Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain

International Journal of Radiation Biology

Volumn 86, Issue 2, 2010, Pages 132-144

  Lee, Won Hee ^a   Sonntag, William E ^b   Mitschelen, Matthew ^b   Yan, Han ^b   Lee, Yong Woo ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

AP 1; Brain inflammation; CREB; Cytokines; NF B; Radiation

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN RADIATION; CONTROLLED STUDY; DNA BINDING; ENCEPHALITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOFLUORESCENCE; MALE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; BRAIN; CELL LINE; CHEMOKINE CCL2; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYTOKINES; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MALE; MICE; NF-KAPPA B; RATS; RATS, INBRED BN; RATS, INBRED F344; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

RATTUS;

EID: 77249171256     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553000903419346     Document Type: Article

References (60)

1. Baluna RG, Eng TY, Thomas CR. 2006. Adhesion molecules in radiotherapy. Radiation Research 166:819-831.
2. Beetz A, Peter RU, Oppel T, Kaffenberger W, Rupec RA, Meyer M, van Beuningen D, Kind P, Messer G. 2000. NF-kB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells. International Journal of Radiation Biology 76:1443-1453.
3. Beg AA, Finco TS, Nantermet PV, Baldwin AS, Jr. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: A mechanism for NF-kappa B activation. Molecular and Cellular Biology 13:3301-3310.
4. Behrends U, Peter RU, Hintermeier-Knabe R, Eissner G, Holler E, Bornkamm GW, Caughman SW, Degitz K. 1994. Ionizing radiation induces human intercellular adhesion molecule-1 in vitro. Journal of Investigative Dermatology 103:726-730.
5. Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F. 1990. Immortalization of murine microglial cells by a v-raf/ v-myc carrying retrovirus. Journal of Neuroimmunology 27: 229-237.
6. Block ML, Zecca L, Hong JS. 2007. Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms. Nature Review Neuroscience 8:57-69.
7. Bouloumie A, Marumo T, Lafontan M, Busse R. 1999. Leptin induces oxidative stress in human endothelial cells. The FASEB Journal 13:1231-1238.
8. Brach MA, Hass R, Sherman ML, Gunji H, Weichselbaum R, Kufe D. 1991. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. Journal of Clinical Investigation 88:691-695.
9. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248-254.
10. Calvo W, Hopewell KW, Reinhold HS, Yeung TK. 1988. Timeand dose-related changes in the white matter of the rat brain after single doses of X rays. The British Journal of Radiology 61:1043-1052.
11. Chiang CS, Hong JH, Stalder A, Sun JR, Withers HR, McBride WH. 1997. Delayed molecular responses to brain irradiation. International Journal of Radiation Biology 72: 45-53.
12. Deng X, Li H, Tang YW. 2003. Cytokine expression in respiratory syncytial virus-infected mice as measured by quantitative reverse-transcriptase PCR. Journal of Virological Methods 107:141-146.
13. Denham JW, Hauer-Jensen M. 2002. The radiotherapeutic injurya complex 'wound'. Radiotherapy and Oncology 63:129-145.
14. Dinarello CA. 1996. Biologic basis for interleukin-1 in disease. Blood 87:2095-2147.
15. Gaber MW, Sabek OM, Fukatsu K, Wilcox HG, Kiani MF, Merchant TE. 2003. Differences in ICAM-1 and TNF-alpha expression between large single fraction and fractionated irradiation in mouse brain. International Journal of Radiation Biology 79:359-366.
16. Gaugler MH, Squiban C, van der Meeren A, Bertho JM, Vandamme M, Mouthon MA. 1997. Late and persistent upregulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro. International Journal of Radiation Biology 72: 201-209.
17. Grosch S, Kaina B. 1999. Transcriptional activation of apurinic/ apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB. Biochemical and Biophysical Research Communications 261:859-863.
