Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease

Science

Volumn 350, Issue 6259, 2015, Pages 430-433

  Kunz, Lukas ^a,b   Schröder, Tobias Navarro ^c   Lee, Hweeling ^a   Montag, Christian ^d   Lachmann, Bernd ^d   Sariyska, Rayna ^d   Reuter, Martin ^b   Stirnberg, Rüdiger ^a   Stöcker, Tony ^a   Messing Floeter, Paul Christian ^a,b   Fell, Juergen ^b   Doeller, Christian F ^c   Axmacher, Nikolai ^a,b,e  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c RADBOUD UNIVERSITY   (Netherlands)

^d UNIVERSITY OF ULM   (Germany)

^e RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4;

ADULT; CELLS AND CELL COMPONENTS; HEALTH RISK; MEMORY; MENTAL HEALTH; PROTEIN; PUBLIC HEALTH;

ALZHEIMER DISEASE; ARTICLE; ENTORHINAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC RISK; HETEROZYGOTE; HIPPOCAMPUS; HUMAN; MENTAL PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY; SPATIAL ORIENTATION; ADULT; FEMALE; GENETICS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOLOGY; RISK FACTOR; YOUNG ADULT;

ADULT; AGE OF ONSET; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; ENTORHINAL CORTEX; FEMALE; HETEROZYGOTE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; RISK FACTORS; SPATIAL MEMORY; SPATIAL NAVIGATION; YOUNG ADULT;

EID: 84944754734     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac8128     Document Type: Article

References (32)

1. H. W. Querfurth, F. M. LaFerla, N. Engl. J. Med. 362, 329-344 (2010).
2. R. A. Sperling, C. R. Jack Jr., P. S. Aisen, Sci. Transl. Med. 3, 111cm33 (2011).
3. E. H. Corder et al., Science 261, 921-923 (1993).
4. C. C. Liu, T. Kanekiyo, H. Xu, G. Bu, Nat. Rev. Neurol. 9, 106-118 (2013).
5. H. Braak, E. Braak, Acta Neuropathol. 82, 239-259 (1991).
6. H. Braak, K. Del Tredici, Acta Neuropathol. 121, 171-181 (2011).
7. E. Ghebremedhin, C. Schultz, E. Braak, H. Braak, Exp. Neurol. 153, 152-155 (1998).
8. T. Hafting, M. Fyhn, S. Molden, M. B. Moser, E. I. Moser, Nature 436, 801-806 (2005).
9. J. Jacobs et al., Nat. Neurosci. 16, 1188-1190 (2013).
10. G. Buzsáki, E. I. Moser, Nat. Neurosci. 16, 130-138 (2013).
11. M. E. Hasselmo, M. P. Brandon, Neural Plast. 2008, 658323 (2008).
12. S. Sreenivasan, I. Fiete, Nat. Neurosci. 14, 1330-1337 (2011).
13. D. Bush, C. Barry, N. Burgess, Trends Neurosci. 37, 136-145 (2014).
14. A. D. Ekstrom et al., Nature 425, 184-188 (2003).
15. C. F. Doeller, C. Barry, N. Burgess, Nature 463, 657-661 (2010).
16. Materials and methods are available as supplementary materials on Science Online.
17. F. Berteau-Pavy, B. Park, J. Raber, Neuroscience 147, 6-17 (2007).
18. M. J. Chadwick, A. E. Jolly, D. P. Amos, D. Hassabis, H. J. Spiers, Curr Biol. 25, 87-92 (2015).
19. S. Y. Bookheimer et al., N. Engl. J. Med. 343, 450-456 (2000).
20. B. A. Strange, M. P. Witter, E. S. Lein, E. I. Moser, Nat. Rev. Neurosci. 15, 655-669 (2014).
21. N. Filippini et al., Proc. Natl. Acad. Sci. U.S.A. 106, 7209-7214 (2009).
22. M. S. Fanselow, H. W. Dong, Neuron 65, 7-19 (2010).
23. A. Bakker et al., Neuron 74, 467-474 (2012).
24. A. W. Bero et al., Nat. Neurosci. 14, 750-756 (2011).
25. K. Hardcastle, S. Ganguli, L. M. Giocomo, Neuron 86, 827-839 (2015).
26. L. Muessig, J. Hauser, T. J. Wills, F. Cacucci, Neuron 86, 1167-1173 (2015).
27. A. J. Trachtenberg, N. Filippini, C. E. Mackay, Neurobiol. Aging 33, 323-334 (2012).
28. C. F. Doeller, J. A. King, N. Burgess, Proc. Natl. Acad. Sci. U.S.A. 105, 5915-5920 (2008).
29. T. Wolbers, J. M. Wiener, H. A. Mallot, C. Büchel, J. Neurosci. 27, 9408-9416 (2007).
30. K. R. Sherrill et al., J. Neurosci. 33, 19304-19313 (2013).
31. C. R. Mondadori et al., Cereb. Cortex 17, 1934-1947 (2007).
32. F. Cacucci, M. Yi, T. J. Wills, P. Chapman, J. O'Keefe, Proc. Natl. Acad. Sci. U.S.A. 105, 7863-7868 (2008).