메뉴 건너뛰기




Volumn 8, Issue 11, 2016, Pages

Beneficial effects of pterocarpan-high soybean leaf extract on metabolic syndrome in overweight and obese Korean subjects: Randomized controlled trial

Author keywords

Inflammation; Metabolic syndrome; MRNA sequencing; PBMCs; Soybean leaf

Indexed keywords

ADIPOCYTOKINE; ALANINE AMINOTRANSFERASE; ANTILIPEMIC AGENT; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; FATTY ACID; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PTEROCARPAN DERIVATIVE; SOYBEAN EXTRACT; TRANSCRIPTOME; TRIACYLGLYCEROL; AUTACOID; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; LIPID; PLANT EXTRACT;

EID: 84996563987     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8110734     Document Type: Article
Times cited : (18)

References (55)
  • 1
    • 0004316772 scopus 로고    scopus 로고
    • Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults
    • National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    • National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults; The Evidance Report; National Institutes of Health Publication No. 98-4083; National Heart, Lung, and Blood Institute: Bethesda, MD, USA, 1998; pp. 1–262.
    • (1998) The Evidance Report; National Institutes of Health Publication No. 98-4083; National Heart, Lung, and Blood Institute , pp. 1-262
  • 2
    • 79959419489 scopus 로고    scopus 로고
    • Aqueous spray-dried green tea extract regulates body weight and epididymal fat accumulation in mice. Korean
    • Park, P.-J.; Kim, C.-W.; Cho, S.-Y.; Rha, C.-S.; Seo, D.-B.; Lee, S.-J. Aqueous spray-dried green tea extract regulates body weight and epididymal fat accumulation in mice. Korean J. Food Sci. Technol. 2010, 42, 103-108.
    • (2010) J. Food Sci. Technol , vol.42 , pp. 103-108
    • Park, P.-J.1    Kim, C.-W.2    Cho, S.-Y.3    Rha, C.-S.4    Seo, D.-B.5    Lee, S.-J.6
  • 3
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions liking obesity to insulin resistance and type 2 diabetes
    • Guilherme, A.; Virbasius, J.V.; Puri, V.; Czech, M.P. Adipocyte dysfunctions liking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 2008, 9, 367–377.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 4
    • 29044447292 scopus 로고    scopus 로고
    • Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-κB pathway in rat liver
    • Boden, G.; She, P.; Mozzoli, M.; Cheung, P.; Gumireddy, K.; Reddy, P.; Xiang, X.; Luo, Z.; Ruderman, N. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-κB pathway in rat liver. Diabetes 2005, 54, 3458–3465.
    • (2005) Diabetes , vol.54 , pp. 3458-3465
    • Boden, G.1    She, P.2    Mozzoli, M.3    Cheung, P.4    Gumireddy, K.5    Reddy, P.6    Xiang, X.7    Luo, Z.8    Ruderman, N.9
  • 5
    • 77951110851 scopus 로고    scopus 로고
    • Obesity is a sign–over-eating is a symptom: An aetiological framework for the assessment and management of obesity
    • Sharma, A.M.; Padwal, R. Obesity is a sign–over-eating is a symptom: An aetiological framework for the assessment and management of obesity. Obes. Rev. 2010, 11, 362–370.
    • (2010) Obes. Rev , vol.11 , pp. 362-370
    • Sharma, A.M.1    Padwal, R.2
  • 6
    • 0022589555 scopus 로고
    • A twin study of human obesity
    • Stunkard, A.J.; Foch, T.T.; Hrubec, Z. A twin study of human obesity. JAMA 1986, 256, 51–54.
    • (1986) JAMA , vol.256 , pp. 51-54
    • Stunkard, A.J.1    Foch, T.T.2    Hrubec, Z.3
  • 7
    • 39149127009 scopus 로고    scopus 로고
    • Sex difference in heritability of BMI in South Korean adolescent twins
    • Hur, Y.M. Sex difference in heritability of BMI in South Korean adolescent twins. Obesity 2007, 15, 2908-2911.
