Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, Tie-2 and Ang-2 in rat brain

Radiation Research

Volumn 176, Issue 6, 2011, Pages 753-760

  Lee, Won Hee ^a   Cho, Hyung Joon ^a   Sonntag, William E ^b   Lee, Yong Woo ^a,c  

^a VT WFU School of Biomedical Engineering and Sciences   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ENDOTHELIAL SPECIFIC RECEPTOR TYROSINE KINASE 2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN RADIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOFLUORESCENCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; APOPTOSIS; BRAIN; CELL PROLIFERATION; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RECEPTOR, TIE-2; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 82955239892     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2647.1     Document Type: Article

References (48)

1. Sheline GE, Wara WM, Smith M. Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 1980; 6:1215-28. (Pubitemid 10016476)
2. Central Brain Tumor Registry of the United States (CBTRUS). Primary brain and central nervous system tumors diagnosed in the United States. [updated 2010 Mar]. Available from: http://www. abta.org.
3. Denham JW, Hauer-Jensen M. The radiotherapeutic injury-a complex 'wound'. Radiother Oncol 2002; 63:129-45.
4. Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 2009; 10:1037-44.
5. Brown WR, Thore CR, Moody DM, Robbins ME, Wheeler KT. Vascular damage after fractionated whole-brain irradiation in rats. Radiat Res 2005; 164:662-8. (Pubitemid 41532562)
6. Lamproglou I, Chen QM, Boisserie G, Mazeron JJ, Poisson M, Baillet F, et al. Radiation-induced cognitive dysfunction: an experimental model in the old rat. Int J Radiat Oncol Biol Phys 1995; 31:65-70.
7. Lee WH, Sonntag WE, Mitschelen M, Yan H, Lee YW. Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain. Int J Radiat Biol 2010; 86:132-44.
8. Lee WH, Sonntag WE, Lee YW. Aging attenuates radiationinduced expression of pro-inflammatory mediators in rat brain. Neurosci Lett 2010; 476:89-93.
9. Lee WH, Warrington JP, Sonntag WE, Lee YW. Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain. Int J Radiat Oncol Biol Phys. Forthcoming 2011. DOI:10.1016/j. ijrobp.2010.12.032.
10. Warrington JP, Csiszar A, Johnson DA, Herman TS, Ahmad S, Lee YW, et al. Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in mice. Am J Physiol Heart Circ Physiol 2011; 300:H736-44.
11. Goligorsky MS. Microvascular rarefaction: The decline and fall of blood vessels. Organogenesis 2010; 6:1-10.
12. Prasad A, Dunnill GS, Mortimer PS, MacGregor GA. Capillary rarefaction in the forearm skin in essential hypertension. J Hypertens 1995; 13:265-8.
13. Rakusan K, Moravec J, Hatt PY. Regional capillary supply in the normal and hypertrophied rat heart. Microvasc Res 1980; 20:319-26. (Pubitemid 11104902)
14. Ljubimova NV, Levitman MK, Plotnikova ED, Eidus LKH. Endothelial cell population dynamics in rat brain after local irradiation. Br J Radiol 1991; 64:934-40.
15. Dimitrievich GS, Fischer-Dzoga K, Griem ML. Radiosensitivity of vascular tissue. I. Differential radiosensitivity of capillaries: a quantitative in vivo study. Radiat Res 1984; 99:511-35. (Pubitemid 14031867)
16. Roth NM, Sontag MR, Kiani MF. Early effects of ionizing radiation on the microvascular networks in normal tissue. Radiat Res 1999; 151:270-7. (Pubitemid 29109137)
17. Lyubimova N, Hopewell JW. Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury. Br J Radiol 2004; 77:488-92. (Pubitemid 38807563)
18. Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999; 18:5356-62. (Pubitemid 29462372)
19. Clark RAF. Wound repair: overview and general considerations. In: Clark RAF, editor. The molecular and cellular biology of wound repair. 2nd ed. New York: Plenum Press; 1996. p. 3-50.
20. Voges J, Treuer H, Sturm V, Büchner C, Lehrke R, Kocher M, et al. Risk analysis of linear accelerator radiosurgery. Int J Radiat Oncol Biol Phys 1996; 36:1055-63. (Pubitemid 27014491)
21. Monje ML, Mizumatsu S, Fike JR, Palmer TD. Irradiation induces neural precursor-cell dysfunction. Nat Med 2002; 8:955-62. (Pubitemid 35033699)
