Erratum: Incidence and risk of hematologic toxicities in cancer patients treated with regorafenib (Oncotarget. (2016) 7 (76827-76839) DOI: 10.18632/oncotarget.12718);Activation of endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance of human small cell lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway

Oncotarget

Volumn 7, Issue 47, 2016, Pages 76827-76839

  Yu, Xin Shuang ^a   Du, Juan ^a   Fan, Yu Jun ^b   Liu, Feng Jun ^a   Cao, Li Li ^a   Liang, Ning ^a   Xu, De Guo ^a   Zhang, Jian Dong ^a  

^a SHANDONG UNIVERSITY   (China)

^b Health and Family planning Commission of Shandong Province   (China)

Author keywords

Apoptosis; Autophagy; Endoplasmic reticulum stress; PI3K AKT mTOR signaling pathway; Small cell lung cancer

Indexed keywords

BECLIN 1; CELL PROTEIN; CISPLATIN; DACTOLISIB; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; LC3 II PROTEIN; LC3 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PEAK PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROCASPASE 3; PROTEIN BAX; PROTEIN KINASE B; TUNICAMYCIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; AUTOPHAGY RELATED PROTEIN; IMIDAZOLE DERIVATIVE; MTOR PROTEIN, HUMAN; QUINOLINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL LINE; CANCER RESISTANCE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; H146 CELL LINE; H209 CELL LINE; H526 CELL LINE; H69 CELL LINE; HUMAN; HUMAN CELL; NCI H446 CELL LINE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMALL CELL LUNG CANCER; UPREGULATION; WESTERN BLOTTING; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; LUNG TUMOR; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMIDAZOLES; LUNG NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; SIGNAL TRANSDUCTION; SMALL CELL LUNG CARCINOMA; TOR SERINE-THREONINE KINASES; TUNICAMYCIN;

EID: 84998992764     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.26577     Document Type: Erratum

References (54)

