Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 7, 2007, Pages 1860-1864

  Hamann, Lawrence G ^a   Manfredi, Mark C ^a   Sun, Chongqing ^a   Krystek Jr , Stanley R ^a   Huang, Yanting ^a   Bi, Yingzhi ^a   Augeri, David J ^a   Wang, Tammy ^a   Zou, Yan ^a   Betebenner, David A ^a   Fura, Aberra ^a   Seethala, Ramakrishna ^a   Golla, Rajasree ^a   Kuhns, Joyce E ^a   Lupisella, John A ^a   Darienzo, Celia J ^a   Custer, Laura L ^a   Price, Jennifer L ^a   Johnson, James M ^a   Biller, Scott A ^a   Zahler, Robert ^a   Ostrowski, Jacek ^a   more..

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Androgen; Aniline; Mutagenicity; Receptor; SARM

Indexed keywords

ANDROGEN RECEPTOR; ANDROGEN RECEPTOR AGONIST; ANILINE; ANILINE DERIVATIVE; HORMONE RECEPTOR STIMULATING AGENT; HYDANTOIN DERIVATIVE; UNCLASSIFIED DRUG;

AMES TEST; ARTICLE; DRUG POTENCY; HYDROLYSIS; MONKEY; MUTAGENIC ACTIVITY;

ANDROGEN ANTAGONISTS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESCHERICHIA COLI; GENES, REPORTER; HYDANTOINS; KINETICS; MACACA FASCICULARIS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MUTAGENESIS; MUTAGENS; RECEPTORS, ANDROGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

MACACA FASCICULARIS;

EID: 33847666094     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.076     Document Type: Article

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