnett, K.3
Talaoc, E.C.4
Mais, D.E.5
Marschke, K.6
Lopez, F.J.7
Viveros, O.H.8
Shen, Y.9
Martinborough, E.10
Hudson, A.11
Zhi, L.12
Negro-Vilar, A.13
-
130
-
-
85019798744
-
LGD2941, an orally-available, nonsteroidal selective androgens receptor modulator (SARM) stimulates bone and muscle growth in male monkeys
-
15-19 September, abstract M389
-
DeManno, D., Miller, G., Vajda, E., Gunawardhana, L., Niefhoff, M. and Weinbauer, G.F. (15-19 September 2006) LGD2941, an orally-available, nonsteroidal selective androgens receptor modulator (SARM) stimulates bone and muscle growth in male monkeys, 28th Annual Meeting of the American Society for Bone and Mineral Research, abstract M389.
-
(2006)
28th Annual Meeting of the American Society for Bone and Mineral Research
-
-
DeManno, D.1
Miller, G.2
Vajda, E.3
Gunawardhana, L.4
Niefhoff, M.5
Weinbauer, G.F.6
-
131
-
-
85019830055
-
LGD2941 is an orally-available, nonsteroidal selective androgens receptor modulator (SARM) with superior bone activity in female rats
-
15-19 September, abstract F400
-
Vajda, E., Chang, W.Y., Talaoc, E.C., Griffiths, K., Burnett, K., Marschke, K., Mais, D.E., Viveros, O.H., Shen, Y., Martinborough, E., Zhi, L. and Negro-Vilar, A. (15-19 September 2006) LGD2941 is an orally-available, nonsteroidal selective androgens receptor modulator (SARM) with superior bone activity in female rats, 28th Annual Meeting of the American Society for Bone and Mineral Research, abstract F400.
-
(2006)
28th Annual Meeting of the American Society for Bone and Mineral Research
-
-
Vajda, E.1
Chang, W.Y.2
Talaoc, E.C.3
Griffiths, K.4
Burnett, K.5
Marschke, K.6
Mais, D.E.7
Viveros, O.H.8
Shen, Y.9
Martinborough, E.10
Zhi, L.11
Negro-Vilar, A.12
-
132
-
-
85019793596
-
-
US 2005/004367
-
Pfizer, Inc., US 2005/004367.
-
-
-
-
133
-
-
85019827371
-
-
WO 2004/072043
-
Pfizer, Inc., WO 2004/072043.
-
-
-
-
134
-
-
85019827370
-
-
US 2005/137228
-
Pfizer, Inc., US 2005/137228.
-
-
-
-
135
-
-
85019773989
-
-
US 7,196,076
-
Merck & Co., Inc., US 7,196,076.
-
-
-
-
136
-
-
85019822869
-
-
WO 2003/077919
-
Merck & Co., Inc., WO 2003/077919.
-
-
-
-
137
-
-
85019805413
-
-
US 2004/0235808
-
Merck & Co., Inc., US 2004/0235808.
-
-
-
-
138
-
-
85019792271
-
-
WO 2004/0100874
-
Merck & Co., Inc., WO 2004/0100874.
-
-
-
-
139
-
-
85019830088
-
-
WO 2006/0026196
-
Merck & Co., Inc., WO 2006/0026196.
-
-
-
-
140
-
-
85019773962
-
-
WO 2005/0005606
-
Merck & Co., Inc., WO 2005/0005606.
-
-
-
-
141
-
-
85019810708
-
-
WO 2005/009949
-
Merck & Co., Inc., WO 2005/009949.
-
-
-
-
142
-
-
85019827319
-
-
WO 2005/099707
-
Merck & Co., Inc., WO 2005/099707.
-
-
-
-
143
-
-
85019798656
-
-
US 2006/0258661
-
Merck & Co., Inc., US 2006/0258661.
-
-
-
-
144
-
-
85019790986
-
-
US 2006/0241107
-
Merck & Co., Inc., US 2006/0241107.
-
-
-
-
145
-
-
85019810733
-
-
WO 2005/0025579
-
Merck & Co., Inc., WO 2005/0025579.
-
-
-
-
146
-
-
85019790994
-
-
WO 2005/004807
-
Merck & Co., Inc., WO 2005/004807.
-
-
-
-
147
-
-
85019819823
-
17-Arylcarbamidomethyl-4-azasteroids as selective androgens receptor modulators
-
25-29 March, abstract MEDI 203
-
Dankulich, W.P., Mitchell, H.J., Prueksaritanont, T., Schmidt, A., Vogel, R.L., Bai, C., McElwee-Witmer, S., Chen, F., Zhang, H.Z., Leu, C.T., Kimmel, D., Pennypacker, B., Masarachia, P., Pun, S., Scafonas, A., Adamski, S. and Meissner, R.S. (25-29 March 2007) 17-Arylcarbamidomethyl-4-azasteroids as selective androgens receptor modulators, 233rd American Chemical Society National Meeting, abstract MEDI 203.
-
(2007)
233rd American Chemical Society National Meeting
-
-
Dankulich, W.P.1
Mitchell, H.J.2
Prueksaritanont, T.3
Schmidt, A.4
Vogel, R.L.5
Bai, C.6
McElwee-Witmer, S.7
Chen, F.8
Zhang, H.Z.9
Leu, C.T.10
Kimmel, D.11
Pennypacker, B.12
Masarachia, P.13
Pun, S.14
Scafonas, A.15
Adamski, S.16
Meissner, R.S.17
-
148
-
-
85019796206
-
-
US 6,858,621
-
Ortho-McNeil Pharmaceutical, Inc., US 6,858,621, (2005).
-
(2005)
-
-
-
149
-
-
85019827927
-
-
JP 2003/073374
-
Kaken Pharmaceutical Co., Ltd, JP 2003/073374.
-
-
-
-
150
-
-
85019800204
-
-
US 6,777,427
-
Kaken Pharmaceutical Co., Ltd, US 6,777,427, (2004).
-
(2004)
-
-
-
151
-
-
4444371195
-
Bone anabolic effects of S-40503, a novel nonsteroidal selective androgens receptor modulator (SARM), in rat models of osteoporosis
-
Hanada, K., Furuya, K., Yamamoto, N., Nejishima, H., Ichikawa, K., Nakamura, T., Miyakawa, M., Amano, S., Sumita, Y. and Oguro, N. (2003) Bone anabolic effects of S-40503, a novel nonsteroidal selective androgens receptor modulator (SARM), in rat models of osteoporosis. Biological & Pharmaceutical Bulletin, 26, 1563-1569.
-
(2003)
Biological & Pharmaceutical Bulletin
, vol.26
, pp. 1563-1569
-
-
Hanada, K.1
Furuya, K.2
Yamamoto, N.3
Nejishima, H.4
Ichikawa, K.5
Nakamura, T.6
Miyakawa, M.7
Amano, S.8
Sumita, Y.9
Oguro, N.10
-
152
-
-
85019814978
-
-
EP 1221439
-
Kaken Pharmaceutical Co., Ltd, EP 1221439, (2001).
