Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer's Disease

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Cherry, Jonathan D ^a   Liu, Bin ^b   Frost, Jeffrey L ^b   Lemere, Cynthia A ^b   Williams, Jacqueline P ^a   Olschowka, John A ^a   O'Banion, M Kerry ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CD68 ANTIGEN; INSULINASE; INTERCELLULAR ADHESION MOLECULE 1; IRON;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; COGNITIVE DEFECT; CONDITIONING; CONTROLLED STUDY; COSMIC RADIATION; ENDOTHELIUM CELL; FEAR; FEMALE; IMMUNOREACTIVITY; MALE; MICROGLIA; MOUSE; NONHUMAN; PARTICLE RADIATION; PATHOLOGY; PATTERN RECOGNITION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN TRANSPORT; RADIATION DOSE; RADIATION EXPOSURE; RISK ASSESSMENT; TISSUE LEVEL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; COGNITION DISORDERS; COSMIC RADIATION; DISEASE MODELS, ANIMAL; MALE; MICE; PLAQUE, AMYLOID; PRESENILIN-1;

MUS;

EID: 84871733794     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053275     Document Type: Article

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