메뉴 건너뛰기




Volumn 770, Issue , 2016, Pages 219-230

Effects of ionizing radiation on the mammalian brain

Author keywords

Brain; Cognitive impairment; Inflammation; Ionizing radiation; Neurogenesis; Oxidative stress

Indexed keywords

ARTICLE; BRAIN CANCER; BRAIN DAMAGE; BRAIN FUNCTION; BRAIN RADIATION; CANCER RISK; CELL ACTIVATION; CEREBROVASCULAR DISEASE; COGNITION; COGNITIVE DEFECT; GLIA CELL; HUMAN; IONIZING RADIATION; LINEAR ENERGY TRANSFER; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIATION RESPONSE; TUMOR MICROENVIRONMENT; ADULT; BRAIN; CHILD; FEMALE; GLIA; MALE; PHYSIOLOGY; RADIATION INJURIES;

EID: 84995970262     PISSN: 13835742     EISSN: 13882139     Source Type: Journal    
DOI: 10.1016/j.mrrev.2016.08.003     Document Type: Article
Times cited : (76)

References (205)
  • 1
    • 0024382757 scopus 로고
    • Radiation and life
    • [1] Hall, E.J., Radiation and life. Bull. N. Y. Acad. Med. 65 (1989), 430–438.
    • (1989) Bull. N. Y. Acad. Med. , vol.65 , pp. 430-438
    • Hall, E.J.1
  • 2
    • 36549007486 scopus 로고    scopus 로고
    • Computed tomography-an increasing source of radiation exposure
    • [2] Brenner, D.J., Hall, E.J., Computed tomography-an increasing source of radiation exposure. N. Engl. J. Med. 357 (2007), 2277–2284.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2277-2284
    • Brenner, D.J.1    Hall, E.J.2
  • 3
    • 55649094424 scopus 로고    scopus 로고
    • Radiation therapy for glial tumors: technical aspects and clinical indications
    • [3] Kantor, G., Laprie, A., Huchet, A., Loiseau, H., Dejean, C., Mazeron, J.J., Radiation therapy for glial tumors: technical aspects and clinical indications. Cancer Radiother. 12 (2008), 687–694.
    • (2008) Cancer Radiother. , vol.12 , pp. 687-694
    • Kantor, G.1    Laprie, A.2    Huchet, A.3    Loiseau, H.4    Dejean, C.5    Mazeron, J.J.6
  • 4
    • 84860739207 scopus 로고    scopus 로고
    • Fast neutron irradiation deteriorates hippocampus-related memory ability in adult mice
    • [4] Yang, M., Kim, H., Kim, J., Kim, S.H., Kim, J.C., Bae, C.S., Kim, J.S., Shin, T., Moon, C., Fast neutron irradiation deteriorates hippocampus-related memory ability in adult mice. J. Vet. Sci. 13 (2012), 1–6.
    • (2012) J. Vet. Sci. , vol.13 , pp. 1-6
    • Yang, M.1    Kim, H.2    Kim, J.3    Kim, S.H.4    Kim, J.C.5    Bae, C.S.6    Kim, J.S.7    Shin, T.8    Moon, C.9
  • 5
    • 77958089961 scopus 로고    scopus 로고
    • Low (60 cGy) doses of (56)Fe HZE-particle radiation lead to a persistent reduction in the glutamatergic readily releasable pool in rat hippocampal synaptosomes
    • [5] Machida, M., Lonart, G., Britten, R.A., Low (60 cGy) doses of (56)Fe HZE-particle radiation lead to a persistent reduction in the glutamatergic readily releasable pool in rat hippocampal synaptosomes. Radiat. Res. 174 (2010), 618–623.
    • (2010) Radiat. Res. , vol.174 , pp. 618-623
    • Machida, M.1    Lonart, G.2    Britten, R.A.3
  • 6
    • 43449127799 scopus 로고    scopus 로고
    • (56)Fe-particle radiation reduces neuronal output and attenuates lipopolysaccharide-induced inhibition of long-term potentiation in the mouse hippocampus
    • [6] Vlkolinsky, R., Krucker, T., Nelson, G.A., Obenaus, A., (56)Fe-particle radiation reduces neuronal output and attenuates lipopolysaccharide-induced inhibition of long-term potentiation in the mouse hippocampus. Radiat. Res. 169 (2008), 523–530.
    • (2008) Radiat. Res. , vol.169 , pp. 523-530
    • Vlkolinsky, R.1    Krucker, T.2    Nelson, G.A.3    Obenaus, A.4
  • 7
    • 34248172876 scopus 로고    scopus 로고
    • Redox changes induced in hippocampal precursor cells by heavy ion irradiation
    • [7] Limoli, C.L., Giedzinski, E., Baure, J., Rola, R., Fike, J.R., Redox changes induced in hippocampal precursor cells by heavy ion irradiation. Radiat. Environ. Biophys. 46 (2007), 167–172.
    • (2007) Radiat. Environ. Biophys. , vol.46 , pp. 167-172
    • Limoli, C.L.1    Giedzinski, E.2    Baure, J.3    Rola, R.4    Fike, J.R.5
  • 9
    • 15544375367 scopus 로고    scopus 로고
    • Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis
    • [9] Sadetzki, S., Chetrit, A., Freedman, L., Stovall, M., Modan, B., Novikov, I., Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis. Radiat. Res. 163 (2005), 424–432.
    • (2005) Radiat. Res. , vol.163 , pp. 424-432
    • Sadetzki, S.1    Chetrit, A.2    Freedman, L.3    Stovall, M.4    Modan, B.5    Novikov, I.6
  • 10
    • 0031704938 scopus 로고    scopus 로고
    • Intracranial tumors after exposure to ionizing radiation during infancy: a pooled analysis of two Swedish cohorts of 28,008 infants with skin hemangioma
    • [10] Karlsson, P., Holmberg, E., Lundell, M., Mattsson, A., Holm, L.E., Wallgren, A., Intracranial tumors after exposure to ionizing radiation during infancy: a pooled analysis of two Swedish cohorts of 28,008 infants with skin hemangioma. Radiat. Res. 150 (1998), 357–364.
    • (1998) Radiat. Res. , vol.150 , pp. 357-364
    • Karlsson, P.1    Holmberg, E.2    Lundell, M.3    Mattsson, A.4    Holm, L.E.5    Wallgren, A.6
  • 11
    • 0346688606 scopus 로고    scopus 로고
    • Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: swedish population based cohort study
    • [11] Hall, P., Adami, H.O., Trichopoulos, D., Pedersen, N.L., Lagiou, P., Ekbom, A., Ingvar, M., Lundell, M., Granath, F., Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: swedish population based cohort study. BMJ, 328, 2004, 19.
    • (2004) BMJ , vol.328 , pp. 19
    • Hall, P.1    Adami, H.O.2    Trichopoulos, D.3    Pedersen, N.L.4    Lagiou, P.5    Ekbom, A.6    Ingvar, M.7    Lundell, M.8    Granath, F.9
  • 12
    • 33746604073 scopus 로고    scopus 로고
    • Cancer risks following diagnostic and therapeutic radiation exposure in children
    • [12] Kleinerman, R.A., Cancer risks following diagnostic and therapeutic radiation exposure in children. Pediatr. Radiol. 36:Suppl. 2 (2006), 121–125.
    • (2006) Pediatr. Radiol. , vol.36 , pp. 121-125
    • Kleinerman, R.A.1
  • 17
    • 0028008434 scopus 로고
    • Cancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality
    • [17] Ron, E., Preston, D.L., Mabuchi, K., Thompson, D.E., Soda, M., Cancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality. Radiat. Res. 137 (1994), S98–112.
    • (1994) Radiat. Res. , vol.137 , pp. S98-112
    • Ron, E.1    Preston, D.L.2    Mabuchi, K.3    Thompson, D.E.4    Soda, M.5
  • 18
    • 84859932436 scopus 로고    scopus 로고
    • Studies of the mortality of atomic bomb survivors, Report 14, 1950–2003: an overview of cancer and noncancer diseases
    • [18] Ozasa, K., Shimizu, Y., Suyama, A., Kasagi, F., Soda, M., Grant, E.J., Sakata, R., Sugiyama, H., Kodama, K., Studies of the mortality of atomic bomb survivors, Report 14, 1950–2003: an overview of cancer and noncancer diseases. Radiat. Res. 177 (2012), 229–243.
    • (2012) Radiat. Res. , vol.177 , pp. 229-243
    • Ozasa, K.1    Shimizu, Y.2    Suyama, A.3    Kasagi, F.4    Soda, M.5    Grant, E.J.6    Sakata, R.7    Sugiyama, H.8    Kodama, K.9
  • 19
    • 0141764894 scopus 로고    scopus 로고
    • Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950–1997
    • [19] Preston, D.L., Shimizu, Y., Pierce, D.A., Suyama, A., Mabuchi, K., Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950–1997. Radiat. Res. 160 (2003), 381–407.
    • (2003) Radiat. Res. , vol.160 , pp. 381-407
    • Preston, D.L.1    Shimizu, Y.2    Pierce, D.A.3    Suyama, A.4    Mabuchi, K.5
  • 20
    • 84962254101 scopus 로고    scopus 로고
    • Exposure to ionizing radiation and brain cancer incidence: the Life Span Study cohort
    • [20] Smoll, N.R., Brady, Z., Scurrah, K., Mathews, J.D., Exposure to ionizing radiation and brain cancer incidence: the Life Span Study cohort. Cancer Epidemiol. 42 (2016), 60–65.