-
(2001)
-
-
-
153
-
-
85019799404
-
-
WO 2004/013104 (in Japanese
-
Kaken Pharmaceutical Co., Ltd, WO 2004/013104 (in Japanese).
-
-
-
-
154
-
-
85019798672
-
-
WO 2004/000816 (in Japanese
-
Kaken Pharmaceutical Co., Ltd, WO 2004/000816 (in Japanese).
-
-
-
-
155
-
-
33947687854
-
Inflammation in prostate carcinogenesis
-
De Marzo, A.M., Platz, E.A., Sutcliffe, S., Xu, J., Gronberg, H., Drake, C.G., Nakai, Y., Isaacs, W.B. and Nelson, W.G. (2007) Inflammation in prostate carcinogenesis. Nature Reviews Cancer, 7, 256-269.
-
(2007)
Nature Reviews Cancer
, vol.7
, pp. 256-269
-
-
De Marzo, A.M.1
Platz, E.A.2
Sutcliffe, S.3
Xu, J.4
Gronberg, H.5
Drake, C.G.6
Nakai, Y.7
Isaacs, W.B.8
Nelson, W.G.9
-
156
-
-
85019796284
-
-
WO 2004/000816 (in Japanese)
-
Kaken Pharmaceutical Co., Ltd, WO 2004/000816 (in Japanese).
-
-
-
-
157
-
-
85019802179
-
-
WO 2005/108351
-
Pfizer Products Inc., WO 2005/108351.
-
-
-
-
158
-
-
85019794893
-
Differential effects of 5α-dihydrotestosterone (DHT) and a novel selective androgen receptor modulator (SARM) on prostate and bone in intact and orchidectomized (ORX) male rats
-
23-27 September, abstract M395
-
Ke, H.Z., Crawford, D.T., Qi, H. et al. (23-27 September 2005) Differential effects of 5α-dihydrotestosterone (DHT) and a novel selective androgen receptor modulator (SARM) on prostate and bone in intact and orchidectomized (ORX) male rats, 27th Annual Meeting of the American Society for Bone and Mineral Research, abstract M395.
-
(2005)
27th Annual Meeting of the American Society for Bone and Mineral Research
-
-
Ke, H.Z.1
Crawford, D.T.2
Qi, H.3
-
159
-
-
85019808230
-
A novel, nonsteroidal selective androgens receptor modulator (SARM) increases periosteal bone formation and inhibits trabecular bone turnover in aged intact and orchidectomized male rats
-
1-5 October, abstract 1216
-
Ke, H.Z., Crawford, D.T., Oi, H. et al. (1-5 October 2004) A novel, nonsteroidal selective androgens receptor modulator (SARM) increases periosteal bone formation and inhibits trabecular bone turnover in aged intact and orchidectomized male rats, 26th Annual Meeting of the American Society for Bone and Mineral Research, abstract 1216.
-
(2004)
26th Annual Meeting of the American Society for Bone and Mineral Research
-
-
Ke, H.Z.1
Crawford, D.T.2
Oi, H.3
-
160
-
-
85019809661
-
-
WO 2005/090282
-
Ligand Pharmaceuticals, Inc., WO 2005/090282.
-
-
-
-
161
-
-
85019797667
-
-
WO 2005/090282
-
Ligand Pharmaceuticals, Inc., WO 2005/090282.
-
-
-
-
162
-
-
85019776435
-
-
WO 2005/042464
-
Karo Bio AB, WO 2005/042464.
-
-
-
-
163
-
-
85019798171
-
Radius and Karo Bio announce licensing agreement for novel SARM compounds
-
12 September
-
Press release, (12 September 2006) Radius and Karo Bio announce licensing agreement for novel SARM compounds, http://www.radiuspharm.com.
-
(2006)
Press release
-
-
-
164
-
-
85019817835
-
-
US 2006/0148893
-
GlaxoSmithKline, Inc., US 2006/0148893.
-
-
-
-
165
-
-
85019809351
-
-
WO2005/000795
-
GlaxoSmithKline, Inc., WO2005/000795.
-
-
-
-
166
-
-
85019809016
-
-
WO2005/085185
-
GlaxoSmithKline, Inc., WO2005/085185.
-
-
-
-
167
-
-
85019776454
-
-
WO 2006/133216
-
(Glaxo)SmithKlineBeecham Corp., WO 2006/133216.
-
-
-
-
168
-
-
85019809390
-
-
US 2006/0142387
-
GlaxoSmithKline, Inc., US 2006/0142387.
-
-
-
-
169
-
-
33846628568
-
Design and synthesis of an array of selective androgens receptor modulators
-
Trump, R.P., Blanc, J.B., Stewart, E.L., Brown, P.J., Caivano, M., Gray, D.W., Hoekstra, W.J., Willson, T.M., Han, B. and Turnbull, P. (2007) Design and synthesis of an array of selective androgens receptor modulators. Journal of Combinatorial Chemistry, 9, 107-114.
-
(2007)
Journal of Combinatorial Chemistry
, vol.9
, pp. 107-114
-
-
Trump, R.P.1
Blanc, J.B.2
Stewart, E.L.3
Brown, P.J.4
Caivano, M.5
Gray, D.W.6
Hoekstra, W.J.7
Willson, T.M.8
Han, B.9
Turnbull, P.10
-
170
-
-
85019794041
-
Pharmacological profiles of GSK2420A, a novel nonsteroidal selective androgens receptor modulator (SARM)
-
2-5 June, abstract P1-623
-
Han, B., Triantafillou, J.A., Shen, Y., Xu, T., Scates, P., Stimpson, S.A. and Turnbull, P.S. (2-5 June 2007) Pharmacological profiles of GSK2420A, a novel nonsteroidal selective androgens receptor modulator (SARM), Endocrine Society 89th Annual Meeting, abstract P1-623.
-
(2007)
Endocrine Society 89th Annual Meeting
-
-
Han, B.1
Triantafillou, J.A.2
Shen, Y.3
Xu, T.4
Scates, P.5
Stimpson, S.A.6
Turnbull, P.S.7
-
171
-
-
85019809120
-
-
US 2005/250740
-
Janssen Pharmaceutica NV, US 2005/250740.
-
-
-
-
172
-
-
85019817903
-
-
US 2005/245485
-
Janssen Pharmaceutica NV, US 2005/245485.
-
-
-
-
173
-
-
85019814141
-
-
US 2006/0116412
-
Johnson & Johnson, US 2006/0116412.
-
-
-
-
174
-
-
85019798421
-
-
US 2006/0111402
-
Johnson & Johnson, US 2006/0111402.
-
-
-
-
175
-
-
33846663836
-
2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgens receptor antagonists
-
Ng, R.A., Guan, J., Alford, V.C., Jr, Lanter, J.C., Allan, G.F., Sbriscia, T., Lundeen, S.G. and Sui, Z. (2007) 2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgens receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 17, 955-958.
