Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain

Experimental and Toxicologic Pathology

Volumn 55, Issue 5, 2004, Pages 379-384

  Ündeǧer, Ülkü ^a   Giray, Belma ^a   Zorlu, A Faruk ^a   Öge, Kamil ^a   Baçaran, Nurçen ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Brain; DNA damage; Ionizing radiation; Lipid peroxidation; Melatonin; Rat

Indexed keywords

ANTIOXIDANT; MELATONIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; CELL PROTECTION; CHROMOSOME REARRANGEMENT; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA STRAND BREAKAGE; DOSIMETRY; FEMALE; GENETIC STABILITY; IONIZING RADIATION; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; RADIATION ABSORPTION; RADIATION PROTECTION; RAT;

ANIMALIA;

EID: 1842577536     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1078/0940-2993-00332     Document Type: Article

References (54)

1. AHLERS, SOLAR P, AHLERSOVA E, et al.: The influence of melatonin on metabolic changes in female rats induced by continuous irradiation and/or administration of 7,12-dimethylbenz/a/anthracene. Neoplasma 1997; 44: 253-257.
2. ANDERSON D, YU TW, PHILIPS BJ, et al.: The effect on various antioxidant and other modifying agents on oxygen-radical generated DNA damage in human lymphocytes in the comet assay. Mutat Res 1994; 307: 261-271.
3. BADR FM, EL HABIT OHM, HARRAZ MM: Radioprotective effect of melatonin assessed by measuring chromosomal damage in mitotic and meiotic cells. Mutat Res 1999; 444: 367-372.
4. BETTAHI I, POZO D, OSUNA C, et al.: Physiological concentrations of melatonin inhibit nitric oxide synthase activity in the rat hypothalamus. J Pineal Res 1996; 20: 205-210.
5. BLASK DE: Melatonin in oncology. In:.YU HS and REITER RJ (Eds): Melatonin: Biosynthesis, Physiological Effects, and Clinical Applications. CRC Press, Boca Raton FL 1993, pp 447-475.
6. BLICKENSTAFF RT, BRANDSTADTER SM, REDDY S et al.: Potential radioprotective agents: 1. Homologs of melatonin. J Pharm Sci 1994; 83: 216-218.
7. COLLINS AR, DOBSON VL, DUSINSKA M, et al.: The comet assay: what can it really tell us? Mutat Res 1997; 375: 183-193.
8. DALE WM, GRAY LH, MEREDITH WJ: The inactivation of an enzyme (carboxypeptidase) by X-and α-radiation. Philos Trans R Soc Lond A 1949; 242: 33- 62.
9. EBADI M: Regulation of the synthesis of melatonin and its significance to neuroendocrinology. In: REITER RJ (Ed.): The Pineal Gland. Raven Press, New York 1984, pp 1-38.
10. FAIRBAIRN DW, OLIVE PL, O'NEILL KL: The comet assay: a comprehensive review. Mutat Res 1995; 339: 37-59.
11. FLOYD RA, CARNEY JM: The role of metal ions in oxidative processes and aging. Toxicol Indust Health 1993; 9: 197-214.
12. FRANKENBERG-SCHWAGER M: Induction repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells. Radiat Environ Biophys 1990; 29: 273-292.
13. GARCIA JJ, REITER RJ, GUERRERO JM, et al.: Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett 1997; 408: 297-300.
14. GUERRERO JM, REITER RJ, ORTIZ GG, et al.: Melatonin prevents increases in neural nitric oxide and cycle GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones unguiculatus). J Pineal Res 1997; 23: 24-31.
15. HALLIWELL B, ARUOMA OI: DNA damage by oxygen-derived species. FEBS Lett 1991; 281: 9-19.
16. KARBOWNIK M, REITER RJ: Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc Soc Exp Biol Med 2000; 225: 9-22.
17. KARBOWNIK M, REITER RJ, QI W, et al.: Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation. Mol Cell Biochem 2000; 211: 137-144.
18. KAYA H, DELIBAŞ N, SERTESER M, et al.: The effect of melatonin on lipid peroxidation during radiotherapy in female rats. Strahlenther Onkol 1999; 175: 285-288.
19. KILIÇ E, ÖZDEMIR YG, BOLAY H, et al.: Pinealactomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J Cerebr. Blood Flow Metab 1999; 19: 511-516.
20. KIM BC, SHON BS, RYOO YW, et al.:. Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. J Dermatol Svi 2001; 26: 194-200.
21. LISSONI P, MERAGALLI S, NOSETTO L, et al.: Increased survival time in brain glioblastomas by radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone. Oncology 1996; 53: 43-46.
22. LOVELL DP, THOMAS G, DOBOW R: Issues related to the experimental design and subsequent statistical analysis of in vivo and in vitro Comet studies. Teratogen. Carcinogen. Mutagen 1993; 19: 109-119.
23. LOWRY OH, ROSEBROUGH NJ, FARR AL, et al.: Protein measurement with Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