    • (2016) Cancer Epidemiol. , vol.42 , pp. 60-65
    • Smoll, N.R.1    Brady, Z.2    Scurrah, K.3    Mathews, J.D.4
  • 21
    • 84864776903 scopus 로고    scopus 로고
    • A. Berrington de Gonzalez, Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study
    • [21] Pearce, M.S., Salotti, J.A., Little, M.P., McHugh, K., Lee, C., Kim, K.P., Howe, N.L., Ronckers, C.M., Rajaraman, P., Sir Craft, A.W., Parker, L., A. Berrington de Gonzalez, Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 380 (2012), 499–505.
    • (2012) Lancet , vol.380 , pp. 499-505
    • Pearce, M.S.1    Salotti, J.A.2    Little, M.P.3    McHugh, K.4    Lee, C.5    Kim, K.P.6    Howe, N.L.7    Ronckers, C.M.8    Rajaraman, P.9    Sir Craft, A.W.10    Parker, L.11
  • 22
    • 84861598337 scopus 로고    scopus 로고
    • Organ doses for reference pediatric and adolescent patients undergoing computed tomography estimated by Monte Carlo simulation
    • [22] Lee, C., Kim, K.P., Long, D.J., Bolch, W.E., Organ doses for reference pediatric and adolescent patients undergoing computed tomography estimated by Monte Carlo simulation. Med. Phys. 39 (2012), 2129–2146.
    • (2012) Med. Phys. , vol.39 , pp. 2129-2146
    • Lee, C.1    Kim, K.P.2    Long, D.J.3    Bolch, W.E.4
  • 25
    • 84899911143 scopus 로고    scopus 로고
    • Paediatric head CT scan and subsequent risk of malignancy and benign brain tumour: a nation-wide population-based cohort study
    • [25] Huang, W.Y., Muo, C.H., Lin, C.Y., Jen, Y.M., Yang, M.H., Lin, J.C., Sung, F.C., Kao, C.H., Paediatric head CT scan and subsequent risk of malignancy and benign brain tumour: a nation-wide population-based cohort study. Br. J. Cancer 110 (2014), 2354–2360.
    • (2014) Br. J. Cancer , vol.110 , pp. 2354-2360
    • Huang, W.Y.1    Muo, C.H.2    Lin, C.Y.3    Jen, Y.M.4    Yang, M.H.5    Lin, J.C.6    Sung, F.C.7    Kao, C.H.8
  • 26
    • 0021152969 scopus 로고
    • In utero exposure to A-bomb radiation and mental retardation; a reassessment
    • [26] Otake, M., Schull, W.J., In utero exposure to A-bomb radiation and mental retardation; a reassessment. Br. J. Radiol. 57 (1984), 409–414.
    • (1984) Br. J. Radiol. , vol.57 , pp. 409-414
    • Otake, M.1    Schull, W.J.2
  • 27
    • 0028953402 scopus 로고
    • Further observations on abnormal brain development caused by prenatal A-bomb exposure to ionizing radiation
    • [27] Yoshimaru, H., Otake, M., Schull, W.J., Funamoto, S., Further observations on abnormal brain development caused by prenatal A-bomb exposure to ionizing radiation. Int. J. Radiat. Biol. 67 (1995), 359–371.
    • (1995) Int. J. Radiat. Biol. , vol.67 , pp. 359-371
    • Yoshimaru, H.1    Otake, M.2    Schull, W.J.3    Funamoto, S.4
  • 28
    • 0032898863 scopus 로고    scopus 로고
    • Cognitive function and prenatal exposure to ionizing radiation
    • [28] Schull, W.J., Otake, M., Cognitive function and prenatal exposure to ionizing radiation. Teratology 59 (1999), 222–226.
    • (1999) Teratology , vol.59 , pp. 222-226
    • Schull, W.J.1    Otake, M.2
  • 29
    • 84969888644 scopus 로고    scopus 로고
    • Radiation effects on cognitive function among atomic bomb survivors exposed at or after adolescence
    • [29] Yamada, M., Landes, R.D., Mimori, Y., Nagano, Y., Sasaki, H., Radiation effects on cognitive function among atomic bomb survivors exposed at or after adolescence. Am. J. Med. 129 (2016), 586–591.
    • (2016) Am. J. Med. , vol.129 , pp. 586-591
    • Yamada, M.1    Landes, R.D.2    Mimori, Y.3    Nagano, Y.4    Sasaki, H.5
  • 31
    • 0019961033 scopus 로고
    • Mental function following scalp irradiation during childhood
    • [31] Ron, E., Modan, B., Floro, S., Harkedar, I., Gurewitz, R., Mental function following scalp irradiation during childhood. Am. J. Epidemiol. 116 (1982), 149–160.
    • (1982) Am. J. Epidemiol. , vol.116 , pp. 149-160
    • Ron, E.1    Modan, B.2    Floro, S.3    Harkedar, I.4    Gurewitz, R.5
  • 32
    • 0033647490 scopus 로고    scopus 로고
    • The neurodevelopmental price of survival in children with malignant brain tumours
    • [32] Riva, D., Giorgi, C., The neurodevelopmental price of survival in children with malignant brain tumours. Childs Nerv. Syst. 16 (2000), 751–754.
    • (2000) Childs Nerv. Syst. , vol.16 , pp. 751-754
    • Riva, D.1    Giorgi, C.2
  • 33
    • 0033954127 scopus 로고    scopus 로고
    • Cognitive and academic outcome following cranial irradiation and chemotherapy in children: a longitudinal study
    • [33] Anderson, V.A., Godber, T., Smibert, E., Weiskop, S., Ekert, H., Cognitive and academic outcome following cranial irradiation and chemotherapy in children: a longitudinal study. Br. J. Cancer 82 (2000), 255–262.
    • (2000) Br. J. Cancer , vol.82 , pp. 255-262
    • Anderson, V.A.1    Godber, T.2    Smibert, E.3    Weiskop, S.4    Ekert, H.5
  • 34
    • 0020084198 scopus 로고
    • Assessment of the long-term effects of primary radiation therapy for brain tumors in children
    • [34] Danoff, B.F., Cowchock, F.S., Marquette, C., Mulgrew, L., Kramer, S., Assessment of the long-term effects of primary radiation therapy for brain tumors in children. Cancer 49 (1982), 1580–1586.
    • (1982) Cancer , vol.49 , pp. 1580-1586
    • Danoff, B.F.1    Cowchock, F.S.2    Marquette, C.3    Mulgrew, L.4    Kramer, S.5
  • 35
    • 3042777393 scopus 로고    scopus 로고
    • Late neurocognitive sequelae in survivors of brain tumours in childhood
    • [35] Mulhern, R.K., Merchant, T.E., Gajjar, A., Reddick, W.E., Kun, L.E., Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol. 5 (2004), 399–408.
    • (2004) Lancet Oncol. , vol.5 , pp. 399-408
    • Mulhern, R.K.1    Merchant, T.E.2    Gajjar, A.3    Reddick, W.E.4    Kun, L.E.5
  • 36
    • 75349083873 scopus 로고    scopus 로고
    • Risk factors for cognitive decline in children treated for brain tumors
    • [36] Duffner, P.K., Risk factors for cognitive decline in children treated for brain tumors. Eur. J. Paediatr. Neurol. 14 (2010), 106–115.
    • (2010) Eur. J. Paediatr. Neurol. , vol.14 , pp. 106-115
    • Duffner, P.K.1
  • 37
    • 0024504664 scopus 로고
    • Effects of radiation therapy on neuropsychological functioning in patients with nasopharyngeal carcinoma
    • [37] Lee, P.W., Hung, B.K., Woo, E.K., Tai, P.T., Choi, D.T., Effects of radiation therapy on neuropsychological functioning in patients with nasopharyngeal carcinoma. J. Neurol. Neurosurg. Psychiatry 52 (1989), 488–492.
    • (1989) J. Neurol. Neurosurg. Psychiatry , vol.52 , pp. 488-492
    • Lee, P.W.1    Hung, B.K.2    Woo, E.K.3    Tai, P.T.4    Choi, D.T.5
  • 38
    • 0028356814 scopus 로고
    • Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy
    • [38] Crossen, J.R., Garwood, D., Glatstein, E., Neuwelt, E.A., Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J. Clin. Oncol. 12 (1994), 627–642.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 627-642
    • Crossen, J.R.1    Garwood, D.2    Glatstein, E.3    Neuwelt, E.A.4
  • 39
    • 0028914873 scopus 로고
    • Neuropsychological effects of cranial radiation: current knowledge and future directions
    • [39] Roman, D.D., Sperduto, P.W., Neuropsychological effects of cranial radiation: current knowledge and future directions. Int. J. Radiat. Oncol. Biol. Phys. 31 (1995), 983–998.
    • (1995) Int. J. Radiat. Oncol. Biol. Phys. , vol.31 , pp. 983-998
    • Roman, D.D.1    Sperduto, P.W.2
  • 42
    • 0345476858 scopus 로고    scopus 로고
    • Radiotherapy of central nervous system tumors in young children: benefits and pitfalls
    • [42] Skowronska-Gardas, A., Radiotherapy of central nervous system tumors in young children: benefits and pitfalls. Med. Pediatr. Oncol. 33 (1999), 572–576.
    • (1999) Med. Pediatr. Oncol. , vol.33 , pp. 572-576
    • Skowronska-Gardas, A.1
  • 43
    • 2642510727 scopus 로고    scopus 로고
    • Neuropsychological dysfunction associated with cancer and cancer therapies: a conceptual review of an emerging target
    • [43] Wefel, J.S., Kayl, A.E., Meyers, C.A., Neuropsychological dysfunction associated with cancer and cancer therapies: a conceptual review of an emerging target. Br. J. Cancer 90 (2004), 1691–1696.
