-
3
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
-
4
-
-
79951713725
-
Apolipoprotein E in Alzheimer's disease and other neurological disorders
-
Verghese PB, Castellano JM, Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol 2011;10:241-252.
-
(2011)
Lancet Neurol
, vol.10
, pp. 241-252
-
-
Verghese, P.B.1
Castellano, J.M.2
Holtzman, D.M.3
-
5
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert JC, Heath S, Even G, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009;41:1094-1099.
-
(2009)
Nat Genet
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
-
6
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
-
Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009;41:1088-1093.
-
(2009)
Nat Genet
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
-
7
-
-
77952307991
-
Genome-wide analysis of genetic loci associated with Alzheimer disease
-
Seshadri S, Fitzpatrick AL, Ikram MA, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010;303:1832-1840.
-
(2010)
JAMA
, vol.303
, pp. 1832-1840
-
-
Seshadri, S.1
Fitzpatrick, A.L.2
Ikram, M.A.3
-
8
-
-
79955464911
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
-
Naj AC, Jun G, Beecham GW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011;43:436-441.
-
(2011)
Nat Genet
, vol.43
, pp. 436-441
-
-
Naj, A.C.1
Jun, G.2
Beecham, G.W.3
-
9
-
-
79955484414
-
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
-
Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011;43:429-435.
-
(2011)
Nat Genet
, vol.43
, pp. 429-435
-
-
Hollingworth, P.1
Harold, D.2
Sims, R.3
-
10
-
-
84872379077
-
Tracking pathophysiological processes in Alzheimer's disease: An updated hypothetical model of dynamic biomarkers
-
Jack CR Jr, Knopman DS, Jagust WJ, et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 2013;12:207-216.
-
(2013)
Lancet Neurol
, vol.12
, pp. 207-216
-
-
Jack, C.R.1
Knopman, D.S.2
Jagust, W.J.3
-
11
-
-
66349085616
-
Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
-
Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res 2009;50(suppl):S183-S188.
-
(2009)
J Lipid Res
, vol.50
, pp. S183-S188
-
-
Mahley, R.W.1
Weisgraber, K.H.2
Huang, Y.3
-
12
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
-
Cramer PE, Cirrito JR, Wesson DW, et al. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 2012;335:1503-1506.
-
(2012)
Science
, vol.335
, pp. 1503-1506
-
-
Cramer, P.E.1
Cirrito, J.R.2
Wesson, D.W.3
-
13
-
-
0001575895
-
Type III hyperlipoproteinemia (dysbetalipoproteinemia): The role of apolipoprotein E in normal and abnormal lipoprotein metabolism
-
Scriver CR, Beaudet AL, Sly WS, Valle D, eds. New York, NY: McGraw-Hill
-
th ed. New York, NY: McGraw-Hill, 2001:2835-2862.
-
(2001)
th Ed.
, pp. 2835-2862
-
-
Mahley, R.W.1
Rall, S.C.2
-
14
-
-
0017773790
-
Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
-
Utermann G, Hees M, Steinmetz A. Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man. Nature 1977;269:604-607.
-
(1977)
Nature
, vol.269
, pp. 604-607
-
-
Utermann, G.1
Hees, M.2
Steinmetz, A.3
-
15
-
-
0033748494
-
Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein E genotype
-
Frikke-Schmidt R, Nordestgaard BG, Agerholm-Larsen B, et al. Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein E genotype. J Lipid Res 2000;41:1812-1822.
-
(2000)
J Lipid Res
, vol.41
, pp. 1812-1822
-
-
Frikke-Schmidt, R.1
Nordestgaard, B.G.2
Agerholm-Larsen, B.3
-
16
-
-
0033835758
-
Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: The ApoEurope study
-
ApoEurope group
-
Siest G, Bertrand P, Qin B, et al. Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group. Clin Chem Lab Med 2000;38:721-730.
-
(2000)
Clin Chem Lab Med
, vol.38
, pp. 721-730
-
-
Siest, G.1
Bertrand, P.2
Qin, B.3
-
17
-
-
84867119124
-
Cerebrospinal fluid apoE levels: An endophenotype for genetic studies for Alzheimer's disease
-
Cruchaga C, Kauwe JS, Nowotny P, et al. Cerebrospinal fluid apoE levels: an endophenotype for genetic studies for Alzheimer's disease. Hum Mol Genet 2012;21:4558-4571.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 4558-4571
-
-
Cruchaga, C.1
Kauwe, J.S.2
Nowotny, P.3
-
18
-
-
44649140474
-
Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease
-
Frikke-Schmidt R, Nordestgaard BG, Stene MC, et al. Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA 2008;299:2524-2532.
-
(2008)
JAMA
, vol.299
, pp. 2524-2532
-
-
Frikke-Schmidt, R.1
Nordestgaard, B.G.2
Stene, M.C.3
-
19
-
-
55249087635
-
Genetically elevated C-reactive protein and ischemic vascular disease
-
Zacho J, Tybjaerg-Hansen A, Jensen JS, et al. Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med 2008;359:1897-1908.