1. Umemura S, Tsuchihara K, Goto K. Genomic profiling of small-cell lung cancer: the era of targeted therapies. Jpn J Clin Oncol. 2015; 45:513-519.
2. Ignatius Ou SH, Zell JA. The applicability of the proposed iaslc staging revisions to small cell lung cancer (sclc) with comparison to the current uicc 6th tnm edition. J Thorac Oncol. 2009; 4:300-310.
3. Semenova EA, Nagel R, Berns A. Origins, genetic landscape, and emerging therapies of small cell lung cancer. Genes Dev. 2015; 29:1447-1462.
4. Sekine I, Nishiwaki Y, Kakinuma R, Kubota K, Hojo F, Matsumoto T, Ohmatsu H, Yokozaki M, Goto K, Kodama T. Late recurrence of small-cell lung cancer: Treatment and outcome. Oncology. 1996; 53:318-321.
5. Morise M NS, Umemura S, Matsumoto S, Yoh K, Goto K, Ohmatsu H, Ohe Y. Low-dose irinotecan as a second-line chemotherapy for recurrent small cell lung cancer. Japanese journal of clinical oncology. 2014; 44:846-851.
6. Hartmann TN, Burger JA, Glodek A, Fujii N, Burger M. Cxcr4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (sclc) cells. Oncogene. 2005; 24:4462-4471.
7. Wang WA, Groenendyk J, Michalak M. Endoplasmic reticulum stress associated responses in cancer. Biochim Biophys Acta. 2014; 1843:2143-2149.
8. Cheng YC, Chang JM, Chen CA, Chen HC. Autophagy modulates endoplasmic reticulum stress-induced cell death in podocytes: a protective role. Exp Biol Med (Maywood). 2015; 240:467-476.
9. Li L, Wang L, Xiao R, Zhu G, Li Y, Liu C, Yang R, Tang Z, Li J, Huang W, Chen L, Zheng X, He Y, et al. The invasion of tobacco mosaic virus RNA induces endoplasmic reticulum stress-related autophagy in HeLa cells. Biosci Rep. 2012; 32:171-186.
10. Kudchodkar SB, Levine B. Viruses and autophagy. Rev Med Virol. 2009; 19:359-378.
11. Ji GR, Yu NC, Xue X, Li ZG. PERK-mediated Autophagy in Osteosarcoma Cells Resists ER Stress-induced Cell Apoptosis. Int J Biol Sci. 2015; 11:803-812.
12. McCarthy N. Autophagy: Directed development. Nat Rev Cancer. 2014; 14:74-75.
13. White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer. 2012; 12:401-410.
14. Huang J LK, Yu Y, Xie M, Kang R, Vernon P, Cao L, Tang D, Ni J. Targeting hmgb1-mediated autophagy as a novel therapeutic strategy for osteosarcoma. Autophagy. 2012; 8:275-277.
15. Lee SO, Jin UH, Kang JH, Kim SB, Guthrie AS, Sreevalsan S, Lee JS, Safe S. The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol Cancer Res. 2014; 12:527-538.
16. Zhang XY, Yang SM, Zhang HP, Yang Y, Sun SB, Chang JP, Tao XC, Yang TY, Liu C, Yang YM. Endoplasmic reticulum stress mediates the arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. Int J Biochem Cell Biol. 2015; 68:158-165.
17. Tian J, Hu X, Qu Q. [Effect and mechanism of endoplasmic reticulum stress on cisplatin resistance in ovarian carcinoma]. [Article in Chinese]. Zhonghua Zhong Liu Za Zhi. 2014; 36:324-328.
18. Chen XL, Fu JP, Shi J, Wan P, Cao H, Tang ZM. CXC195 induces apoptosis and endoplastic reticulum stress in human hepatocellular carcinoma cells by inhibiting the PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 2015; 12:8229-8236.
19. Hou H SH, Lu P, Ge C, Zhang L, Li H, Zhao F, Tian H, Zhang L, Chen T, Yao M, Li J. Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinoma. Molecular cancer therapeutics. 2013; 12:2874-2884.
20. Bae EY, Lee SW, Seong S, Cho W, Ahn JS, Cho HS. Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells. Molecules. 2015; 20:8988-8996.
21. Han X, Zhang X, Li H, Huang S, Zhang S, Wang F, Shi Y. Tunicamycin enhances the antitumor activity of trastuzumab on breast cancer in vitro and in vivo. Oncotarget. 2015; 6:38912-38925. doi: 10.18632/oncotarget.5334.
22. Zhang X, Yuan Y, Jiang L, Zhang J, Gao J, Shen Z, Zheng Y, Deng T, Yan H, Li W, Hou WW, Lu J, Shen Y, et al. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014; 10:1801-1813.
23. Gaudette BT, Iwakoshi NN, Boise LH. Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation. J Biol Chem. 2014; 289:23629-23640.
24. Luo G, Li Q, Zhang X, Shen L, Xie J, Zhang J, Kitakaze M, Huang X, Liao Y. Ablation of C/EBP homologous protein increases the acute phase mortality and doesn't attenuate cardiac remodeling in mice with myocardial infarction. Biochem Biophys Res Commun. 2015; 464:201-207.
25. McAlpine CS, Werstuck GH. Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3alpha/beta regulate foam cell formation. J Lipid Res. 2014; 55:2320-2333.
26. Liu X, Kwak D, Lu Z, Xu X, Fassett J, Wang H, Wei Y, Cavener DR, Hu X, Hall J, Bache RJ, Chen Y. Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling. Hypertension. 2014; 64:738-744.
27. Chen R, Rato C, Yan Y, Crespillo-Casado A, Clarke HJ, Harding HP, Marciniak SJ, Read RJ, Ron D. G-actin provides substrate-specificity to eukaryotic initiation factor 2alpha holophosphatases. Elife. 2015; 4.