    • (2004) Br. J. Cancer , vol.90 , pp. 1691-1696
    • Wefel, J.S.1    Kayl, A.E.2    Meyers, C.A.3
  • 44
    • 0026115710 scopus 로고
    • A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Brain damage among the prenatally exposed
    • [44] Otake, M., Schull, W.J., Yoshimaru, H., A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Brain damage among the prenatally exposed. J. Radiat. Res. 32:Suppl (1991), 249–264.
    • (1991) J. Radiat. Res. , vol.32 , pp. 249-264
    • Otake, M.1    Schull, W.J.2    Yoshimaru, H.3
  • 45
    • 0000868231 scopus 로고
    • Etiology of ill-health in children born after maternal pelvic irradiation. II. Defective children born after postconception pelvic irradiation
    • [45] Goldstein, L., Murphy, D.P., Etiology of ill-health in children born after maternal pelvic irradiation. II. Defective children born after postconception pelvic irradiation. Am. J. Roentgenol. 22 (1929), 322–331.
    • (1929) Am. J. Roentgenol. , vol.22 , pp. 322-331
    • Goldstein, L.1    Murphy, D.P.2
  • 46
    • 84865575181 scopus 로고    scopus 로고
    • Cerebrovascular disease and mechanisms of cognitive impairment: evidence from clinicopathological studies in humans
    • [46] Kalaria, R.N., Cerebrovascular disease and mechanisms of cognitive impairment: evidence from clinicopathological studies in humans. Stroke 43 (2012), 2526–2534.
    • (2012) Stroke , vol.43 , pp. 2526-2534
    • Kalaria, R.N.1
  • 47
    • 0026686226 scopus 로고
    • Studies of the mortality of A-bomb survivors. 9. Mortality 1950–1985: part 3. Noncancer mortality based on the revised doses (DS86)
    • [47] Shimizu, Y., Kato, H., Schull, W.J., Hoel, D.G., Studies of the mortality of A-bomb survivors. 9. Mortality 1950–1985: part 3. Noncancer mortality based on the revised doses (DS86). Radiat. Res. 130 (1992), 249–266.
    • (1992) Radiat. Res. , vol.130 , pp. 249-266
    • Shimizu, Y.1    Kato, H.2    Schull, W.J.3    Hoel, D.G.4
  • 48
    • 0032853329 scopus 로고    scopus 로고
    • Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950–1990
    • [48] Shimizu, Y., Pierce, D.A., Preston, D.L., Mabuchi, K., Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950–1990. Radiat. Res. 152 (1999), 374–389.
    • (1999) Radiat. Res. , vol.152 , pp. 374-389
    • Shimizu, Y.1    Pierce, D.A.2    Preston, D.L.3    Mabuchi, K.4
  • 53
    • 58149240065 scopus 로고    scopus 로고
    • Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers
    • [53] Muirhead, C.R., O'Hagan, J.A., Haylock, R.G., Phillipson, M.A., Willcock, T., Berridge, G.L., Zhang, W., Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br. J. Cancer 100 (2009), 206–212.
    • (2009) Br. J. Cancer , vol.100 , pp. 206-212
    • Muirhead, C.R.1    O'Hagan, J.A.2    Haylock, R.G.3    Phillipson, M.A.4    Willcock, T.5    Berridge, G.L.6    Zhang, W.7
  • 55
    • 0023152383 scopus 로고
    • Long term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis
    • [55] Darby, S.C., Doll, R., Gill, S.K., Smith, P.G., Long term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis. Br. J. Cancer 55 (1987), 179–190.
    • (1987) Br. J. Cancer , vol.55 , pp. 179-190
    • Darby, S.C.1    Doll, R.2    Gill, S.K.3    Smith, P.G.4
  • 56
    • 84858134328 scopus 로고    scopus 로고
    • Mental health consequences of the Chernobyl disaster
    • [56] Bromet, E.J., Mental health consequences of the Chernobyl disaster. J. Radiol. Prot. 32 (2012), N71–75.
    • (2012) J. Radiol. Prot. , vol.32 , pp. N71-75
    • Bromet, E.J.1
  • 57
    • 84872693923 scopus 로고    scopus 로고
    • Cosmic radiation may cause dementia
    • [57] Kurien, B.T., Cosmic radiation may cause dementia. BMJ, 346, 2013, f225.
    • (2013) BMJ , vol.346 , pp. f225
    • Kurien, B.T.1
  • 58
    • 84874381808 scopus 로고    scopus 로고
    • Long-term effects of ionising radiation on the brain: cause for concern?
    • [58] Kempf, S.J., Azimzadeh, O., Atkinson, M.J., Tapio, S., Long-term effects of ionising radiation on the brain: cause for concern?. Radiat. Environ. Biophys. 52 (2013), 5–16.
    • (2013) Radiat. Environ. Biophys. , vol.52 , pp. 5-16
    • Kempf, S.J.1    Azimzadeh, O.2    Atkinson, M.J.3    Tapio, S.4
  • 60
    • 84871733794 scopus 로고    scopus 로고
    • Galactic cosmic radiation leads to cognitive impairment and increased abeta plaque accumulation in a mouse model of Alzheimer's disease
    • [60] Cherry, J.D., Liu, B., Frost, J.L., Lemere, C.A., Williams, J.P., Olschowka, J.A., O'Banion, M.K., Galactic cosmic radiation leads to cognitive impairment and increased abeta plaque accumulation in a mouse model of Alzheimer's disease. PLoS One, 7, 2012, e53275.
    • (2012) PLoS One , vol.7 , pp. e53275
    • Cherry, J.D.1    Liu, B.2    Frost, J.L.3    Lemere, C.A.4    Williams, J.P.5    Olschowka, J.A.6    O'Banion, M.K.7
  • 61
    • 84963579466 scopus 로고    scopus 로고
    • Ion mobility-enhanced MS(E)-based label-free analysis reveals effects of low-dose radiation post contextual fear conditioning training on the mouse hippocampal proteome
    • [61] Huang, L., Wickramasekara, S.I., Akinyeke, T., Stewart, B.S., Jiang, Y., Raber, J., Maier, C.S., Ion mobility-enhanced MS(E)-based label-free analysis reveals effects of low-dose radiation post contextual fear conditioning training on the mouse hippocampal proteome. J. Proteomics 140 (2016), 24–36.
    • (2016) J. Proteomics , vol.140 , pp. 24-36
    • Huang, L.1    Wickramasekara, S.I.2    Akinyeke, T.3    Stewart, B.S.4    Jiang, Y.5    Raber, J.6    Maier, C.S.7
  • 62
    • 84895926485 scopus 로고    scopus 로고
    • Proteomics in radiation research: present status and future perspectives
    • [62] Azimzadeh, O., Atkinson, M.J., Tapio, S., Proteomics in radiation research: present status and future perspectives. Radiat. Environ. Biophys. 53 (2014), 31–38.
    • (2014) Radiat. Environ. Biophys. , vol.53 , pp. 31-38
    • Azimzadeh, O.1    Atkinson, M.J.2    Tapio, S.3
  • 63
    • 84896764678 scopus 로고    scopus 로고
    • Radiation proteomics: a brief overview
    • [63] Leszczynski, D., Radiation proteomics: a brief overview. Proteomics 14 (2014), 481–488.
    • (2014) Proteomics , vol.14 , pp. 481-488
    • Leszczynski, D.1
  • 64
    • 33846518931 scopus 로고    scopus 로고
    • Radiation response of neural precursor cells
    • (x)
    • [64] Fike, J.R., Rola, R., Limoli, C.L., Radiation response of neural precursor cells. Neurosurg. Clin. N. Am. 18 (2007), 115–127 (x).
    • (2007) Neurosurg. Clin. N. Am. , vol.18 , pp. 115-127
    • Fike, J.R.1    Rola, R.2    Limoli, C.L.3
  • 65
    • 60649107163 scopus 로고    scopus 로고
    • Neural precursor cells and central nervous system radiation sensitivity
    • [65] Fike, J.R., Rosi, S., Limoli, C.L., Neural precursor cells and central nervous system radiation sensitivity. Semin. Radiat. Oncol. 19 (2009), 122–132.
    • (2009) Semin. Radiat. Oncol. , vol.19 , pp. 122-132
    • Fike, J.R.1    Rosi, S.2    Limoli, C.L.3
  • 68
    • 0036178613 scopus 로고    scopus 로고
    • NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure
    • [68] McBride, W.H., Pajonk, F., Chiang, C.S., Sun, J.R., NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure. Mil. Med. 167 (2002), 66–67.
    • (2002) Mil. Med. , vol.167 , pp. 66-67
    • McBride, W.H.1    Pajonk, F.2    Chiang, C.S.3    Sun, J.R.4
  • 72
    • 0033398652 scopus 로고    scopus 로고
    • An experimental study of radiation-induced cognitive dysfunction in an adult rat model
    • [72] Yoneoka, Y., Satoh, M., Akiyama, K., Sano, K., Fujii, Y., Tanaka, R., An experimental study of radiation-induced cognitive dysfunction in an adult rat model. Br. J. Radiol. 72 (1999), 1196–1201.
    • (1999) Br. J. Radiol. , vol.72 , pp. 1196-1201
    • Yoneoka, Y.1    Satoh, M.2    Akiyama, K.3    Sano, K.4    Fujii, Y.5    Tanaka, R.6
  • 73
    • 34249792386 scopus 로고    scopus 로고
    • Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: a potential rat model of vascular dementia
    • [73] Brown, W.R., Blair, R.M., Moody, D.M., Thore, C.R., Ahmed, S., Robbins, M.E., Wheeler, K.T., Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: a potential rat model of vascular dementia. J. Neurol. Sci. 257 (2007), 67–71.