-
(2007)
Bioorganic & Medicinal Chemistry Letters
, vol.17
, pp. 955-958
-
-
Ng, R.A.1
Guan, J.2
Alford, V.C.3
Lanter, J.C.4
Allan, G.F.5
Sbriscia, T.6
Lundeen, S.G.7
Sui, Z.8
-
176
-
-
33847176936
-
Synthesis of potent and tissueselective androgens receptor modulators (SARMs): 2-(2,2,2)-trifluoroethylbenzimidazole scaffold
-
Ng, R.A., Lanter, J.C., Alford, V.C., Allan, G.F., Sbriscia, T., Lundeen, S.G. and Sui, Z. (2007) Synthesis of potent and tissueselective androgens receptor modulators (SARMs): 2-(2,2,2)-trifluoroethylbenzimidazole scaffold. Bioorganic & Medicinal Chemistry Letters, 17, 1784-1787.
-
(2007)
Bioorganic & Medicinal Chemistry Letters
, vol.17
, pp. 1784-1787
-
-
Ng, R.A.1
Lanter, J.C.2
Alford, V.C.3
Allan, G.F.4
Sbriscia, T.5
Lundeen, S.G.6
Sui, Z.7
-
177
-
-
33846081930
-
Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgens receptor modulators
-
Zhang, X., Li, X., Allan, G.F., Sbriscia, T., Linton, O., Lundeen, S.G. and Sui, Z. (2007) Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgens receptor modulators. Bioorganic &Medicinal Chemistry Letters, 17, 439-443.
-
(2007)
Bioorganic &Medicinal Chemistry Letters
, vol.17
, pp. 439-443
-
-
Zhang, X.1
Li, X.2
Allan, G.F.3
Sbriscia, T.4
Linton, O.5
Lundeen, S.G.6
Sui, Z.7
-
178
-
-
33751396873
-
A selective androgens receptor modulator that reduces prostate tumor size and prevents orchidectomy-induced bone loss in rats
-
Allan, G., Lai, M.T., Sbriscia, T., Linton, O., Haynes-Johnson, D., Bhattacharjee, S., Dodds, R., Fiordeliso, J., Lanter, J., Sui, Z. and Lundeen, S. (2007) A selective androgens receptor modulator that reduces prostate tumor size and prevents orchidectomy-induced bone loss in rats. The Journal of Steroid Biochemistry and Molecular Biology, 103, 76-83.
-
(2007)
The Journal of Steroid Biochemistry and Molecular Biology
, vol.103
, pp. 76-83
-
-
Allan, G.1
Lai, M.T.2
Sbriscia, T.3
Linton, O.4
Haynes-Johnson, D.5
Bhattacharjee, S.6
Dodds, R.7
Fiordeliso, J.8
Lanter, J.9
Sui, Z.10
Lundeen, S.11
-
179
-
-
33749258203
-
Synthesis and SAR of novel hydantoin derivatives as selective androgens receptor modulators
-
Zhang, X., Allan, G.F., Sbriscia, T., Linton, O., Lundeen, S.G. and Sui, Z. (2006) Synthesis and SAR of novel hydantoin derivatives as selective androgens receptor modulators. Bioorganic & Medicinal Chemistry Letters, 16, 5763-5766.
-
(2006)
Bioorganic & Medicinal Chemistry Letters
, vol.16
, pp. 5763-5766
-
-
Zhang, X.1
Allan, G.F.2
Sbriscia, T.3
Linton, O.4
Lundeen, S.G.5
Sui, Z.6
-
180
-
-
33747131535
-
Discovery of indole-containing tetracycles as a new scaffold for androgens receptor ligands
-
Zhang, X., Li, X., Allan, G.F., Musto, A., Lundeen, S.G. and Sui, Z. (2006) Discovery of indole-containing tetracycles as a new scaffold for androgens receptor ligands. Bioorganic & Medicinal Chemistry Letters, 16, 3233-3237.
-
(2006)
Bioorganic & Medicinal Chemistry Letters
, vol.16
, pp. 3233-3237
-
-
Zhang, X.1
Li, X.2
Allan, G.F.3
Musto, A.4
Lundeen, S.G.5
Sui, Z.6
-
181
-
-
8844274931
-
The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgens receptor antagonists
-
Balog, A., Salvati, M.E., Shan, W.,Mathur, A., Leith, L.W., Wei, D.D., Attar, R.M., Geng, J., Rizzo, C.A., Wang, C., Krystek, S.R., Tokarski, J.S., Hunt, J.T., Gottardis, M. and Weinmann, R. (2004) The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgens receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 14, 6107-6111.
-
(2004)
Bioorganic & Medicinal Chemistry Letters
, vol.14
, pp. 6107-6111
-
-
Balog, A.1
Salvati, M.E.2
Shan, W.3
Mathur, A.4
Leith, L.W.5
Wei, D.D.6
Attar, R.M.7
Geng, J.8
Rizzo, C.A.9
Wang, C.10
Krystek, S.R.11
Tokarski, J.S.12
Hunt, J.T.13
Gottardis, M.14
Weinmann, R.15
-
182
-
-
33847666094
-
Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgens receptor modulators
-
Hamann, L.G., Manfredi, M.C., Sun, C., Krystek, S.R., Jr, Huang, Y., Bi, Y., Augeri, D.J., Wang, T., Zou, Y., Betebenner, D.A., Fura, A., Seethala, R., Golla, R., Kuhns, J.E., Lupisella, J.A., Darienzo, C.J., Custer, L.L., Price, J.L., Johnson, J.M., Biller, S.A., Zahler, R. and Ostrowski, J. (2007) Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgens receptor modulators. Bioorganic & Medicinal Chemistry Letters, 17, 1860-1864.
-
(2007)
Bioorganic & Medicinal Chemistry Letters
, vol.17
, pp. 1860-1864
-
-
Hamann, L.G.1
Manfredi, M.C.2
Sun, C.3
Krystek, S.R.4
Huang, Y.5
Bi, Y.6
Augeri, D.J.7
Wang, T.8
Zou, Y.9
Betebenner, D.A.10
Fura, A.11
Seethala, R.12
Golla, R.13
Kuhns, J.E.14
Lupisella, J.A.15
Darienzo, C.J.16
Custer, L.L.17
Price, J.L.18
Johnson, J.M.19
Biller, S.A.20
Zahler, R.21
Ostrowski, J.22
more..
-
183
-
-
33845927114
-
Discovery of potent, orally-active, and muscle-selective androgens receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold
-
Sun, C., Robl, J.A., Wang, T.C., Huang, Y., Kuhns, J.E., Lupisella, J.A., Beehler, B.C., Golla, R., Sleph, P.G., Seethala, R., Fura, A., Krystek, S.R., Jr, An, Y., Malley, M.F., Sack, J.S., Salvati, M.E., Grover, G.J., Ostrowski, J. and Hamann, L.G. (2006) Discovery of potent, orally-active, and muscle-selective androgens receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold. Journal of Medicinal Chemistry, 49, 7596-7599.