    • (2007) Obesity , vol.15 , pp. 2908-2911
    • Hur, Y.M.1
  • 8
    • 84996497137 scopus 로고    scopus 로고
    • Korean familial resemblance in fat mass and fat free mass: Cardiovascular genome study
    • Cho, E.Y.; Park, H.Y.; Jee, S.H.; Jang, Y.S.; Bae, S.J.; Lee, J.H.; Jang, Y. Korean familial resemblance in fat mass and fat free mass: Cardiovascular genome study. Korean J. Lipidol. 2001, 11, 537–547.
    • (2001) Korean J. Lipidol , vol.11 , pp. 537-547
    • Cho, E.Y.1    Park, H.Y.2    Jee, S.H.3    Jang, Y.S.4    Bae, S.J.5    Lee, J.H.6    Jang, Y.7
  • 9
    • 84923375731 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cells as a potential source of biomarkers to test the efficacy of weight-loss strategies
    • Reynés, B.; Díaz-Rúa, R.; Cifre, M.; Oliver, P.; Palou, A. Peripheral blood mononuclear cells as a potential source of biomarkers to test the efficacy of weight-loss strategies. Obesity 2015, 23, 28–31.
    • (2015) Obesity , vol.23 , pp. 28-31
    • Reynés, B.1    Díaz-Rúa, R.2    Cifre, M.3    Oliver, P.4    Palou, A.5
  • 11
    • 84893089631 scopus 로고    scopus 로고
    • Identification of early transcriptome-based biomarkers related to lipid metabolism in peripheral blood mononuclear cells of rats nutritionally programmed for improved metabolic health
    • Konieczna, J.; Sánchez, J.; van Schothorst, E.M.; Torrens, J.M.; Bunschoten, A.; Palou, M.; Picó, C.; Keijer, J.; Palou, A. Identification of early transcriptome-based biomarkers related to lipid metabolism in peripheral blood mononuclear cells of rats nutritionally programmed for improved metabolic health. Genes Nutr. 2014, 9, 366.
    • (2014) Genes Nutr , vol.9 , pp. 366
    • Konieczna, J.1    Sánchez, J.2    Van Schothorst, E.M.3    Torrens, J.M.4    Bunschoten, A.5    Palou, M.6    Picó, C.7    Keijer, J.8    Palou, A.9
  • 12
    • 84923064920 scopus 로고    scopus 로고
    • Meta-analysis of studies on breast cancer risk and diet in Chinese women
    • Wu, Y.C.; Zheng, D.; Sun, J.J.; Zou, Z.K.; Ma, Z.L. Meta-analysis of studies on breast cancer risk and diet in Chinese women. Int. J. Clin. Exp. Med. 2015, 15, 73–85.
    • (2015) Int. J. Clin. Exp. Med , vol.15 , pp. 73-85
    • Wu, Y.C.1    Zheng, D.2    Sun, J.J.3    Zou, Z.K.4    Ma, Z.L.5
  • 13
    • 84957434781 scopus 로고    scopus 로고
    • Soy and isoflavone consumption and risk of gastrointestinal cancer: A systematic review and meta-analysis
    • Tse, G.; Eslick, G.D. Soy and isoflavone consumption and risk of gastrointestinal cancer: A systematic review and meta-analysis. Eur. J. Nutr. 2016, 55, 63–73.
    • (2016) Eur. J. Nutr , vol.55 , pp. 63-73
    • Tse, G.1    Eslick, G.D.2
  • 14
    • 0031917223 scopus 로고    scopus 로고
    • Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women
    • Nagata, C.; Takatsuka, N.; Kurisu, Y.; Shimizu, H. Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J. Nutr. 1998, 128, 209–213.
    • (1998) J. Nutr , vol.128 , pp. 209-213
    • Nagata, C.1    Takatsuka, N.2    Kurisu, Y.3    Shimizu, H.4
  • 15
    • 77953745547 scopus 로고    scopus 로고
    • A brief historical overview of the past two decades of soy and isoflavone research
    • Messina, M. A brief historical overview of the past two decades of soy and isoflavone research. J. Nutr. 2010, 140, 1350S–1354S.
    • (2010) J. Nutr , vol.140 , pp. 1350S-1354S
    • Messina, M.1
  • 16
    • 67349280310 scopus 로고    scopus 로고
    • Soy, phytoestrogens and metabolism: A review
    • Cederroth, C.R.; Nef, S. Soy, phytoestrogens and metabolism: A review. Mol. Cell Endocrinol. 2009, 304, 30–42.
