메뉴 건너뛰기




Volumn 13, Issue 11, 2016, Pages 1200-1207

Alzheimer’s disease genetic risk factor APOE-ε4 also affects normal brain function

Author keywords

Amyloid; Apolippoprotein E; Dendritic spine; Entorhinal cortex; Hippocampus; Prevention; Risk factor; Targeted replacement mice

Indexed keywords

APOPROTEIN; APOPROTEIN EPSILON 4; ISOPROTEIN; UNCLASSIFIED DRUG; APOLIPOPROTEIN E4;

EID: 84995745550     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205013666160401115127     Document Type: Review
Times cited : (85)

References (123)
  • 1
    • 84865529158 scopus 로고    scopus 로고
    • Clinical and biomarker changes in dominantly inherited Alzheimer’s disease
    • Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, et al. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med 367(9): 795-804 (2012).
    • (2012) N Engl J Med , vol.367 , Issue.9 , pp. 795-804
    • Bateman, R.J.1    Xiong, C.2    Benzinger, T.L.3    Fagan, A.M.4    Goate, A.5    Fox, N.C.6
  • 3
    • 84912143249 scopus 로고    scopus 로고
    • The evolution of preclinical Alzheimer’s disease: Implications for prevention trials
    • Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer’s disease: implications for prevention trials. Neuron 84(3): 608-22 (2014).
    • (2014) Neuron , vol.84 , Issue.3 , pp. 608-622
    • Sperling, R.1    Mormino, E.2    Johnson, K.3
  • 4
    • 84938907794 scopus 로고    scopus 로고
    • Brain imaging and blood biomarker abnormalities in children with autosomal dominant Alzheimer disease: A cross-sectional study
    • Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, et al. Brain imaging and blood biomarker abnormalities in children with autosomal dominant Alzheimer disease: a cross-sectional study. JAMA Neurol 72(8): 912-9 (2015).
    • (2015) JAMA Neurol , vol.72 , Issue.8 , pp. 912-919
    • Quiroz, Y.T.1    Schultz, A.P.2    Chen, K.3    Protas, H.D.4    Brickhouse, M.5    Fleisher, A.S.6
  • 5
    • 0034575124 scopus 로고    scopus 로고
    • Apolipoprotein E: Far more than a lipid transport protein
    • Mahley RW, Rall SC, Jr. Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genom Hum Genet 1: 507-37 (2000).
    • (2000) Annu Rev Genom Hum Genet , vol.1 , pp. 507-537
    • Mahley, R.W.1    Rall, S.C.2
  • 6
    • 84930014969 scopus 로고    scopus 로고
    • APOEepsilon2 is associated with milder clinical and pathological Alzheimer disease
    • Serrano-Pozo A, Qian J, Monsell SE, Betensky RA, Hyman BT. APOEepsilon2 is associated with milder clinical and pathological Alzheimer disease. Ann Neurol 77(6): 917-29 (2015).
    • (2015) Ann Neurol , vol.77 , Issue.6 , pp. 917-929
    • Serrano-Pozo, A.1    Qian, J.2    Monsell, S.E.3    Betensky, R.A.4    Hyman, B.T.5
  • 7
    • 84919392782 scopus 로고    scopus 로고
    • Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: A genome-wide association study
    • Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol 71(11): 1394-404 (2014).
    • (2014) JAMA Neurol , vol.71 , Issue.11 , pp. 1394-1404
    • Naj, A.C.1    Jun, G.2    Reitz, C.3    Kunkle, B.W.4    Perry, W.5    Park, Y.S.6
  • 8
  • 9
    • 84875250937 scopus 로고    scopus 로고
    • Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: A prospective cohort study
    • Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O, et al. Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study. Lancet Neurol 12(4): 357-67 (2013).
    • (2013) Lancet Neurol , vol.12 , Issue.4 , pp. 357-367
    • Villemagne, V.L.1    Burnham, S.2    Bourgeat, P.3    Brown, B.4    Ellis, K.A.5    Salvado, O.6
  • 10
    • 84879902011 scopus 로고    scopus 로고
    • APOE-epsilon2 and APOE-epsilon4 correlate with increased amyloid accumulation in cerebral vasculature
    • Nelson PT, Pious NM, Jicha GA, Wilcock DM, Fardo DW, Estus S, et al. APOE-epsilon2 and APOE-epsilon4 correlate with increased amyloid accumulation in cerebral vasculature. J Neuropathol Exp Neurol 72(7): 708-15 (2013).
    • (2013) J Neuropathol Exp Neurol , vol.72 , Issue.7 , pp. 708-715
    • Nelson, P.T.1    Pious, N.M.2    Jicha, G.A.3    Wilcock, D.M.4    Fardo, D.W.5    Estus, S.6
  • 11
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer’s disease: Allelic variation and receptor interactions
    • Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer’s disease: allelic variation and receptor interactions. Neuron 11(4): 575-80 (1993).
    • (1993) Neuron , vol.11 , Issue.4 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 12
    • 84874334207 scopus 로고    scopus 로고
    • Levels of soluble apolipoprotein E/amyloid-beta Abeta complex are reduced and oligomeric Abeta increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples
    • Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, et al. Levels of soluble apolipoprotein E/amyloid-beta (Abeta) complex are reduced and oligomeric Abeta increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem 288(8): 5914-26 (2013).
    • (2013) J Biol Chem , vol.288 , Issue.8 , pp. 5914-5926
    • Tai, L.M.1    Bilousova, T.2    Jungbauer, L.3    Roeske, S.K.4    Youmans, K.L.5    Yu, C.6
  • 13
    • 84907805707 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease
    • Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Palsson E, et al. Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease. JAMA Psychiatry 71(10): 1183-91 (2014).