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, pp. 7596-7599
-
-
Sun, C.1
Robl, J.A.2
Wang, T.C.3
Huang, Y.4
Kuhns, J.E.5
Lupisella, J.A.6
Beehler, B.C.7
Golla, R.8
Sleph, P.G.9
Seethala, R.10
Fura, A.11
Krystek, S.R.12
An, Y.13
Malley, M.F.14
Sack, J.S.15
Salvati, M.E.16
Grover, G.J.17
Ostrowski, J.18
Hamann, L.G.19
-
184
-
-
33845902528
-
Pharmacological and X-ray structural characterization of a novel selective androgens receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats
-
Ostrowski, J., Kuhns, J.E., Lupisella, J.A., Manfredi, M.C., Beehler, B.C., Krystek, S.R., Jr, Bi, Y., Sun, C., Seethala, R., Golla, R., Sleph, P.G., Fura, A., An, Y., Kish, K.F., Sack, J.S., Mookhtiar, K.A., Grover, G.J. and Hamann, L.G. (2007) Pharmacological and X-ray structural characterization of a novel selective androgens receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology, 148, 4-12.
-
(2007)
Endocrinology
, vol.148
, pp. 4-12
-
-
Ostrowski, J.1
Kuhns, J.E.2
Lupisella, J.A.3
Manfredi, M.C.4
Beehler, B.C.5
Krystek, S.R.6
Bi, Y.7
Sun, C.8
Seethala, R.9
Golla, R.10
Sleph, P.G.11
Fura, A.12
An, Y.13
Kish, K.F.14
Sack, J.S.15
Mookhtiar, K.A.16
Grover, G.J.17
Hamann, L.G.18
-
185
-
-
33845879132
-
Muscle-bound? A tissue-selective nonsteroidal androgens receptor modulator
-
Wilson, E.M. (2007) Muscle-bound? A tissue-selective nonsteroidal androgens receptor modulator. Endocrinology, 148, 1-3.
-
(2007)
Endocrinology
, vol.148
, pp. 1-3
-
-
Wilson, E.M.1
-
186
-
-
85019812985
-
-
WO 2006/124447
-
Eli Lilly & Co., WO 2006/124447.
-
-
-
-
187
-
-
85019805390
-
-
WO 2005/115361
-
Acadia Pharmaceuticals, Inc., WO 2005/115361.
-
-
-
-
188
-
-
85019798475
-
-
US 2006/0160845
-
Acadia Pharmaceuticals, Inc., US 2006/0160845.
-
-
-
-
189
-
-
85019788869
-
Acadia Pharmaceuticals announces advancements in two preclinical programs
-
Press release, 21 February
-
Press release, (21 February 2006) Acadia Pharmaceuticals announces advancements in two preclinical programs, http://www.acadia-pharm.com.
-
(2006)
-
-
-
190
-
-
85019785623
-
-
US 2006/0106067
-
Takeda Pharmaceuticals of North America, Inc., US 2006/0106067.
-
-
-
-
191
-
-
85019804005
-
-
WO 2004/016576
-
Takeda Pharmaceutical Co., Ltd, WO 2004/016576.
-
-
-
-
192
-
-
85019804028
-
-
WO 2004/041782
-
Akzo Nobel NV, WO 2004/041782.
-
-
-
-
193
-
-
85019794328
-
-
WO 2005/102998
-
Akzo Nobel NV, WO 2005/102998.
-
-
-
-
194
-
-
34249081708
-
Novel series of potent, nonsteroidal, selective androgens receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones
-
Higuchi, R.I., Arienti, K.L., Lopez, F.J., Mani, N.S., Mais, D.E., Caferro, T.R., Long, Y.O., Jones, T.K., Edwards, J.P., Zhi, L., Schrader, W.T., Negro-Vilar, A. and Marschke, K.B. (2007) Novel series of potent, nonsteroidal, selective androgens receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones. Journal of Medicinal Chemistry, 50, 2486-2496.
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, pp. 2486-2496
-
-
Higuchi, R.I.1
Arienti, K.L.2
Lopez, F.J.3
Mani, N.S.4
Mais, D.E.5
Caferro, T.R.6
Long, Y.O.7
Jones, T.K.8
Edwards, J.P.9
Zhi, L.10
Schrader, W.T.11
Negro-Vilar, A.12
Marschke, K.B.13
-
195
-
-
27844611242
-
Structural basis for accommodation of nonsteroidal ligands in the androgens receptor
-
Bohl, C.E., Miller, D.D., Chen, J., Bell, C.E. and Dalton, J.T. (2005) Structural basis for accommodation of nonsteroidal ligands in the androgens receptor. The Journal of Biological Chemistry, 280, 37747-37754.
-
(2005)
The Journal of Biological Chemistry
, vol.280
, pp. 37747-37754
-
-
Bohl, C.E.1
Miller, D.D.2
Chen, J.3
Bell, C.E.4
Dalton, J.T.5
-
196
-
-
0035942197
-
Crystallographic structures of the ligand-binding domains of the androgens receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone
-
Sack, J.S., Kish, K.F., Wang, C., Attar, R.M., Kiefer, S.E., An, Y., Wu, G.Y., Scheffler, J.E., Salvati, M.E., Krystek, S.R., Jr, Weinmann, R. and Einspahr, H.M. (2001) Crystallographic structures of the ligand-binding domains of the androgens receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone. Proceedings of the National Academy of Sciences of the United States of America, 98, 4904-4909.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 4904-4909
-
-
Sack, J.S.1
Kish, K.F.2
Wang, C.3
Attar, R.M.4
Kiefer, S.E.5
An, Y.6
Wu, G.Y.7
Scheffler, J.E.8
Salvati, M.E.9
Krystek, S.R.10
Weinmann, R.11
Einspahr, H.M.12
-
197
-
-
33646138016
-
Comparison of crystal structures of human androgens receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity
-
Pereira de Jesus-Tran, K., Cote, P.L., Cantin, L., Blanchet, J., Labrie, F. and Breton, R. (2006) Comparison of crystal structures of human androgens receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Protein Science:APublication of the Protein Society, 15, 987-999.
-
(2006)
Protein Science:APublication of the Protein Society
, vol.15
, pp. 987-999
-
-
Pereira de Jesus-Tran, K.1
Cote, P.L.2
Cantin, L.3
Blanchet, J.4
Labrie, F.5
Breton, R.6
-
198
-
-
34250365377
-
Crystal structure of the T877A human androgens receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design
-
Bohl, C.E., Wu, Z., Miller, D.D., Bell, C.E. and Dalton, J.T. (2007) Crystal structure of the T877A human androgens receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. The Journal of Biological Chemistry, 282, 13648-13655.
-
(2007)
The Journal of Biological Chemistry
, vol.282
, pp. 13648-13655
-
-
Bohl, C.E.1
Wu, Z.2
Miller, D.D.3
Bell, C.E.4
Dalton, J.T.5
-
199
-
-
33847664135
-
Ockhams razor and selective androgens receptor modulators (SARMs): are we overlooking the role of 5α-reductase?