    • (2009) Mol. Cell Endocrinol , vol.304 , pp. 30-42
    • Cederroth, C.R.1    Nef, S.2
  • 17
  • 18
    • 78751580538 scopus 로고    scopus 로고
    • The most abundant polyphenol of soy leaves, coumestrol, displays potent α-glucosidase inhibitory activity
    • Yuk, H.J.; Lee, J.H.; Curtis-Longb, M.J.; Lee, J.W.; Kim, Y.S.; Ryu, H.W.; Park, C.G.; Jeong, T.-S. The most abundant polyphenol of soy leaves, coumestrol, displays potent α-glucosidase inhibitory activity. Food Chem. 2011, 126, 1057–1063.
    • (2011) Food Chem , vol.126 , pp. 1057-1063
    • Yuk, H.J.1    Lee, J.H.2    Curtis-Longb, M.J.3    Lee, J.W.4    Kim, Y.S.5    Ryu, H.W.6    Park, C.G.7    Jeong, T.-S.8
  • 19
    • 80053143566 scopus 로고    scopus 로고
    • Anti-diabetic effects of a kaempferol glycoside-rich fraction from unripe soybean (Edamame, Glycine max L. Merrill. ‘Jindai’) leaves on KK-A(y) mice
    • Zang, Y.; Sato, H.; Igarashi, K. Anti-diabetic effects of a kaempferol glycoside-rich fraction from unripe soybean (Edamame, Glycine max L. Merrill. ‘Jindai’) leaves on KK-A(y) mice. Biosci. Biotechnol. Biochem. 2011, 75, 1677–1684.
    • (2011) Biosci. Biotechnol. Biochem , vol.75 , pp. 1677-1684
    • Zang, Y.1    Sato, H.2    Igarashi, K.3
  • 21
    • 84898056846 scopus 로고    scopus 로고
    • Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (Neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells
    • Kuete, V.; Sandjo, L.P.; Kwamou, G.M.; Wiench, B.; Nkengfack, A.E.; Efferth, T. Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells. Phytomedicine 2014, 21, 682-688.
    • (2014) Phytomedicine , vol.21 , pp. 682-688
    • Kuete, V.1    Sandjo, L.P.2    Kwamou, G.M.3    Wiench, B.4    Nkengfack, A.E.5    Efferth, T.6
  • 22
    • 84883254841 scopus 로고    scopus 로고
    • Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2. BMC
    • Liu, S.; Hsieh, D.; Yang, Y.L.; Xu, Z.; Peto, C.; Jablons, D.M.; You, L. Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2. BMC. Pharmacol. Toxicol. 2013, 11, 14–36.
    • (2013) Pharmacol. Toxicol , vol.11 , pp. 14-36
    • Liu, S.1    Hsieh, D.2    Yang, Y.L.3    Xu, Z.4    Peto, C.5    Jablons, D.M.6    You, L.7
  • 23
    • 84885359067 scopus 로고    scopus 로고
    • Phytoestrogens mediated anti-inflammatory effect through suppression of IRF-1 and pSTAT1 expressions in lipopolysaccharide-activated microglia
    • Jantaratnotai, N.; Utaisincharoen, P.; Sanvarinda, P.; Thampithak, A.; Sanvarinda, Y. Phytoestrogens mediated anti-inflammatory effect through suppression of IRF-1 and pSTAT1 expressions in lipopolysaccharide-activated microglia. Int. Immunopharmacol. 2013, 17, 483–488.
    • (2013) Int. Immunopharmacol , vol.17 , pp. 483-488
    • Jantaratnotai, N.1    Utaisincharoen, P.2    Sanvarinda, P.3    Thampithak, A.4    Sanvarinda, Y.5
  • 26
    • 0041302294 scopus 로고    scopus 로고
    • Soy leaf lowers the ratio of non-HDL to HDL cholesterol in hamsters
    • Ho, H.M.; Leung, L.K.; Chan, F.L.; Huang, Y.; Chen, Z.Y. Soy leaf lowers the ratio of non-HDL to HDL cholesterol in hamsters. J. Agric. Food Chem. 2003, 51, 4554–4558.
