Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells

PLoS Pathogens

Volumn 11, Issue 10, 2015, Pages

  Ke, Ruian ^a,b   Lewin, Sharon R ^c,d,e   Elliott, Julian H ^d   Perelson, Alan S ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e BURNET INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

VORINOSTAT; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID;

ARTICLE; CD4 T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; RNA TRANSLATION; TRANSCRIPTION INITIATION; UPREGULATION; VIRUS LATENCY; VIRUS LOAD; VIRUS RELEASE; DRUG EFFECTS; GENETICS;

HISTONE DEACETYLASE INHIBITORS; HIV; HUMANS; HYDROXAMIC ACIDS; TRANSCRIPTIONAL ACTIVATION; VIRUS LATENCY;

EID: 84946013715     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005237     Document Type: Article

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