-
Gao, W. and Dalton, J.T. (2007) Ockhams razor and selective androgens receptor modulators (SARMs): are we overlooking the role of 5α-reductase? Molecular Interventions, 7, 10-13.
-
(2007)
Molecular Interventions
, vol.7
, pp. 10-13
-
-
Gao, W.1
Dalton, J.T.2
-
200
-
-
9444286210
-
Therapeutic androgens receptor ligands
-
Allan, G.F. and Sui, Z. (2003) Therapeutic androgens receptor ligands. Nuclear Receptor Signaling, 1, e009.
-
(2003)
Nuclear Receptor Signaling
, vol.1
, pp. e009
-
-
Allan, G.F.1
Sui, Z.2
-
201
-
-
4344605682
-
Estrogen, progesterone and epithelial ovarian cancer
-
Ho, S.M. (2003) Estrogen, progesterone and epithelial ovarian cancer. Reproductive Biology and Endocrinology, 1, 73.
-
(2003)
Reproductive Biology and Endocrinology
, vol.1
, pp. 73
-
-
Ho, S.M.1
-
202
-
-
3843145374
-
Estrogens and antiestrogens:key mediators of prostate carcinogenesis and new therapeutic candidates
-
Ho, S.M. (2004) Estrogens and antiestrogens:key mediators of prostate carcinogenesis and new therapeutic candidates. Journal of Cellular Biochemistry, 91, 491-503.
-
(2004)
Journal of Cellular Biochemistry
, vol.91
, pp. 491-503
-
-
Ho, S.M.1
-
203
-
-
1442351143
-
Coregulator function: a key to understanding tissue specificity of selective receptor modulators
-
Smith, C.L. and O'Malley, B.W. (2004) Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocrine Reviews, 25, 45-71.
-
(2004)
Endocrine Reviews
, vol.25
, pp. 45-71
-
-
Smith, C.L.1
O'Malley, B.W.2
-
204
-
-
33646853725
-
Aromatase in the context of breast and endometrial cancer. A review
-
Jongen, V.H., Hollema, H., Van Der Zee, A.G. and Heineman, M.J. (2006) Aromatase in the context of breast and endometrial cancer. A review. Minerva Endocrinologica, 31, 47-60.
-
(2006)
Minerva Endocrinologica
, vol.31
, pp. 47-60
-
-
Jongen, V.H.1
Hollema, H.2
Van Der Zee, A.G.3
Heineman, M.J.4
-
205
-
-
0033305674
-
Androgen-induced regrowth in the castrated rat ventral prostate: role of 5α-reductase
-
Wright, A.S., Douglas, R.C., Thomas, L.N., Lazier, C.B. and Rittmaster, R.S. (1999) Androgen-induced regrowth in the castrated rat ventral prostate: role of 5α-reductase. Endocrinology, 140, 4509-4515.
-
(1999)
Endocrinology
, vol.140
, pp. 4509-4515
-
-
Wright, A.S.1
Douglas, R.C.2
Thomas, L.N.3
Lazier, C.B.4
Rittmaster, R.S.5
-
206
-
-
0026726806
-
Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation
-
Allan, G.F., Leng, X., Tsai, S.Y., Weigel, N.L., Edwards, D.P., Tsai, M.J. and O'Malley, B.W. (1992) Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation. The Journal of Biological Chemistry, 267, 19513-19520.
-
(1992)
The Journal of Biological Chemistry
, vol.267
, pp. 19513-19520
-
-
Allan, G.F.1
Leng, X.2
Tsai, S.Y.3
Weigel, N.L.4
Edwards, D.P.5
Tsai, M.J.6
O'Malley, B.W.7
-
207
-
-
0027081043
-
Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding
-
Allan, G.F., Tsai, S.Y., Tsai, M.J. and O'Malley, B.W. (1992) Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding. Proceedings of the National Academy of Sciences of the United States of America, 89, 11750-11754.
-
(1992)
Proceedings of the National Academy of Sciences of the United States of America
, vol.89
, pp. 11750-11754
-
-
Allan, G.F.1
Tsai, S.Y.2
Tsai, M.J.3
O'Malley, B.W.4
-
208
-
-
33750457376
-
Cellline and tissue-specific signatures of androgens receptor-coregulator transcription
-
Bebermeier, J.H., Brooks, J.D., DePrimo, S.E., Werner, R., Deppe, U., Demeter, J., Hiort, O. and Holterhus, P.M. (2006) Cellline and tissue-specific signatures of androgens receptor-coregulator transcription. Journal of Molecular Medicine (Berlin, Germany), 84, 919-931.
-
(2006)
Journal of Molecular Medicine (Berlin, Germany)
, vol.84
, pp. 919-931
-
-
Bebermeier, J.H.1
Brooks, J.D.2
DePrimo, S.E.3
Werner, R.4
Deppe, U.5
Demeter, J.6
Hiort, O.7
Holterhus, P.M.8
-
209
-
-
1542316852
-
Estrogen receptor-α interaction with the CREB binding protein coactivator is regulated by the cellular environment
-
Jaber, B.M., Mukopadhyay, R. and Smith, C.L. (2004) Estrogen receptor-α interaction with the CREB binding protein coactivator is regulated by the cellular environment. Journal of Molecular Endocrinology, 32, 307-323.
-
(2004)
Journal of Molecular Endocrinology
, vol.32
, pp. 307-323
-
-
Jaber, B.M.1
Mukopadhyay, R.2
Smith, C.L.3
-
210
-
-
29744452248
-
Influence of oestradiol and tamoxifen on oestrogen receptors-α and -β protein degradation and nongenomic signalling pathways in uterine and breast carcinoma cells
-
Horner-Glister, E., Maleki-Dizaji, M., Guerin, C.J., Johnson, S.M., Styles, J. and White, I.N. (2005) Influence of oestradiol and tamoxifen on oestrogen receptors-α and -β protein degradation and nongenomic signalling pathways in uterine and breast carcinoma cells. Journal of Molecular Endocrinology, 35, 421-432.
-
(2005)
Journal of Molecular Endocrinology
, vol.35
, pp. 421-432
-
-
Horner-Glister, E.1
Maleki-Dizaji, M.2
Guerin, C.J.3
Johnson, S.M.4
Styles, J.5
White, I.N.6
-
211
-
-
0036218706
-
Evaluation of ligand-dependent changes in AR structure using peptide probes
-
Chang, C.Y. and McDonnell, D.P. (2002) Evaluation of ligand-dependent changes in AR structure using peptide probes. Molecular Endocrinology, 16, 647-660.