    • (2014) JAMA Psychiatry , vol.71 , Issue.10 , pp. 1183-1191
    • Lautner, R.1    Palmqvist, S.2    Mattsson, N.3    Reasson, U.4    Wallin, A.5    Palsson, E.6
  • 15
    • 84871268485 scopus 로고    scopus 로고
    • APOE4-specific changes in Abeta accumulation in a new transgenic mouse model of Alzheimer disease
    • Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, et al. APOE4-specific changes in Abeta accumulation in a new transgenic mouse model of Alzheimer disease. J Biol Chem 287(50): 41774-86 (2012).
    • (2012) J Biol Chem , vol.287 , Issue.50 , pp. 41774-41786
    • Youmans, K.L.1    Tai, L.M.2    Nwabuisi-Heath, E.3    Jungbauer, L.4    Kanekiyo, T.5    Gan, M.6
  • 16
    • 84902310908 scopus 로고    scopus 로고
    • APOE epsilon4 is associated with disproportionate progressive hippocampal atrophy in AD
    • Manning EN, Barnes J, Cash DM, Bartlett JW, Leung KK, Ourselin S, et al. APOE epsilon4 is associated with disproportionate progressive hippocampal atrophy in AD. PLoS One 9(5): e97608 (2014).
    • (2014) Plos One , vol.9 , Issue.5
    • Manning, E.N.1    Barnes, J.2    Cash, D.M.3    Bartlett, J.W.4    Leung, K.K.5    Ourselin, S.6
  • 17
    • 77953431148 scopus 로고    scopus 로고
    • Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer’s disease
    • Wolk DA, Dickerson BC, Neuroimaging AsD. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer’s disease. Proc Nat Acad Sci USA 107(22): 10256-61 (2010).
    • (2010) Proc Nat Acad Sci USA , vol.107 , Issue.22 , pp. 10256-10261
    • Wolk, D.A.1    Dickerson, B.C.2    Neuroimaging, A.3
  • 18
    • 84909578703 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer’s diseases
    • Huang Y, Mahley RW. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer’s diseases. Neurobiol Dis 72 Pt A: 3-12 (2014).
    • (2014) Neurobiol Dis , vol.72 , pp. 3-12
    • Huang, Y.1    Mahley, R.W.2
  • 20
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    • Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258(5081): 468-71 (1992).
    • (1992) Science , vol.258 , Issue.5081 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 21
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71(2): 343-53 (1992).
    • (1992) Cell , vol.71 , Issue.2 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3    Aalto-Setala, K.4    Walsh, A.5    Verstuyft, J.G.6
  • 22
    • 84907970354 scopus 로고    scopus 로고
    • Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function
    • Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, et al. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol 71(10): 1228-36 (2014).
    • (2014) JAMA Neurol , vol.71 , Issue.10 , pp. 1228-1236
    • Mak, A.C.1    Pullinger, C.R.2    Tang, L.F.3    Wong, J.S.4    Deo, R.C.5    Schwarz, J.M.6
  • 23
    • 0033564771 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: Isoform-specific effects on neurodegeneration
    • Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, et al. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J Neurosci 19(12): 4867-80 (1999).
    • (1999) J Neurosci , vol.19 , Issue.12 , pp. 4867-4880
    • Buttini, M.1    Orth, M.2    Bellosta, S.3    Akeefe, H.4    Pitas, R.E.5    Wyss-Coray, T.6
  • 24
    • 0028059454 scopus 로고
    • Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice
    • Hayek T, Oiknine J, Brook JG, Aviram M. Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice. Biochem Biophys Res Commun 201(3): 1567-74 (1994).
    • (1994) Biochem Biophys Res Commun , vol.201 , Issue.3 , pp. 1567-1574
    • Hayek, T.1    Oiknine, J.2    Brook, J.G.3    Aviram, M.4
  • 25
    • 0035949490 scopus 로고    scopus 로고
    • Introduction of human apolipoprotein E4 “domain interaction” into mouse apolipoprotein
    • Raffai RL, Dong LM, Farese RV, Jr., Weisgraber KH. Introduction of human apolipoprotein E4 “domain interaction” into mouse apolipoprotein E. Proc Natl Acad Sci USA 98(20): 11587-91 (2001).
    • (2001) E. Proc Natl Acad Sci USA , vol.98 , Issue.20 , pp. 11587-11591
    • Raffai, R.L.1    Dong, L.M.2    Farese, R.V.3    Weisgraber, K.H.4
  • 26
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • Sullivan PM, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick RL, et al. Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 272(29): 17972-80 (1997).
    • (1997) J Biol Chem , vol.272 , Issue.29 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3    Knouff, C.4    Najib, J.5    Reddick, R.L.6
  • 27
    • 1542291105 scopus 로고    scopus 로고
    • Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice
    • Sullivan PM, Mace BE, Maeda N, Schmechel DE. Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. Neuroscience 124(4): 725-33 (2004).
    • (2004) Neuroscience , vol.124 , Issue.4 , pp. 725-733
    • Sullivan, P.M.1    Mace, B.E.2    Maeda, N.3    Schmechel, D.E.4
  • 28
    • 15944410978 scopus 로고    scopus 로고
    • Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology
    • Wang C, Wilson WA, Moore SD, Mace BE, Maeda N, Schmechel DE, et al. Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol Dis 18(2): 390-8 (2005).
    • (2005) Neurobiol Dis , vol.18 , Issue.2 , pp. 390-398
    • Wang, C.1    Wilson, W.A.2    Moore, S.D.3    Mace, B.E.4    Maeda, N.5    Schmechel, D.E.6
  • 29
    • 84877792642 scopus 로고    scopus 로고
    • ApoE4 induces Abeta42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
    • Liraz O, Boehm-Cagan A, Michaelson DM. ApoE4 induces Abeta42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. Mol Neurodegener 8: 16 (2013).
    • (2013) Mol Neurodegener , vol.8 , pp. 16
    • Liraz, O.1    Boehm-Cagan, A.2    Michaelson, D.M.3
  • 30
    • 84877865229 scopus 로고    scopus 로고
    • Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex
    • Rodriguez GA, Burns MP, Weeber EJ, Rebeck GW. Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learn Mem 20(5): 256-66 (2013).