    • (2003) J. Agric. Food Chem , vol.51 , pp. 4554-4558
    • Ho, H.M.1    Leung, L.K.2    Chan, F.L.3    Huang, Y.4    Chen, Z.Y.5
  • 27
    • 84912128254 scopus 로고    scopus 로고
    • Pterocarpan-enriched soy leaf extract ameliorates insulin sensitivity and pancreatic β-cell proliferation in type 2 diabetic mice
    • Kim, U.H.; Yoon, J.H.; Li, H.; Kang, J.H.; Ji, H.S.; Park, K.H.; Shin, D.H.; Park, H.Y.; Jeong, T.-S. Pterocarpan-enriched soy leaf extract ameliorates insulin sensitivity and pancreatic β-cell proliferation in type 2 diabetic mice. Molecules 2014, 19, 18493–18510.
    • (2014) Molecules , vol.19 , pp. 18493-18510
    • Kim, U.H.1    Yoon, J.H.2    Li, H.3    Kang, J.H.4    Ji, H.S.5    Park, K.H.6    Shin, D.H.7    Park, H.Y.8    Jeong, T.-S.9
  • 28
    • 84903287206 scopus 로고    scopus 로고
    • The beneficial effect of soybean (Glycine max (L.) Merr.) leaf extracts in adults with prediabetes: A randomized placebo controlled trial
    • Choi, M.-S.; Ryu, R.; Seo, Y.R.; Jeong, T.-S.; Shin, D.H.; Park, Y.B.; Kim, S.R.; Jung, U.J. The beneficial effect of soybean (Glycine max (L.) Merr.) leaf extracts in adults with prediabetes: A randomized placebo controlled trial. Food Funct. 2014, 5, 1621–1630.
    • (2014) Food Funct , vol.5 , pp. 1621-1630
    • Choi, M.-S.1    Ryu, R.2    Seo, Y.R.3    Jeong, T.-S.4    Shin, D.H.5    Park, Y.B.6    Kim, S.R.7    Jung, U.J.8
  • 29
    • 80053175452 scopus 로고    scopus 로고
    • Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: A randomized control trial
    • Kim, J.E.; Jeon, S.M.; Park, K.H.; Lee, W.S.; Jeong, T.S.; McGregor, R.A.; Choi, M.S. Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: A randomized control trial. Nutr. J. 2011, 10, 1–12.
    • (2011) Nutr. J , vol.10 , pp. 1-12
    • Kim, J.E.1    Jeon, S.M.2    Park, K.H.3    Lee, W.S.4    Jeong, T.S.5    McGregor, R.A.6    Choi, M.S.7
  • 30
    • 85066456886 scopus 로고    scopus 로고
    • Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies
    • WHO, Expert Consultation
    • WHO, Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004, 363, 157–163.
    • (2004) Lancet , vol.363 , pp. 157-163
  • 31
    • 0037471604 scopus 로고    scopus 로고
    • Antioxidant activity of apple peels
    • Wolfe, K.; Wu, X.; Liu, R.H. Antioxidant activity of apple peels. J. Agric. Food. Chem. 2003, 51, 609–614.
    • (2003) J. Agric. Food. Chem , vol.51 , pp. 609-614
    • Wolfe, K.1    Wu, X.2    Liu, R.H.3
  • 32
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald, W.T.; Levy, R.I.; Fredrickson, D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972, 18, 499–502.
    • (1972) Clin. Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 33
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews, D.R.; Hosker, J.P.; Rudenski, A.S.; Naylor, B.A.; Treacher, D.F.; Turner, R.C. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28, 412–419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 34
    • 84870532154 scopus 로고    scopus 로고
    • accessed on 27 April 2016
    • Gene Expression Omnibus. Available online: http://www.ncbi.nlm.nih.gov/geo/(accessed on 27 April 2016).
    • Gene Expression Omnibus
  • 35
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen, T.D.; Livak, K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 2008, 3, 1101–1108.
    • (2008) Nat. Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 37
    • 84937886920 scopus 로고    scopus 로고
    • Anti-obesity effects of soy leaf via regulation of adipogenic transcription factors and fat oxidation in diet-induced obese mice and 3T3-L1 adipocytes
    • Li, H.; Kang, J.H.; Han, J.M.; Cho, M.H.; Chung, Y.J.; Park, K.H.; Shin, D.H.; Park, H.Y.; Choi, M.S.; Jeong, T.S. Anti-obesity effects of soy leaf via regulation of adipogenic transcription factors and fat oxidation in diet-induced obese mice and 3T3-L1 adipocytes. J. Med. Food 2015, 18, 899–908.
