Hippocampal volume differences between healthy young apolipoprotein e ε2 and ε4 carriers

Journal of Alzheimer's Disease

Volumn 26, Issue 2, 2011, Pages 207-210

  Alexopoulos, Panagiotis ^a   Richter Schmidinger, Tanja ^a   Horn, Marco ^a   Maus, Sebastian ^a   Reichel, Martin ^a   Sidiropoulos, Christos ^a,b   Rhein, Cosima ^a   Lewczuk, Piotr ^a   Doerfler, Arnd ^c   Kornhuber, Johannes ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b HENRY FORD HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

apolipoprotein E; hippocampal volume; memory function; young healthy individuals

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E4;

ADULT; ADULTHOOD; ALLELE; ALZHEIMER DISEASE; ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENETIC ASSOCIATION; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MEMORY; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 80052821751     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110356     Document Type: Article

References (20)

1. Cherbuin N, Leach LS, Christensen H, Anstey KJ (2007) Neuroimaging and APOE genotype: a systematic qualitative review. Dement Geriatr Cogn Disord 24, 348-362. (Pubitemid 350036691)
2. Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H (2010) APOE epsilon2 alleleis associated with larger regional cortical thicknesses and volumes. Dement Geriatr Cogn Disord 30, 229-237.
3. Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S (1993) Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342, 697-699. (Pubitemid 23279761)
4. Savitz J, Solms M, Ramesar R (2006) Apolipoprotein E variants and cognition in healthy individuals: a critical opinion. Brain Res Rev 51, 125-135. (Pubitemid 43782534)
5. Richter-Schmidinger T, Alexopoulos P, Horn M, Maus S, Reichel M, Rhein C, Lewczuk P, Sidiropoulos C, Kneib T, Perneczky R, Doerfler A, Kornhuber J (2011) I Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults. J Neural Transm 118, 249-257.
6. Minati L, Edginton T, Bruzzone MG, Giaccone G (2009) Current concepts in Alzheimer's disease: a multidisciplinary review. Am J Alzheimers Dis Other Demen 24, 95-121.
7. Pantel J, O'Leary DS, Cretsinger K, Bockholt HJ, Keefe H, Magnotta VA, Andreasen NC (2000) A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus 10, 752-758.
8. Baller G, Brand, M., Kalbe, E., KEssler, J. (2006) IGD. Inven-tar zur Gedächtnisdiagnostik., Hofgrefe Verlag GmbH & Co. KG, Göttingen, Bern, Wien, Toronto, Seattle, Oxford, Prag.
9. Hixson JE, Vernier DT (1990) Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 31, 545-548. (Pubitemid 20107994)
10. Lewczuk P, Kornhuber J, Vanderstichele H, Vanmechelen E, Esselmann H, Bibl M, Wolf S, Otto M, Reulbach U, Kolsch H, Jessen F, Schroder J, Schonknecht P, Hampel H, Peters O, Weimer E, Perneczky R, Jahn H, Luckhaus C, Lamla U, Supprian T, Maler JM, Wiltfang J (2008) Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study. Neurobiol Aging 29, 812-818. (Pubitemid 351601894)
11. Shaw P, Lerch JP, Pruessner JC, Taylor KN, Rose AB, Green-stein D, Clasen L, Evans A, Rapoport JL, Giedd JN (2007) Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study. Lancet Neurol 6, 494-500. (Pubitemid 46734757)
12. Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, Weeber EJ, Turner RS, Xu B, Rebeck GW, Hoe HS (2009) ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. J Neurosci 29, 15317-15322.
13. Kharrazi H, Vaisi-Raygani A, Rahimi Z, Tavilani H, Aminian M, Pourmotabbed T (2008) Association between enzymatic and non-enzymatic antioxidant defense mechanism with apolipoprotein E genotypes in Alzheimer disease. Clin Biochem 41, 932-936.
14. Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J (2004) Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc Natl Acad Sci USA 101, 284-289. (Pubitemid 38084242)
15. Heise V, Filippini N, Ebmeier KP, Mackay CE (2010) The APOE varepsilon4 allele modulates brain white matter integrity in healthy adults. Mol Psychiatry, doi:10.1038/mp.2010.90.
16. Scarmeas N, Habeck CG, Hilton J, Anderson KE, Flynn J, Park A, Stern Y (2005) APOE related alterations in cerebral activation even at college age. J Neurol Neurosurg Psychiatry 76, 1440-1444. (Pubitemid 41360988)
17. Valla J, Yaari R, Wolf AB, Kusne Y, Beach TG, Roher AE, Corneveaux JJ, Huentelman MJ, Caselli RJ, Reiman EM (2010) Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE epsilon4 allele, the major late-onset Alzheimer's susceptibility gene. J Alzheimers Dis 22, 307-313.
18. Hedden T, Gabrieli JD (2004) Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci 5, 87-96. (Pubitemid 38160284)
19. Perneczky R, Alexopoulos P, Schmid G, Sorg C, Forstl H, Diehl-Schmid J, Kurz A (2011) [Cognitive reserve and its relevance for the prevention and diagnosis of dementia.]. Ner-venarzt 82, 325-335.
20. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Jack CR, Jr., Aisen PS, Petersen RC, Weiner MW (2010) Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects. Neurology 75, 1976-1981.