    • (2013) Learn Mem , vol.20 , Issue.5 , pp. 256-266
    • Rodriguez, G.A.1    Burns, M.P.2    Weeber, E.J.3    Rebeck, G.W.4
  • 31
    • 84896855511 scopus 로고    scopus 로고
    • Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice
    • Salomon-Zimri S, Boehm-Cagan A, Liraz O, Michaelson DM. Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice. Neurodegener Dis 13(2-3): 86-92 (2014).
    • (2014) Neurodegener Dis , vol.13 , Issue.2-3 , pp. 86-92
    • Salomon-Zimri, S.1    Boehm-Cagan, A.2    Liraz, O.3    Michaelson, D.M.4
  • 32
    • 48949099311 scopus 로고    scopus 로고
    • Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks
    • Bour A, Grootendorst J, Vogel E, Kelche C, Dodart JC, Bales K, et al. Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. Behav Brain Res 193(2): 174-82 (2008).
    • (2008) Behav Brain Res , vol.193 , Issue.2 , pp. 174-182
    • Bour, A.1    Grootendorst, J.2    Vogel, E.3    Kelche, C.4    Dodart, J.C.5    Bales, K.6
  • 33
    • 0032168460 scopus 로고    scopus 로고
    • Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
    • Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, et al. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci USA 95(18): 10914-9 (1998).
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.18 , pp. 10914-10919
    • Raber, J.1    Wong, D.2    Buttini, M.3    Orth, M.4    Bellosta, S.5    Pitas, R.E.6
  • 35
    • 82755174052 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice
    • Siegel JA, Haley GE, Raber J. Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice. Neurobiol Aging 33(2): 345-58 (2012).
    • (2012) Neurobiol Aging , vol.33 , Issue.2 , pp. 345-358
    • Siegel, J.A.1    Haley, G.E.2    Raber, J.3
  • 36
    • 72849145019 scopus 로고    scopus 로고
    • ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo
    • Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, et al. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. J Neurosci 29(48): 15317-22 (2009).
    • (2009) J Neurosci , vol.29 , Issue.48 , pp. 15317-15322
    • Dumanis, S.B.1    Tesoriero, J.A.2    Babus, L.W.3    Nguyen, M.T.4    Trotter, J.H.5    Ladu, M.J.6
  • 37
    • 77958023983 scopus 로고    scopus 로고
    • Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
    • Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, et al. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci 30(41): 13707-17 (2010).
    • (2010) J Neurosci , vol.30 , Issue.41 , pp. 13707-13717
    • Rews-Zwilling, Y.1    Bien-Ly, N.2    Xu, Q.3    Li, G.4    Bernardo, A.5    Yoon, S.Y.6
  • 38
    • 84902086838 scopus 로고    scopus 로고
    • Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice
    • Klein RC, Acheson SK, Mace BE, Sullivan PM, Moore SD. Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice. Neurobiol Aging 35(9): 2046-52 (2014).
    • (2014) Neurobiol Aging , vol.35 , Issue.9 , pp. 2046-2052
    • Klein, R.C.1    Acheson, S.K.2    Mace, B.E.3    Sullivan, P.M.4    Moore, S.D.5
  • 41
    • 84923338451 scopus 로고    scopus 로고
    • Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice
    • Yong SM, Lim ML, Low CM, Wong BS. Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice. Sci Rep 4: 6580 (2014).
    • (2014) Sci Rep , vol.4 , pp. 6580
    • Yong, S.M.1    Lim, M.L.2    Low, C.M.3    Wong, B.S.4
  • 42
    • 84870937275 scopus 로고    scopus 로고
    • Genotype affects the pre-synaptic compartment of glutamatergic nerve terminals
    • Dumanis SB, DiBattista AM, Miessau M, Moussa CE, Rebeck GW. APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals. J Neurochem 124(1): 4-14 (2013).
    • (2013) J Neurochem , vol.124 , Issue.1 , pp. 4-14
    • Dumanis, S.B.1    Dibattista, A.M.2    Miessau, M.3    Moussa, C.E.4    Rebeck, G.5
  • 43
    • 84858031544 scopus 로고    scopus 로고
    • The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil DHA diet and are modified by cholesterol
    • Kariv-Inbal Z, Yacobson S, Berkecz R, Peter M, Janaky T, Lutjohann D, et al. The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol. J Alzheimers Dis 28(3): 667-83 (2012).
    • (2012) J Alzheimers Dis , vol.28 , Issue.3 , pp. 667-683
    • Kariv-Inbal, Z.1    Yacobson, S.2    Berkecz, R.3    Peter, M.4    Janaky, T.5    Lutjohann, D.6
  • 44
    • 84870871335 scopus 로고    scopus 로고
    • Apolipoprotein E acts at pre-synaptic sites…among others
    • Barger SW. Apolipoprotein E acts at pre-synaptic sites…among others. J Neurochem 124(1): 1-3 (2013).
    • (2013) J Neurochem , vol.124 , Issue.1 , pp. 1-3
    • Barger, S.W.1
  • 45
    • 83455230813 scopus 로고    scopus 로고
    • Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer’s disease: A systematic review and meta-analysis
    • Ward A, Crean S, Mercaldi CJ, Collins JM, Boyd D, Cook MN, et al. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer’s disease: a systematic review and meta-analysis. Neuroepidemiology 38(1): 1-17 (2012).
    • (2012) Neuroepidemiology , vol.38 , Issue.1 , pp. 1-17
    • Ward, A.1    Crean, S.2    Mercaldi, C.J.3    Collins, J.M.4    Boyd, D.5    Cook, M.N.6
  • 46
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278(16): 1349-56 (1997).
    • (1997) JAMA , vol.278 , Issue.16 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6
  • 47
    • 76749163252 scopus 로고    scopus 로고
    • Apolipoprotein E4 and sex affect neurobehavioral performance in primary school children
    • Acevedo SF, Piper BJ, Craytor MJ, Benice TS, Raber J. Apolipoprotein E4 and sex affect neurobehavioral performance in primary school children. Pediatr Res 67(3): 293-9 (2010).