18. Guha M, Bai W, Nadler JL, Natarajan R. 2000. Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells via hyperglycemia-induced oxidant stressdependent and-independent pathways. Journal of Biological Chemistry 275:17728-17739.
19. Hallahan D, Kuchibhotla J, Wyble C. 1996. Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium. Cancer Research 56:5150-5155.
20. Han SK, Song JY, Yun YS, Yi SY. 2006. Effect of gamma radiation on cytokine expression and cytokine-receptor mediated STAT activation. International Journal of Radiation Biology 82:686-697.
21. Haveman J, Geerdink AG, Rodermond HM. 1998. TNF, IL-1 and IL-6 in circulating blood after total-body and localized irradiation in rats. Oncology Reports 5:679-683.
22. Hodges H, Katzung N, Sowinski P, Hopewell JW, Wilkinson JH, Bywaters T, Rezvani M. 1997. Late behavioural and neuropathological effects of local brain irradiation in the rat. Behavioural Brain Research 91:99-114.
23. Hong JH, Chiang CS, Campbell IL, Sun JR, Withers HR, McBride WH. 1995. Induction of acute phase gene expression by brain irradiation. International Journal of Radiation Oncology, Biology and Physics 33:619-626.
24. Hong JH, Chiang CS, Tsao CY, Lin PY, McBride WH, Wu CJ. 1999. Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation. International Journal of Radiation Biology 75:1421-1427.
25. Iwata E, Asanuma M, Nishibayashi S, Kondo Y, Ogawa N. 1997. Different effects of oxidative stress on activation of transcription factors in primary cultured rat neuronal and glial cells. Brain Research Molecular-Brain Research 50:213-220.
26. Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. 2002. Radiation-induced pulmonary fibrosis: Examination of chemokine and chemokine receptor families. Radiation Research 157:256-265.
27. Kim SH, Lim DJ, Chung YG, Cho TH, Lim SJ, Kim WJ, Suh JK. 2002. Expression of TNF-a and TGF-b1 in the rat brain after a single high-dose irradiation. Journal of Korean Medical Science 17:242-248.
28. Kishimoto T. 2005. Interleukin-6: From basic science to medicine - 40 years in immunology. Annual Review of Immunology 23:1-21.
29. Kyrkanides S, Moore AH, Olschowka JA, Daeschner JC, Williams JP, Hansen JT, Kerry O'Banion M. 2002. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Research-Molecular Brain Research 104:159-169.
30. Lakshminarayanan V, Drab-Weiss EA, Roebuck KA. 1998. H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kB to the interleukin-8 promoter in endothelial and epithelial cells. Journal of Biological Chemistry 273: 32670-32678.
31. Lee YW, Eum SY, Nath A, Toborek M. 2004. Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells. Cardiovascular Research 63:139-148.
32. Lee YW, Hennig B, Toborek M. 2003. Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells. American Journal of Physiology-Heart and Circulatory Physiology 284:H185-192.
33. Lee YW, Hirani AA, Kyprianou N, Toborek M. 2005. Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells. Inflammation Research 54:380-389.
34. Linard C, Marquette C, Mathieu J, Pennequin A, Clarencon D, Mathe D. 2004. Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: Effect of an NF-kappaB inhibitor. International Journal of Radiation Oncology, Biology and Physics 58:427-434.
35. Linard C, Ropenga A, Vozenin-Brotons MC, Chapel A, Mathe D. 2003. Abdominal irradiation increases inflammatory cytokine expression and activates NF-kappa B in rat ileal muscularis layer. American Journal of Physiology-Gastrointestinal and Liver Physiology 285:G556-G565.
36. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 27DDCT method. Methods 25:402-408.
37. Locksley RM, Killeen N, Lenardo MJ. 2001. The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell 104:487-501.
38. Marquette C, Linard C, Galonnier M, Van Uye A, Mathieu J, Gourmelon P, Clarencon D. 2003. IL-1b, TNF-a and IL-6 induction in the rat brain after partial-body irradiation: Role of vagal afferents. International Journal of Radiation Biology 79: 777-785.
