Understanding the basis for the association of apoE4 with Alzheimer's disease: Opening the door for therapeutic approaches

Current Alzheimer Research

Volumn 6, Issue 5, 2009, Pages 415-418

  Zhong, Ning ^a   Weisgraber, Karl H ^a,b,c  

^a GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; ARGININE;

ALZHEIMER DISEASE; ASTROCYTE; CARBOXY TERMINAL SEQUENCE; CAUSAL ATTRIBUTION; COGNITIVE DEFECT; CONFERENCE PAPER; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ALLELES; ALZHEIMER DISEASE; ANIMALS; APOLIPOPROTEIN E4; ASTROCYTES; MICE; MICE, TRANSGENIC; NEURONS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY;

EID: 70249137220     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720509789207921     Document Type: Conference Paper

References (17)

1. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-923 (1993).
2. Saunders AM, Strittmatter WJ, Schmechel D, St George-Hyslop PH, Pericak-Vance MA, Joo SH, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467-1472 (1993). (Pubitemid 23230526)
3. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90: 1977-1981 (1993).
4. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. J Am Med Assoc 278: 1349-1356 (1997).
5. Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci USA 103: 5644-5651 (2006).
6. Huang Y, Weisgraber KH, Mucke L and Mahley RW. The APOE polymorphism and 1-year outcome in ischemic stroke: genotype-gender interaction. J Mol Neurosci 23: 189-204 (2004).
7. Dong L-M, Weisgraber KH. Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J Biol Chem 271: 19053-19057 (1996).
8. Morrow JA, Hatters DM, Lu B, Höchtl P, Oberg KA, Rupp B, et al. Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease. J Biol Chem 277: 50380-50385 (2002). (Pubitemid 36042188)
9. Raffaï RL, Dong L-M, Farese RV, Jr., Weisgraber KH. (2001) Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc Natl Acad Sci USA 98: 11587-11591.
10. Hatters DM, Peters-Libeu CA and Weisgraber KH. Engineering conformational destabilization into mouse apolipoprotein E. J Biol Chem 280: 26477-26482 (2005).
11. Ramaswamy G, Xu Q, Huang Y and Weisgraber KH. Effect of domain interaction on apolipoprotein E levels in mouse brain. J Neurosci 25: 10658-10663 (2005). (Pubitemid 41681913)
12. Zhong N, Scearce-Levie K, Ramaswamy G, Weisgraber KH. (2008) Apolipoprotein E4 domain interaction: Synaptic and cognitive deficits in mice. Alzheimers Dement 4: 179-192. (Pubitemid 351682263)
13. Lindholm D, Wootz H and Korhonen L. ER stress and neurodegenerative diseases. Cell Death Differentiation 13: 385-392 (2006).
14. Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, et al. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci USA 102: 18700-18705 (2005). (Pubitemid 43011289)
15. Cohen E, Bieschke J, Perciavalle RM, Kelly JW and Dillin A. Opposing activities protect against age-onset proteotoxicity. Science 313: 1604-1610 (2006). (Pubitemid 44414028)
16. Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW and Huang Y. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. J Neurosci 26: 4985-4994 (2006).
17. Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, et al. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci USA 100: 10966-10971 (2003). (Pubitemid 37140136)