    • (2007) J. Neurol. Sci. , vol.257 , pp. 67-71
    • Brown, W.R.1    Blair, R.M.2    Moody, D.M.3    Thore, C.R.4    Ahmed, S.5    Robbins, M.E.6    Wheeler, K.T.7
  • 75
    • 84862908289 scopus 로고    scopus 로고
    • Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia
    • [75] Warrington, J.P., Csiszar, A., Mitschelen, M., Lee, Y.W., Sonntag, W.E., Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia. PLoS One, 7, 2012, e30444.
    • (2012) PLoS One , vol.7 , pp. e30444
    • Warrington, J.P.1    Csiszar, A.2    Mitschelen, M.3    Lee, Y.W.4    Sonntag, W.E.5
  • 77
    • 0029959333 scopus 로고    scopus 로고
    • In utero exposure to low-doses of ionizing radiation decelerates neuronal migration in the developing rat brain
    • [77] Fushiki, S., Matsushita, K., Yoshioka, H., Schull, W.J., In utero exposure to low-doses of ionizing radiation decelerates neuronal migration in the developing rat brain. Int. J. Radiat. Biol. 70 (1996), 53–60.
    • (1996) Int. J. Radiat. Biol. , vol.70 , pp. 53-60
    • Fushiki, S.1    Matsushita, K.2    Yoshioka, H.3    Schull, W.J.4
  • 80
    • 79953331219 scopus 로고    scopus 로고
    • A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates
    • [80] Robbins, M.E., Bourland, J.D., Cline, J.M., Wheeler, K.T., Deadwyler, S.A., A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Radiat. Res. 175 (2011), 519–525.
    • (2011) Radiat. Res. , vol.175 , pp. 519-525
    • Robbins, M.E.1    Bourland, J.D.2    Cline, J.M.3    Wheeler, K.T.4    Deadwyler, S.A.5
  • 81
    • 84865197231 scopus 로고    scopus 로고
    • Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets
    • [81] Lee, Y.W., Cho, H.J., Lee, W.H., Sonntag, W.E., Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets. Biomol. Ther. (Seoul) 20 (2012), 357–370.
    • (2012) Biomol. Ther. (Seoul) , vol.20 , pp. 357-370
    • Lee, Y.W.1    Cho, H.J.2    Lee, W.H.3    Sonntag, W.E.4
  • 82
    • 84877096168 scopus 로고    scopus 로고
    • Molecular pathways: radiation-induced cognitive impairment
    • [82] Greene-Schloesser, D., Moore, E., Robbins, M.E., Molecular pathways: radiation-induced cognitive impairment. Clin. Cancer Res. 19 (2013), 2294–2300.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2294-2300
    • Greene-Schloesser, D.1    Moore, E.2    Robbins, M.E.3
  • 83
    • 15544370150 scopus 로고    scopus 로고
    • Adult neurogenesis: from precursors to network and physiology
    • [83] Abrous, D.N., Koehl, M., Le Moal, M., Adult neurogenesis: from precursors to network and physiology. Physiol. Rev. 85 (2005), 523–569.
    • (2005) Physiol. Rev. , vol.85 , pp. 523-569
    • Abrous, D.N.1    Koehl, M.2    Le Moal, M.3
  • 84
    • 33644507720 scopus 로고    scopus 로고
    • Adult neurogenesis and functional plasticity in neuronal circuits
    • [84] Lledo, P.M., Alonso, M., Grubb, M.S., Adult neurogenesis and functional plasticity in neuronal circuits. Nat. Rev. Neurosci. 7 (2006), 179–193.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 179-193
    • Lledo, P.M.1    Alonso, M.2    Grubb, M.S.3
  • 85
    • 0038182466 scopus 로고    scopus 로고
    • Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
    • [85] Madsen, T.M., Kristjansen, P.E., Bolwig, T.G., Wortwein, G., Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 119 (2003), 635–642.
    • (2003) Neuroscience , vol.119 , pp. 635-642
    • Madsen, T.M.1    Kristjansen, P.E.2    Bolwig, T.G.3    Wortwein, G.4
  • 86
    • 3843075154 scopus 로고    scopus 로고
    • Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    • [86] Raber, J., Rola, R., LeFevour, A., Morhardt, D., Curley, J., Mizumatsu, S., VandenBerg, S.R., Fike, J.R., Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat. Res. 162 (2004), 39–47.
    • (2004) Radiat. Res. , vol.162 , pp. 39-47
    • Raber, J.1    Rola, R.2    LeFevour, A.3    Morhardt, D.4    Curley, J.5    Mizumatsu, S.6    VandenBerg, S.R.7    Fike, J.R.8
  • 87
    • 11844289586 scopus 로고    scopus 로고
    • A role for adult neurogenesis in spatial long-term memory
    • [87] Snyder, J.S., Hong, N.S., McDonald, R.J., Wojtowicz, J.M., A role for adult neurogenesis in spatial long-term memory. Neuroscience 130 (2005), 843–852.
    • (2005) Neuroscience , vol.130 , pp. 843-852
    • Snyder, J.S.1    Hong, N.S.2    McDonald, R.J.3    Wojtowicz, J.M.4
  • 88
    • 52249094171 scopus 로고    scopus 로고
    • Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis
    • [88] Kim, J.S., Lee, H.J., Kim, J.C., Kang, S.S., Bae, C.S., Shin, T., Jin, J.K., Kim, S.H., Wang, H., Moon, C., Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. J. Radiat. Res. 49 (2008), 517–526.
    • (2008) J. Radiat. Res. , vol.49 , pp. 517-526
    • Kim, J.S.1    Lee, H.J.2    Kim, J.C.3    Kang, S.S.4    Bae, C.S.5    Shin, T.6    Jin, J.K.7    Kim, S.H.8    Wang, H.9    Moon, C.10
  • 89
    • 3042799716 scopus 로고    scopus 로고
    • Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    • [89] Rola, R., Raber, J., Rizk, A., Otsuka, S., VandenBerg, S.R., Morhardt, D.R., Fike, J.R., Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp. Neurol. 188 (2004), 316–330.
    • (2004) Exp. Neurol. , vol.188 , pp. 316-330
    • Rola, R.1    Raber, J.2    Rizk, A.3    Otsuka, S.4    VandenBerg, S.R.5    Morhardt, D.R.6    Fike, J.R.7
  • 91
    • 0035861386 scopus 로고    scopus 로고
    • The hippocampus and declarative memory: cognitive mechanisms and neural codes
    • [91] Eichenbaum, H., The hippocampus and declarative memory: cognitive mechanisms and neural codes. Behav. Brain Res. 127 (2001), 199–207.
    • (2001) Behav. Brain Res. , vol.127 , pp. 199-207
    • Eichenbaum, H.1
  • 92
    • 33645096734 scopus 로고    scopus 로고
    • Inhibition of neurogenesis interferes with hippocampus-dependent memory function
    • [92] Winocur, G., Wojtowicz, J.M., Sekeres, M., Snyder, J.S., Wang, S., Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16 (2006), 296–304.
    • (2006) Hippocampus , vol.16 , pp. 296-304
    • Winocur, G.1    Wojtowicz, J.M.2    Sekeres, M.3    Snyder, J.S.4    Wang, S.5
  • 93
    • 84930615910 scopus 로고    scopus 로고
    • Development of the adult neurogenic niche in the hippocampus of mice
    • [93] Nicola, Z., Fabel, K., Kempermann, G., Development of the adult neurogenic niche in the hippocampus of mice. Front. Neuroanat., 9, 2015, 53.
    • (2015) Front. Neuroanat. , vol.9 , pp. 53
    • Nicola, Z.1    Fabel, K.2    Kempermann, G.3
  • 96
    • 0009711059 scopus 로고    scopus 로고
    • Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus
    • [96] Peissner, W., Kocher, M., Treuer, H., Gillardon, F., Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Res. Mol. Brain Res. 71 (1999), 61–68.
    • (1999) Brain Res. Mol. Brain Res. , vol.71 , pp. 61-68
    • Peissner, W.1    Kocher, M.2    Treuer, H.3    Gillardon, F.4
  • 97
    • 33846582416 scopus 로고    scopus 로고
    • Unraveling the fundamental molecular mechanisms of morphological and cognitive defects in the irradiated brain
    • [97] Verheyde, J., Benotmane, M.A., Unraveling the fundamental molecular mechanisms of morphological and cognitive defects in the irradiated brain. Brain Res. Rev. 53 (2007), 312–320.
    • (2007) Brain Res. Rev. , vol.53 , pp. 312-320
    • Verheyde, J.1    Benotmane, M.A.2
  • 98
    • 0029925149 scopus 로고    scopus 로고
    • Apoptosis is induced in the subependyma of young adult rats by ionizing irradiation
    • [98] Bellinzona, M., Gobbel, G.T., Shinohara, C., Fike, J.R., Apoptosis is induced in the subependyma of young adult rats by ionizing irradiation. Neurosci. Lett. 208 (1996), 163–166.
    • (1996) Neurosci. Lett. , vol.208 , pp. 163-166
    • Bellinzona, M.1    Gobbel, G.T.2    Shinohara, C.3    Fike, J.R.4
  • 99
    • 0036735783 scopus 로고    scopus 로고
    • Irradiation induces neural precursor-cell dysfunction
    • [99] Monje, M.L., Mizumatsu, S., Fike, J.R., Palmer, T.D., Irradiation induces neural precursor-cell dysfunction. Nat. Med. 8 (2002), 955–962.