22. Hodges H, Katzung N, Sowinski P, Hopewell JW, Wilkinson JH, Bywaters T, et al. Late behavioural and neuropathological effects of local brain irradiation in the rat. Behav Brain Res 1998; 91:99-114. (Pubitemid 28167875)
23. Calvo W, Hopewell JW, Reinhold HS, Yeung TK. Time-and dose-related changes in the white matter of the rat brain after single doses of X rays. Br J Radiol 1988; 61:1043-52. (Pubitemid 18264264)
24. Monje ML, Palmer T. Radiation injury and neurogenesis. Curr Opin Neurol 2003; 16:129-34. (Pubitemid 36521196)
25. Kim SH, Lim DJ, Chung YG, Cho TH, Lim SJ, Kim WJ, et al. Expression of TNF-a and TGF-b1 in the rat brain after a single high-dose irradiation. J Korean Med Sci 2002; 17:242-8.
26. Conner KR, Forbes ME, Lee WH, Lee YW, Riddle DR. AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain. Radiat Res 2011; 176:71-83.
27. Toborek M, Lee YW, Kaiser S, Hennig B. Measurement of inflammatory properties of fatty acids in human endothelial cells. Methods Enzymol 2002; 352:198-219. (Pubitemid 41103184)
28. Deng X, Li H, Tang YW. Cytokine expression in respiratory syncytial virus-infected mice as measured by quantitative reversetranscriptase PCR. J Virol Methods 2003; 107:141-6. (Pubitemid 36005498)
29. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCT method. Methods 2001; 25:402-8. (Pubitemid 34164012)
30. Otsuka S, Coderre JA, Micca PL, Morris GM, Hopewell JW, Rola R, et al. Depletion of neural precursor cells after local brain irradiation is due to radiation dose to the parenchyma, not the vasculature. Radiat Res 2006; 165:582-91.
31. Rola R, Raber J, Rizk A, Otsuka S, VandenBerg SR, Morhardt DR, et al. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol 2004; 188:316-30. (Pubitemid 38891593)
32. Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, et al. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res 2004; 162:39-47. (Pubitemid 39044717)
33. Madsen TM, Kristjansen PE, Bolwig TG, Wortwein G. Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 2003; 119:635-42. (Pubitemid 36694791)
34. Pena LA, Fuks Z, Kolesnick RN. Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res 2000; 60:321-7. (Pubitemid 30070758)
35. Li YQ, Chen P, Jain V, Reilly RM, Wong CS. Early radiationinduced endothelial cell loss and blood-spinal cord barrier breakdown in the rat spinal cord. Radiat Res 2004; 161:143-52. (Pubitemid 38129807)
36. Hanahan D. Signaling vascular morphogenesis and maintenance. Science 1997; 277:48-50. (Pubitemid 27450640)
37. Miller JW, Adamis AP, Shima DT, D'Amore PA, Moulton RS, O'Reilly MS, et al. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol 1994; 145:574-84. (Pubitemid 24285965)
38. Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol 1999; 237:1-30. (Pubitemid 28554856)
39. Plate KH. Mechanisms of angiogenesis in the brain. J Neuropathol Exp Neurol 1999; 58:313-20. (Pubitemid 29187893)
40. Breier G, Albrecht U, Sterrer S, Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992; 114:521-32.
41. Alavi A, Hood JD, Frausto R, Stupack DG, Cheresh DA. Role of Raf in vascular protection from distinct apoptotic stimuli. Science 2003; 301:94-6. (Pubitemid 36801568)
42. Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 1996; 87:1161-9. (Pubitemid 27010100)
43. Witzenbichler B, Maisonpierre PC, Jones P, Yancopoulos GD, Isner JM. Chemotactic properties of angiopoietin-1 and-2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. J Biol Chem 1998; 273:18514-21. (Pubitemid 28334780)
44. Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W. Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr Biol 1998; 8:529-32. (Pubitemid 28203073)
45. Hayes AJ, Huang WQ, Mallah J, Yang D, Lippman ME, Li LY. Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells. Microvasc Res 1999; 58:224-37. (Pubitemid 29531872)
46. Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 1995; 376:70-4.
47. Peters KG, Kontos CD, Lin PC, Wong AL, Rao P, Huang L, et al. Functional significance of Tie2 signaling in the adult vasculature. Recent Prog Horm Res 2004; 59:51-71.
48. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature 2000; 407:242-8.