-
(2008)
N Engl J Med
, vol.359
, pp. 1897-1908
-
-
Zacho, J.1
Tybjaerg-Hansen, A.2
Jensen, J.S.3
-
20
-
-
67049167090
-
Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
-
Kamstrup PR, Tybjaerg-Hansen A, Steffensen R, Nordestgaard BG. Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA 2009;301:2331-2339.
-
(2009)
JAMA
, vol.301
, pp. 2331-2339
-
-
Kamstrup, P.R.1
Tybjaerg-Hansen, A.2
Steffensen, R.3
Nordestgaard, B.G.4
-
21
-
-
0015348189
-
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
-
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
-
(1972)
Clin Chem
, vol.18
, pp. 499-502
-
-
Friedewald, W.T.1
Levy, R.I.2
Fredrickson, D.S.3
-
22
-
-
4544339875
-
Gender- and age-specific contributions of additional DNA sequence variation in the 5′ regulatory region of the APOE gene to prediction of measures of lipid metabolism
-
Frikke-Schmidt R, Sing CF, Nordestgaard BG, Tybjaerg-Hansen A. Gender- and age-specific contributions of additional DNA sequence variation in the 5′ regulatory region of the APOE gene to prediction of measures of lipid metabolism. Hum Genet 2004;115:331-345.
-
(2004)
Hum Genet
, vol.115
, pp. 331-345
-
-
Frikke-Schmidt, R.1
Sing, C.F.2
Nordestgaard, B.G.3
Tybjaerg-Hansen, A.4
-
23
-
-
13444269543
-
Haploview: Analysis and visualization of LD and haplotype maps
-
Barret JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265.
-
(2005)
Bioinformatics
, vol.21
, pp. 263-265
-
-
Barret, J.C.1
Fry, B.2
Maller, J.3
Daly, M.J.4
-
24
-
-
0033567222
-
Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies
-
Clarke R, Shipley M, Lewington S, et al. Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies. Am J Epidemiol 1999;150:341-353.
-
(1999)
Am J Epidemiol
, vol.150
, pp. 341-353
-
-
Clarke, R.1
Shipley, M.2
Lewington, S.3
-
25
-
-
85027942027
-
High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia
-
Vijayaraghavan S, Maetzler W, Reinmold M, et al. High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia. Alzheimers Dement 2014;10:530.e1-540.e1.
-
(2014)
Alzheimers Dement
, vol.10
, pp. 530.e1-540.e1
-
-
Vijayaraghavan, S.1
Maetzler, W.2
Reinmold, M.3
-
26
-
-
78650678688
-
Decreased clearance of CNS beta-amyloid in Alzheimer's disease
-
Mawuenyega KG, Sigurdson W, Ovod V, et al. Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science 2010;330:1774.
-
(2010)
Science
, vol.330
, pp. 1774
-
-
Mawuenyega, K.G.1
Sigurdson, W.2
Ovod, V.3
-
27
-
-
84866106602
-
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
-
Hu WT, Holtzman DM, Fagan AM, et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology 2012;79:897-905.
-
(2012)
Neurology
, vol.79
, pp. 897-905
-
-
Hu, W.T.1
Holtzman, D.M.2
Fagan, A.M.3
-
28
-
-
84867340530
-
Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease
-
Soares HD, Potter WZ, Pickering E, et al. Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease. Arch Neurol 2012;69:1310-1317.
-
(2012)
Arch Neurol
, vol.69
, pp. 1310-1317
-
-
Soares, H.D.1
Potter, W.Z.2
Pickering, E.3
-
29
-
-
84873178640
-
Blood and plasma-based proteomic biomarker research in Alzheimer's disease
-
Lista S, Faltraco F, Prvulovic D, Hampel H. Blood and plasma-based proteomic biomarker research in Alzheimer's disease. Prog Neurobiol 2013;101-102:1-17.
-
(2013)
Prog Neurobiol
, vol.101-102
, pp. 1-17
-
-
Lista, S.1
Faltraco, F.2
Prvulovic, D.3
Hampel, H.4
-
30
-
-
0030779128
-
Isoform-specific effects of apolipoprotein E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta
-
Martel CL, Mackic JB, Matsubara E, et al. Isoform-specific effects of apolipoprotein E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. J Neurochem 1997;69:1995-2004.
-
(1997)
J Neurochem
, vol.69
, pp. 1995-2004
-
-
Martel, C.L.1
Mackic, J.B.2
Matsubara, E.3
-
31
-
-
0025878638
-
Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation
-
Linton MF, Gish R, Hubl ST, et al. Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation. J Clin Invest 1991;88:270-281.
-
(1991)
J Clin Invest
, vol.88
, pp. 270-281
-
-
Linton, M.F.1
Gish, R.2
Hubl, S.T.3
-
32
-
-
0042691314
-
Differential metabolism of apoE isoforms in plasma and CSF
-
Wahrle SE, Holtzman DM. Differential metabolism of apoE isoforms in plasma and CSF. Exp Neurol 2003;183:4-6.