    • (2010) Pediatr Res , vol.67 , Issue.3 , pp. 293-299
    • Acevedo, S.F.1    Piper, B.J.2    Craytor, M.J.3    Benice, T.S.4    Raber, J.5
  • 48
    • 34250001454 scopus 로고    scopus 로고
    • Effects of sex and APOE epsilon4 on object recognition and spatial navigation in the elderly
    • Berteau-Pavy F, Park B, Raber J. Effects of sex and APOE epsilon4 on object recognition and spatial navigation in the elderly. Neuroscience 147(1): 6-17 (2007).
    • (2007) Neuroscience , vol.147 , Issue.1 , pp. 6-17
    • Berteau-Pavy, F.1    Park, B.2    Raber, J.3
  • 49
    • 77953798688 scopus 로고    scopus 로고
    • Effects of epsilon4 on object recognition in the non-demented elderly
    • Haley GE, Berteau-Pavy F, Parkv B, Raber J. Effects of epsilon4 on object recognition in the non-demented elderly. Curr Aging Sci 3(2): 127-37 (2010).
    • (2010) Curr Aging Sci , vol.3 , Issue.2 , pp. 127-137
    • Haley, G.E.1    Berteau-Pavy, F.2    Parkv, B.3    Raber, J.4
  • 50
    • 84947037774 scopus 로고    scopus 로고
    • Sex, but not apolipoprotein E polymorphism, differences in spatial performance in young adults
    • Yasen AL, Raber J, Miller JK, Piper BJ. Sex, but not apolipoprotein E polymorphism, differences in spatial performance in young adults. Arch Sex Behav 44(8): 2219-26 (2015).
    • (2015) Arch Sex Behav , vol.44 , Issue.8 , pp. 2219-2226
    • Yasen, A.L.1    Raber, J.2    Miller, J.K.3    Piper, B.J.4
  • 51
    • 84928995981 scopus 로고    scopus 로고
    • Association of the apolipoprotein E genotype with memory performance and executive functioning in cognitively intact elderly
    • Luck T, Then FS, Luppa M, Schroeter ML, Arelin K, Burkhardt R, et al. Association of the apolipoprotein E genotype with memory performance and executive functioning in cognitively intact elderly. Neuropsychology 29(3): 382-7 (2015).
    • (2015) Neuropsychology , vol.29 , Issue.3 , pp. 382-387
    • Luck, T.1    Then, F.S.2    Luppa, M.3    Schroeter, M.L.4    Arelin, K.5    Burkhardt, R.6
  • 53
    • 79952238579 scopus 로고    scopus 로고
    • IQ, educational attainment, memory and plasma lipids: Associations with apolipoprotein E genotype in 5995 children
    • Taylor AE, Guthrie PA, Smith GD, Golding J, Sattar N, Hingorani AD, et al. IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children. Biol Psychiatry 70(2): 152-8 (2011).
    • (2011) Biol Psychiatry , vol.70 , Issue.2 , pp. 152-158
    • Taylor, A.E.1    Guthrie, P.A.2    Smith, G.D.3    Golding, J.4    Sattar, N.5    Hingorani, A.D.6
  • 54
    • 0034711604 scopus 로고    scopus 로고
    • Intelligence and event-related potentials for young female human volunteer apolipoprotein E epsilon4 and non-epsilon4 carriers
    • Yu YW, Lin CH, Chen SP, Hong CJ, Tsai SJ. Intelligence and event-related potentials for young female human volunteer apolipoprotein E epsilon4 and non-epsilon4 carriers. Neurosci Lett 294(3): 179-81 (2000).
    • (2000) Neurosci Lett , vol.294 , Issue.3 , pp. 179-181
    • Yu, Y.W.1    Lin, C.H.2    Chen, S.P.3    Hong, C.J.4    Tsai, S.J.5
  • 55
    • 84856960961 scopus 로고    scopus 로고
    • APOE epsilon4 differentially influences change in memory performance depending on age. The SMART-MR study
    • Jochemsen HM, Muller M, van der Graaf Y, Geerlings MI. APOE epsilon4 differentially influences change in memory performance depending on age. The SMART-MR study. Neurobiol Aging 33(4): 832 e15-22 (2012).
    • (2012) Neurobiol Aging 33 , vol.832 , Issue.4 , pp. e15-e22
    • Jochemsen, H.M.1    Muller, M.2    Van Der Graaf, Y.3    Geerlings, M.I.4
  • 57
    • 84868235352 scopus 로고    scopus 로고
    • APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures
    • Rusted JM, Evans SL, King SL, Dowell N, Tabet N, Tofts PS. APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures. Neuroimage 65: 364-73 (2013).
    • (2013) Neuroimage , vol.65 , pp. 364-373
    • Rusted, J.M.1    Evans, S.L.2    King, S.L.3    Dowell, N.4    Tabet, N.5    Tofts, P.S.6
  • 58
    • 79955451703 scopus 로고    scopus 로고
    • The apolipoprotein e antagonistic pleiotropy hypothesis: Review and recommendations
    • 2011
    • Tuminello ER, Han SD. The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations. Int J Alzheimers Dis 2011: 726197 (2011).
    • (2011) Int J Alzheimers Dis
    • Tuminello, E.R.1    Han, S.D.2
  • 59
    • 85050580055 scopus 로고    scopus 로고
    • Are the effects of APOE 4 on cognitive function in nonclinical populations age- and gender-dependent?
    • Rusted J, Carare RO. Are the effects of APOE 4 on cognitive function in nonclinical populations age- and gender-dependent? Neurodegener Dis Manag 5(1): 37-48 (2015).
    • (2015) Neurodegener Dis Manag , vol.5 , Issue.1 , pp. 37-48
    • Rusted, J.1    Carare, R.O.2
  • 60
    • 34548736492 scopus 로고    scopus 로고
    • Association of apolipoprotein E genotypes with lipid levels and coronary risk
    • Bennet AM, Di Angelantonio E, Ye Z, Wensley F, Dahlin A, Ahlbom A, et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 298(11): 1300-11 (2007).