    • (2002) Nat. Med. , vol.8 , pp. 955-962
    • Monje, M.L.1    Mizumatsu, S.2    Fike, J.R.3    Palmer, T.D.4
  • 100
  • 101
    • 0034718139 scopus 로고    scopus 로고
    • X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats
    • [101] Tada, E., Parent, J.M., Lowenstein, D.H., Fike, J.R., X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 99 (2000), 33–41.
    • (2000) Neuroscience , vol.99 , pp. 33-41
    • Tada, E.1    Parent, J.M.2    Lowenstein, D.H.3    Fike, J.R.4
  • 102
    • 0030907041 scopus 로고    scopus 로고
    • Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
    • [102] Parent, J.M., Yu, T.W., Leibowitz, R.T., Geschwind, D.H., Sloviter, R.S., Lowenstein, D.H., Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 17 (1997), 3727–3738.
    • (1997) J. Neurosci. , vol.17 , pp. 3727-3738
    • Parent, J.M.1    Yu, T.W.2    Leibowitz, R.T.3    Geschwind, D.H.4    Sloviter, R.S.5    Lowenstein, D.H.6
  • 103
    • 84863386463 scopus 로고    scopus 로고
    • Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain
    • [103] Lee, W.H., Warrington, J.P., Sonntag, W.E., Lee, Y.W., Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain. Int. J. Radiat. Oncol. Biol. Phys. 82 (2012), 1559–1566.
    • (2012) Int. J. Radiat. Oncol. Biol. Phys. , vol.82 , pp. 1559-1566
    • Lee, W.H.1    Warrington, J.P.2    Sonntag, W.E.3    Lee, Y.W.4
  • 104
    • 84873877145 scopus 로고    scopus 로고
    • Neurobiological toxicity of radiation in hippocampal cells
    • [104] Kim, J.S., Yang, M., Kim, S.H., Shin, T., Moon, C., Neurobiological toxicity of radiation in hippocampal cells. Histol. Histopathol. 28 (2013), 301–310.
    • (2013) Histol. Histopathol. , vol.28 , pp. 301-310
    • Kim, J.S.1    Yang, M.2    Kim, S.H.3    Shin, T.4    Moon, C.5
  • 105
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • [105] Palmer, T.D., Willhoite, A.R., Gage, F.H., Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425 (2000), 479–494.
    • (2000) J. Comp. Neurol. , vol.425 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 106
    • 0028957769 scopus 로고
    • Evidence of internucleosomal DNA fragmentation and identification of dying cells in X-ray-induced cell death in the developing brain
    • [106] Ferrer, I., Macaya, A., Blanco, R., Olive, M., Cinos, C., Munell, F., Planas, A.M., Evidence of internucleosomal DNA fragmentation and identification of dying cells in X-ray-induced cell death in the developing brain. Int. J. Dev. Neurosci. 13 (1995), 21–28.
    • (1995) Int. J. Dev. Neurosci. , vol.13 , pp. 21-28
    • Ferrer, I.1    Macaya, A.2    Blanco, R.3    Olive, M.4    Cinos, C.5    Munell, F.6    Planas, A.M.7
  • 107
  • 108
    • 0030738416 scopus 로고    scopus 로고
    • Apoptosis in the subependyma of young adult rats after single and fractionated doses of X-rays
    • [108] Shinohara, C., Gobbel, G.T., Lamborn, K.R., Tada, E., Fike, J.R., Apoptosis in the subependyma of young adult rats after single and fractionated doses of X-rays. Cancer Res. 57 (1997), 2694–2702.
    • (1997) Cancer Res. , vol.57 , pp. 2694-2702
    • Shinohara, C.1    Gobbel, G.T.2    Lamborn, K.R.3    Tada, E.4    Fike, J.R.5
  • 111
    • 0021189273 scopus 로고
    • Radiosensitivity of vascular tissue. I. Differential radiosensitivity of capillaries: a quantitative in vivo study
    • [111] Dimitrievich, G.S., Fischer-Dzoga, K., Griem, M.L., Radiosensitivity of vascular tissue. I. Differential radiosensitivity of capillaries: a quantitative in vivo study. Radiat. Res. 99 (1984), 511–535.
    • (1984) Radiat. Res. , vol.99 , pp. 511-535
    • Dimitrievich, G.S.1    Fischer-Dzoga, K.2    Griem, M.L.3
  • 112
    • 0024437527 scopus 로고
    • The response of the microvascular system to radiation: a review
    • [112] Baker, D.G., Krochak, R.J., The response of the microvascular system to radiation: a review. Cancer Invest. 7 (1989), 287–294.
    • (1989) Cancer Invest. , vol.7 , pp. 287-294
    • Baker, D.G.1    Krochak, R.J.2
  • 113
    • 0033046803 scopus 로고    scopus 로고
    • Early effects of ionizing radiation on the microvascular networks in normal tissue
    • [113] Roth, N.M., Sontag, M.R., Kiani, M.F., Early effects of ionizing radiation on the microvascular networks in normal tissue. Radiat. Res. 151 (1999), 270–277.
    • (1999) Radiat. Res. , vol.151 , pp. 270-277
    • Roth, N.M.1    Sontag, M.R.2    Kiani, M.F.3
  • 114
    • 0033773554 scopus 로고    scopus 로고
    • Late effects of ionizing radiation on the microvascular networks in normal tissue
    • [114] Nguyen, V., Gaber, M.W., Sontag, M.R., Kiani, M.F., Late effects of ionizing radiation on the microvascular networks in normal tissue. Radiat. Res. 154 (2000), 531–536.
    • (2000) Radiat. Res. , vol.154 , pp. 531-536
    • Nguyen, V.1    Gaber, M.W.2    Sontag, M.R.3    Kiani, M.F.4
  • 115
    • 0025991922 scopus 로고
    • Endothelial cell population dynamics in rat brain after local irradiation
    • [115] Ljubimova, N.V., Levitman, M.K., Plotnikova, E.D., Eidus, L., Endothelial cell population dynamics in rat brain after local irradiation. Br. J. Radiol. 64 (1991), 934–940.
    • (1991) Br. J. Radiol. , vol.64 , pp. 934-940
    • Ljubimova, N.V.1    Levitman, M.K.2    Plotnikova, E.D.3    Eidus, L.4
  • 116
    • 3042591060 scopus 로고    scopus 로고
    • Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury
    • [116] Lyubimova, N., Hopewell, J.W., Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury. Br. J. Radiol. 77 (2004), 488–492.
    • (2004) Br. J. Radiol. , vol.77 , pp. 488-492
    • Lyubimova, N.1    Hopewell, J.W.2
  • 117
    • 27444446186 scopus 로고    scopus 로고
    • Vascular damage after fractionated whole-brain irradiation in rats
    • [117] Brown, W.R., Thore, C.R., Moody, D.M., Robbins, M.E., Wheeler, K.T., Vascular damage after fractionated whole-brain irradiation in rats. Radiat. Res. 164 (2005), 662–668.
    • (2005) Radiat. Res. , vol.164 , pp. 662-668
    • Brown, W.R.1    Thore, C.R.2    Moody, D.M.3    Robbins, M.E.4    Wheeler, K.T.5
  • 119
    • 0141619303 scopus 로고    scopus 로고
    • Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation
    • [119] Li, Y.Q., Chen, P., Haimovitz-Friedman, A., Reilly, R.M., Wong, C.S., Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation. Cancer Res. 63 (2003), 5950–5956.
    • (2003) Cancer Res. , vol.63 , pp. 5950-5956
    • Li, Y.Q.1    Chen, P.2    Haimovitz-Friedman, A.3    Reilly, R.M.4    Wong, C.S.5
  • 122
    • 17844367103 scopus 로고    scopus 로고
    • Molecular targets in radiation-induced blood-brain barrier disruption
    • [122] Nordal, R.A., Wong, C.S., Molecular targets in radiation-induced blood-brain barrier disruption. Int. J. Radiat. Oncol. Biol. Phys. 62 (2005), 279–287.
    • (2005) Int. J. Radiat. Oncol. Biol. Phys. , vol.62 , pp. 279-287
    • Nordal, R.A.1    Wong, C.S.2
  • 123
    • 0032936851 scopus 로고    scopus 로고
    • The cell biology of the blood-brain barrier
    • [123] Rubin, L.L., Staddon, J.M., The cell biology of the blood-brain barrier. Annu. Rev. Neurosci. 22 (1999), 11–28.
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 11-28
    • Rubin, L.L.1    Staddon, J.M.2
  • 124
    • 82955239892 scopus 로고    scopus 로고
    • Radiation attenuates physiological angiogenesis by differential expression of VEGF Ang-1, tie-2 and Ang-2 in rat brain
    • [124] Lee, W.H., Cho, H.J., Sonntag, W.E., Lee, Y.W., Radiation attenuates physiological angiogenesis by differential expression of VEGF Ang-1, tie-2 and Ang-2 in rat brain. Radiat. Res. 176 (2011), 753–760.
    • (2011) Radiat. Res. , vol.176 , pp. 753-760
    • Lee, W.H.1    Cho, H.J.2    Sonntag, W.E.3    Lee, Y.W.4
  • 125
    • 84881100953 scopus 로고    scopus 로고
    • Cranial irradiation compromises neuronal architecture in the hippocampus
    • [125] Parihar, V.K., Limoli, C.L., Cranial irradiation compromises neuronal architecture in the hippocampus. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 12822–12827.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 12822-12827
    • Parihar, V.K.1    Limoli, C.L.2
  • 126
    • 0025801548 scopus 로고
    • Dendritic and synaptic pathology in mental retardation
    • [126] Huttenlocher, P.R., Dendritic and synaptic pathology in mental retardation. Pediatr. Neurol. 7 (1991), 79–85.