39. Molla M, Gironella M, Salas A, Miquel R, Perez-del-Pulgar S, Conill C, Engel P, Biete A, Pique JM, Panes J. 2001. Role of P-selectin in radiation-induced intestinal inflammatory damage. International Journal of Cancer 96:99-109.
40. Molla M, Panes J. 2007. Radiation-induced intestinal inflammation. World Journal of Gastroenterology 13:3043-3046.
41. Monje ML, Mizumatsu S, Fike JR, Palmer TD. 2002. Irradiation induces neural precursor-cell dysfunction. Nature Medicine 8: 955-962.
42. Monje ML, Palmer TD. 2003. Radiation injury and neurogenesis. Current Opinion in Neurology 16:129-134.
43. Moore AH, Olschowka JA, Williams JP, Okunieff P, O'Banion MK. 2005. Regulation of prostaglandin E2 synthesis after brain irradiation. International Journal of Radiation Oncology, Biology and Physics 62:267-272.
44. Mori K, Tani M, Kamata K, Kawamura H, Urata Y, Goto S, Kuwano M, Shibata S, Kondo T. 2000. Mitogen-activated protein kinase, ERK1/2, is essential for the induction of vascular endothelial growth factor by ionizing radiation mediated by activator protein-1 in human glioblastoma cells. Free Radical Research 33:157-166.
45. Moulder JE, Cohen EP. 2007. Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Seminar Radiation Oncology 17:141-148.
46. Olschowka JA, Kyrkanides S, Harvey BK, O'Banion MK, Williams JP, Rubin P, Hansen JT. 1997. ICAM-1 induction in the mouse CNS following irradiation. Brain, Behavior, and Immunity 11:273-285.
47. Park JS, Qiao L, Su ZZ, Hinman D, Willoughby K, McKinstry R, Yacoub A, Duigou GJ, Young CS, Grant S, Hagan MP, Ellis E, Fisher PB, Dent P. 2001. Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways. Oncogene 20:3266-3280.
48. Raju U, Gumin GJ, Tofilon PJ. 2000. Radiation-induced transcription factor activation in the rat cerebral cortex. International Journal of Radiation Biology 76:1045-1053.
49. Ross R. 1993. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362:801-809.
50. Ross R. 1999. Atherosclerosis is an inflammatory disease. American Heart Journal 138:S419-420.
51. Schindler MK, Forbes ME, Robbins ME, Riddle DR. 2008. Aging-dependent changes in the radiation response of the adult rat brain. International Journal of Radiation Oncology, Biology and Physics 70:826-834.
52. Schultheiss TE, Stephens LC. 1992. Invited review: Permanent radiation myelopathy. British Journal of Radiology 65:737-753.
53. Sheline GE, Wara WM, Smith V. 1980. Therapeutic irradiation and brain injury. International Journal of Radiation Oncology, Biology and Physics 6:1215-1228.
54. Shi L, Adams MM, Long A, Carter CC, Bennett C, Sonntag WE, Nicolle MM, Robbins M, D'Agostino R, Brunso-Bechtold JK. 2006. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiation Research 166: 892-899.
55. Son EW, Rhee DK, Pyo S. 2006. Gamma-irradiation-induced intercellular adhesion molecule-1 (ICAM-1) expression is associated with catalase: Activation of Ap-1 and JNK. Journal of Toxicology and Environmental Health, Part A 69:2137-2155.
56. Toborek M, Lee YW, Kaiser S, Hennig B. 2002. Measurement of inflammatory properties of fatty acids in human endothelial cells. Methods in Enzymology 352:198-219. (Pubitemid 41103184)
57. Voges J, Treuer H, Sturm V, Büchner C, Lehrke R, Kocher M, Staar S, Kuchta J, Müller R. 1996. Risk analysis of linear accelerator radiosurgery. International Journal of Radiation Oncology, Biology and Physics 36:1055-1063.
58. Wung BS, Cheng JJ, Hsieh HJ, Shyy YJ, Wang DL. 1997. Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circulation Research 81:1-7.
59. Xiao Z, Su Y, Yang S, Yin L, Wang W, Yi Y, Fenton BM, Zhang L, Okunieff P. 2006. Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis. International Journal of Radiation Oncology, Biology and Physics 65: 882-889.
60. Zhou D, Yu T, Chen G, Brown SA, Yu Z, Mattson MP, Thompson JS. 2001. Effects of NF-kB1 (p50) targeted gene disruption on ionizing radiation-induced NF-kB activation and TNF-a, IL-1a, IL-1b and IL-6 mRNA expression in vivo. International Journal of Radiation Biology 77:763-772.