Radiotherapy of central nervous system tumors in young children: Benefits and pitfalls

Medical and Pediatric Oncology

Volumn 33, Issue 6, 1999, Pages 572-576

  Skowrońska Gardas, Anna ^a,b  

^a INSTITUTE OF ONCOLOGY   (Poland)

^b NONE   (Poland)

Author keywords

Brain tumors; Children; Radiotherapy

Indexed keywords

ARTICLE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; RISK BENEFIT ANALYSIS; TREATMENT OUTCOME;

CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD, PRESCHOOL; DEVELOPMENTAL DISABILITIES; DISEASE-FREE SURVIVAL; FEMALE; GROWTH DISORDERS; HUMANS; INFANT; MALE; MENTAL RETARDATION; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; RADIOTHERAPY; RISK FACTORS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 0345476858     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-911X(199912)33:6<572::AID-MPO9>3.0.CO;2-P     Document Type: Article

References (24)

1. Bloom H, Glees J, Bell J. The treatment and long-term prognosis of children with intracranial tumours: a study of 610 cases, 1950-1981. Int J Rad Oncol Biol Phys 1990;18:723-745.
2. Horowitz M, Mulhern R, Kun L, et al. Primary brain tumours in the very young child: postoperative chemotherapy in combined modality treatment. Cancer 1988;61:428-434.
3. Di Rocco C, Lanelli A, Cedolie A. Intracranial tumours of the first year of life. Child Nerv Syst 1991;7:150-155.
4. Cervoni L, Canlore G. Medulloblastoma in paediatric age: a single institution review of prognostic factors. Child Nerv Syst 1995;11: 80-84.
5. Roszkowski M, Barszcz S, Dramińska D, et al. Results of combined treatment of cerebellar medulloblastomas in children with chemotherapy preceding radiotherapy. Neurol Neurochir Pol 1994;28:719-732.
6. Danoff B, Cowchok S, Marguette C, et al. Assessment of the long-term effects of primary radiation therapy for brain tumours on children. Cancer 1982;49:1580-1586.
7. Duffner P, Cohan M, Thomas P. Late effects of treatment on the intelligence of children with posterior fossa tumours. Cancer 1983;51:233-237.
8. Jannon L, Bloom H. Long-term psychological effects in children treated for intracranial tumours. Int J Rad Oncol Biol Phys 1990; 18:747-753.
9. Packer R, Sutton L, Atkins T, et al. A prospective study of cognitive function in children receiving whole brain RT and CT-2 years results. J Neurosurg 1989;70:707-713.
10. Radcliffe J, Bunin G, Sutton L, et al. Cognitive deficits in long-term survivors of childhood: effects of whole brain radiation Int J Dev Neurosci 1994;12:327-334.
11. Spunberg J, Chang M, Goldman M, et al. Quality of long-term survival following irradiation for intracranial tumours of the age of two. Int J Rad Oncol Biol Phys 1981;7:727-736.
12. Aronin P, Young D, Castleberry Q, Parrot D. Chemotherapy as the initial postoperative management for malignant brain tumors in infants. Concepts Paediatr Neurosurg 1989;9:122-138.
13. Brada M, Pinkerton C, James N. Treatment of brain tumours in children less than 3 years of age. Eur J Cancer 1993;29A:2075-2076.
14. Chastagner P, Sommelet D. Role of chemotherapy in the treatment of brain tumors. Paediatrics 1991;46:47-58.
15. Strauss L, Killmond T, Carson B, et al. Efficacy of postoperative chemotherapy using cisplatin plus etoposide in young children with brain tumors. Med Pediatr Oncol 1991;19:16-21.
16. Hopperisch E, Burnet L, Loroussike F, et al. Intellectual outcome in children with malignant tumor of the posterior fossa. Influence of the field of irradiation and quality of surgery. Child Nerv Syst 1995;11:340-345.
17. Kao G, Goldwein J, Schultz D, et al. The impact of preoperative factors on subsequent intelligence quotient deficits in children treated for medulloblastoma (posterior fossa primitive neuroectodermal tumors). Cancer 1994;74:965-971.
18. Duffner P, Horowitz M, Krischer J, et al. Postoperative chemotherapy and delayed radiation in children less then three years of age with malignant brain tumors. N Engl J Med 1993;328:1725-1731.
19. Geyer R, Zeltzer P, Boyett J, et al. Survival of infants with primitive neuroectodermal tumors or malignant ependymomas of the CNS treated with eight drugs in 1 day: a report from the Children's Cancer Group. J Clin Oncol 1994;12:1607-1615.
20. Gajier A, Mulhern K, Heideman R, et al. Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy. J Clin Oncol 1994; 12:1212-1216.
21. Goldwein J, Radcliffe J, Johnson J, et al. Updated results of a pilot study of low dose craniospinal irradiation plus chemotherapy for children under five with cerebellar primitive neuroectodermal tumours (medulloblastoma). Int J Rad Oncol Biol Phys 1996;34: 899-904.
22. Aggarwal R, Young D, Kumar P, et al. Efficacy and feasibility of stereotactic radiosurgery in the primary management of unfavourable paediatric ependymoma. Radiother Oncol 1997;43:269-273.
23. Fisher P, Needle M, Canaan A, et al. Salvage therapy after post-operative chemotherapy for primary brain tumors in infants and very young children. Cancer 1998;83:566-574.
24. Saran F, Driever P, Thilman C, et al. Survival of very young children with medulloblastoma (primitive neuroectodermal tumor of the posterior fossa) treated with craniospinal irradiation. Int J Rad Oncol Biol Phys 1998;42:959-967.