28. Tuval-Kochen L PS, Keshet G, Lerenthal Y, Nakar C, Golani T, Toren A, Yahalom J, Pfeffer R, Lawrence Y. Eukaryotic initiation factor 2alpha-a downstream effector of mammalian target of rapamycin-modulates DNA repair and cancer response to treatment. PloS one. 2013; 8:e77260.
29. Uehara Y, Hirose J, Yamabe S, Okamoto N, Okada T, Oyadomari S, Mizuta H. Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein. Osteoarthritis Cartilage. 2014; 22:1007-1017.
30. Li H, Hu J, Wu S, Wang L, Cao X, Zhang X, Dai B, Cao M, Shao R, Zhang R, Majidi M, Ji L, Heymach JV, et al. Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget. 2016; 7:3548-3558. doi: 10.18632/oncotarget.6516.
31. Sarris EG, Saif MW, Syrigos KN. The Biological Role of PI3K Pathway in Lung Cancer. Pharmaceuticals (Basel). 2012; 5:1236-1264.
32. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005; 4:988-1004.
33. Kraus AC, Ferber I, Bachmann SO, Specht H, Wimmel A, Gross MW, Schlegel J, Suske G, Schuermann M. In vitro chemo-and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT, MAP kinase pathways. Oncogene. 2002; 21:8683-8695.
34. Tsurutani J, Fukuoka J, Tsurutani H, Shih JH, Hewitt SM, Travis WD, Jen J, Dennis PA. Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors. J Clin Oncol. 2006; 24:306-314.
35. Lee H, Kim JS, Kim E. Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways. PLoS One. 2012; 7:e50624.
36. Xu JL, Wang ZW, Hu LM, Yin ZQ, Huang MD, Hu ZB, Shen HB, Shu YQ. Genetic variants in the PI3K/PTEN/AKT/mTOR pathway predict platinum-based chemotherapy response of advanced non-small cell lung cancers in a Chinese population. Asian Pac J Cancer Prev. 2012; 13:2157-2162.
37. Qin L, Wang Z, Tao L, Wang Y. Er stress negatively regulates akt/tsc/mtor pathway to enhance autophagy. Autophagy. 2010; 6:239-247.
38. Guo J FZ, Huang Z, Wang H, Lu W. MicroRNA-217 functions as a tumour suppressor gene and correlates with cell resistance to cisplatin in lung cancer. Molecules and cells. 2014; 37:664-671.
39. Qin W, Xie W, Yang X, Xia N, Yang K. Inhibiting microRNA-449 Attenuates Cisplatin-Induced Injury in NRK-52E Cells Possibly via Regulating the SIRT1/P53/BAX Pathway. Med Sci Monit. 2016; 22:818-823.
40. Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014; 740:364-378.
41. Basu A, Krishnamurthy S. Cellular responses to Cisplatin-induced DNA damage. J Nucleic Acids. 2010; 2010.
42. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int. 2008; 73:994-1007.
43. Zhao G CC, Yang T, Qiu X, Liao B, Li W, Ji Z, Zhao J, Zhao H, Guo M, Ma Q, Xiao C, Fan Q, et al. Microrna-221 induces cell survival and cisplatin resistance through pi3k/akt pathway in human osteosarcoma. PLoS One. 2013; 8:e53906.
44. Hayakawa J OM, Kurachi H, Kanda Y, Hisamoto K, Nishio Y, Adachi K, Tasaka K, Kanzaki T, Murata Y. Inhibition of bad phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res. 2000; 60:5988-5994.
45. Liu M, Qi Z, Liu B, Ren Y, Li H, Yang G, Zhang Q. RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway. Oncotarget. 2015; 6:25281-25294. doi: 10.18632/oncotarget.4634.
46. Qin L, Xu T, Xia L, Wang X, Zhang X, Zhang X, Zhu Z, Zhong S, Wang C, Shen Z. Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment. Drug Des Devel Ther. 2016; 10:1035-1045.
47. Chen J SR, Li L, Xu ZP, Gu W. Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU, PI3K/mTOR dual inhibitor BEZ235 through apoptotic pathways. International journal of nanomedicine. 2014; 9:3403-3411.
48. Sun Z, Li Q, Zhang S, Chen J, Huang L, Ren J, Chang Y, Liang Y, Wu G. NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation. Onco Targets Ther. 2015; 8:269-277.
49. Mizushima N. Methods for monitoring autophagy. Int J Biochem Cell Biol. 2004; 36:2491-2502.
50. Guo GF, Jiang WQ, Zhang B, Cai YC, Xu RH, Chen XX, Wang F, Xia LP. Autophagy-related proteins beclin-1 and lc3 predict cetuximab efficacy in advanced colorectal cancer. World J Gastroenterol. 2011; 17:4779-4786.
51. Bu X, Zhao Y, Zhang Z, Wang M, Li M, Yan Y. Recombinant newcastle disease virus (rl-rvg) triggers autophagy and apoptosis in gastric carcinoma cells by inducing er stress. Am J Cancer Res. 2016; 6:924-936.
52. Wong J, Welschinger R, Hewson J, Bradstock KF, Bendall LJ. Efficacy of dual pi-3k and mtor inhibitors in vitro and in vivo in acute lymphoblastic leukemia. Oncotarget. 2014; 5:10460-10472. doi: 10.18632/oncotarget.2260.
53. Kim HS, Kim TJ, Yoo YM. Melatonin combined with endoplasmic reticulum stress induces cell death via the pi3k/akt/mtor pathway in b16f10 melanoma cells. PLoS One. 2014; 9:e92627.
54. Pang XL, He G, Liu YB, Wang Y, Zhang B. Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation. World J Gastroenterol. 2013; 19:1736-1748.