    • (2015) J. Med. Food , vol.18 , pp. 899-908
    • Li, H.1    Kang, J.H.2    Han, J.M.3    Cho, M.H.4    Chung, Y.J.5    Park, K.H.6    Shin, D.H.7    Park, H.Y.8    Choi, M.S.9    Jeong, T.S.10
  • 38
    • 23044509686 scopus 로고    scopus 로고
    • Assessment of glycemia in diabetes mellitus: Hemoglobin A1c
    • Saudek, C.D.; Kalyani, R.R.; Derr, R.L. Assessment of glycemia in diabetes mellitus: Hemoglobin A1c. J. Assoc. Physicians India 2005, 53, 299–305.
    • (2005) J. Assoc. Physicians India , vol.53 , pp. 299-305
    • Saudek, C.D.1    Kalyani, R.R.2    Derr, R.L.3
  • 39
    • 84939801121 scopus 로고    scopus 로고
    • Soy leaf extract containing kaempferol glycosides and pheophorbides improves glucose homeostasis by enhancing pancreatic β-cell function and suppressing hepatic lipid accumulation in db/db mice
    • Li, H.; Ji, H.S.; Kang, J.H.; Shin, D.H.; Park, H.Y.; Choi, M.S.; Lee, C.H.; Lee, I.K.; Yun, B.S.; Jeong, T.S. Soy leaf extract containing kaempferol glycosides and pheophorbides improves glucose homeostasis by enhancing pancreatic β-cell function and suppressing hepatic lipid accumulation in db/db mice. J. Agric. Food Chem. 2015, 19, 7198–7210.
    • (2015) J. Agric. Food Chem , vol.19 , pp. 7198-7210
    • Li, H.1    Ji, H.S.2    Kang, J.H.3    Shin, D.H.4    Park, H.Y.5    Choi, M.S.6    Lee, C.H.7    Lee, I.K.8    Yun, B.S.9    Jeong, T.S.10
  • 40
    • 84941192506 scopus 로고    scopus 로고
    • Relation of combined non-high density lipoprotein-cholesterol and apolipoprotein B with atherosclerosis in adults with type 1 diabetes mellitus
    • Bjornstad, P.; Eckel, R.H.; Pyle, L.; Rewers, M.; Maahs, D.M.; Snell-Bergeon, J.K. Relation of combined non-high density lipoprotein-cholesterol and apolipoprotein B with atherosclerosis in adults with type 1 diabetes mellitus. Am. J. Cardiol. 2015, 16, 1057–1062.
    • (2015) Am. J. Cardiol , vol.16 , pp. 1057-1062
    • Bjornstad, P.1    Eckel, R.H.2    Pyle, L.3    Rewers, M.4    Maahs, D.M.5    Snell-Bergeon, J.K.6
  • 41
    • 79952075826 scopus 로고    scopus 로고
    • Dose-response study of sajabalssuk ethanol extract from Artemisia princeps Pampanini on blood glucose in subjects with impaired fasting glucose or mild type 2 diabetes
    • Choi, J.Y.; Shin, S.K.; Jeon, S.M.; Baek, N.I.; Chung, H.G.; Jeong, T.S.; Lee, K.T.; Lee, M.K.; Choi, M.-S. Dose-response study of sajabalssuk ethanol extract from Artemisia princeps Pampanini on blood glucose in subjects with impaired fasting glucose or mild type 2 diabetes. J. Med. Food 2011, 14, 101–107.
    • (2011) J. Med. Food , vol.14 , pp. 101-107
    • Choi, J.Y.1    Shin, S.K.2    Jeon, S.M.3    Baek, N.I.4    Chung, H.G.5    Jeong, T.S.6    Lee, K.T.7    Lee, M.K.8    Choi, M.-S.9
  • 42
    • 0346788906 scopus 로고    scopus 로고
    • The glucose-fatty acid cycle: A physiological perspective
    • Frayn, K.N. The glucose-fatty acid cycle: A physiological perspective. Biochem. Soc. Trans. 2003, 31, 1115–1119.