-
(2003)
Exp Neurol
, vol.183
, pp. 4-6
-
-
Wahrle, S.E.1
Holtzman, D.M.2
-
33
-
-
57449084208
-
apoE isoform-specific disruption of amyloid beta clearance from mouse brain
-
Deane R, Sagare A, Hamm K, et al. apoE isoform-specific disruption of amyloid beta clearance from mouse brain. J Clin Invest 2008;118:4002-4013.
-
(2008)
J Clin Invest
, vol.118
, pp. 4002-4013
-
-
Deane, R.1
Sagare, A.2
Hamm, K.3
-
34
-
-
77349123800
-
APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure
-
Bekris LM, Galloway NM, Montine TJ, et al. APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure. Am J Med Genet Part B 2010;153B:409-417.
-
(2010)
Am J Med Genet Part B
, vol.153 B
, pp. 409-417
-
-
Bekris, L.M.1
Galloway, N.M.2
Montine, T.J.3
-
35
-
-
3843140614
-
ADLAPH: A molecular haplotyping method based on allele-discriminating long-range PCR
-
Yu CE, Devlin B, Galloway N, et al. ADLAPH: A molecular haplotyping method based on allele-discriminating long-range PCR. Genomics 2004;84:600-612.
-
(2004)
Genomics
, vol.84
, pp. 600-612
-
-
Yu, C.E.1
Devlin, B.2
Galloway, N.3
-
36
-
-
34248142174
-
Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: Patterns of linkage disequilibrium and disease/marker association
-
Yu CE, Seltman H, Peskind ER, el al. Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association. Genomics 2007;89:655-665.
-
(2007)
Genomics
, vol.89
, pp. 655-665
-
-
Yu, C.E.1
Seltman, H.2
Peskind, E.R.3
-
37
-
-
0031278270
-
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
-
Bales KR, Verina T, Dodel RC, et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet 1997;17:263-264.
-
(1997)
Nat Genet
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
Verina, T.2
Dodel, R.C.3
-
38
-
-
0033593027
-
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
-
Bales KR, Verina T, Cummins DJ, et al. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 1999;96:15233-15238.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 15233-15238
-
-
Bales, K.R.1
Verina, T.2
Cummins, D.J.3
-
39
-
-
9144224765
-
ApoE and clusterin cooperatively suppress Abeta levels and deposition: Evidence that ApoE regulates extracellular Abeta metabolism in vivo
-
DeMattos RB, Cirrito JR, Parsadanian M, et al. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron 2004;41:193-202.
-
(2004)
Neuron
, vol.41
, pp. 193-202
-
-
DeMattos, R.B.1
Cirrito, J.R.2
Parsadanian, M.3
-
40
-
-
84861418194
-
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
-
Bell RD, Winkler EA, Singh I, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 2012;485:512-516.
-
(2012)
Nature
, vol.485
, pp. 512-516
-
-
Bell, R.D.1
Winkler, E.A.2
Singh, I.3
-
41
-
-
78649487239
-
Pericytes are required for blood-brain barrier integrity during embryogenesis
-
Daneman R, Zhou L, Kebede AA, Barres BA. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 2010;468:562-566.
-
(2010)
Nature
, vol.468
, pp. 562-566
-
-
Daneman, R.1
Zhou, L.2
Kebede, A.A.3
Barres, B.A.4
-
42
-
-
78649467527
-
Pericytes regulate the blood-brain barrier
-
Armulik A, Genove G, Mae M, et al. Pericytes regulate the blood-brain barrier. Nature 2010;468:557-561.
-
(2010)
Nature
, vol.468
, pp. 557-561
-
-
Armulik, A.1
Genove, G.2
Mae, M.3
-
43
-
-
81555200043
-
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
-
Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 2011;12:723-738.
-
(2011)
Nat Rev Neurosci
, vol.12
, pp. 723-738
-
-
Zlokovic, B.V.1
-
44
-
-
84869217993
-
Total ApoE and ApoE4 isoform assay in an Alzheimer's disease case-control study by targeted mass spectrometry (n = 669): A pilot assay for methionine-containing proteotypic peptides
-
Simon R, Girod M, Fonbonne C, et al. Total ApoE and ApoE4 isoform assay in an Alzheimer's disease case-control study by targeted mass spectrometry (n = 669): a pilot assay for methionine-containing proteotypic peptides. Mol Cell Proteomics 2012;11:1389-1403.
-
(2012)
Mol Cell Proteomics
, vol.11
, pp. 1389-1403
-
-
Simon, R.1
Girod, M.2
Fonbonne, C.3
-
45
-
-
84876297937
-
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
-
Ulrich JD, Burchett JM, Restivo JL, et al. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Mol Neurodegener 2013;8:13.
-
(2013)
Mol Neurodegener
, vol.8
, pp. 13
-
-
Ulrich, J.D.1
Burchett, J.M.2
Restivo, J.L.3
|