24. MAESTRONI GJM: The immunoendocrine role of melatonin. J Pineal Res 1993; 14: 121-126.
25. MORGAN WF, DAY JP, KAPLAN MI, et al.: Genomic instability induced by ionizing radiation. Radiat Res 1996; 146: 247-258.
26. MURNANE JP: Role of induced genetic instability in the mutagenic effects of chemicals and radiation. Mutat Res 1996; 367: 11-23.
27. OHKAWA H, OHISHI N, YAGI K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-358.
28. ONO S, CAI L, CHERIAN MG: Effects of gamma radiation on levels of brain metallothionein and lipid peroxidation in transgenic mice. Radiat Res 1998; 150: 52-57.
29. POZO D, REITER RJ, CALVO JM, et al.: Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. J Cell Biochem 1997; 65: 430-442.
30. PEZYBYSZEWSKI WM, WIDEL M, PALYVODA O: Lipid peroxidation, DNA damage, and cellular morphology of R1 rhabdomysarcoma cell line irradiated in vitro by gamma-rays with different dose rates. Teratogen Carcinogen Mutagen 2002; 22: 93-102.
31. REITER RJ: Melatonin: That ubiquitously acting pineal hormone. News Physiol Sci 1991; 6: 223-227.
32. REITER RJ: Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995; 9: 526-533.
33. REITER RJ, MELEHIORRI D, SEWERYNEK E, et al.: A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995; 18: 1-11.
34. REITER RJ: Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals. Eur J Endocrinol. 1996; 134: 412-420.
35. REITER RJ: Oxidative damage in the central nervous system: Protection by melatonin. Prog Neurobiol 1998; 56: 359-384.
36. REJHOLCOVA M, WILHELM J: Time course of lipophilic activity and lipid peroxidation after whole-body γ irradiation of rats. Radiat Res 1989; 117: 21-25.
37. RONAI E, BENKO G: Effect of acute 60 Co-gamma-irradiation on the in vivo lipid peroxidation in experimental animals. Acta Physiol Hung 1984; 63: 13-19.
38. SINGH NP, DANNER DB, TICE RR, et al.: DNA damage and repair with age in individual human lymphocytes. Mutat Res 1990; 237: 123-130.
39. SINGH NP, STEPHENS RE, SCHNEIDER EL: Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int Radiat Biol 1994; 66: 23-28.
40. SLYCHENKOV VS, OMELYANCHIK SN, MOISEENOK AG, et al.: Pantothenol protects rats against some deleterious effects of gamma radiation. Free Radic Biol Med 1998; 24: 894-899.
41. STASICA P, ULANSKI P, ROSIAK JM: Melatonin as a hydroxyl radical scavenger. J Pineal Res 1998; 25: 65-66.
42. TAN DX, CHEN LD, POEGGELER B, et al.: Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocrin J 1993; 1: 57-60.
43. TAN DX, MANCHESTER LC, REITER RJ, et al.: A novel melatonin metabolite, cyclic 3-hydroxymelatonin: A biomarker of in vivo hydroxyl radical generation. Biochem Biophys Res Commun 1998; 253: 614-620.
44. TICE RR: The single cell gel/comet assay: a microgel electrophoretic technique for the detection of DNA damage and repair in individual cells. In: PHILIPS DH and VENITT S (Eds.): Environmental Mutagenesis. Bios Scientific Publishers, Oxford 1995, pp. 315-339.
45. UEDA T, TOYOSHIMA Y, MORITANI T, et al.: Protective effect of dipyridamole against lethality and lipid peroxidation in liver and spleen of the ddy mouse after whole-body irradiation. Int J Radiat Biol 1996; 69: 199-204.
46. VIJAYALAXMI, REITER RJ, MELTZ, ML: Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutat Res 1995a; 346: 23-31.
47. VIJAYALAXMI, REITER RJ, SEWERYNEK E., et al.: Marked reduction of radiation-induced micronuclei in human blood lymphpocytes pre-treated with melatonin. Radiat Res 1995b; 143: 102-106.
48. VIJAYALAXMI, REITER RJ, HERMAN TS, et al.: Melatonin and radioprotection from genetic damage: In vivo/in vitro studies with human volunteers. Mutat Res 1996; 371: 221-228.
49. VIJAYALAXMI, REITER RJ, HERMAN TS, et al.: Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes. Mutat Res 1998; 397: 203-208.
50. VIJAYALAXMI, MELTZ ML, REITER RJ, et al.: Melatonin and protection from genetic damage in blood and bone marrow: Whole-body irradiation studies in mice. J Pineal Res 1999; 27: 221-225.
51. WALDHAUSER F, DIETZEL M: Daily and annual rhythms in human melatonin secretion: Role in puberty control. Ann NY Acad Sci 1985; 453: 205-214.
52. WALLACE SS: Enzymatic processing of radiation-induced free radical damage in DNA. Radiat Res 1998; 150: 60-79.
53. WARD JF: DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability. Prog Nucl Acid Res Mol Biol 1998; 35: 95-125.
54. ZORLU AF, SERVET İ, KILINÇ K, et al.: The effect of multi and single fraction whole brain irradiation on rat brain lipid peroxidation. Turkish J Cancer 1994; 24: 71-77.