Dose-response study of sajabalssuk ethanol extract from Artemisia princeps Pampanini on blood glucose in subjects with impaired fasting glucose or mild type 2 diabetes

Journal of Medicinal Food

Volumn 14, Issue 1-2, 2011, Pages 101-107

  Choi, Ji Young ^a,b   Shin, Su Kyung ^a   Jeon, Seon Min ^a   Baek, Nam In ^c   Chung, Hae Gon ^d   Jeong, Tae Sook ^e   Lee, Kyung Tae ^c   Lee, Mi Kyung ^f   Choi, Myung Sook ^a  

^a Kyungpook National University   (South Korea)

^b Bio Industry Center   (South Korea)

^c Kyung Hee University   (South Korea)

^d GangHwa Agricultural R and D Center   (South Korea)

^e Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^f Sunchon National University   (South Korea)

Author keywords

Artemisia princeps Pampanini; ethanol extract; fasting blood glucose; free fatty acids; hemoglobin A1c

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIDIABETIC AGENT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; C PEPTIDE; CALCIUM; CHOLESTEROL; EUPATILIN; FATTY ACID; GLUCAGON; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; INSULIN; IRON; JASEOCIDIN; LACTOSE; PINITOL; PLACEBO; PLANT EXTRACT; PROTEIN; RIBOFLAVIN; SAJABALSSUK ETHANOL EXTRACT; THIAMINE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTEMISIA; ARTICLE; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DIETARY FIBER; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; ENZYME ACTIVITY; EVENING DOSAGE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEDICINAL PLANT; MORNING DOSAGE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SAJABALSSUK; SUPPLEMENTATION; SYSTOLIC BLOOD PRESSURE; THERAPY EFFECT;

ADULT; AGED; ARTEMISIA; BLOOD GLUCOSE; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; FASTING; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; PLANT EXTRACTS; YOUNG ADULT;

ARTEMISIA PRINCEPS; MUS;

EID: 79952075826     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2010.1266     Document Type: Article

References (25)

1. Nathan DM: Long-term complications of diabetes mellitus. N Engl J Med 1993;328:1676-1685.
2. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusituupa M; Finnish Diabetes Prevention Study Group: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-1350. (Pubitemid 32378388)
3. DeVegt F, Dekker JM, Jager A, Hienkens E, Kostense PJ, Stehouwer CD, Nijpets G, Bouter LM, Heine RJ: Relations of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch populations: the Hoorn Study. JAMA 2001;285:2109-2113. (Pubitemid 32367828)
4. American Diabetes Association: Standards of medical care for patients with diabetes mellitus. Diabetes Care 2006;29(Suppl 1):S1-S85.
5. Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M: Hypoglycemic effect of extracts from Lager-stroemia speciosa L. Leaves in genetically diabetic KK-Ay mice. Biosci Biotechnol Biochem 1996;60:204-208.
6. Jung UJ, Baek NI, Chung HG, Bang MH, Yoo JS, Jeong TS, Lee KT, Kang YJ, Lee MK, Kim HJ, Yeo JY, Choi MS: The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice. Food Chem Toxicol 2007;45:2022-2029. (Pubitemid 47238218)
7. World Health Orgamization: WHO Traditional Medicine Strategy 2002-2005. World Health Organization, Geneva, 2002.
8. Kang YJ, Jung UJ, Lee MK, Kim HJ, Jeon SM, Park YB, Chung HG, Baek NI, Lee KT, Jeong TS, Choi MS: Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice. Diabetes Res Clin Pract 2008;82:25-32.
9. Aline M, Charles EL, Marco R, Jeanne M, Odile GN: Determination of the total phenolic, flavonoid and praline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem 2005;91:571-577.
10. Lee JM, Son ES, Oh SS, Han DS: Contents of total flavonoid and biological activities of edible plants. Korean J Dietary Culture 2001;16:504-514.
11. Vosough-Ghanbari S, Rahimi R, Kharabaf S, Zeinali S, Mohammadirad A, Amini S, Yasa N, Salehnia A, Toliat T, Nikfar S, Larijani B, Abdollahi M: Effects of Satureja khuzestanica on serum glucose, lipids and markers of oxidative stress in patients with type 2 diabetes mellitus: a double-blind randomized controlled trial. Evid Based Complement Alternat Med 2008 Feb 27 [Epub ahead of print].
12. Hsu TF, Kise M, Wang MF, Ito Y, Yang MD, Aoto H, Yoshihara R, Yokoyama J, Kunii D, Yamamoto S: Effects of pre-germinated brown rice on blood glucose and lipid levels in free-living patients with impaired fasting glucose or type 2 diabetes. J Nutr Sci Vitaminol (Tokyo) 2008;54:163-168. (Pubitemid 351754005)
13. Shafrir E: Animal models of non-insulin-dependent diabetes. Diabetes Metab Rev 1992;8:179-208.
14. Reaven GM: Pathophysiology of insulin resistance in human disease. Physiol Rev 1995;75:473-486.
15. Kruszynska YT, Olefsky JM: Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. Investig Med 1996;44:413-428. (Pubitemid 126820690)
16. Frayn KN: The glucose-fatty acid cycle: a physiological perspective. Biochem Soc Trans 2003;31:1115-1119.
17. Boden G: Obesity and free fatty acids. Endocrinol Metab Clin North Am 2008;37:635-646.
18. Ye J: Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle. Endocr Metab Immune Disord Drug Targets 2007;7:65-74.
19. Piro S, Spampinato D, Spadaro L, Oliveri CE, Purrello F, Rabuazzo AM: Direct apoptotic effects of free fatty acids on human endothelial cells. Nutr Metab Cardiovasc Dis 2008;18:96-104. (Pubitemid 351291669)
20. Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S: The current state of serum biomarkers of hepatotoxicity. Toxicology 2008;245:194-205.
21. Bell DS: Hypertension and diabetes: a toxic combination. Endocr Pract 2008;14:1031-1039.
22. Bates SH, Jones RB, Bailey CJ: Insulin-like effect of pinitol. Br J Pharmacol 2000;130:1944-1948. (Pubitemid 30655807)
23. Narayanan CR, Joshi DD, Mujumdar AM, Dhekne VV: Pinitol - a new anti-diabetic compound from the leaves of Bougainvillea spectabilis. Curr Sci 1987;56:139-141.
24. Kim JI, Kim JC, Kang MJ, Lee MS, Kim JJ, Cha IJ: Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study. Eur J Clin Nutr 2005;59:456-458. (Pubitemid 40403302)
25. Davis A, Christinansen M, Horowitz JF, Klein S, Hellerstein MK, Ostlund RE Jr: Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care 2000;23:1000-1005. (Pubitemid 30480031)