-
(2002)
Molecular Endocrinology
, vol.16
, pp. 647-660
-
-
Chang, C.Y.1
McDonnell, D.P.2
-
212
-
-
0033513582
-
Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries:discovery of peptide antagonists of estrogen receptors α and β
-
Chang, C., Norris, J.D., Gron, H., Paige, L.A., Hamilton, P.T., Kenan, D.J., Fowlkes, D. and McDonnell, D.P. (1999) Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries:discovery of peptide antagonists of estrogen receptors α and β. Molecular and Cellular Biology, 19, 8226-8239.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 8226-8239
-
-
Chang, C.1
Norris, J.D.2
Gron, H.3
Paige, L.A.4
Hamilton, P.T.5
Kenan, D.J.6
Fowlkes, D.7
McDonnell, D.P.8
-
213
-
-
33744489573
-
Linking ligand-induced alterations in androgens receptor structure to differential gene expression: a first step in the rational design of selective androgens receptor modulators
-
Kazmin, D., Prytkova, T., Cook, C.E., Wolfinger, R., Chu, T.M., Beratan, D., Norris, J.D., Chang, C.Y. and McDonnell, D.P. (2006) Linking ligand-induced alterations in androgens receptor structure to differential gene expression: a first step in the rational design of selective androgens receptor modulators. Molecular Endocrinology, 20, 1201-1217.
-
(2006)
Molecular Endocrinology
, vol.20
, pp. 1201-1217
-
-
Kazmin, D.1
Prytkova, T.2
Cook, C.E.3
Wolfinger, R.4
Chu, T.M.5
Beratan, D.6
Norris, J.D.7
Chang, C.Y.8
McDonnell, D.P.9
-
214
-
-
33644784779
-
Ligand-specific allosteric regulation of coactivator functions of androgens receptor in prostate cancer cells
-
Baek, S.H., Ohgi, K.A., Nelson, C.A., Welsbie, D., Chen, C., Sawyers, C.L., Rose, D.W. and Rosenfeld, M.G. (2006) Ligand-specific allosteric regulation of coactivator functions of androgens receptor in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 103, 3100-3105.
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, pp. 3100-3105
-
-
Baek, S.H.1
Ohgi, K.A.2
Nelson, C.A.3
Welsbie, D.4
Chen, C.5
Sawyers, C.L.6
Rose, D.W.7
Rosenfeld, M.G.8
-
215
-
-
0032213938
-
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
-
McInerney, E.M., Rose, D.W., Flynn, S.E., Westin, S., Mullen, T.M., Krones, A., Inostroza, J., Torchia, J., Nolte, R.T., Assa-Munt, N., Milburn, M.V., Glass, C.K. and Rosenfeld, M.G. (1998) Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes and Development, 12, 3357-3368.
-
(1998)
Genes and Development
, vol.12
, pp. 3357-3368
-
-
McInerney, E.M.1
Rose, D.W.2
Flynn, S.E.3
Westin, S.4
Mullen, T.M.5
Krones, A.6
Inostroza, J.7
Torchia, J.8
Nolte, R.T.9
Assa-Munt, N.10
Milburn, M.V.11
Glass, C.K.12
Rosenfeld, M.G.13
-
216
-
-
18044371228
-
Androgen receptor-cofactor interactions as targets for new drug discovery
-
Chang, C.Y. and McDonnell, D.P. (2005) Androgen receptor-cofactor interactions as targets for new drug discovery. Trends in Pharmacological Sciences, 26, 225-228.
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, pp. 225-228
-
-
Chang, C.Y.1
McDonnell, D.P.2
-
217
-
-
0036219918
-
Androgen receptor (AR) coregulators: an overview
-
Heinlein, C.A. and Chang, C. (2002) Androgen receptor (AR) coregulators: an overview. Endocrine Reviews, 23, 175-200.
-
(2002)
Endocrine Reviews
, vol.23
, pp. 175-200
-
-
Heinlein, C.A.1
Chang, C.2
-
218
-
-
0030986236
-
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
-
Heery, D.M., Kalkhoven, E., Hoare, S. and Parker, M.G. (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature, 387, 733-736.
-
(1997)
Nature
, vol.387
, pp. 733-736
-
-
Heery, D.M.1
Kalkhoven, E.2
Hoare, S.3
Parker, M.G.4
-
219
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau, A.K., Barstad, D., Loria, P.M., Cheng, L., Kushner, P.J., Agard, D.A. and Greene, G.L. (1998) The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell, 95, 927-937.
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
Cheng, L.4
Kushner, P.J.5
Agard, D.A.6
Greene, G.L.7
-
220
-
-
0033583033
-
Cloning and characterization of androgens receptor coactivator, ARA55, in human prostate
-
Fujimoto, N., Yeh, S., Kang, H.Y., Inui, S., Chang, H.C., Mizokami, A. and Chang, C. (1999) Cloning and characterization of androgens receptor coactivator, ARA55, in human prostate. The Journal of Biological Chemistry, 274, 8316-8321.
-
(1999)
The Journal of Biological Chemistry
, vol.274
, pp. 8316-8321
-
-
Fujimoto, N.1
Yeh, S.2
Kang, H.Y.3
Inui, S.4
Chang, H.C.5
Mizokami, A.6
Chang, C.7
-
221
-
-
0033605597
-
Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgens receptor
-
Kang, H.Y., Yeh, S., Fujimoto, N. and Chang, C. (1999) Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgens receptor. The Journal of Biological Chemistry, 274, 8570-8576.
-
(1999)
The Journal of Biological Chemistry
, vol.274
, pp. 8570-8576
-
-
Kang, H.Y.1
Yeh, S.2
Fujimoto, N.3
Chang, C.4
-
222
-
-
10344225657
-
Testosterone influenced the expression of Notch1, Notch2 and Jagged1 induced by lipopolysaccharide in macrophages
-
Guo, D., Zhang, H., Liu, L., Wang, L., Cheng, Y. and Qiao, Z. (2004) Testosterone influenced the expression of Notch1, Notch2 and Jagged1 induced by lipopolysaccharide in macrophages. Experimental and Toxicologic Pathology, 56, 173-179.
-
(2004)
Experimental and Toxicologic Pathology
, vol.56
, pp. 173-179
-
-
Guo, D.1
Zhang, H.2
Liu, L.3
Wang, L.4
Cheng, Y.5
Qiao, Z.6
-
223
-
-
16544387699
-
Nongenomic androgens activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts
-
Kang, H.Y., Cho, C.L., Huang, K.L., Wang, J.C., Hu, Y.C., Lin, H.K., Chang, C. and Huang, K.E. (2004) Nongenomic androgens activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts. Journal of Bone and Mineral Research, 19, 1181-1190.
-
(2004)
Journal of Bone and Mineral Research
, vol.19
, pp. 1181-1190
-
-
Kang, H.Y.1
Cho, C.L.2
Huang, K.L.3
Wang, J.C.4
Hu, Y.C.5
Lin, H.K.6
Chang, C.7
Huang, K.E.8
-
224
-
-
33745036538
-
Testosterone attenuates p38 MAPK pathway during Leishmania donovani infection of macrophages
-
Liu, L., Wang, L., Zhao, Y., Wang, Y., Wang, Z. and Qiao, Z. (2006) Testosterone attenuates p38 MAPK pathway during Leishmania donovani infection of macrophages. Parasitology Research, 99, 189-193.
