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Volumn 19, Issue 7, 2004, Pages 1181-1190

Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts

Author keywords

Androgen receptor; Androgens; Molecular pathway; Nongenomic actions; Osteoblasts

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTRADIOL; HYDROXYFLUTAMIDE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TESTOSTERONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CALCIUM; CHROMONE DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHOLINE DERIVATIVE; ONCOPROTEIN; PHOSPHOLIPASE C; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

EID: 16544387699     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.040306     Document Type: Article
Times cited : (101)

References (41)
  • 1
    • 0035070608 scopus 로고    scopus 로고
    • Effects of estrogen/androgen therapy on bone mineral density parameters
    • Notelovitz M 2001 Effects of estrogen/androgen therapy on bone mineral density parameters. J Reprod Med 46(Suppl 3):325-331.
    • (2001) J Reprod Med , vol.46 , Issue.3 SUPPL. , pp. 325-331
    • Notelovitz, M.1
  • 3
    • 0027175622 scopus 로고
    • Flutamide-mediated androgen blockade evokes osteopenia in the female rat
    • Goulding A, Gold E 1993 Flutamide-mediated androgen blockade evokes osteopenia in the female rat. J Bone Miner Res 8:763-769.
    • (1993) J Bone Miner Res , vol.8 , pp. 763-769
    • Goulding, A.1    Gold, E.2
  • 6
    • 0033605597 scopus 로고    scopus 로고
    • Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor
    • Kang HY, Yeh S, Fujimoto N, Chang C 1999 Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. J Biol Chem 274:8570-8576.
    • (1999) J Biol Chem , vol.274 , pp. 8570-8576
    • Kang, H.Y.1    Yeh, S.2    Fujimoto, N.3    Chang, C.4
  • 7
    • 0035853055 scopus 로고    scopus 로고
    • From transforming growth factor-beta signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells
    • Kang HY, Lin HK, Hu YC, Yeh S, Huang KE, Chang C 2001 From transforming growth factor-beta signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proc Natl Acad Sci USA 98:3018-3023.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3018-3023
    • Kang, H.Y.1    Lin, H.K.2    Hu, Y.C.3    Yeh, S.4    Huang, K.E.5    Chang, C.6
  • 8
    • 0037113990 scopus 로고    scopus 로고
    • Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4
    • Kang HY, Huang KE, Chang SY, Ma WL, Lin WJ, Chang C 2002 Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4. J Biol Chem 277:43749-43756.
    • (2002) J Biol Chem , vol.277 , pp. 43749-43756
    • Kang, H.Y.1    Huang, K.E.2    Chang, S.Y.3    Ma, W.L.4    Lin, W.J.5    Chang, C.6
  • 9
    • 0036793098 scopus 로고    scopus 로고
    • The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions
    • Heinlein CA, Chang C 2002 The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol 16:2181-2187.
    • (2002) Mol Endocrinol , vol.16 , pp. 2181-2187
    • Heinlein, C.A.1    Chang, C.2
  • 11
    • 0029867670 scopus 로고    scopus 로고
    • Reversible interruption of gap junctional communication by testosterone propionate in cultured Sertoli cells and cardiac myocytes
    • Pluciennik F, Verrecchia F, Bastide B, Herve JC, Joffre M, Deleze J 1996 Reversible interruption of gap junctional communication by testosterone propionate in cultured Sertoli cells and cardiac myocytes. J Membr Biol 149:169-177.
    • (1996) J Membr Biol , vol.149 , pp. 169-177
    • Pluciennik, F.1    Verrecchia, F.2    Bastide, B.3    Herve, J.C.4    Joffre, M.5    Deleze, J.6
  • 12
    • 0020466963 scopus 로고
    • Depressant effect of androgens on the cat brain electrical activity and its antagonism by ruthenium red
    • Kubli-Garfias C, Canchola E, Arauz-Contreras J, Feria-Velasco A 1982 Depressant effect of androgens on the cat brain electrical activity and its antagonism by ruthenium red. Neuroscience 7:2777-2782.
    • (1982) Neuroscience , vol.7 , pp. 2777-2782
    • Kubli-Garfias, C.1    Canchola, E.2    Arauz-Contreras, J.3    Feria-Velasco, A.4
  • 15
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC 2002 The phosphoinositide 3-kinase pathway. Science 296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 16
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
    • Chan TO, Rittenhouse SE, Tsichlis PN 1999 AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 68:965-1014.
    • (1999) Annu Rev Biochem , vol.68 , pp. 965-1014
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 17
    • 0036849331 scopus 로고    scopus 로고
    • PKB binding proteins. Getting in on the Akt
    • Brazil DP, Park J, Hemmings BA 2002 PKB binding proteins. Getting in on the Akt. Cell 111:293-303.
    • (2002) Cell , vol.111 , pp. 293-303
    • Brazil, D.P.1    Park, J.2    Hemmings, B.A.3
  • 18
    • 0037057801 scopus 로고    scopus 로고
    • The nuclear phosphoinositide 3-kinase/AKT pathway: A new second messenger system
    • Neri LM, Borgatti P, Capitani S, Martelli AM 2002 The nuclear phosphoinositide 3-kinase/AKT pathway: A new second messenger system. Biochim Biophys Acta 1584:73-80.
    • (2002) Biochim Biophys Acta , vol.1584 , pp. 73-80
    • Neri, L.M.1    Borgatti, P.2    Capitani, S.3    Martelli, A.M.4
  • 19
    • 0035912833 scopus 로고    scopus 로고
    • Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor
