Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells

Phytomedicine

Volumn 21, Issue 5, 2014, Pages 682-688

  Kuete, Victor ^a,b   Sandjo, Louis P ^c   Kwamou, Guy M N ^c   Wiench, Benjamin ^a   Nkengfack, Augustin E ^c   Efferth, Thomas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF DSCHANG   (Cameroon)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

Author keywords

Apoptosis; Cell cycle distribution; Cytotoxicity; Isoflavonoids; Mitochondrial membrane potential; Pterocarpan

Indexed keywords

10,10 DIMETHYL 6,6A,10,13A TETRAHYDROFURO[3,2 C:4,5 G']DICHROMEN 3 O1; 7 HYDROXY 3 (4 HYDROXY 3 (3 METHYLBUT 2 EN 1 YL)PHENYL) CHROMEN 4 ONE; 7 HYDROXY 3 (7 METHOXY 2,2 DIMETHYL 2H CHROMEN 6 YL)CHROMAN 4 ONE; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; DOXORUBICIN; ISOFLAVONOID; MULTIDRUG RESISTANCE PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; BENZOPYRAN DERIVATIVE; CASPASE; ISOFLAVONE DERIVATIVE; ISONEORAUTENOL; NEOBAVAISOFLAVONE; SIGMOIDIN H;

APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL CYCLE G1 PHASE; CELLULAR DISTRIBUTION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DETERMINATION; ERYTHRINA EXCELSA; ERYTHRINA SENEGALENSIS; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RESAZURIN ASSAY; TRADITIONAL MEDICINE; VACUUM COLUMN CHROMATOGRAPHY; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; ERYTHRINA; HCT116 CELL LINE; ISOLATION AND PURIFICATION; METABOLISM;

ERYTHRINA EXCELSA; ERYTHRINA SENEGALENSIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOFURANS; BENZOPYRANS; CASPASES; CELL CYCLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ERYTHRINA; HCT116 CELLS; HUMANS; ISOFLAVONES; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES;

EID: 84898056846     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.10.017     Document Type: Article

References (31)