    • (1991) Pediatr. Neurol. , vol.7 , pp. 79-85
    • Huttenlocher, P.R.1
  • 128
    • 0019494341 scopus 로고
    • Some morphometric aspects of the brain in senile dementia of the Alzheimer type
    • [128] Terry, R.D., Peck, A., DeTeresa, R., Schechter, R., Horoupian, D.S., Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann. Neurol. 10 (1981), 184–192.
    • (1981) Ann. Neurol. , vol.10 , pp. 184-192
    • Terry, R.D.1    Peck, A.2    DeTeresa, R.3    Schechter, R.4    Horoupian, D.S.5
  • 129
    • 0033797735 scopus 로고    scopus 로고
    • Dendritic anomalies in disorders associated with mental retardation
    • [129] Kaufmann, W.E., Moser, H.W., Dendritic anomalies in disorders associated with mental retardation. Cereb. Cortex 10 (2000), 981–991.
    • (2000) Cereb. Cortex , vol.10 , pp. 981-991
    • Kaufmann, W.E.1    Moser, H.W.2
  • 130
    • 84892468738 scopus 로고    scopus 로고
    • Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation
    • [130] Parihar, V.K., Pasha, J., Tran, K.K., Craver, B.M., Acharya, M.M., Limoli, C.L., Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation. Brain Struct. Funct. 220 (2015), 1161–1171.
    • (2015) Brain Struct. Funct. , vol.220 , pp. 1161-1171
    • Parihar, V.K.1    Pasha, J.2    Tran, K.K.3    Craver, B.M.4    Acharya, M.M.5    Limoli, C.L.6
  • 131
    • 84864023887 scopus 로고    scopus 로고
    • Cranial irradiation alters dendritic spine density and morphology in the hippocampus
    • [131] Chakraborti, A., Allen, A., Allen, B., Rosi, S., Fike, J.R., Cranial irradiation alters dendritic spine density and morphology in the hippocampus. PLoS One, 7, 2012, e40844.
    • (2012) PLoS One , vol.7 , pp. e40844
    • Chakraborti, A.1    Allen, A.2    Allen, B.3    Rosi, S.4    Fike, J.R.5
  • 132
    • 0036323447 scopus 로고    scopus 로고
    • MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction
    • [132] Harada, A., Teng, J., Takei, Y., Oguchi, K., Hirokawa, N., MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J. Cell Biol. 158 (2002), 541–549.
    • (2002) J. Cell Biol. , vol.158 , pp. 541-549
    • Harada, A.1    Teng, J.2    Takei, Y.3    Oguchi, K.4    Hirokawa, N.5
  • 133
    • 80052161487 scopus 로고    scopus 로고
    • Loss of PSD-95 enrichment is not a prerequisite for spine retraction
    • [133] Woods, G.F., Oh, W.C., Boudewyn, L.C., Mikula, S.K., Zito, K., Loss of PSD-95 enrichment is not a prerequisite for spine retraction. J. Neurosci. 31 (2011), 12129–12138.
    • (2011) J. Neurosci. , vol.31 , pp. 12129-12138
    • Woods, G.F.1    Oh, W.C.2    Boudewyn, L.C.3    Mikula, S.K.4    Zito, K.5
  • 134
    • 57149094240 scopus 로고    scopus 로고
    • Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein)
    • [134] Rosi, S., Andres-Mach, M., Fishman, K.M., Levy, W., Ferguson, R.A., Fike, J.R., Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein). Cancer Res. 68 (2008), 9763–9770.
    • (2008) Cancer Res. , vol.68 , pp. 9763-9770
    • Rosi, S.1    Andres-Mach, M.2    Fishman, K.M.3    Levy, W.4    Ferguson, R.A.5    Fike, J.R.6
  • 135
    • 0034995459 scopus 로고    scopus 로고
    • Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus
    • [135] Snyder, J.S., Kee, N., Wojtowicz, J.M., Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J. Neurophysiol. 85 (2001), 2423–2431.
    • (2001) J. Neurophysiol. , vol.85 , pp. 2423-2431
    • Snyder, J.S.1    Kee, N.2    Wojtowicz, J.M.3
  • 137
    • 84934442052 scopus 로고    scopus 로고
    • Ionizing radiation effects on cells, organelles and tissues on proteome level
    • [137] Tapio, S., Ionizing radiation effects on cells, organelles and tissues on proteome level. Adv. Exp. Med. Biol. 990 (2013), 37–48.
    • (2013) Adv. Exp. Med. Biol. , vol.990 , pp. 37-48
    • Tapio, S.1
  • 138
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • [138] Markesbery, W.R., Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23 (1997), 134–147.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 139
    • 57649155208 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance
    • [139] Zhou, C., Huang, Y., Przedborski, S., Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann. N. Y. Acad. Sci. 1147 (2008), 93–104.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 93-104
    • Zhou, C.1    Huang, Y.2    Przedborski, S.3
  • 140
    • 0027490317 scopus 로고
    • Radiation-induced astrocytic and microglial responses in mouse brain
    • [140] Chiang, C.S., McBride, W.H., Withers, H.R., Radiation-induced astrocytic and microglial responses in mouse brain. Radiother. Oncol. 29 (1993), 60–68.
    • (1993) Radiother. Oncol. , vol.29 , pp. 60-68
    • Chiang, C.S.1    McBride, W.H.2    Withers, H.R.3
  • 142
    • 77249171256 scopus 로고    scopus 로고
    • Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain
    • [142] Lee, W.H., Sonntag, W.E., Mitschelen, M., Yan, H., Lee, Y.W., Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain. Int. J. Radiat. Biol. 86 (2010), 132–144.
    • (2010) Int. J. Radiat. Biol. , vol.86 , pp. 132-144
    • Lee, W.H.1    Sonntag, W.E.2    Mitschelen, M.3    Yan, H.4    Lee, Y.W.5
  • 143
    • 0033103773 scopus 로고    scopus 로고
    • TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury
    • [143] Kyrkanides, S., Olschowka, J.A., Williams, J.P., Hansen, J.T., O'Banion, M.K., TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury. J. Neuroimmunol. 95 (1999), 95–106.
    • (1999) J. Neuroimmunol. , vol.95 , pp. 95-106
    • Kyrkanides, S.1    Olschowka, J.A.2    Williams, J.P.3    Hansen, J.T.4    O'Banion, M.K.5
  • 144
    • 56349166510 scopus 로고    scopus 로고
    • PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways
    • [144] Ramanan, S., Kooshki, M., Zhao, W., Hsu, F.C., Robbins, M.E., PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. Free Radic. Biol. Med. 45 (2008), 1695–1704.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 1695-1704
    • Ramanan, S.1    Kooshki, M.2    Zhao, W.3    Hsu, F.C.4    Robbins, M.E.5
  • 145
    • 0042170274 scopus 로고    scopus 로고
    • Differences in ICAM-1 and TNF-alpha expression between large single fraction and fractionated irradiation in mouse brain
    • [145] Gaber, M.W., Sabek, O.M., Fukatsu, K., Wilcox, H.G., Kiani, M.F., Merchant, T.E., Differences in ICAM-1 and TNF-alpha expression between large single fraction and fractionated irradiation in mouse brain. Int. J. Radiat. Biol. 79 (2003), 359–366.
    • (2003) Int. J. Radiat. Biol. , vol.79 , pp. 359-366
    • Gaber, M.W.1    Sabek, O.M.2    Fukatsu, K.3    Wilcox, H.G.4    Kiani, M.F.5    Merchant, T.E.6
  • 146
    • 33845362722 scopus 로고    scopus 로고
    • Adhesion molecules in radiotherapy
    • [146] Baluna, R.G., Eng, T.Y., Thomas, C.R., Adhesion molecules in radiotherapy. Radiat. Res. 166 (2006), 819–831.
    • (2006) Radiat. Res. , vol.166 , pp. 819-831
    • Baluna, R.G.1    Eng, T.Y.2    Thomas, C.R.3
  • 148
    • 0036283219 scopus 로고    scopus 로고
    • The radiotherapeutic injury–a complex ‘wound’
    • [148] Denham, J.W., Hauer-Jensen, M., The radiotherapeutic injury–a complex ‘wound’. Radiother. Oncol. 63 (2002), 129–145.
    • (2002) Radiother. Oncol. , vol.63 , pp. 129-145
    • Denham, J.W.1    Hauer-Jensen, M.2
  • 150
    • 79959760367 scopus 로고    scopus 로고
    • AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain
    • [150] Conner, K.R., Forbes, M.E., Lee, W.H., Lee, Y.W., Riddle, D.R., AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain. Radiat. Res. 176 (2011), 71–83.
    • (2011) Radiat. Res. , vol.176 , pp. 71-83
    • Conner, K.R.1    Forbes, M.E.2    Lee, W.H.3    Lee, Y.W.4    Riddle, D.R.5
  • 152
    • 80053255939 scopus 로고    scopus 로고
    • Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain
    • [152] Moravan, M.J., Olschowka, J.A., Williams, J.P., O'Banion, M.K., Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat. Res. 176 (2011), 459–473.
    • (2011) Radiat. Res. , vol.176 , pp. 459-473
    • Moravan, M.J.1    Olschowka, J.A.2    Williams, J.P.3    O'Banion, M.K.4
  • 154
    • 80051967142 scopus 로고    scopus 로고
    • Concise review: stem cell effects in radiation risk
    • [154] Prise, K.M., Saran, A., Concise review: stem cell effects in radiation risk. Stem Cells 29 (2011), 1315–1321.