-
(2006)
Parasitology Research
, vol.99
, pp. 189-193
-
-
Liu, L.1
Wang, L.2
Zhao, Y.3
Wang, Y.4
Wang, Z.5
Qiao, Z.6
-
225
-
-
0034864155
-
Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor
-
Huber, D.M., Bendixen, A.C., Pathrose, P., Srivastava, S., Dienger, K.M., Shevde, N.K. and Pike, J.W. (2001) Androgens suppress osteoclast formation induced by RANKL and macrophage-colony stimulating factor. Endocrinology, 142, 3800-3808.
-
(2001)
Endocrinology
, vol.142
, pp. 3800-3808
-
-
Huber, D.M.1
Bendixen, A.C.2
Pathrose, P.3
Srivastava, S.4
Dienger, K.M.5
Shevde, N.K.6
Pike, J.W.7
-
226
-
-
33748787116
-
Ligand-independent androgens receptor activity is activation function-2-independent and resistant to antiandrogens in androgens refractory prostate cancer cells
-
Dehm, S.M. and Tindall, D.J. (2006) Ligand-independent androgens receptor activity is activation function-2-independent and resistant to antiandrogens in androgens refractory prostate cancer cells. The Journal of Biological Chemistry, 281, 27882-27893.
-
(2006)
The Journal of Biological Chemistry
, vol.281
, pp. 27882-27893
-
-
Dehm, S.M.1
Tindall, D.J.2
-
227
-
-
0035831020
-
Nongenotropic, sex-nonspecific signaling through the estrogen or androgens receptors:dissociation from transcriptional activity
-
Kousteni, S., Bellido, T., Plotkin, L.I., O'Brien, C.A., Bodenner, D.L., Han, L., Han, K., DiGregorio, G.B., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Roberson, P.K., Weinstein, R.S., Jilka, R.L. and Manolagas, S.C. (2001) Nongenotropic, sex-nonspecific signaling through the estrogen or androgens receptors:dissociation from transcriptional activity. Cell, 104, 719-730.
-
(2001)
Cell
, vol.104
, pp. 719-730
-
-
Kousteni, S.1
Bellido, T.2
Plotkin, L.I.3
O'Brien, C.A.4
Bodenner, D.L.5
Han, L.6
Han, K.7
DiGregorio, G.B.8
Katzenellenbogen, J.A.9
Katzenellenbogen, B.S.10
Roberson, P.K.11
Weinstein, R.S.12
Jilka, R.L.13
Manolagas, S.C.14
-
228
-
-
0038517838
-
Selective modulation of genomic and nongenomic androgens responses by androgens receptor ligands
-
Lutz, L.B., Jamnongjit, M., Yang, W.H., Jahani, D., Gill, A. and Hammes, S.R. (2003) Selective modulation of genomic and nongenomic androgens responses by androgens receptor ligands. Molecular Endocrinology, 17, 1106-1116.
-
(2003)
Molecular Endocrinology
, vol.17
, pp. 1106-1116
-
-
Lutz, L.B.1
Jamnongjit, M.2
Yang, W.H.3
Jahani, D.4
Gill, A.5
Hammes, S.R.6
-
229
-
-
0027299036
-
7 α-methyl-nortestosterone (MENT): the optimal androgens for male contraception
-
Sundaram, K., Kumar, N. and Bardin, C.W. (1993) 7 α-methyl-nortestosterone (MENT): the optimal androgens for male contraception. Annals of Medicine, 25, 199-205.
-
(1993)
Annals of Medicine
, vol.25
, pp. 199-205
-
-
Sundaram, K.1
Kumar, N.2
Bardin, C.W.3
-
230
-
-
33746894825
-
Pharmacokinetics and pharmacodynamics of nonsteroidal androgens receptor ligands
-
Gao, W., Kim, J. and Dalton, J.T. (2006) Pharmacokinetics and pharmacodynamics of nonsteroidal androgens receptor ligands. Pharmaceutical Research, 23, 1641-1658.
-
(2006)
Pharmaceutical Research
, vol.23
, pp. 1641-1658
-
-
Gao, W.1
Kim, J.2
Dalton, J.T.3
-
231
-
-
11244283494
-
Testosterone therapy - what, when and to whom?
-
Jockenhovel, F. (2004) Testosterone therapy - what, when and to whom? Aging Male, 7, 319-324.
-
(2004)
Aging Male
, vol.7
, pp. 319-324
-
-
Jockenhovel, F.1
-
232
-
-
16344390576
-
Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men
-
Mazer, N., Bell, D., Wu, J., Fischer, J., Cosgrove, M. and Eilers, B. (2005) Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men. Journal of Sexual Medicine, 2, 213-226.
-
(2005)
Journal of Sexual Medicine
, vol.2
, pp. 213-226
-
-
Mazer, N.1
Bell, D.2
Wu, J.3
Fischer, J.4
Cosgrove, M.5
Eilers, B.6
-
233
-
-
85019814525
-
GTx announces Ostarine™ improved insulin resistance among elderly patients in a recently completed phase II clinical trial
-
Press release, 17 April
-
Press release, (17 April 2007) GTx announces Ostarine™ improved insulin resistance among elderly patients in a recently completed phase II clinical trial, http://www.gtxinc.com.
-
(2007)
-
-
-
234
-
-
18044399645
-
Clinical significance of weight loss in cancer patients: rationale for the use of anabolic agents in the treatment of cancer-related cachexia
-
Langer, C.J., Hoffman, J.P. and Ottery, F.D. (2001) Clinical significance of weight loss in cancer patients: rationale for the use of anabolic agents in the treatment of cancer-related cachexia. Nutrition, 17 (1 Suppl), S1-S20.
-
(2001)
Nutrition
, vol.17
, Issue.1
, pp. S1-S20
-
-
Langer, C.J.1
Hoffman, J.P.2
Ottery, F.D.3
-
235
-
-
1942530824
-
Physical and sexual function in women with chronic kidney disease
-
Kurella, M., Ireland, C., Hlatky, M.A., Shlipak, M.G., Yaffe, K., Hulley, S.B. and Chertow, G.M. (2004) Physical and sexual function in women with chronic kidney disease. American Journal of Kidney Diseases, 43, 868-876.
-
(2004)
American Journal of Kidney Diseases
, vol.43
, pp. 868-876
-
-
Kurella, M.1
Ireland, C.2
Hlatky, M.A.3
Shlipak, M.G.4
Yaffe, K.5
Hulley, S.B.6
Chertow, G.M.7
-
236
-
-
33645703903
-
Therapeutic potential of the SARMs: Revisiting the androgens receptor for drug discovery
-
Segal, S., Narayanan, R. and Dalton, J.T. (2006) Therapeutic potential of the SARMs: Revisiting the androgens receptor for drug discovery. Expert Opin Invest Drugs, 15, 377-387.
