The biological role of PI3K pathway in lung cancer

Pharmaceuticals

Volumn 5, Issue 11, 2012, Pages 1236-1264

  Sarris, Evangelos G ^a   Saif, Muhammad W ^b   Syrigos, Kostas N ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Lung cancer; Molecular pathways; PI3K pathway inhibitors

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 DIALLYLAMINOMETHYLENE 1,3,4,7,10,11,12,13,14,15,16,17 DODECAHYDRO 6 HYDROXY 1 METHOXYMETHYL 10,13 DIMETHYL 3,7,17 TRIOXO 2 OXACYCLOPENTA[A]PHENANTHREN 11 YL ACETATE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; BEVACIZUMAB; BUPARLISIB; CARBOPLATIN; CISPLATIN; DOCETAXEL; ERLOTINIB; ETOPOSIDE; EVEROLIMUS; GEFITINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PACLITAXEL; PELITINIB; PEMETREXED; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PICTILISIB; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; RIDAFOROLIMUS; SAR 245409; SELUMETINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG; WORTMANNIN; XL 147; XL 765;

ACUTE KIDNEY FAILURE; ADVANCED CANCER; AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ANOREXIA; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTERY THROMBOSIS; ASTHENIA; BREAST CANCER; CANCER SURVIVAL; CELL CYCLE ARREST; DEHYDRATION; DIARRHEA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG ERUPTION; DRUG FEVER; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG POTENTIATION; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; DYSPNEA; ENZYME ACTIVATION; ENZYME ACTIVITY; FATIGUE; GENE ACTIVATION; GENE MUTATION; GLUCOSE TOLERANCE; GRAFT REJECTION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; HYPOXIA; INFECTION; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LUNG TOXICITY; MAXIMUM TOLERATED DOSE; MOLECULARLY TARGETED THERAPY; MOOD CHANGE; MUCOSA INFLAMMATION; NAUSEA; NEUTROPENIA; NONHUMAN; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PLEURA EFFUSION; PNEUMONIA; PROGRESSION FREE SURVIVAL; PROTEIN DEPLETION; PROTEINURIA; PRURITUS; RECOMMENDED DRUG DOSE; REVIEW; SIDE EFFECT; SIGNAL TRANSDUCTION; SKIN TOXICITY; SOLID TUMOR; STOMATITIS; THROMBOCYTOPENIA; TREATMENT DURATION; VOMITING;

EID: 84870288120     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph5111236     Document Type: Review

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