    • (2011) Stem Cells , vol.29 , pp. 1315-1321
    • Prise, K.M.1    Saran, A.2
  • 155
    • 84876978226 scopus 로고    scopus 로고
    • Selective inhibition of microglia-mediated neuroinflammation mitigates radiation-induced cognitive impairment
    • [155] Jenrow, K.A., Brown, S.L., Lapanowski, K., Naei, H., Kolozsvary, A., Kim, J.H., Selective inhibition of microglia-mediated neuroinflammation mitigates radiation-induced cognitive impairment. Radiat. Res. 179 (2013), 549–556.
    • (2013) Radiat. Res. , vol.179 , pp. 549-556
    • Jenrow, K.A.1    Brown, S.L.2    Lapanowski, K.3    Naei, H.4    Kolozsvary, A.5    Kim, J.H.6
  • 156
    • 37349127393 scopus 로고    scopus 로고
    • Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies
    • [156] Monje, M.L., Vogel, H., Masek, M., Ligon, K.L., Fisher, P.G., Palmer, T.D., Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies. Ann. Neurol. 62 (2007), 515–520.
    • (2007) Ann. Neurol. , vol.62 , pp. 515-520
    • Monje, M.L.1    Vogel, H.2    Masek, M.3    Ligon, K.L.4    Fisher, P.G.5    Palmer, T.D.6
  • 157
    • 84882737277 scopus 로고    scopus 로고
    • Effects of ionizing radiation on mitochondria
    • [157] Kam, W.W., Banati, R.B., Effects of ionizing radiation on mitochondria. Free Radic. Biol. Med. 65 (2013), 607–619.
    • (2013) Free Radic. Biol. Med. , vol.65 , pp. 607-619
    • Kam, W.W.1    Banati, R.B.2
  • 158
    • 84867483822 scopus 로고    scopus 로고
    • Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
    • [158] Azzam, E.I., Jay-Gerin, J.P., Pain, D., Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett. 327 (2012), 48–60.
    • (2012) Cancer Lett. , vol.327 , pp. 48-60
    • Azzam, E.I.1    Jay-Gerin, J.P.2    Pain, D.3
  • 159
    • 0034174681 scopus 로고    scopus 로고
    • Radiation response of cell organelles
    • [159] Somosy, Z., Radiation response of cell organelles. Micron 31 (2000), 165–181.
    • (2000) Micron , vol.31 , pp. 165-181
    • Somosy, Z.1
  • 161
    • 78650071220 scopus 로고    scopus 로고
    • Mitochondria and neuroplasticity
    • [161] Cheng, A., Hou, Y., Mattson, M.P., Mitochondria and neuroplasticity. ASN Neuro, 2, 2010, e00045.
    • (2010) ASN Neuro , vol.2 , pp. e00045
    • Cheng, A.1    Hou, Y.2    Mattson, M.P.3
  • 162
    • 77956813407 scopus 로고    scopus 로고
    • Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo
    • [162] Voloboueva, L.A., Lee, S.W., Emery, J.F., Palmer, T.D., Giffard, R.G., Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo. J. Neurosci. 30 (2010), 12242–12251.
    • (2010) J. Neurosci. , vol.30 , pp. 12242-12251
    • Voloboueva, L.A.1    Lee, S.W.2    Emery, J.F.3    Palmer, T.D.4    Giffard, R.G.5
  • 164
    • 80053653782 scopus 로고    scopus 로고
    • Inflammation, mitochondria, and the inhibition of adult neurogenesis
    • [164] Voloboueva, L.A., Giffard, R.G., Inflammation, mitochondria, and the inhibition of adult neurogenesis. J. Neurosci. Res. 89 (2011), 1989–1996.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 1989-1996
    • Voloboueva, L.A.1    Giffard, R.G.2
  • 165
    • 84870540270 scopus 로고    scopus 로고
    • Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
    • [165] Mattson, M.P., Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metab. 16 (2012), 706–722.
    • (2012) Cell Metab. , vol.16 , pp. 706-722
    • Mattson, M.P.1
  • 166
    • 84929657075 scopus 로고    scopus 로고
    • Low-dose ionizing radiation rapidly affects mitochondrial and synaptic signaling pathways in murine hippocampus and cortex
    • [166] Kempf, S.J., Moertl, S., Sepe, S., von Toerne, C., Hauck, S.M., Atkinson, M.J., Mastroberardino, P.G., Tapio, S., Low-dose ionizing radiation rapidly affects mitochondrial and synaptic signaling pathways in murine hippocampus and cortex. J. Proteome Res. 14 (2015), 2055–2064.
    • (2015) J. Proteome Res. , vol.14 , pp. 2055-2064
    • Kempf, S.J.1    Moertl, S.2    Sepe, S.3    von Toerne, C.4    Hauck, S.M.5    Atkinson, M.J.6    Mastroberardino, P.G.7    Tapio, S.8
  • 167
    • 84946854664 scopus 로고    scopus 로고
    • Neonatal irradiation leads to persistent proteome alterations involved in synaptic plasticity in the mouse hippocampus and cortex
    • [167] Kempf, S.J., Sepe, S., von Toerne, C., Janik, D., Neff, F., Hauck, S.M., Atkinson, M.J., Mastroberardino, P.G., Tapio, S., Neonatal irradiation leads to persistent proteome alterations involved in synaptic plasticity in the mouse hippocampus and cortex. J. Proteome Res. 14 (2015), 4674–4686.
    • (2015) J. Proteome Res. , vol.14 , pp. 4674-4686
    • Kempf, S.J.1    Sepe, S.2    von Toerne, C.3    Janik, D.4    Neff, F.5    Hauck, S.M.6    Atkinson, M.J.7    Mastroberardino, P.G.8    Tapio, S.9
  • 169
    • 33644850757 scopus 로고    scopus 로고
    • Whole-brain radiotherapy in the management of brain metastasis
    • [169] Khuntia, D., Brown, P., Li, J., Mehta, M.P., Whole-brain radiotherapy in the management of brain metastasis. J. Clin. Oncol. 24 (2006), 1295–1304.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1295-1304
    • Khuntia, D.1    Brown, P.2    Li, J.3    Mehta, M.P.4
  • 170
    • 33644870352 scopus 로고    scopus 로고
    • Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors
    • [170] Meyers, C.A., Brown, P.D., Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors. J. Clin. Oncol. 24 (2006), 1305–1309.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1305-1309
    • Meyers, C.A.1    Brown, P.D.2
  • 171
    • 0028695963 scopus 로고
    • Cognitive impairment and quality of life in long-term survivors of malignant brain tumors
    • [171] Giovagnoli, A.R., Boiardi, A., Cognitive impairment and quality of life in long-term survivors of malignant brain tumors. Ital. J. Neurol. Sci. 15 (1994), 481–488.
    • (1994) Ital. J. Neurol. Sci. , vol.15 , pp. 481-488
    • Giovagnoli, A.R.1    Boiardi, A.2
  • 172
    • 0347355034 scopus 로고    scopus 로고
    • Phase II study of alpha-tocopherol in improving the cognitive function of patients with temporal lobe radionecrosis
    • [172] Chan, A.S., Cheung, M.C., Law, S.C., Chan, J.H., Phase II study of alpha-tocopherol in improving the cognitive function of patients with temporal lobe radionecrosis. Cancer 100 (2004), 398–404.
    • (2004) Cancer , vol.100 , pp. 398-404
    • Chan, A.S.1    Cheung, M.C.2    Law, S.C.3    Chan, J.H.4
  • 173
    • 79953064740 scopus 로고    scopus 로고
    • Gross morphometric reduction of rats’ cerebellum by gamma irradiation was mitigated by pretreatment with Vernonia amygdalina leaf extract
    • [173] Owoeye, O., Farombi, E.O., Onwuka, S.K., Gross morphometric reduction of rats’ cerebellum by gamma irradiation was mitigated by pretreatment with Vernonia amygdalina leaf extract. Rom. J. Morphol. Embryol. 52 (2011), 81–88.
    • (2011) Rom. J. Morphol. Embryol. , vol.52 , pp. 81-88
    • Owoeye, O.1    Farombi, E.O.2    Onwuka, S.K.3
  • 174
    • 33845973382 scopus 로고    scopus 로고
    • Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid
    • [174] Manda, K., Ueno, M., Moritake, T., Anzai, K., Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid. Behav. Brain Res. 177 (2007), 7–14.
    • (2007) Behav. Brain Res. , vol.177 , pp. 7-14
    • Manda, K.1    Ueno, M.2    Moritake, T.3    Anzai, K.4
  • 175
    • 0742270915 scopus 로고    scopus 로고
    • Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: an experimental study
    • [175] Erol, F.S., Topsakal, C., Ozveren, M.F., Kaplan, M., Ilhan, N., Ozercan, I.H., Yildiz, O.G., Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: an experimental study. Neurosurg. Rev. 27 (2004), 65–69.
    • (2004) Neurosurg. Rev. , vol.27 , pp. 65-69
    • Erol, F.S.1    Topsakal, C.2    Ozveren, M.F.3    Kaplan, M.4    Ilhan, N.5    Ozercan, I.H.6    Yildiz, O.G.7
  • 176
    • 1842577536 scopus 로고    scopus 로고
    • Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain
    • [176] Undeger, U., Giray, B., Zorlu, A.F., Oge, K., Bacaran, N., Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain. Exp. Toxicol. Pathol. 55 (2004), 379–384.
    • (2004) Exp. Toxicol. Pathol. , vol.55 , pp. 379-384
    • Undeger, U.1    Giray, B.2    Zorlu, A.F.3    Oge, K.4    Bacaran, N.5
  • 177
    • 34547107081 scopus 로고    scopus 로고
    • A radiobiological review on melatonin: a novel radioprotector
    • [177] Shirazi, A., Ghobadi, G., Ghazi-Khansari, M., A radiobiological review on melatonin: a novel radioprotector. J. Radiat. Res. 48 (2007), 263–272.