-
(2006)
Expert Opin Invest Drugs
, vol.15
, pp. 377-387
-
-
Segal, S.1
Narayanan, R.2
Dalton, J.T.3
-
237
-
-
0033008861
-
Physical functioning and exercise capacity in patients on dialysis
-
Johansen, K.L. (1999) Physical functioning and exercise capacity in patients on dialysis. Advances in Renal Replacement Therapy, 6, 141-148.
-
(1999)
Advances in Renal Replacement Therapy
, vol.6
, pp. 141-148
-
-
Johansen, K.L.1
-
238
-
-
1242306657
-
Integrated health system for chronic disease management: lessons learned from France
-
Stuart, M. and Weinrich, M. (2004) Integrated health system for chronic disease management: lessons learned from France. Chest, 125, 695-703.
-
(2004)
Chest
, vol.125
, pp. 695-703
-
-
Stuart, M.1
Weinrich, M.2
-
240
-
-
16344387528
-
Hypogonadism in men with chronic obstructive pulmonary disease: prevalence and quality of life
-
Laghi, F., Antonescu-Turcu, A., Collins, E., Segal, J., Tobin, D.E., Jubran, A. and Tobin, M.J. (2005) Hypogonadism in men with chronic obstructive pulmonary disease: prevalence and quality of life. American Journal of Respiratory and Critical Care Medicine, 171, 728-733.
-
(2005)
American Journal of Respiratory and Critical Care Medicine
, vol.171
, pp. 728-733
-
-
Laghi, F.1
Antonescu-Turcu, A.2
Collins, E.3
Segal, J.4
Tobin, D.E.5
Jubran, A.6
Tobin, M.J.7
-
242
-
-
0032522560
-
Epidemiology of sarcopenia among the elderly in New Mexico
-
Baumgartner, R.N., Koehler, K.M., Gallagher, D., Romero, L., Heymsfield, S.B., Ross, R.R., Garry, P.J. and Lindeman, R.D. (1998) Epidemiology of sarcopenia among the elderly in New Mexico. American Journal of Epidemiology, 147, 755-763.
-
(1998)
American Journal of Epidemiology
, vol.147
, pp. 755-763
-
-
Baumgartner, R.N.1
Koehler, K.M.2
Gallagher, D.3
Romero, L.4
Heymsfield, S.B.5
Ross, R.R.6
Garry, P.J.7
Lindeman, R.D.8
-
243
-
-
1542349014
-
Sarcopenia and frailty in geriatric patients: implications for training and prevention
-
Muhlberg, W. and Sieber, C. (2004) Sarcopenia and frailty in geriatric patients: implications for training and prevention. Zeitschrift fur Gerontologie und Geriatrie, 37, 2-8.
-
(2004)
Zeitschrift fur Gerontologie und Geriatrie
, vol.37
, pp. 2-8
-
-
Muhlberg, W.1
Sieber, C.2
-
244
-
-
10344231424
-
Emerging drugs for sarcopenia: age-related muscle wasting
-
Lynch, G.S. (2004) Emerging drugs for sarcopenia: age-related muscle wasting. Expert Opinion on Emerging Drugs, 9, 345-361.
-
(2004)
Expert Opinion on Emerging Drugs
, vol.9
, pp. 345-361
-
-
Lynch, G.S.1
-
245
-
-
21044455484
-
Osteoblasts and osteoclasts in bone remodeling and inflammation
-
Tanaka, Y., Nakayamada, S. and Okada, Y. (2005) Osteoblasts and osteoclasts in bone remodeling and inflammation. Current Drug Targets Inflammation & Allergy, 4, 325-328.
-
(2005)
Current Drug Targets Inflammation & Allergy
, vol.4
, pp. 325-328
-
-
Tanaka, Y.1
Nakayamada, S.2
Okada, Y.3
-
246
-
-
16344384714
-
Treatment of postmenopausal osteoporosis
-
Greenblatt, D. (2005) Treatment of postmenopausal osteoporosis. Pharmacotherapy, 25, 574-584.
-
(2005)
Pharmacotherapy
, vol.25
, pp. 574-584
-
-
Greenblatt, D.1
-
247
-
-
23944434417
-
Parathyroid hormone (1-84) and treatment of osteoporosis
-
Shrader, S.P. and Ragucci, K.R. (2005) Parathyroid hormone (1-84) and treatment of osteoporosis. Annals of Pharmacotherapy, 39, 1511-1516.
-
(2005)
Annals of Pharmacotherapy
, vol.39
, pp. 1511-1516
-
-
Shrader, S.P.1
Ragucci, K.R.2
-
248
-
-
22544467523
-
Discovery and therapeutic promise of selective androgens receptor modulators
-
Chen, J., Kim, J. and Dalton, J.T. (2005) Discovery and therapeutic promise of selective androgens receptor modulators. Molecular Interventions, 5, 173-188.
-
(2005)
Molecular Interventions
, vol.5
, pp. 173-188
-
-
Chen, J.1
Kim, J.2
Dalton, J.T.3
-
249
-
-
0029587677
-
Osteopenia as a feature of the androgens insensitivity syndrome
-
Soule, S.G., Conway, G., Prelevic, G.M., Prentice, M., Ginsburg, J. and Jacobs, H.S. (1995) Osteopenia as a feature of the androgens insensitivity syndrome. Clinical Endocrinology, 43, 671-675.
-
(1995)
Clinical Endocrinology
, vol.43
, pp. 671-675
-
-
Soule, S.G.1
Conway, G.2
Prelevic, G.M.3
Prentice, M.4
Ginsburg, J.5
Jacobs, H.S.6
-
250
-
-
0025884279
-
Androgen treatment prevents loss of cancellous bone in the orchidectomized rat
-
Wakley, G.K., Schutte, H.D., Jr, Hannon, K.S. and Turner, R.T. (1991) Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. Journal of Bone and Mineral Research, 6, 325-330.
-
(1991)
Journal of Bone and Mineral Research
, vol.6
, pp. 325-330
-
-
Wakley, G.K.1
Schutte, H.D.2
Hannon, K.S.3
Turner, R.T.4
-
251
-
-
0030776746
-
Effects of dihydrotestosterone on bone biochemical markers in sham and oophorectomized rats
-
Mason, R.A. and Morris, H.A. (1997) Effects of dihydrotestosterone on bone biochemical markers in sham and oophorectomized rats. Journal of Bone and Mineral Research, 12, 1431-1437.
-
(1997)
Journal of Bone and Mineral Research
, vol.12
, pp. 1431-1437
-
-
Mason, R.A.1
Morris, H.A.2
-
252
-
-
0027175622
-
Flutamide-mediated androgens blockade evokes osteopenia in the female rat
-
Goulding, A. and Gold, E. (1993) Flutamide-mediated androgens blockade evokes osteopenia in the female rat. Journal of Bone and Mineral Research, 8, 763-769.
-
(1993)
Journal of Bone and Mineral Research
, vol.8
, pp. 763-769
-
-
Goulding, A.1
Gold, E.2
|