    • (2007) JAMA , vol.298 , Issue.11 , pp. 1300-1311
    • Bennet, A.M.1    Di Angelantonio, E.2    Ye, Z.3    Wensley, F.4    Dahlin, A.5    Ahlbom, A.6
  • 61
    • 84883759456 scopus 로고    scopus 로고
    • Seizures and epileptiform activity in the early stages of Alzheimer disease
    • Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, et al. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol 70(9): 1158-66 (2013).
    • (2013) JAMA Neurol , vol.70 , Issue.9 , pp. 1158-1166
    • Vossel, K.A.1    Beagle, A.J.2    Rabinovici, G.D.3    Shu, H.4    Lee, S.E.5    Naasan, G.6
  • 62
    • 0033624166 scopus 로고    scopus 로고
    • APOE epsilon4 genotype is associated with an earlier onset of chronic temporal lobe epilepsy
    • Briellmann RS, Torn-Broers Y, Busuttil BE, Major BJ, Kalnins RM, Olsen M, et al. APOE epsilon4 genotype is associated with an earlier onset of chronic temporal lobe epilepsy. Neurology 55(3): 435-7 (2000).
    • (2000) Neurology , vol.55 , Issue.3 , pp. 435-437
    • Briellmann, R.S.1    Torn-Broers, Y.2    Busuttil, B.E.3    Major, B.J.4    Kalnins, R.M.5    Olsen, M.6
  • 63
    • 0037782431 scopus 로고    scopus 로고
    • Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele
    • Diaz-Arrastia R, Gong Y, Fair S, Scott KD, Garcia MC, Carlile MC, et al. Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele. Arch Neurol 60(6): 818-22 (2003).
    • (2003) Arch Neurol , vol.60 , Issue.6 , pp. 818-822
    • Diaz-Arrastia, R.1    Gong, Y.2    Fair, S.3    Scott, K.D.4    Garcia, M.C.5    Carlile, M.C.6
  • 64
    • 0242403213 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer’s disease patients
    • Ji Y, Gong Y, Gan W, Beach T, Holtzman DM, Wisniewski T. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer’s disease patients. Neuroscience 122(2): 305-15 (2003).
    • (2003) Neuroscience , vol.122 , Issue.2 , pp. 305-315
    • Ji, Y.1    Gong, Y.2    Gan, W.3    Beach, T.4    Holtzman, D.M.5    Wisniewski, T.6
  • 65
    • 84892388855 scopus 로고    scopus 로고
    • Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: A cross-sectional imaging study
    • Dean DC, 3rd, Jerskey BA, Chen K, Protas H, Thiyyagura P, Roontiva A, et al. Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. JAMA Neurol 71(1): 11-22 (2014).
    • (2014) JAMA Neurol , vol.71 , Issue.1 , pp. 11-22
    • Dean, D.C.1    Jerskey, B.A.2    Chen, K.3    Protas, H.4    Thiyyagura, P.5    Roontiva, A.6
  • 66
    • 84898870011 scopus 로고    scopus 로고
    • Common variants in psychiatric risk genes predict brain structure at birth
    • Knickmeyer RC, Wang J, Zhu H, Geng X, Woolson S, Hamer RM, et al. Common variants in psychiatric risk genes predict brain structure at birth. Cereb Cortex 24(5): 1230-46 (2014).
    • (2014) Cereb Cortex , vol.24 , Issue.5 , pp. 1230-1246
    • Knickmeyer, R.C.1    Wang, J.2    Zhu, H.3    Geng, X.4    Woolson, S.5    Hamer, R.M.6
  • 67
    • 84933670618 scopus 로고    scopus 로고
    • Two Alzheimer’s disease risk genes increase entorhinal cortex volume in young adults
    • DiBattista AM, Stevens BW, Rebeck GW, Green AE. Two Alzheimer’s disease risk genes increase entorhinal cortex volume in young adults. Front Hum Neurosci 8: 779 (2014).
    • (2014) Front Hum Neurosci , vol.8 , pp. 779
    • Dibattista, A.M.1    Stevens, B.W.2    Rebeck, G.W.3    Green, A.E.4
  • 69
    • 57749171545 scopus 로고    scopus 로고
    • Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer’s disease
    • Filippini N, Rao A, Wetten S, Gibson RA, Borrie M, Guzman D, et al. Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer’s disease. Neuroimage 44(3): 724-8 (2009).
    • (2009) Neuroimage , vol.44 , Issue.3 , pp. 724-728
    • Filippini, N.1    Rao, A.2    Wetten, S.3    Gibson, R.A.4    Borrie, M.5    Guzman, D.6
  • 72
  • 74
  • 75
    • 84866759212 scopus 로고    scopus 로고
    • Gray matter network associated with risk for Alzheimer’s disease in young to middle-aged adults
    • Alexander GE, Bergfield KL, Chen K, Reiman EM, Hanson KD, Lin L, et al. Gray matter network associated with risk for Alzheimer’s disease in young to middle-aged adults. Neurobiol Aging 33(12): 2723-32 (2012).
    • (2012) Neurobiol Aging , vol.33 , Issue.12 , pp. 2723-2732
    • Alexander, G.E.1    Bergfield, K.L.2    Chen, K.3    Reiman, E.M.4    Hanson, K.D.5    Lin, L.6
  • 77
    • 84878240439 scopus 로고    scopus 로고
    • Apolipoprotein epsilon4-allele as a significant risk factor for conversion from mild cognitive impairment to Alzheimer’s disease: A meta-analysis of prospective studies
    • Fei M, Jianhua W. Apolipoprotein epsilon4-allele as a significant risk factor for conversion from mild cognitive impairment to Alzheimer’s disease: a meta-analysis of prospective studies. J Mol Neurosci 50(2): 257-63 (2013).