    • (2003) Biochem. Soc. Trans , vol.31 , pp. 1115-1119
    • Frayn, K.N.1
  • 43
    • 50449086746 scopus 로고    scopus 로고
    • Obesity and free fatty acids
    • Boden, G. Obesity and free fatty acids. Endocrinol. Metab. Clin. N. Am. 2008, 37, 635-46.
    • (2008) Endocrinol. Metab. Clin. N. Am , vol.37 , pp. 635-646
    • Boden, G.1
  • 44
    • 15944408334 scopus 로고    scopus 로고
    • A burning question: Does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?
    • Tataranni, P.A.; Ortega, E. A burning question: Does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes? Diabetes 2005, 54, 917–927.
    • (2005) Diabetes , vol.54 , pp. 917-927
    • Tataranni, P.A.1    Ortega, E.2
  • 45
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn, P.; Wood, I.S. Adipokines: Inflammation and the pleiotropic role of white adipose tissue. Br. J. Nutr. 2004, 92, 347–355.
    • (2004) Br. J. Nutr , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 49
    • 84897879212 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor impairs plasminogen activator inhibitor-1 expression via inhibiting TNF-α-activated MAPK/AP-1 signaling cascade
    • 231012
    • Chen, W.L.; Sheu, J.R.; Hsiao, C.J.; Hsiao, S.H.; Chung, C.L.; Hsiao, G. Histone deacetylase inhibitor impairs plasminogen activator inhibitor-1 expression via inhibiting TNF-α-activated MAPK/AP-1 signaling cascade. Biomed. Res. Int. 2014, 2014, 231012.
    • (2014) Biomed. Res. Int , vol.2014
    • Chen, W.L.1    Sheu, J.R.2    Hsiao, C.J.3    Hsiao, S.H.4    Chung, C.L.5    Hsiao, G.6
  • 50
    • 0042093781 scopus 로고    scopus 로고
    • Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: Reversal with weight reduction
    • Kim, Y.B.; Kotani, K.; Ciaraldi, T.P.; Henry, R.R.; Kahn, B.B. Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: Reversal with weight reduction. Diabetes 2003, 52, 1935–1942.
    • (2003) Diabetes , vol.52 , pp. 1935-1942
    • Kim, Y.B.1    Kotani, K.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 51
    • 84855217298 scopus 로고    scopus 로고
    • Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis
    • Tawaramoto, K.; Kotani, K.; Hashiramoto, M.; Kanda, Y.; Nagare, T.; Sakaue, H.; Ogawa, W.; Emoto, N.; Yanagisawa, M.; Noda, T.; et al. Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis. Mol. Endocrinol. 2012, 26, 95–109.
    • (2012) Mol. Endocrinol , vol.26 , pp. 95-109
    • Tawaramoto, K.1    Kotani, K.2    Hashiramoto, M.3    Kanda, Y.4    Nagare, T.5    Sakaue, H.6    Ogawa, W.7    Emoto, N.8    Yanagisawa, M.9    Noda, T.10
  • 52
    • 84875019579 scopus 로고    scopus 로고
    • CC chemokine receptors and chronic inflammation–therapeutic opportunities and pharmacological challenges
    • White, G.E.; Iqbal, A.J.; Greaves, D.R. CC chemokine receptors and chronic inflammation–therapeutic opportunities and pharmacological challenges. Pharmacol. Rev. 2013, 8, 47–89.
    • (2013) Pharmacol. Rev , vol.8 , pp. 47-89
    • White, G.E.1    Iqbal, A.J.2    Greaves, D.R.3
  • 54
    • 79251589063 scopus 로고    scopus 로고
    • Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes
    • Jagannathan-Bogdan, M.; McDonnell, M.E.; Shin, H.; Rehman, Q.; Hasturk, H.; Apovian, C.M.; Nikolajczyk, B.S. Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J. Immunol. 2011, 186, 1162–1172.
    • (2011) J. Immunol , vol.186 , pp. 1162-1172
    • Jagannathan-Bogdan, M.1    McDonnell, M.E.2    Shin, H.3    Rehman, Q.4    Hasturk, H.5    Apovian, C.M.6    Nikolajczyk, B.S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.