    • (2007) J. Radiat. Res. , vol.48 , pp. 263-272
    • Shirazi, A.1    Ghobadi, G.2    Ghazi-Khansari, M.3
  • 178
    • 49749088893 scopus 로고    scopus 로고
    • PPAR regulation of inflammatory signaling in CNS diseases
    • [178] Bright, J.J., Kanakasabai, S., Chearwae, W., Chakraborty, S., PPAR regulation of inflammatory signaling in CNS diseases. PPAR Res., 2008, 2008, 658520.
    • (2008) PPAR Res. , vol.2008 , pp. 658520
    • Bright, J.J.1    Kanakasabai, S.2    Chearwae, W.3    Chakraborty, S.4
  • 179
    • 43949146665 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: key regulators of neuroinflammation after traumatic brain injury
    • [179] Stahel, P.F., Smith, W.R., Bruchis, J., Rabb, C.H., Peroxisome proliferator-activated receptors: key regulators of neuroinflammation after traumatic brain injury. PPAR Res., 2008, 2008, 538141.
    • (2008) PPAR Res. , vol.2008 , pp. 538141
    • Stahel, P.F.1    Smith, W.R.2    Bruchis, J.3    Rabb, C.H.4
  • 180
    • 84868309553 scopus 로고    scopus 로고
    • Role of PPARs in radiation-induced brain injury
    • [180] Ramanan, S., Zhao, W., Riddle, D.R., Robbins, M.E., Role of PPARs in radiation-induced brain injury. PPAR Res., 2010, 2010, 234975.
    • (2010) PPAR Res. , vol.2010 , pp. 234975
    • Ramanan, S.1    Zhao, W.2    Riddle, D.R.3    Robbins, M.E.4
  • 181
    • 70349560028 scopus 로고    scopus 로고
    • The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation
    • [181] Ramanan, S., Kooshki, M., Zhao, W., Hsu, F.C., Riddle, D.R., Robbins, M.E., The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 75 (2009), 870–877.
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.75 , pp. 870-877
    • Ramanan, S.1    Kooshki, M.2    Zhao, W.3    Hsu, F.C.4    Riddle, D.R.5    Robbins, M.E.6
  • 182
    • 84893669763 scopus 로고    scopus 로고
    • The peroxisomal proliferator-activated receptor (PPAR) alpha agonist fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment
    • [182] Greene-Schloesser, D., Payne, V., Peiffer, A.M., Hsu, F.C., Riddle, D.R., Zhao, W., Chan, M.D., Metheny-Barlow, L., Robbins, M.E., The peroxisomal proliferator-activated receptor (PPAR) alpha agonist fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Radiat. Res. 181 (2014), 33–44.
    • (2014) Radiat. Res. , vol.181 , pp. 33-44
    • Greene-Schloesser, D.1    Payne, V.2    Peiffer, A.M.3    Hsu, F.C.4    Riddle, D.R.5    Zhao, W.6    Chan, M.D.7    Metheny-Barlow, L.8    Robbins, M.E.9
  • 183
    • 33845604482 scopus 로고    scopus 로고
    • Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment
    • [183] Zhao, W., Payne, V., Tommasi, E., Diz, D.I., Hsu, F.C., Robbins, M.E., Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment. Int. J. Radiat. Oncol. Biol. Phys. 67 (2007), 6–9.
    • (2007) Int. J. Radiat. Oncol. Biol. Phys. , vol.67 , pp. 6-9
    • Zhao, W.1    Payne, V.2    Tommasi, E.3    Diz, D.I.4    Hsu, F.C.5    Robbins, M.E.6
  • 184
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • [184] Monje, M.L., Toda, H., Palmer, T.D., Inflammatory blockade restores adult hippocampal neurogenesis. Science 302 (2003), 1760–1765.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 185
    • 0036496910 scopus 로고    scopus 로고
    • The role of angiotensin II in cognition and behaviour
    • [185] Gard, P.R., The role of angiotensin II in cognition and behaviour. Eur. J. Pharmacol. 438 (2002), 1–14.
    • (2002) Eur. J. Pharmacol. , vol.438 , pp. 1-14
    • Gard, P.R.1
  • 187
    • 2342655011 scopus 로고    scopus 로고
    • The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memory
    • [187] Wright, J.W., Harding, J.W., The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memory. Prog. Neurobiol. 72 (2004), 263–293.
    • (2004) Prog. Neurobiol. , vol.72 , pp. 263-293
    • Wright, J.W.1    Harding, J.W.2
  • 188
    • 33947512453 scopus 로고    scopus 로고
    • Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury
    • [188] Moulder, J.E., Cohen, E.P., Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin. Radiat. Oncol. 17 (2007), 141–148.
    • (2007) Semin. Radiat. Oncol. , vol.17 , pp. 141-148
    • Moulder, J.E.1    Cohen, E.P.2
  • 189
    • 77249168824 scopus 로고    scopus 로고
    • Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus
    • [189] Jenrow, K.A., Brown, S.L., Liu, J., Kolozsvary, A., Lapanowski, K., Kim, J.H., Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus. Radiat. Oncol., 5, 2010, 6.
    • (2010) Radiat. Oncol. , vol.5 , pp. 6
    • Jenrow, K.A.1    Brown, S.L.2    Liu, J.3    Kolozsvary, A.4    Lapanowski, K.5    Kim, J.H.6
  • 190
    • 84864445722 scopus 로고    scopus 로고
    • Chronic administration of the angiotensin-converting enzyme inhibitor ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment
    • [190] Lee, T.C., Greene-Schloesser, D., Payne, V., Diz, D.I., Hsu, F.C., Kooshki, M., Mustafa, R., Riddle, D.R., Zhao, W., Chan, M.D., Robbins, M.E., Chronic administration of the angiotensin-converting enzyme inhibitor ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat. Res. 178 (2012), 46–56.
    • (2012) Radiat. Res. , vol.178 , pp. 46-56
    • Lee, T.C.1    Greene-Schloesser, D.2    Payne, V.3    Diz, D.I.4    Hsu, F.C.5    Kooshki, M.6    Mustafa, R.7    Riddle, D.R.8    Zhao, W.9    Chan, M.D.10    Robbins, M.E.11
  • 193
    • 84861661728 scopus 로고    scopus 로고
    • A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor
    • [193] Gehring, K., Patwardhan, S.Y., Collins, R., Groves, M.D., Etzel, C.J., Meyers, C.A., Wefel, J.S., A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor. J. Neurooncol. 107 (2012), 165–174.
    • (2012) J. Neurooncol. , vol.107 , pp. 165-174
    • Gehring, K.1    Patwardhan, S.Y.2    Collins, R.3    Groves, M.D.4    Etzel, C.J.5    Meyers, C.A.6    Wefel, J.S.7
  • 197
    • 79960436555 scopus 로고    scopus 로고
    • Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction
    • [197] Acharya, M.M., Christie, L.A., Lan, M.L., Giedzinski, E., Fike, J.R., Rosi, S., Limoli, C.L., Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction. Cancer Res. 71 (2011), 4834–4845.
    • (2011) Cancer Res. , vol.71 , pp. 4834-4845
    • Acharya, M.M.1    Christie, L.A.2    Lan, M.L.3    Giedzinski, E.4    Fike, J.R.5    Rosi, S.6    Limoli, C.L.7
  • 199
    • 84924905197 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation
    • [199] Piao, J., Major, T., Auyeung, G., Policarpio, E., Menon, J., Droms, L., Gutin, P., Uryu, K., Tchieu, J., Soulet, D., Tabar, V., Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation. Cell Stem Cell 16 (2015), 198–210.
    • (2015) Cell Stem Cell , vol.16 , pp. 198-210
    • Piao, J.1    Major, T.2    Auyeung, G.3    Policarpio, E.4    Menon, J.5    Droms, L.6    Gutin, P.7    Uryu, K.8    Tchieu, J.9    Soulet, D.10    Tabar, V.11
  • 201
    • 57349113992 scopus 로고    scopus 로고
    • Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice
    • [201] Wu, C.W., Chang, Y.T., Yu, L., Chen, H.I., Jen, C.J., Wu, S.Y., Lo, C.P., Kuo, Y.M., Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice. J. Appl. Physiol. (1985) 105 (2008), 1585–1594.
    • (2008) J. Appl. Physiol. (1985) , vol.105 , pp. 1585-1594
    • Wu, C.W.1    Chang, Y.T.2    Yu, L.3    Chen, H.I.4    Jen, C.J.5    Wu, S.Y.6    Lo, C.P.7    Kuo, Y.M.8
  • 204
    • 78549282823 scopus 로고    scopus 로고
    • Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation
    • [204] Wong-Goodrich, S.J., Pfau, M.L., Flores, C.T., Fraser, J.A., Williams, C.L., Jones, L.W., Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation. Cancer Res. 70 (2010), 9329–9338.
    • (2010) Cancer Res. , vol.70 , pp. 9329-9338
    • Wong-Goodrich, S.J.1    Pfau, M.L.2    Flores, C.T.3    Fraser, J.A.4    Williams, C.L.5    Jones, L.W.6
  • 205
    • 84962664380 scopus 로고    scopus 로고
    • Treatment of Alzheimer disease with CT scans: a case report
    • (1559325816640073)
    • [205] Cuttler, J.M., Moore, E.R., Hosfeld, V.D., Nadolski, D.L., Treatment of Alzheimer disease with CT scans: a case report. Dose Response, 14, 2016 (1559325816640073).
    • (2016) Dose Response , vol.14
    • Cuttler, J.M.1    Moore, E.R.2    Hosfeld, V.D.3    Nadolski, D.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.