    • (2013) J Mol Neurosci , vol.50 , Issue.2 , pp. 257-263
    • Fei, M.1    Jianhua, W.2
  • 78
    • 77954034488 scopus 로고    scopus 로고
    • Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    • Shen L, Kim S, Risacher SL, Nho K, Swaminathan S, West JD, et al. Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. Neuroimage 53(3): 1051-63 (2010).
    • (2010) Neuroimage , vol.53 , Issue.3 , pp. 1051-1063
    • Shen, L.1    Kim, S.2    Risacher, S.L.3    Nho, K.4    Swaminathan, S.5    West, J.D.6
  • 80
    • 84902085340 scopus 로고    scopus 로고
    • 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons
    • Knopman DS, Jack CR, Jr., Wiste HJ, Lundt ES, Weigand SD, Vemuri P, et al. 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons. Neurobiol Aging 35(9): 2096-106 (2014).
    • (2014) Neurobiol Aging , vol.35 , Issue.9 , pp. 2096-2106
    • Knopman, D.S.1    Jack, C.R.2    Wiste, H.J.3    Lundt, E.S.4    Weigand, S.D.5    Vemuri, P.6
  • 81
    • 0035853154 scopus 로고    scopus 로고
    • Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer’s disease
    • Reiman EM, Caselli RJ, Chen K, Alexander GE, Bandy D, Frost J. Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer’s disease. Proc Natl Acad Sci USA 98(6): 3334-9 (2001).
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.6 , pp. 3334-3339
    • Reiman, E.M.1    Caselli, R.J.2    Chen, K.3    Alexander, G.E.4    Bandy, D.5    Frost, J.6
  • 82
    • 16644390659 scopus 로고    scopus 로고
    • Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (Carriers of the epsilon4 allele
    • Scarmeas N, Habeck C, Anderson KE, Hilton J, Devanand DP, Pelton GH, et al. Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (carriers of the epsilon4 allele). Am J Geriatr Psychiatry 12(6): 596-605(2004).
    • (2004) Am J Geriatr Psychiatry , vol.12 , Issue.6 , pp. 596-605
    • Scarmeas, N.1    Habeck, C.2    Erson, K.E.3    Hilton, J.4    Devanand, D.P.5    Pelton, G.H.6
  • 84
    • 42649122950 scopus 로고    scopus 로고
    • Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers
    • Deeny SP, Poeppel D, Zimmerman JB, Roth SM, Brandauer J, Witkowski S, et al. Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers. Biol Psychol 78(2): 179-87 (2008).
    • (2008) Biol Psychol , vol.78 , Issue.2 , pp. 179-187
    • Deeny, S.P.1    Poeppel, D.2    Zimmerman, J.B.3    Roth, S.M.4    Brandauer, J.5    Witkowski, S.6
  • 87
    • 84892490222 scopus 로고    scopus 로고
    • A combined effect of two Alzheimer’s risk genes on medial temporal activity during executive attention in young adults
    • Green AE, Gray JR, Deyoung CG, Mhyre TR, Padilla R, Dibattista AM, et al. A combined effect of two Alzheimer’s risk genes on medial temporal activity during executive attention in young adults. Neuropsychologia 56: 1-8 (2014).
    • (2014) Neuropsychologia , vol.56 , pp. 1-8
    • Green, A.E.1    Gray, J.R.2    Deyoung, C.G.3    Mhyre, T.R.4    Padilla, R.5    Dibattista, A.M.6
  • 88
    • 84944754734 scopus 로고    scopus 로고
    • Reduced grid-cell-like representations in adults at genetic risk for Alzheimer’s disease
    • Kunz L, Schroder TN, Lee H, Montag C, Lachmann B, Sariyska R, et al. Reduced grid-cell-like representations in adults at genetic risk for Alzheimer’s disease. Science 350(6259): 430-3 (2015).
    • (2015) Science , vol.350 , Issue.6259 , pp. 430-433
    • Kunz, L.1    Schroder, T.N.2    Lee, H.3    Montag, C.4    Lachmann, B.5    Sariyska, R.6
  • 90
    • 84880820987 scopus 로고    scopus 로고
    • Effects of the apolipoprotein E epsilon4 allele on functional MRI during n-back working memory tasks in healthy middle-aged adults
    • Chen CJ, Chen CC, Wu D, Chi NF, Chen PC, Liao YP, et al Effects of the apolipoprotein E epsilon4 allele on functional MRI during n-back working memory tasks in healthy middle-aged adults. AJNR Am J Neuroradiol 34(6): 1197-202 (2013).
    • (2013) AJNR am J Neuroradiol , vol.34 , Issue.6 , pp. 1197-1202
    • Chen, C.J.1    Chen, C.C.2    Wu, D.3    Chi, N.F.4    Chen, P.C.5    Liao, Y.P.6
  • 92
    • 79954585189 scopus 로고    scopus 로고
    • Reduced levels of human apoE4 protein in an animal model of cognitive impairment
    • Sullivan PM, Han B, Liu F, Mace BE, Ervin JF, Wu S, et al. Reduced levels of human apoE4 protein in an animal model of cognitive impairment. Neurobiol Aging 32(5): 791-801 (2011).
    • (2011) Neurobiol Aging , vol.32 , Issue.5 , pp. 791-801
    • Sullivan, P.M.1    Han, B.2    Liu, F.3    Mace, B.E.4    Ervin, J.F.5    Wu, S.6
  • 93
    • 70249137220 scopus 로고    scopus 로고
    • Understanding the basis for the association of apoE4 with Alzheimer’s disease: Opening the door for therapeutic approaches
    • Zhong N, Weisgraber KH. Understanding the basis for the association of apoE4 with Alzheimer’s disease: opening the door for therapeutic approaches. Curr Alzheimer Res 6(5): 415-8 (2009).