    • Lin HK, Yeh S, Kang HY, Chang C 2001 Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci USA 98:7200-7205.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7200-7205
    • Lin, H.K.1    Yeh, S.2    Kang, H.Y.3    Chang, C.4
  • 20
    • 0036683093 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitination and degradation of androgen receptor by Akt require Mdm2 E3 ligase
    • Lin HK, Wang L, Hu YC, Altuwaijri S, Chang C 2002 Phosphorylation- dependent ubiquitination and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J 21:4037-4048.
    • (2002) EMBO J , vol.21 , pp. 4037-4048
    • Lin, H.K.1    Wang, L.2    Hu, Y.C.3    Altuwaijri, S.4    Chang, C.5
  • 24
    • 0032949669 scopus 로고    scopus 로고
    • Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor alpha- and beta-isoforms, and of the androgen receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cells
    • Gruber R, Czerwenka K, Wolf F, Ho GM, Willheim M, Peterlik M 1999 Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor alpha- and beta-isoforms, and of the androgen receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cells. Bone 24:465-473.
    • (1999) Bone , vol.24 , pp. 465-473
    • Gruber, R.1    Czerwenka, K.2    Wolf, F.3    Ho, G.M.4    Willheim, M.5    Peterlik, M.6
  • 25
    • 0028290639 scopus 로고
    • Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein
    • Lieberherr M, Grosse B 1994 Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein. J Biol Chem 269:7217-7223.
    • (1994) J Biol Chem , vol.269 , pp. 7217-7223
    • Lieberherr, M.1    Grosse, B.2
  • 26
    • 0032830850 scopus 로고    scopus 로고
    • Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages
    • Benten WP, Lieberherr M, Stamm O, Wrehlke C, Guo Z, Wunderlich F 1999 Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. Mol Biol Cell 10:3113-3123.
    • (1999) Mol Biol Cell , vol.10 , pp. 3113-3123
    • Benten, W.P.1    Lieberherr, M.2    Stamm, O.3    Wrehlke, C.4    Guo, Z.5    Wunderlich, F.6
  • 28
    • 0032506514 scopus 로고    scopus 로고
    • Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
    • Yano S, Tokumitsu H, Soderling TR 1998 Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396:584-587.
    • (1998) Nature , vol.396 , pp. 584-587
    • Yano, S.1    Tokumitsu, H.2    Soderling, T.R.3
  • 30
    • 0034647674 scopus 로고    scopus 로고
    • Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors
    • Borgatti P, Martelli AM, Bellacosa A, Casto R, Massari L, Capitani S, Neri LM 2000 Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors. FEBS Lett 477:27-32.
    • (2000) FEBS Lett , vol.477 , pp. 27-32
    • Borgatti, P.1    Martelli, A.M.2    Bellacosa, A.3    Casto, R.4    Massari, L.5    Capitani, S.6    Neri, L.M.7
  • 31
    • 0038517838 scopus 로고    scopus 로고
    • Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligands
    • Lutz LB, Jamnongjit M, Yang WH, Jahani D, Gill A, Hammes SR 2003 Selective modulation of genomic and nongenomic androgen responses by androgen receptor ligands. Mol Endocrinol 17:1106-1116.
    • (2003) Mol Endocrinol , vol.17 , pp. 1106-1116
    • Lutz, L.B.1    Jamnongjit, M.2    Yang, W.H.3    Jahani, D.4    Gill, A.5    Hammes, S.R.6
  • 32
    • 0344885580 scopus 로고    scopus 로고
    • Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
    • Zhu Y, Bond J, Thomas P 2003 Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Proc Natl Acad Sci USA 100:2237-2242.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2237-2242
    • Zhu, Y.1    Bond, J.2    Thomas, P.3
  • 33
    • 0344885581 scopus 로고    scopus 로고
    • Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
    • Zhu Y, Rice CD, Pang Y, Pace M, Thomas P 2003 Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Proc Natl Acad Sci USA 100:2231-2236.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2231-2236
    • Zhu, Y.1    Rice, C.D.2    Pang, Y.3    Pace, M.4    Thomas, P.5
  • 35
    • 0032189236 scopus 로고    scopus 로고
    • Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line
    • Hofbauer LC, Hicok KC, Khosla S 1998 Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line. J Cell Biochem 71:96-108.
    • (1998) J Cell Biochem , vol.71 , pp. 96-108
    • Hofbauer, L.C.1    Hicok, K.C.2    Khosla, S.3
  • 36
    • 0028474516 scopus 로고
    • Cytokines and growth factors which regulate bone cell function
    • Seino Y 1994 Cytokines and growth factors which regulate bone cell function. Acta Astronaut 33:131-136.
    • (1994) Acta Astronaut , vol.33 , pp. 131-136
    • Seino, Y.1
  • 39
    • 0036799377 scopus 로고    scopus 로고
    • PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
    • Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL 2002 PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8:1145-1152.
    • (2002) Nat Med , vol.8 , pp. 1145-1152
    • Shin, I.1    Yakes, F.M.2    Rojo, F.3    Shin, N.Y.4    Bakin, A.V.5    Baselga, J.6    Arteaga, C.L.7
  • 41
    • 0034813080 scopus 로고    scopus 로고
    • Role of the cyclin-dependent kinase inhibitor p27(Kip1) in androgen-induced inhibition of CAMA-1 breast cancer cell proliferation
    • Lapointe J, Labrie C 2001 Role of the cyclin-dependent kinase inhibitor p27(Kip1) in androgen-induced inhibition of CAMA-1 breast cancer cell proliferation. Endocrinology 142:4331-4338.
    • (2001) Endocrinology , vol.142 , pp. 4331-4338
    • Lapointe, J.1    Labrie, C.2


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