1. E.S. Alnemri, D.J. Livingston, D.W. Nicholson, G. Salvesen, N.A. Thornberry, W.W. Wong, and J. Yuan Human ICE/CED-3 protease nomenclature Cell 87 1996 171
2. Annonymous Cancer multidrug resistance Nature Biotechnology 18 2000 18 20
3. D.A. Bass, J.W. Parce, L.R. Dechatelet, P. Szejda, M.C. Seeds, and M. Thomas Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation Journal of Immunology 130 1983 1910 1917
4. J.L. Biedler, and B.A. Spengler Reverse transformation of multidrug-resistant cells Cancer and Metastasis Reviews 13 1994 191 207
5. J. Boik Natural Compounds in Cancer Therapy 2001 Oregon Medical Press Minnesota, USA
6. G. Brahemi, F.R. Kona, A. Fiasella, D. Buac, J. Soukupova, A. Brancale, A.M. Burger, and A.D. Westwell Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer Journal of Medicinal Chemistry 53 2010 2757 2765
7. S.K. Chaudhuri, L. Huang, F. Fullas, D.M. Brown, M.C. Wani, and M.E. Wall Isolation and structure identification of an active DNA strand-scission agent, (+)-3,4-di-hydroxy-8,9-methylenedioxypterocarpan Journal of Natural Products 58 1995 1966 1969
8. A. Cossarizza, R. Ferraresi, L. Troiano, E. Roat, L. Gibellini, L. Bertoncelli, M. Nasi, and M. Pinti Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry Nature Protocols 4 2009 1790 1797
9. F. Cottiglia, L. Casu, L. Bonsignore, M. Casu, C. Floris, M. Leonti, J. Gertsch, and J. Heilmann New cytotoxic prenylated isoflavonoids from Bituminaria morisiana Planta Medica 71 2005 254 260
10. L.A. Doyle, W. Yang, L.V. Abruzzo, T. Krogmann, Y. Gao, A.K. Rishi, and D.D. Ross A multidrug resistance transporter from human MCF-7 breast cancer cells Proceedings of the National Academy of Sciences USA 95 1998 15665 21567
11. T. Efferth The human ATP-binding cassette transporter genes: from the bench to the bedside Current Molecular Medicine 1 2001 45 65
12. T. Efferth, A. Sauerbrey, M.E. Halatsch, D.D. Ross, and E. Gebhart Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines Naunyn-Schmiedeberg's Archives of Pharmacology 367 2003 56 67
13. T. Efferth, A. Sauerbrey, A. Olbrich, E. Gebhart, P. Rauch, H.O. Weber, J.G. Hengstler, M.E. Halatsch, M. Volm, K.D. Tew, D.D. Ross, and J.O. Funk Molecular modes of action of artesunate in tumor cell lines Molecular Pharmacology 64 2003 382 394
14. T. Eichhorn, and T. Efferth P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs Journal of Ethnopharmacology 141 2012 557 570
15. W.S. el-Deiry Role of oncogenes in resistance and killing by cancer therapeutic agents Current Opinion in Oncology 9 1997 79 87
16. J. Gillet, T. Efferth, D. Steinbach, J. Hamels, F. de Longueville, V. Bertholet, and J. Remacle Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes Cancer Research 64 2004 8987 8993
17. J.P. Gillet, T. Efferth, and J. Remacle Chemotherapy-induced resistance by ATP-binding cassette transporter genes Biochimica et Biophysica Acta 1775 2007 237 262
18. M.M. Gottesman, and V. Ling The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research FEBS Letters 580 2006 998 1009
19. C. Ito, T. Murata, M. Itoigawa, K. Nakao, M. Kumagai, N. Kaneda, and H. Furukawa Induction of apoptosis by isoflavonoids from the leaves of Millettia taiwaniana in human leukemia HL-60 cells Planta Medica 72 2006 424 429
20. A. Kimmig, V. Gekeler, M. Neumann, G. Frese, R. Handgretinger, G. Kardos, H. Diddens, and D. Niethammer Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells Cancer Research 50 1990 6793 6799
21. V. Kuete, L. Sandjo, J. Nantchouang Ouete, H. Fouotsa, B. Wiench, and T. Efferth Cytotoxicity and modes of action of three naturally occuring xanthones (8-hydroxycudraxanthone G, morusignin I and cudraxanthone I) against sensitive and multidrug-resistant cancer cell lines Phytomedicine 2013 10.1016/j.phymed.2013.08.018
22. V. Kuete, L. Sandjo, B. Wiench, and T. Efferth Cytotoxicity and modes of action of four Cameroonian dietary spices ethno-medically used to treat cancers: Echinops giganteus, Xylopia aethiopica, Imperata cylindrica and Piper capense Journal of Ethnopharmacology 149 2013 245 253
23. V. Kuete, P.D. Tchakam, B. Wiench, B. Ngameni, H.K. Wabo, M.F. Tala, M.L. Moungang, B.T. Ngadjui, T. Murayama, and T. Efferth Cytotoxicity and modes of action of four naturally occuring benzophenones: 2,2′,5,6′- tetrahydroxybenzophenone, guttiferone E, isogarcinol and isoxanthochymol Phytomedicine 20 2013 528 536
24. G.C. Militao, I.N. Dantas, C. Pessoa, M.J. Falcao, E.R. Silveira, M.A. Lima, R. Curi, T. Lima, M.O. Moraes, and L.V. Costa-Lotufo Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells Life Sciences 78 2006 2409 2417
25. G.C. Militao, S.M. Pinheiro, I.N. Dantas, C. Pessoa, M.O. de Moraes, L.C. Costa-Lotufo, M.A. Lima, and E.R. Silveira Bioassay-guided fractionation of pterocarpans from roots of Harpalyce brasiliana Benth Bioorganic and Medicinal Chemistry 15 2007 6687 6691
26. A. Nkengfack, J. Kouam, T. Vouffo, M. Meyer, M. Tempesta, and Z. Fomum An isoflavanone and a coumestan from Erythrina sigmoidea Phytochemistry 35 1994 521 526
27. A.E. Nkengfack, J.C. Vardamides, Z.T. Fomum, and M. Meyer Prenylated isoflavanone from Erythrina eriotricha Phytochemistry 40 1995 1803 1808
28. J. O'Brien, I. Wilson, T. Orton, and F. Pognan Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity European Journal of Biochemistry 267 2000 5421 5426
29. M. Saraswathy, and S. Gong Different strategies to overcome multidrug resistance in cancer Biotechnology Advances. 2013 10.1016/j.biotechadv.2013.06. 004
30. E. Szliszka, Z.P. Czuba, L. Sedek, A. Paradysz, and W. Krol Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia Pharmacological Reports 63 2011 139 148
31. W. Watjen, A. Kulawik, A.K. Suckow-Schnitker, Y. Chovolou, R. Rohrig, S. Ruhl, A. Kampkotter, J. Addae-Kyereme, C.W. Wright, and C.M. Passreiter Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation Toxicology 242 2007 71 79