    • (2009) Curr Alzheimer Res , vol.6 , Issue.5 , pp. 415-418
    • Zhong, N.1    Weisgraber, K.H.2
  • 94
    • 84867119124 scopus 로고    scopus 로고
    • Cerebrospinal fluid APOE levels: An endophenotype for genetic studies for Alzheimer’s disease
    • Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, et al. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer’s disease. Hum Mol Genet 21(20): 4558-71 (2012).
    • (2012) Hum Mol Genet , vol.21 , Issue.20 , pp. 4558-4571
    • Cruchaga, C.1    Kauwe, J.S.2    Nowotny, P.3    Bales, K.4    Pickering, E.H.5    Mayo, K.6
  • 95
    • 84899898187 scopus 로고    scopus 로고
    • Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer’s disease patients and controls
    • Martinez-Morillo E, Hansson O, Atagi Y, Bu G, Minthon L, Diamandis EP, et al. Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer’s disease patients and controls. Acta Neuropathol 127(5): 633-43 (2014).
    • (2014) Acta Neuropathol , vol.127 , Issue.5 , pp. 633-643
    • Martinez-Morillo, E.1    Hansson, O.2    Atagi, Y.3    Bu, G.4    Minthon, L.5    Diamandis, E.P.6
  • 96
  • 97
    • 0022350033 scopus 로고
    • Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
    • Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Investig 76(4): 1501-13 (1985).
    • (1985) J Clin Investig , vol.76 , Issue.4 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 99
    • 0023280054 scopus 로고
    • Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain
    • Pitas RE, Boyles JK, Lee SH, Hui D, Weisgraber KH. Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. J Biol Chem 262(29): 14352-60 (1987).
    • (1987) J Biol Chem , vol.262 , Issue.29 , pp. 14352-14360
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3    Hui, D.4    Weisgraber, K.H.5
  • 100
    • 14744305790 scopus 로고    scopus 로고
    • Genetics and molecular biology: ABCA1 in brain apolipoprotein E metabolism and lipidation
    • Lee J, Bu G. Genetics and molecular biology: ABCA1 in brain apolipoprotein E metabolism and lipidation. Curr Opin Lipidol 16(1): 115-7 (2005).
    • (2005) Curr Opin Lipidol , vol.16 , Issue.1 , pp. 115-117
    • Lee, J.1    Bu, G.2
  • 101
    • 84928740328 scopus 로고    scopus 로고
    • Opposing effects of viral mediated brain expression of apolipoprotein E2 (ApoE2) and apoE4 on apoE lipidation and Abeta metabolism in apoE4- targeted replacement mice
    • Hu J, Liu CC, Chen XF, Zhang YW, Xu H, Bu G. Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Abeta metabolism in apoE4- targeted replacement mice. Mol Neurodegen 10: 6(2015).
    • (2015) Mol Neurodegen , vol.10 , pp. 6
    • Hu, J.1    Liu, C.C.2    Chen, X.F.3    Zhang, Y.W.4    Xu, H.5    Bu, G.6
  • 103
    • 14244255485 scopus 로고    scopus 로고
    • The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer’s disease
    • Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, et al. The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer’s disease. J Biol Chem 280(6): 4079-88 (2005).
    • (2005) J Biol Chem , vol.280 , Issue.6 , pp. 4079-4088
    • Koldamova, R.P.1    Lefterov, I.M.2    Staufenbiel, M.3    Wolfe, D.4    Huang, S.5    Glorioso, J.C.6
  • 104
    • 33947610707 scopus 로고    scopus 로고
    • The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer’s disease
    • Riddell DR, Zhou H, Comery TA, Kouranova E, Lo CF, Warwick HK, et al. The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer’s disease. Mol Cell Neurosci 34(4): 621-8 (2007).
    • (2007) Mol Cell Neurosci , vol.34 , Issue.4 , pp. 621-628
    • Riddell, D.R.1    Zhou, H.2    Comery, T.A.3    Kouranova, E.4    Lo, C.F.5    Warwick, H.K.6
  • 105
    • 77958594257 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice
    • Donkin JJ, Stukas S, Hirsch-Reinshagen V, Namjoshi D, Wilkinson A, May S, et al. ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. J Biol Chem 285(44): 34144-54 (2010).
    • (2010) J Biol Chem , vol.285 , Issue.44 , pp. 34144-34154
    • Donkin, J.J.1    Stukas, S.2    Hirsch-Reinshagen, V.3    Namjoshi, D.4    Wilkinson, A.5    May, S.6
  • 106
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
    • Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, et al. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 335(6075): 1503-6 (2012).
    • (2012) Science , vol.335 , Issue.6075 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3    Lee, C.Y.4    Karlo, J.C.5    Zinn, A.E.6
  • 107
    • 84957558849 scopus 로고    scopus 로고
    • ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice
    • Corona AW, Kodoma N, Casali BT, Landreth GE. ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice. J Neuroimmune Pharmacol 11(1): 61-72 (2016).
    • (2016) J Neuroimmune Pharmacol , vol.11 , Issue.1 , pp. 61-72
    • Corona, A.W.1    Kodoma, N.2    Casali, B.T.3    Landreth, G.E.4
  • 108
    • 84946429411 scopus 로고    scopus 로고
    • MicroRNA-33 Regulates ApoE Lipidation and Amyloid-beta Metabolism in the Brain
    • Kim J, Yoon H, Horie T, Burchett JM, Restivo JL, Rotllan N, et al. microRNA-33 Regulates ApoE Lipidation and Amyloid-beta Metabolism in the Brain. J Neurosci 35(44): 14717-26 (2015).
    • (2015) J Neurosci , vol.35 , Issue.44 , pp. 14717-14726
    • Kim, J.1    Yoon, H.2    Horie, T.3    Burchett, J.M.4    Restivo, J.L.5    Rotllan, N.6
  • 109
    • 84898938661 scopus 로고    scopus 로고
    • Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway
    • Zhao J, Fu Y, Liu CC, Shinohara M, Nielsen HM, Dong Q, et al. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. J Biol Chem 289(16): 11282-92 (2014).
    • (2014) J Biol Chem , vol.289 , Issue.16 , pp. 11282-11292
    • Zhao, J.1    Fu, Y.2    Liu, C.C.3    Shinohara, M.4    Nielsen, H.M.5    Dong, Q.6
  • 110
    • 84942940398 scopus 로고    scopus 로고
    • Apolipoprotein E enhances MicroRNA-146a in monocytes and macrophages to suppress nuclear factor-kappaB-driven inflammation and atherosclerosis
    • Li K, Ching D, Luk FS, Raffai RL. Apolipoprotein E enhances MicroRNA-146a in monocytes and macrophages to suppress nuclear factor-kappaB-driven inflammation and atherosclerosis. Circ Res 117(1): e1-e11 (2015).
    • (2015) Circ Res , vol.117 , Issue.1 , pp. ee1-e11
    • Li, K.1    Ching, D.2    Luk, F.S.3    Raffai, R.L.4
  • 111
    • 67649104088 scopus 로고    scopus 로고
    • APOE genotype-specific differences in the innate immune response
    • Vitek MP, Brown CM, Colton CA. APOE genotype-specific differences in the innate immune response. Neurobiol Aging 30(9): 1350-60 (2009).
    • (2009) Neurobiol Aging , vol.30 , Issue.9 , pp. 1350-1360
    • Vitek, M.P.1    Brown, C.M.2    Colton, C.A.3
  • 112
    • 66249122077 scopus 로고    scopus 로고
    • Low-density lipoprotein receptors regulate microglial inflammation through c-Jun Nterminal kinase
    • Pocivavsek A, Burns MP, Rebeck GW. Low-density lipoprotein receptors regulate microglial inflammation through c-Jun Nterminal kinase. Glia 57(4): 444-53 (2009).
    • (2009) Glia , vol.57 , Issue.4 , pp. 444-453
    • Pocivavsek, A.1    Burns, M.P.2    Rebeck, G.W.3
  • 114
    • 0033554880 scopus 로고    scopus 로고
    • Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury
    • Friedman G, Froom P, Sazbon L, Grinblatt I, Shochina M, Tsenter J, et al. Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury. Neurology 52(2): 244-8 (1999).
    • (1999) Neurology , vol.52 , Issue.2 , pp. 244-248
    • Friedman, G.1    Froom, P.2    Sazbon, L.3    Grinblatt, I.4    Shochina, M.5    Tsenter, J.6
  • 115
    • 84863029161 scopus 로고    scopus 로고
    • APOE genotype alters glial activation and loss of synaptic markers in mice
    • Zhu Y, Nwabuisi-Heath E, Dumanis SB, Tai LM, Yu C, Rebeck GW, et al. APOE genotype alters glial activation and loss of synaptic markers in mice. Glia 60(4): 559-69 (2012).
    • (2012) Glia , vol.60 , Issue.4 , pp. 559-569
    • Zhu, Y.1    Nwabuisi-Heath, E.2    Dumanis, S.B.3    Tai, L.M.4    Yu, C.5    Rebeck, G.W.6
  • 116
    • 1542467336 scopus 로고    scopus 로고
    • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
    • Lynch JR, Tang W, Wang H, Vitek MP, Bennett ER, Sullivan PM, et al. APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. J Biol Chem 278(49): 48529-33 (2003).
    • (2003) J Biol Chem , vol.278 , Issue.49 , pp. 48529-48533
    • Lynch, J.R.1    Tang, W.2    Wang, H.3    Vitek, M.P.4    Bennett, E.R.5    Sullivan, P.M.6
  • 117
    • 27744552618 scopus 로고    scopus 로고
    • Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade
    • Ophir G, Amariglio N, Jacob-Hirsch J, Elkon R, Rechavi G, Michaelson DM. Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade. Neurobiol Dis 20(3): 709-18 (2005).
    • (2005) Neurobiol Dis , vol.20 , Issue.3 , pp. 709-718
    • Ophir, G.1    Amariglio, N.2    Jacob-Hirsch, J.3    Elkon, R.4    Rechavi, G.5    Michaelson, D.M.6
  • 118
    • 1642534291 scopus 로고    scopus 로고
    • APOE genotype-specific differences in human and mouse macrophage nitric oxide production
    • Colton CA, Needham LK, Brown C, Cook D, Rasheed K, Burke JR, et al. APOE genotype-specific differences in human and mouse macrophage nitric oxide production. J Neuroimmunol 147(1-2):62-7 (2004).
    • (2004) J Neuroimmunol , vol.147 , Issue.1-2 , pp. 62-67
    • Colton, C.A.1    Needham, L.K.2    Brown, C.3    Cook, D.4    Rasheed, K.5    Burke, J.R.6
  • 119
    • 37849044699 scopus 로고    scopus 로고
    • NSAID use and dementia risk in the Cardiovascular Health Study: Role of APOE and NSAID type
    • Szekely CA, Breitner JC, Fitzpatrick AL, Rea TD, Psaty BM, Kuller LH, et al. NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type. Neurology 70(1): 17-24 (2008).
    • (2008) Neurology , vol.70 , Issue.1 , pp. 17-24
    • Szekely, C.A.1    Breitner, J.C.2    Fitzpatrick, A.L.3    Rea, T.D.4    Psaty, B.M.5    Kuller, L.H.6
  • 120
  • 121
    • 84902084909 scopus 로고    scopus 로고
    • Bexarotene reduces network excitability in models of Alzheimer’s disease and epilepsy
    • Bomben V, Holth J, Reed J, Cramer P, Landreth G, Noebels J. Bexarotene reduces network excitability in models of Alzheimer’s disease and epilepsy. Neurobiol Aging 35(9): 2091-5 (2014).
    • (2014) Neurobiol Aging , vol.35 , Issue.9 , pp. 2091-2095
    • Bomben, V.1    Holth, J.2    Reed, J.3    Cramer, P.4    Landreth, G.5    Noebels, J.6
  • 122
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90(5): 1977-81 (1993).
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.5 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3    Pericak-Vance, M.4    Enghild, J.5    Salvesen, G.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.